| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cynthia Picard, Gabriel Aumont-Rodrigue, Judes Poirie. Apolipoprotein B gene regulation under healthy and neuropathological conditions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108839. |
we have recently identified apolipoprotein b (apob) as a putative csf indicator of early synaptic and tau pathology in cognitively unimpaired individuals with a parental history of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. |
caspase-6-cleaved tau is relevant in alzheimer's disease but not in 4-repeat tauopathies: diagnostic and therapeutic implications. |
2022-02-03 |
2023-08-13 |
Not clear |
| Antonia M H Piergies, Panos Theofilas, Song Li, Cathrine Petersen, Alexander J Ehrenberg, Rana April Eser, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Salvatore Spina, William W Seeley, Bruce L Miller, Michelle R Arkin, Lea T Grinber. Caspase-6-cleaved tau is relevant in Alzheimer's disease but not in 4-repeat tauopathies: Diagnostic and therapeutic implications. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108846. |
we previously demonstrated that neuronal active caspase-6 co-occurs with phosphorylated tau (p-tau) during the earliest stages of alzheimer's disease (ad) and that the percentage of neurons positive for both active caspase-6 and p-tau increases as the disease progresses. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ozkan Is, Xue Wang, Tulsi Patel, Zachary Quicksall, Laura Lewis-Tuffin, Kaancan Deniz, Frederick Q Tutor-New, Troy Carnwath, Thuy Nguyen, Kimberly G Malphrus, Melissa E Murray, Dennis W Dickson, Mariet Allen, Nilufer Ertekin-Tane. Pathology-related alterations in gene expression in Alzheimer's disease: Single cell resolution. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108849. |
alzheimer's disease is pathologically defined by the presence of extracellular amyloid beta plaques and intracellular tau tangles, resulting in neurodegeneration and reactive gliosis in affected brain regions such as temporal cortex (tcx). |
2022-02-03 |
2023-08-13 |
Not clear |
| Jatin Machhi, Pravin Yeapuri, Yaman Lu, R Lee Mosley, Howard E Gendelma. CD4+ T cell effector activities accelerate Alzheimer's disease pathologies. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108872. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by cognitive impairments linked to pathological deposition of misfolded self-protein amyloid beta (aβ) which in kind facilitates tau aggregation and neurodegeneration. |
2022-02-03 |
2023-08-13 |
Not clear |
| Saskia J Pollack, Dina Dakkak, Tong Guo, Patricia Gómez-Suaga, Wendy Noble, Diane P Hange. Defects in the autophagy lysosomal pathway in a cell model of disease-associated tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108903. |
intracellular accumulation of insoluble tau is an important hallmark of alzheimer's disease (ad) and related tauopathies. |
2022-02-03 |
2023-08-13 |
mouse |
| Whitney M Freeze, Susanne J van Veluw, Willemijn J Jansen, Heidi I L Jacob. Locus coeruleus hypopigmentation is associated with an increased risk of cerebral microangiopathy in autopsy cases with cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108930. |
the locus coeruleus (lc) is the main source of noradrenaline (na) production in the brain, and one of the earliest sites of hyperphosphorylated tau in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
human |
| Heidi I L Jacobs, Alex Becker, Kenneth Kwong, Diana Munera, Liliana A Ramirez-Gomez, Justin S Sanchez, Emma G Thibault, Clara Vila-Castelar, Ana Y Baena, Reisa A Sperling, Keith A Johnson, Francisco Lopera, Yakeel T Quiro. Locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108958. |
locus coeruleus integrity predicts tau accumulation and memory dysfunction in autosomal dominant alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewer. Klotho-VS heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108970. |
klotho-vs heterozygosity modifies amyloid-dependent tau accumulation and memory impairment in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Colin Groo. Associations between the APOE-ε2 and APOE-ε4 alleles with resistance and resilience against Alzheimer's disease pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108977. |
