All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Benjamin C Creekmore, Kathryn Kixmoeller, Ben E Black, Edward B Lee, Yi-Wei Chan. Ultrastructure of human brain tissue vitrified from autopsy revealed by cryo-ET with cryo-plasma FIB milling. Nature communications. vol 15. issue 1. 2024-03-27. PMID:38531877. lamellae generated in alzheimer's disease brain tissue reveal intact subcellular structures including components of autophagy and potential pathologic tau fibrils. 2024-03-27 2024-03-29 human
Soheil Saghafi, Timothy Rumbell, Viatcheslav Gurev, James Kozloski, Francesco Tamagnini, Kyle C A Wedgwood, Casey O Diekma. Inferring Parameters of Pyramidal Neuron Excitability in Mouse Models of Alzheimer's Disease Using Biophysical Modeling and Deep Learning. Bulletin of mathematical biology. vol 86. issue 5. 2024-03-26. PMID:38528167. alzheimer's disease (ad) is believed to occur when abnormal amounts of the proteins amyloid beta and tau aggregate in the brain, resulting in a progressive loss of neuronal function. 2024-03-26 2024-03-28 mouse
Nickolay K Isaev, Elizaveta E Genrikhs, Elena V Stelmashoo. Methylene blue and its potential in the treatment of traumatic brain injury, brain ischemia, and Alzheimer's disease. Reviews in the neurosciences. 2024-03-26. PMID:38530227. in this case, the long-term neurodegeneration of the brain is similar to the neurodegeneration characteristic of alzheimer's disease (ad) and is associated with the accumulation of beta amyloid and tau protein. 2024-03-26 2024-03-28 Not clear
Gourav Singh, Gauri Shankar, Samir Ranjan Panda, Sunil Kumar, Sanskriti Rai, Himanshu Verma, Prabhat Kumar, Prasanta Kumar Nayak, V G M Naidu, Saripella Srikrishna, Saroj Kumar, Gyan Mod. Design, Synthesis, and Biological Evaluation of Ferulic Acid Template-Based Novel Multifunctional Ligands Targeting NLRP3 Inflammasome for the Management of Alzheimer's Disease. ACS chemical neuroscience. 2024-03-25. PMID:38525886. alzheimer's disease (ad) is the most common cause of dementia, which arises due to low levels of acetyl and butyrylcholines, an increase in oxidative stress, inflammation, metal dyshomeostasis, aβ and tau aggregations. 2024-03-25 2024-03-27 Not clear
Przemysław R Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay R Varma, Nicholas J Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Tammaryn Lashley, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K Karikar. Plasma p-tau212 antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology. Nature communications. vol 15. issue 1. 2024-03-24. PMID:38521766. blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with alzheimer's disease (ad) neuropathologic change and clinical stage. 2024-03-24 2024-03-26 human
Dorothea Böken, Dezerae Cox, Melanie Burke, Jeff Y L Lam, Taxiarchis Katsinelos, John S Danial, Emre Fertan, William A McEwan, James B Rowe, David Klenerma. Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples. Angewandte Chemie (International ed. in English). 2024-03-24. PMID:38523073. single-molecule characterization and super-resolution imaging of alzheimer's disease-relevant tau aggregates in human samples. 2024-03-24 2024-03-27 human
Dorothea Böken, Dezerae Cox, Melanie Burke, Jeff Y L Lam, Taxiarchis Katsinelos, John S Danial, Emre Fertan, William A McEwan, James B Rowe, David Klenerma. Single-Molecule Characterization and Super-Resolution Imaging of Alzheimer's Disease-Relevant Tau Aggregates in Human Samples. Angewandte Chemie (International ed. in English). 2024-03-24. PMID:38523073. hyperphosphorylation and aggregation of the protein tau play key roles in the development of alzheimer's disease (ad). 2024-03-24 2024-03-27 human
Tohidul Islam, Hlin Kvartsberg, Anuradha Sehrawat, Przemysław R Kac, Bruno Becker, Maria Olsson, Eric E Abrahamson, Henrik Zetterberg, Milos D Ikonomovic, Kaj Blennow, Thomas K Karikar. Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble aggregates. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-03-23. PMID:38520322. tau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of alzheimer's disease (ad) and related disorders. 2024-03-23 2024-03-26 Not clear
