| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miriam Ryvicker, Yolanda Barrón, Jiyoun Song, Maryam Zolnoori, Shivani Shah, Julia G Burgdorf, James M Noble, Maxim Topa. Using Natural Language Processing to Identify Home Health Care Patients at Risk for Diagnosis of Alzheimer's Disease and Related Dementias. Journal of applied gerontology : the official journal of the Southern Gerontological Society. 2024-04-01. PMID:38556756. |
this study aimed to: (1) validate a natural language processing (nlp) system developed for the home health care setting to identify signs and symptoms of alzheimer's disease and related dementias (adrd) documented in clinicians' free-text notes; (2) determine whether signs and symptoms detected via nlp help to identify patients at risk of a new adrd diagnosis within four years after admission. |
2024-04-01 |
2024-04-03 |
Not clear |
| Sarah Buchholz, Hans Zempe. The six brain-specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-04-01. PMID:38556838. |
the six brain-specific tau isoforms and their role in alzheimer's disease and related neurodegenerative dementia syndromes. |
2024-04-01 |
2024-04-03 |
human |
| Irene Cumplido-Mayoral, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Armand González-Escalante, Federica Anastasi, Marta Milà-Alomà, David López-Martos, Muge Akinci, Carles Falcón, Mahnaz Shekari, Raffaele Cacciaglia, Eider M Arenaza-Urquijo, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Marc Suárez-Calvet, Oriol Grau-Rivera, Verónica Vilaplana, Juan Domingo Gisper. The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study. The lancet. Healthy longevity. vol 5. issue 4. 2024-03-31. PMID:38555920. |
we aimed to assess the mediating role of brain-age delta in the association between modifiable risk factors of dementia and longitudinal cognitive decline in middle-aged and older individuals who are asymptomatic, stratified by alzheimer's disease pathology. |
2024-03-31 |
2024-04-03 |
Not clear |
| Geidy E Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P Cline, Natalie Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia I Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beac. Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542104. |
alzheimer's disease dementia (add) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, both of which are brain areas associated with memory and cognition. |
2024-03-28 |
2024-03-30 |
human |
| Geidy E Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P Cline, Natalie Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia I Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beac. Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542104. |
protein was extracted from the cingulate gyrus, hippocampus, frontal, primary visual, and entorhinal cortex from cognitively unimpaired controls, subjects with mild cognitive impairment (mci), and subjects with dementia that have different levels of alzheimer's pathology. |
2024-03-28 |
2024-03-30 |
human |
| Francesca Biagioni, Michela Ferrucci, Gloria Lazzeri, Mariarosaria Scioli, Alessandro Frati, Stefano Puglisi-Allegra, Francesco Forna. Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration. International journal of molecular sciences. vol 25. issue 6. 2024-03-28. PMID:38542133. |
the present investigation was designed based on the evidence that, in neurodegenerative disorders, such as alzheimer's dementia (ad) and parkinson's disease (pd), damage to the locus coeruleus (lc) arising norepinephrine (ne) axons (lc-ne) is documented and hypothesized to foster the onset and progression of neurodegeneration within target regions. |
2024-03-28 |
2024-03-30 |
mouse |
| Anli A Liu, William B Bar. Overlapping and distinct phenotypic profiles in Alzheimer's disease and late onset epilepsy: a biologically-based approach. Frontiers in neurology. vol 14. 2024-03-28. PMID:38545454. |
due to shared hippocampal dysfunction, patients with alzheimer's dementia and late-onset epilepsy (loe) report memory decline. |
2024-03-28 |
2024-03-30 |
Not clear |
| Rita Ferreira, António J Bastos-Leit. Arterial spin labelling magnetic resonance imaging and perfusion patterns in neurocognitive and other mental disorders: a systematic review. Neuroradiology. 2024-03-27. PMID:38536448. |
the studies were published between 2011 and 2023 and included participants with subjective cognitive decline plus; neurocognitive disorders, including mild cognitive impairment (mci), alzheimer's disease (ad), frontotemporal lobar degeneration (ftld), dementia with lewy bodies (dlb) and vascular cognitive impairment (vci); as well as schizophrenia spectrum disorders, bipolar and major depressive disorders, autism spectrum disorder, attention-deficit/hyperactivity disorder, panic disorder and alcohol use disorder. |
2024-03-27 |
2024-03-30 |
human |
| Kushagra Nagori, Madhulika Pradhan, Mukesh Sharma, Ajazuddin, Hemant R Badwaik, Kartik T Nakhat. Current Progress on Central Cholinergic Receptors as Therapeutic Targets for Alzheimer's Disease. Current Alzheimer research. 2024-03-26. PMID:38529600. |
therefore, the cholinergic system has been of prime focus when concerned with alzheimer's disease (ad), the most common cause of dementia. |
2024-03-26 |
2024-03-28 |
Not clear |
| Lianne M Reus, Iris E Jansen, Betty M Tijms, Pieter Jelle Visser, Niccoló Tesi, Sven J van der Lee, Lisa Vermunt, Carel F W Peeters, Lisa A De Groot, Yanaika S Hok-A-Hin, Alice Chen-Plotkin, David J Irwin, William T Hu, Lieke H Meeter, John C van Swieten, Henne Holstege, Marc Hulsman, Afina W Lemstra, Yolande A L Pijnenburg, Wiesje M van der Flier, Charlotte E Teunissen, Marta Del Campo Mila. Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia. Brain : a journal of neurology. 2024-03-25. PMID:38527854. |