to examine associations between the apoe-ε2 and apoe-ε4 alleles and core alzheimer's disease (ad) pathological hallmarks as measured by amyloid-β (aβ) and tau pet in older individuals without dementia. |
2022-02-03 |
2023-08-13 |
Not clear |
| Panos Theofilas, Andrew J Ambrose, David Butler, Chao Wang, Dulce O Morales, Cathrine Petersen, Brian Chin, Teddy Yang, Shireen Khan, Raymond Ng, Rakez Kayed, Celeste M Karch, Bruce L Miller, Jason E Gestwicki, Li Gan, Sally Temple, Michelle R Arkin, Lea T Grinber. Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC-induced neurons with the V337M MAPT mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108991. |
tau post-translational modifications (ptms) are associated with progressive tau accumulation and neuronal loss in tauopathies, including forms of frontotemporal lobar degeneration (ftld) and alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
tau seeds are widespread in the brain at the earliest stages of alzheimer's disease-related changes. |
2022-02-03 |
2023-08-13 |
Not clear |
| Matteo Manca, Mikayla Huntley, Heidi Standke, David Coughlin, Doug R Galasko, Allison Krau. Tau seeds are widespread in the brain at the earliest stages of Alzheimer's disease-related changes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109008. |
alzheimer's disease (ad) is pathologically characterized by the systematic spread of 3r/4r tau species with progressing disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Laura J Blair, Marangelie Criado-Marrer. Contribution of ER stress to tau-mediated toxicity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109058. |
in alzheimer's disease (ad), the accumulation of tau is linked with cell death, but the major cell death pathway remains to be identified. |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
proteins translated from tau circular rnas as drivers for alzheimer's disease and frontotemporal dementia. |
2022-02-03 |
2023-08-13 |
mouse |
| Justin R Welden, Giorgi Margvelani, Chi Jing Leow, Jessica Blackburn, Peter T Nelson, Stefan Stam. Proteins translated from tau circular RNAs as drivers for Alzheimer's disease and frontotemporal dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109060. |
neurofibrillary tangles formed by the microtubule protein tau (mapt) are the pathologic hallmark of tauopathies, including alzheimer's disease and ∼1/2 of frontotemporal lobar degeneration (ftld-tau) cases. |
2022-02-03 |
2023-08-13 |
mouse |
| Dibyadeep Datta, SueAnn Mentone, Yury Morozov, Christopher H van Dyck, Amy F T Arnste. Subcellular localization of PDE4D and HCN1 in rhesus macaque entorhinal cortex layer II: Signature of vulnerability in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109064. |
tau pathology emerges in a distinct spatial and temporal pattern in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
human |
| Xue Wang, Mariet Allen, Joseph S Reddy, Minerva M Carrasquillo, Yan W Asmann, Cory C Funk, Thuy Nguyen, Kimberly G Malphrus, Steven G Younkin, Dennis W Dickson, Nathan D Price, Todd E Golde, Nilufer Ertekin-Tane. Conserved architecture of brain transcriptome changes between Alzheimer's disease and progressive supranuclear palsy in pathologically affected and unaffected regions. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109068. |
alzheimer's disease (ad) is a complex proteinopathy with abnormal accumulation of amyloid β and tau in which the temporal cortex (tcx) is severely affected. |
2022-02-03 |
2023-08-13 |
Not clear |
| Claire Chevalier, Moira Marizzoni, Giulia Quattrini, Nicola Lopizzo, Diego Albani, Jorge Jovicich, Annamaria Cattaneo, Giovanni B Frison. Peripheral inflammation and AD-related hippocampal neurodegeneration in prodromal AD patients. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109076. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the presence of beta-amyloid (aβ42) and phosphorylated tau (p-tau) deposits in the brain, neurodegeneration in specific brain regions, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Mark Stephen Kindy, Dorothy K. GM6 attenuates Alzheimer's disease pathology through a reduction in fibrinogen levels and by regulation of Aβ, p-tau and inflammation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109082. |
alzheimer's disease (ad) is characterized by cerebral amyloid-b (ab) deposition, vascular alterations, tau pathology, microglia activation, and inflammation. |
2022-02-03 |
2023-08-13 |
Not clear |