Takuya Oshima, Mandy S J Kater, Christiaan F M Huffels, Evelyn M Wesseling, Jinte Middeldorp, Elly M Hol, Mark H G Verheijen, August B Smit, Erik W G M Boddeke, Bart J L Egge. Early amyloid-induced changes in microglia gene expression in male APP/PS1 mice. Journal of neuroscience research. vol 102. issue 3. 2024-03-22. PMID:38515329. alzheimer's disease (ad) is a progressive neurodegenerative disease and the most common cause of dementia, characterized by deposition of extracellular amyloid-beta (aβ) aggregates and intraneuronal hyperphosphorylated tau. 2024-03-22 2024-03-24 mouse
Jingji Wang, Yilan Zhen, Jun Yang, Shaojie Yang, Guoqi Zh. Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis? CNS neuroscience & therapeutics. vol 30. issue 3. 2024-03-22. PMID:38516808. accumulation of amyloid beta, tau hyperphosphorylation, and microglia activation are the three highly acknowledged pathological factors of alzheimer's disease (ad). 2024-03-22 2024-03-24 Not clear
Jiaxin Yue, Yonggang Sh. Uncovering Heterogeneity in Alzheimer's Disease from Graphical Modeling of the Tau Spatiotemporal Topography. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 14224. 2024-03-21. PMID:38510994. uncovering heterogeneity in alzheimer's disease from graphical modeling of the tau spatiotemporal topography. 2024-03-21 2024-03-23 human
Jiaxin Yue, Yonggang Sh. Uncovering Heterogeneity in Alzheimer's Disease from Graphical Modeling of the Tau Spatiotemporal Topography. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. vol 14224. 2024-03-21. PMID:38510994. growing evidence from post-mortem and in vivo studies have demonstrated the substantial variability of tau pathology spreading patterns in alzheimer's disease(ad). 2024-03-21 2024-03-23 human
Tabassum Khair Barbhuiya, Dulari K Jayarathna, Raechelle Gilmour, Caroline Smet-Nocca, Neha S Gandh. Characterization of Posttranslationally Modified PHF-1 Tau Peptides Using Gaussian Accelerated Molecular Dynamics Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512658. the microtubule-associated protein, tau, is an intrinsically disordered protein that plays a crucial role in neurodegenerative diseases like alzheimer's disease. 2024-03-21 2024-03-24 Not clear
David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512662. aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. 2024-03-21 2024-03-24 Not clear
Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. tau aggregates are considered a pathological hallmark of alzheimer's disease. 2024-03-21 2024-03-24 Not clear
Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. the screening of molecules against tau aggregation is a novel strategy for alzheimer's disease. 2024-03-21 2024-03-24 Not clear
Subashchandrabose Chinnathambi, Tushar Dube. Photo-Excited Dyes: Emerging Technique Against Tau Protein Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512663. in recent studies, the photo-excited dyes showed an inhibitory effect on alzheimer's disease-related tau protein aggregation and toxicity. 2024-03-21 2024-03-24 Not clear
Hariharakrishnan Chidambaram, Smita Eknath Desale, Subashchandrabose Chinnathamb. Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512659. alzheimer's disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by tau and amyloid-β, respectively, in the brain microenvironment. 2024-03-21 2024-03-24 Not clear
Yanxian Li. Preparation of Tau Condensates by Liquid-Liquid Phase Separation to Study Tau Amyloid Aggregation. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512667. amyloid aggregation of tau is a hallmark of alzheimer's disease and other neurodegenerative diseases. 2024-03-21 2024-03-24 Not clear
Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512671. in neurodegenerative disorders referred to as tauopathies including alzheimer's disease, tau is abnormally hyperphosphorylated and forms fibrillar inclusions in neurons progressing throughout different brain area during the course of the disease. 2024-03-21 2024-03-24 mouse