we tested to what extent effects of known dementia risk loci can be observed in csf levels of 665 proteins (proximity extension-based (pea) immunoassays) in a deeply-phenotyped mixed-memory clinic cohort (n=502, mean age (sd) = 64.1 [8.7] years, 181 female [35.4%]), including patients with alzheimer's disease (ad, n=213), dementia with lewy bodies (dlb, n=50) and frontotemporal dementia (ftd, n=93), and controls (n=146). |
2024-03-25 |
2024-03-28 |
Not clear |
| Jinmyoung Cho, Laura P Sands, Alan B Stevens, Heather G Allore, Molly J Horstma. Profile of Caregiving Activities and Association With Physical Health Among Dementia Spousal Caregivers. Innovation in aging. vol 8. issue 3. 2024-03-25. PMID:38524243. |
this study aims to identify patterns of caregiving intensity and assess associations between caregiving intensity and multidimensional physical health indicators and health behaviors among spousal caregivers of persons with alzheimer's disease and related dementia. |
2024-03-25 |
2024-03-27 |
Not clear |
| Paul Armstrong, Hüseyin Güngör, Pariya Anongjanya, Clare Tweedy, Edward Parkin, Jamie Johnston, Ian M Carr, Neil Dawson, Steven J Clapcot. Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-03-24. PMID:38521860. |
meta-analysis of genome-wide association study data has implicated pde4b in the pathogenesis of alzheimer's disease (ad), the leading cause of senile dementia. |
2024-03-24 |
2024-03-26 |
mouse |
| Heather E Dark, Michael R Duggan, Keenan A Walke. Plasma biomarkers for Alzheimer's and related dementias: A review and outlook for clinical neuropsychology. Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists. 2024-03-23. PMID:38520383. |
whereas plasma nfl has shown promise as a non-specific marker of neuronal injury, plasma ptau181, ptau217, ptau231, and gfap have demonstrated desirable levels of sensitivity and specificity for identification of individuals with alzheimer's disease pathology and alzheimer's dementia. |
2024-03-23 |
2024-03-26 |
Not clear |
| Yitong Ling, Shiqi Yuan, Xiaxuan Huang, Shanyuan Tan, Hongtao Cheng, Anding Xu, Jun Ly. Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 79. issue 4. 2024-03-22. PMID:38029284. |
cox proportional hazards models were used to assess the associations between folate/folic acid supplementation status and the risk of alzheimer's disease (ad) and vascular dementia (vd). |
2024-03-22 |
2024-03-24 |
human |
| Malin Aspö, Maria Sundell, Myroslava Protsiv, Fleur Wiggenraad, Marie Rydén, Francesca Mangialasche, Miia Kivipelto, Leonie N C Visse. The expectations and experiences of patients regarding the diagnostic workup at a specialized memory clinic: An interview study. Health expectations : an international journal of public participation in health care and health policy. vol 27. issue 2. 2024-03-22. PMID:38515262. |
because of the shift towards earlier diagnosis of dementia and/or alzheimer's disease (ad), increasing numbers of individuals with subjective cognitive decline (scd) and mild cognitive impairment (mci) are seen in memory clinics. |
2024-03-22 |
2024-03-24 |
Not clear |
| Mengxue Zhang, Yanjie Qu, Qian Li, Chao Gu, Limin Zhang, Hongxu Chen, Minrui Ding, Tong Zhang, Rongrong Zhen, Hongmei A. Correlation Between Prefrontal Functional Connectivity and the Degree of Cognitive Impairment in Alzheimer's Disease: A Functional Near-Infrared Spectroscopy Study. Journal of Alzheimer's disease : JAD. 2024-03-22. PMID:38517784. |
the development of alzheimer's disease (ad) can be divided into subjective cognitive decline (scd), mild cognitive impairment (mci), and dementia. |
2024-03-22 |
2024-03-25 |
Not clear |
| Chaofan Geng, Leilei Tan, Chenche. Neuropsychiatric symptoms profile and markers of Alzheimer disease-type pathology in patients with Lewy body dementias. Brain research. 2024-03-22. PMID:38519009. |
to determine whether lewy body dementia (lbd) patients with likely copathology of alzheimer's disease (ad) exhibit greater neuropsychiatric symptom (nps) compared to those without likely ad-type copathology. |
2024-03-22 |
2024-03-25 |
Not clear |
| Sharon E Bigger, Robin Ann Foreman, Christiana Keinath, Gail L Towsle. Transitions between skilled home health and hospice for persons living with dementia: a systematic review of literature. Annals of palliative medicine. 2024-03-21. PMID:38509644. |
in the united states (us), nearly one third of skilled home health (hh) patients and nearly one half of hospice patients have diagnoses of alzheimer's disease and related dementias (adrd), conditions often characterized by a slow decline in cognition and function. |
2024-03-21 |
2024-03-23 |
Not clear |
| Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medin. Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions. eLife. vol 12. 2024-03-21. PMID:38512130. |
by unifying spatial gene expression, structural mri, and cell deconvolution, here we describe how the human brain distribution of canonical cell types extensively predicts tissue damage in 13 neurodegenerative conditions, including early- and late-onset alzheimer's disease, parkinson's disease, dementia with lewy bodies, amyotrophic lateral sclerosis, mutations in presenilin-1, and 3 clinical variants of frontotemporal lobar degeneration (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat and four-repeat tauopathies and tdp43 proteinopathies types a and c. we reconstructed comprehensive whole-brain reference maps of cellular abundance for six major cell types and identified characteristic axes of spatial overlapping with atrophy. |
2024-03-21 |
2024-03-23 |
human |
| Debomoy K Lahiri, Deborah K Soko. Alzheimer's Drugs APPlication for Down syndrome? Ageing research reviews. 2024-03-21. PMID:38513771. |
accumulation of the amyloid β (aβ) peptide, derived from aβ precursor protein (app), is a trait of down syndrome (ds), as is early development of dementia like alzheimer's disease (ad). |
2024-03-21 |
2024-03-24 |
human |