| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heidi I L Jacobs, Adrienne O'Donnell, Claudia L Satizabal, Cristina Lois, Daniel Kojis, Bernard J Hanseeuw, Emma Thibault, Justin S Sanchez, Rachel F Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A Sperling, Keith A Johnson, Alexa S Beiser, Sudha Seshadr. Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. Journal of Alzheimer's disease : JAD. 2022-02-25. PMID:35213372. |
the brainstem is among the first regions to accumulate alzheimer's disease (ad)-related hyperphosphorylated tau pathology during aging. |
2022-02-25 |
2023-08-13 |
Not clear |
| Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Sagar Gaikwad, Mauro Montalbano, Arijit Bhuyan, Stephanie Garcia, Salome McAllen, Minal Sonawane, Cynthia Jerez, Yingxin Zhao, Rakez Kaye. Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease. The Journal of biological chemistry. 2022-02-24. PMID:35202653. |
lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of alzheimer's disease. |
2022-02-24 |
2023-08-13 |
human |
| Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Sagar Gaikwad, Mauro Montalbano, Arijit Bhuyan, Stephanie Garcia, Salome McAllen, Minal Sonawane, Cynthia Jerez, Yingxin Zhao, Rakez Kaye. Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer's disease. The Journal of biological chemistry. 2022-02-24. PMID:35202653. |
ubiquitin-modified tau aggregates are abundantly found in human brains diagnosed with alzheimer's disease (ad) and other tauopathies. |
2022-02-24 |
2023-08-13 |
human |
| Fabian Kreilaus, Magdalena Przybyla, Lars Ittner, Tim Kar. Cannabidiol (CBD) treatment improves spatial memory in 14-month-old female TAU58/2 transgenic mice. Behavioural brain research. 2022-02-24. PMID:35202719. |
frontotemporal dementia (ftd) and alzheimer's disease (ad) share the pathological hallmark of intracellular neurofibrillary tangles, which result from the hyperphosphorylation of microtubule associated protein tau. |
2022-02-24 |
2023-08-13 |
mouse |
| Laura Torres-Garcia, Joana M P Domingues, Edoardo Brandi, Caroline Haikal, Janitha M Mudannayake, Inês C Brás, Ellen Gerhardt, Wen Li, Alexander Svanbergsson, Tiago F Outeiro, Gunnar K Gouras, Jia-Yi L. Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation. Scientific reports. vol 12. issue 1. 2022-02-23. PMID:35194057. |
parkinson's disease (pd) and alzheimer's disease (ad) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins, α-synuclein (asyn) in pd, and amyloid-β (aβ) and tau in ad. |
2022-02-23 |
2023-08-13 |
mouse |
| Denis S Smirnov, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Joel Simrén, Juan Lantero-Rodriguez, Thomas K Karikari, Annie Hiniker, Robert A Rissman, David P Salmon, Douglas Galask. Plasma biomarkers for Alzheimer's Disease in relation to neuropathology and cognitive change. Acta neuropathologica. 2022-02-23. PMID:35195758. |
plasma biomarkers related to amyloid, tau, and neurodegeneration (atn) show great promise for identifying these pathological features of alzheimer's disease (ad) as shown by recent clinical studies and selected autopsy studies. |
2022-02-23 |
2023-08-13 |
human |
| Emily Eufaula Beaman, Anders Nissen Bonde, Sara Marie Ulv Larsen, Brice Ozenne, Terhi Johanna Lohela, Maiken Nedergaard, Gunnar Hilmar Gíslason, Gitte Moos Knudsen, Sebastian Camillo Hols. Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension. Brain : a journal of neurology. 2022-02-23. PMID:35196379. |
alzheimer's disease is a neurodegenerative disorder where pathological accumulation of amyloid-β and tau begin years before symptom onset. |
2022-02-23 |
2023-08-13 |
Not clear |
| Gabriel Cassinelli Petersen, Michelle Roytman, Gloria C Chiang, Yi Li, Marc L Gordon, Ana M Francesch. Overview of tau PET molecular imaging. Current opinion in neurology. 2022-02-22. PMID:35191407. |
this article reviews tau pet imaging with an emphasis on first-generation and second-generation tau radiotracers and their application in neurodegenerative disorders, including alzheimer's disease and non-alzheimer's disease tauopathies. |
2022-02-22 |
2023-08-13 |
Not clear |
| Cécilia Tremblay, Geidy E Serrano, Anthony J Intorcia, Jasmine Curry, Lucia I Sue, Courtney M Nelson, Jessica E Walker, Michael J Glass, Richard A Arce, Adam S Fleisher, Michael J Pontecorvo, Alireza Atri, Thomas J Montine, Kewei Chen, Thomas G Beac. Hemispheric Asymmetry and Atypical Lobar Progression of Alzheimer-Type Tauopathy. Journal of neuropathology and experimental neurology. 2022-02-22. PMID:35191506. |
the spread of neurofibrillary tau pathology in alzheimer disease (ad) mostly follows a stereotypical pattern of topographical progression but atypical patterns associated with interhemispheric asymmetry have been described. |
2022-02-22 |
2023-08-13 |
Not clear |
