All Relations between Alzheimer Disease and conditioned response

Publication Sentence Publish Date Extraction Date Species
A Oohira, Y Kushima, F Matsui, E Watanab. Detection of Alzheimer's beta-amyloid precursor related proteins bearing chondroitin sulfate both in the juvenile rat brain and in the conditioned medium of primary cultured astrocytes. Neuroscience letters. vol 189. issue 1. 1995-08-10. PMID:7603617. alzheimer's beta-amyloid precursor related proteins bearing chondroitin sulfate chains were detected in the conditioned media of primary cultured astrocytes obtained from fetal rat brains by western blotting using the monoclonal antibody 22c11 against alzheimer's beta-amyloid precursor protein (app), but not in the media of cortical neurons. 1995-08-10 2023-08-12 rat
D L Alko. Molecular mechanisms of associative memory and their clinical implications. Behavioural brain research. vol 66. issue 1-2. 1995-06-29. PMID:7538770. based on this hypothesis, the first element of our research strategy was to (1) identify fundamental network architectures that learn and remember simple associative relationships such as those of pavlovian conditioned responses; (2) demonstrate that the network biophysical and biochemical mechanisms of associative learning and memory in fundamental network architectures are conserved across species as diverse as those of snails, rabbits, and other mammals; (3) demonstrate that conserved memory mechanisms are targets of pathologic involvement in a human disease characterized by memory loss such as early alzheimer's disease; (4) and derive mathematical and logical descriptions of the functions of biological associative network architectures during learning and memory. 1995-06-29 2023-08-12 human
N Suzuki, T T Cheung, X D Cai, A Odaka, L Otvos, C Eckman, T E Golde, S G Younki. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (New York, N.Y.). vol 264. issue 5163. 1994-06-22. PMID:8191290. human neuroblastoma (m17) cells transfected with constructs expressing wild-type beta app or the beta app717 mutants linked to familial alzheimer's disease were compared by (i) isolation of metabolically labeled 4-kilodalton a beta from conditioned medium, digestion with cyanogen bromide, and analysis of the carboxyl-terminal peptides released, or (ii) analysis of the a beta in conditioned medium with sandwich enzyme-linked immunosorbent assays that discriminate a beta 1-40 from the longer a beta 1-42. 1994-06-22 2023-08-12 human
T Itakura, M Umemoto, I Kamei, H Imai, H Yokote, S Yukawa, N Koma. Autotransplantation of peripheral cholinergic neurons into the brains of Alzheimer model rats. Acta neurochirurgica. vol 115. issue 3-4. 1992-07-15. PMID:1605081. all of the control rats showed conditioned passive avoidance responses, while only one alzheimer model rat retained is shocked-conditions behaviour before 24 hours (p less than 0.01). 1992-07-15 2023-08-11 rat
J P Anderson, F S Esch, P S Keim, K Sambamurti, I Lieberburg, N K Robaki. Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells. Neuroscience letters. vol 128. issue 1. 1991-11-05. PMID:1922940. we have identified the secretory cleavage site in the alzheimer amyloid precursor (app) in a non-transfected neuronal cell line, using cyanogen bromide digests of app purified from medium conditioned by pc-12 cells which were differentiated to a neuronal phenotype. 1991-11-05 2023-08-11 Not clear
C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. hippocampal neurons from 18- to 19-day-old embryos were maintained in medium conditioned by skin fibroblasts from young, aged or alzheimer donors. 1990-08-01 2023-08-11 Not clear
C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and alzheimer donors. 1990-08-01 2023-08-11 Not clear
C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. sub-confluent cultures of cells from normal young, aged and alzheimer donors conditioned serum-free medium for 2 days. 1990-08-01 2023-08-11 Not clear
C Peterson, C W Cotma. Decreased survival of hippocampal neurons in medium conditioned by fibroblasts from aged and Alzheimer donors. Brain research. vol 515. issue 1-2. 1990-08-01. PMID:2357575. neuron survival four days after plating was found to be the highest in medium conditioned by young greater than aged greater than alzheimer cells. 1990-08-01 2023-08-11 Not clear
P R Solomon, M F Beal, W W Pendlebur. Age-related disruption of classical conditioning: a model systems approach to memory disorders. Neurobiology of aging. vol 9. issue 5-6. 1989-02-16. PMID:3062464. our strategy for using the conditioned eyeblink preparation for studying age-related memory deficits is four-fold and includes investigating conditioning deficits in: (1) humans across the life span, (2) rabbits across the life span, (3) alzheimer's disease patients, and (4) rabbits with aluminum-induced neurofibrillary degeneration. 1989-02-16 2023-08-11 rabbit
P R Solomon, W W Pendlebur. A model systems approach to age-related memory disorders. Neurotoxicology. vol 9. issue 3. 1989-01-19. PMID:3059245. our strategy for using the conditioned eyeblink preparation for studying age-related memory deficits is fourfold and includes investigating conditioning deficits in: (1) humans across the life-span, (2) rabbits across the life-span, (3) alzheimer's disease patients, and (4) rabbits with aluminum-induced neurofibrillary degeneration. 1989-01-19 2023-08-11 rabbit
J A Kessle. Deficiency of a cholinergic differentiating factor in fibroblasts of patients with Alzheimer's disease. Annals of neurology. vol 21. issue 1. 1987-04-15. PMID:3827219. in contrast, medium conditioned by alzheimer fibroblasts induced only about one-third as much cat activity, a highly significant reduction (p less than 0.01). 1987-04-15 2023-08-11 human