| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhengyun Han, Xingmao Yang, Shuiqing Huan. Sleep deprivation: A risk factor for the pathogenesis and progression of Alzheimer's disease. Heliyon. vol 10. issue 7. 2024-04-16. PMID:38623196. |
sleep deprivation promotes aβ deposition and tau hyperphosphorylation, which is a risk factor for the pathogenesis and progression of alzheimer's disease (ad). |
2024-04-16 |
2024-04-18 |
Not clear |
| Subha Kalyaanamoorthy, Stanley Kojo Opare, Xiaoxiao Xu, Aravindhan Ganesan, Praveen P N Ra. Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology. Current Alzheimer research. 2024-04-16. PMID:38623984. |
post-translational modifications in tau and their roles in alzheimer's pathology. |
2024-04-16 |
2024-04-18 |
Not clear |
| Subha Kalyaanamoorthy, Stanley Kojo Opare, Xiaoxiao Xu, Aravindhan Ganesan, Praveen P N Ra. Post-Translational Modifications in Tau and Their Roles in Alzheimer's Pathology. Current Alzheimer research. 2024-04-16. PMID:38623984. |
microtubule-associated protein tau (also known as tau) has been shown to accumulate into paired helical filaments and neurofibrillary tangles, which are known hallmarks of alzheimer's disease (ad) pathology. |
2024-04-16 |
2024-04-18 |
Not clear |
| Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condell. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617229. |
cryo-em structures reveal tau filaments from down syndrome adopt alzheimer's disease fold. |
2024-04-15 |
2024-04-17 |
Not clear |
| Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Suyeon Ju, R Todd Constable, Carolyn Frederick. Whole-brain functional connectivity predicts groupwise and sex-specific tau PET in preclincal Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617320. |
whole-brain functional connectivity predicts groupwise and sex-specific tau pet in preclincal alzheimer's disease. |
2024-04-15 |
2024-04-17 |
Not clear |
| Hamid Abuwarda, Anne Trainer, Corey Horien, Xilin Shen, Suyeon Ju, R Todd Constable, Carolyn Frederick. Whole-brain functional connectivity predicts groupwise and sex-specific tau PET in preclincal Alzheimer's disease. bioRxiv : the preprint server for biology. 2024-04-15. PMID:38617320. |
preclinical alzheimer's disease, characterized by the initial accumulation of amyloid and tau pathologies without symptoms, presents a critical opportunity for early intervention. |
2024-04-15 |
2024-04-17 |
Not clear |
| Xiyong Xiang, Siyu Xia, Shan Li, Yirong Zeng, Lixuan Wang, Yan Zho. Study on the role and mechanism of Tan IIA in Alzheimer's disease based on CREB-BDNF-TrkB pathway. Neuroscience letters. 2024-04-14. PMID:38616003. |
the occurrence and development of alzheimer's disease (ad) is closely related to neuronal loss, inflammatory response, cholinergic imbalance, and tau protein hyperphosphorylation. |
2024-04-14 |
2024-04-17 |
rat |
| Peter T Nelson, David W Fardo, Xian Wu, Khine Zin Aung, Matthew D Cykowski, Yuriko Katsumat. Limbic-predominant age-related TDP-43 encephalopathy (LATE-NC): Co-pathologies and genetic risk factors provide clues about pathogenesis. Journal of neuropathology and experimental neurology. 2024-04-13. PMID:38613823. |
although "pure" late-nc is not rare, late-nc often coexists in the same brains with alzheimer disease neuropathologic change, brain arteriolosclerosis, hippocampal sclerosis of aging, and/or age-related tau astrogliopathy (artag). |
2024-04-13 |
2024-04-16 |
human |
| Helena Colvee-Martin, Juan Rayo Parra, Gabriel Antonio Gonzalez, Warren Barker, Ranjan Duar. Neuropathology, Neuroimaging, and Fluid Biomarkers in Alzheimer's Disease. Diagnostics (Basel, Switzerland). vol 14. issue 7. 2024-04-13. PMID:38611617. |
the known hallmarks of alzheimer's disease include amyloid-β plaques and neurofibrillary tau tangles. |
2024-04-13 |
2024-04-15 |
Not clear |
| Helena Colvee-Martin, Juan Rayo Parra, Gabriel Antonio Gonzalez, Warren Barker, Ranjan Duar. Neuropathology, Neuroimaging, and Fluid Biomarkers in Alzheimer's Disease. Diagnostics (Basel, Switzerland). vol 14. issue 7. 2024-04-13. PMID:38611617. |
it is now clear that an imbalance between production and clearance of the amyloid beta protein and related aβ peptides, especially aβ42, is a very early, initiating factor in alzheimer's disease (ad) pathogenesis, leading to aggregates of hyperphosphorylation and misfolded tau protein, inflammation, and neurodegeneration. |
2024-04-13 |
2024-04-15 |
Not clear |
| Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R Harrington, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model. Cells. vol 13. issue 7. 2024-04-12. PMID:38607082. |
basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of alzheimer's disease (ad). |
2024-04-12 |
2024-04-14 |
mouse |
| Liara Rizzi, Lea T Grinber. Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-04-12. PMID:38610041. |
publisher correction: exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-04-12 |
2024-04-15 |
Not clear |
| Jacob Ziontz, Theresa M Harrison, Xi Chen, Joseph Giorgio, Jenna N Adams, Zehao Wang, William Jagus. Behaviorally meaningful functional networks mediate the effect of Alzheimer's pathology on cognition. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 4. 2024-04-11. PMID:38602736. |
tau pathology is associated with cognitive impairment in both aging and alzheimer's disease, but the functional and structural bases of this relationship remain unclear. |
2024-04-11 |
2024-04-13 |
Not clear |
| Motonobu Fujishima, Yohei Kawasaki, Toshiharu Mitsuhashi, Hiroshi Matsud. Impact of amyloid and tau positivity on longitudinal brain atrophy in cognitively normal individuals. Alzheimer's research & therapy. vol 16. issue 1. 2024-04-10. PMID:38600602. |
individuals on the preclinical alzheimer's continuum, particularly those with both amyloid and tau positivity (a + t +), display a rapid cognitive decline and elevated disease progression risk. |
2024-04-10 |
2024-04-13 |
Not clear |
| Ann-Charlotte Granholm, Eric D Hamlet. The Role of Tau Pathology in Alzheimer's Disease and Down Syndrome. Journal of clinical medicine. vol 13. issue 5. 2024-04-09. PMID:38592182. |
the role of tau pathology in alzheimer's disease and down syndrome. |
2024-04-09 |
2024-04-11 |
Not clear |
| Tim Bathe, Gabriela P Hery, Jonathan A B Villareal, Jennifer L Phillips, Eric M Cohen, Rohan V Sharma, Wangchen Tsering, Stefan Proko. Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies. Acta neuropathologica communications. vol 12. issue 1. 2024-04-08. PMID:38581050. |
to better characterize the interplay between different extracellular and intracellular protein pathologies and the brain's intrinsic immune system in nd, we set out to comprehensively profile the local immune response in postmortem brain samples of individuals with "pure" beta-amyloid and tau pathology (ad), "pure" α-synuclein pathology in lewy body diseases (lbd), as well as cases with alzheimer's disease neuropathological changes (adnc) and lewy body pathology (mix). |
2024-04-08 |
2024-04-10 |
human |
| Ke Hou, Peng Ge, Michael R Sawaya, Joshua L Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon, David S Eisenber. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585812. |
how short peptides can disassemble ultra-stable tau fibrils extracted from alzheimer's disease brain by a strain-relief mechanism. |
2024-04-08 |
2024-04-10 |
Not clear |
| Ke Hou, Peng Ge, Michael R Sawaya, Joshua L Dolinsky, Yuan Yang, Yi Xiao Jiang, Liisa Lutter, David R Boyer, Xinyi Cheng, Justin Pi, Jeffrey Zhang, Jiahui Lu, Shixin Yang, Zhiheng Yu, Juli Feigon, David S Eisenber. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer's disease brain by a strain-relief mechanism. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585812. |
reducing fibrous aggregates of protein tau is a possible strategy for halting progression of alzheimer's disease (ad). |
2024-04-08 |
2024-04-10 |
Not clear |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
to comprehensively investigate the common and unique protein interactors associated with the variety of tau lesions present across different human tauopathies, alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp), were selected to represent the major tauopathy diseases. |
2024-04-08 |
2024-04-10 |
human |
| Kira Breunig, Xiufen Lei, Mauro Montalbano, Gabriela D A Guardia, Shiva Ostadrahimi, Victoria Alers, Adam Kosti, Jennifer Chiou, Nicole Klein, Corina Vinarov, Lily Wang, Mujia Li, Weidan Song, W Lee Kraus, David S Libich, Stefano Tiziani, Susan T Weintraub, Pedro A F Galante, Luiz O F Penalv. SERBP1 interacts with PARP1 and is present in PARylation-dependent protein complexes regulating splicing, cell division, and ribosome biogenesis. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585848. |
we uncovered novel serbp1 roles in splicing, cell division, and ribosomal biogenesis and showed its participation in pathological stress granules and tau aggregates in alzheimer's disease brains. |
2024-04-08 |
2024-04-10 |
Not clear |