| Abhisek Mukherjee, Rabab Al-Lahham, Mark E Corkins, Sourav Samanta, Ann M Schmeichel, Wolfgang Singer, Phillip A Low, Thimmaiah Govindaraju, Claudio Sot. Identification of Multicolor Fluorescent Probes for Heterogeneous Aβ Deposits in Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2022-02-21. PMID:35185519. |
accumulation of amyloid-beta (aβ) into amyloid plaques and hyperphosphorylated tau into neurofibrillary tangles (nfts) are pathological hallmarks of alzheimer's disease (ad). |
2022-02-21 |
2023-08-13 |
human |
| Jéssica Abdo Gonçalves Tosatti, Adriana Fialho da Silva Fontes, Paulo Caramelli, Karina Braga Gome. Effects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer's Disease: A Systematic Review of Randomized Controlled Trials. Drugs & aging. 2022-02-21. PMID:35187615. |
alzheimer's disease (ad) comprises 60-70% of diagnosed dementia cases, and is characterized by the deposition of β-amyloid peptide and the formation of neurofibrillary tangles of tau protein. |
2022-02-21 |
2023-08-13 |
Not clear |
| Solomiia Boyko, Witold K Surewic. Tau liquid-liquid phase separation in neurodegenerative diseases. Trends in cell biology. 2022-02-19. PMID:35181198. |
aggregation of the microtubule-associated protein tau plays a major role in alzheimer's disease and several other neurodegenerative disorders. |
2022-02-19 |
2023-08-13 |
Not clear |
| Tammy T Tran, Caroline L Speck, Michela Gallagher, Arnold Bakke. Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment. Neurobiology of aging. vol 112. 2022-02-19. PMID:35182842. |
specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (amci) phase of alzheimer's disease. |
2022-02-19 |
2023-08-13 |
human |
| Elena Ficulle, Sarubini Kananathan, David Airey, Severine I Gharbi, Neil Humphryes-Kirilov, James Scherschel, Charlotte Dunbar, Brian J Eastwood, Emma Laing, David A Collier, Suchira Bos. A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-02-18. PMID:35177665. |
a human tau seeded neuronal cell model recapitulates molecular responses associated with alzheimer's disease. |
2022-02-18 |
2023-08-13 |
human |
| Elena Ficulle, Sarubini Kananathan, David Airey, Severine I Gharbi, Neil Humphryes-Kirilov, James Scherschel, Charlotte Dunbar, Brian J Eastwood, Emma Laing, David A Collier, Suchira Bos. A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-02-18. PMID:35177665. |
we seeded rat primary cortical neurons with tau isolated from alzheimer's disease brains to induce a time-dependent increase in endogenous tau inclusions. |
2022-02-18 |
2023-08-13 |
human |
| Caitlin S Latimer, Jade G Stair, Joshua C Hincks, Heather N Currey, Thomas D Bird, C Dirk Keene, Brian C Kraemer, Nicole F Liachk. TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic C. elegans. Disease models & mechanisms. 2022-02-18. PMID:35178571. |
while amyloid (a) β and tau aggregates define the neuropathology of alzheimer's disease (ad), tdp-43 has recently emerged as a co-morbid pathology in over half of patients with ad. |
2022-02-18 |
2023-08-13 |
caenorhabditis_elegans |
| Niklas Mattsson-Carlgren, Lea T Grinberg, Adam Boxer, Rik Ossenkoppele, Magnus Jonsson, William Seeley, Alexander Ehrenberg, Salvatore Spina, Shorena Janelidze, Julio Rojas-Martinex, Howard Rosen, Renaud La Joie, Orit Lesman-Segev, Leonardo Iaccarino, Gwendlyn Kollmorgen, Peter Ljubenkov, Udo Eichenlaub, Maria Luisa Gorno-Tempini, Bruce Miller, Oskar Hansson, Gil Dan Rabinovic. Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration. Neurology. 2022-02-17. PMID:35173015. |
to determine how fully automated elecsys® csf immunoassays for β-amyloid (aβ) and tau biomarkers, and an ultrasensitive simoa assay for neurofilament light chain (nfl), correlate with neuropathological changes of alzheimer's disease (ad) and frontotemporal lobar degeneration (ftld). |
2022-02-17 |
2023-08-13 |
Not clear |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
tau proteins in blood as biomarkers of alzheimer's disease and other proteinopathies. |
2022-02-17 |
2023-08-13 |
human |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
alzheimer's disease (ad), the most common age-dependent neurodegenerative disorder, is characterized neuropathologically by extracellular aβ plaques and intracellular tau neurofibrillary tangles. |
2022-02-17 |
2023-08-13 |
human |
| Federico Verd. Tau proteins in blood as biomarkers of Alzheimer's disease and other proteinopathies. Journal of neural transmission (Vienna, Austria : 1996). 2022-02-17. PMID:35175385. |
this review discusses the recent developments in the field of plasma tau proteins as diagnostic, pathophysiological and prognostic biomarkers of alzheimer's disease; additional findings from the fields of genetic forms of ad and of non-ad proteinopathies are also summarized. |
2022-02-17 |
2023-08-13 |
human |