All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. alzheimer's disease (ad) is a neurodegenerative disease characterized by excessive deposition of β amyloid (aβ), hyperphosphorylation of tau protein, and neuronal cell death. 2022-01-17 2023-08-13 mouse
Claire J Ciampa, Jourdan H Parent, Theresa M Harrison, Rebekah M Fain, Matthew J Betts, Anne Maass, Joseph R Winer, Suzanne L Baker, Mustafa Janabi, Daniella J Furman, Mark D'Esposito, William J Jagust, Anne S Berr. Associations among locus coeruleus catecholamines, tau pathology, and memory in aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-01-16. PMID:35034099. the locus coeruleus (lc) is the brain's major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of alzheimer's disease (ad)-related tau pathology. 2022-01-16 2023-08-13 Not clear
Prita R Asih, Kristie Stefanoska, Emmanuel Prikas, Arne Ittne. High level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged APP-transgenic alzheimer's mice. Neuroscience. 2022-01-15. PMID:35031398. high level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged app-transgenic alzheimer's mice. 2022-01-15 2023-08-13 mouse
Steven G Fagan, Sibylle Bechet, Kumlesh K De. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology. 2022-01-15. PMID:35031916. therapeutic strategies for alzheimer's disease (ad) have largely focused on the regulation of amyloid pathology while those targeting tau pathology, and inflammatory mechanisms are less explored. 2022-01-15 2023-08-13 mouse
Alberto Fernando Oliveira Justo, Claudia Kimie Suemot. The modulation of neuroinflammation by inducible nitric oxide synthase. Journal of cell communication and signaling. 2022-01-15. PMID:35031946. the accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in alzheimer's disease. 2022-01-15 2023-08-13 mouse
Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twins show comparable tau PET load and spatial distribution. Brain : a journal of neurology. 2022-01-13. PMID:35022652. tau accumulation starts during the preclinical phase of alzheimer's disease and is closely associated with cognitive decline. 2022-01-13 2023-08-13 human
Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twins show comparable tau PET load and spatial distribution. Brain : a journal of neurology. 2022-01-13. PMID:35022652. considering also the presence of dissimilarities in tau pathology in identical twin-pairs, our results additionally support a role for (potentially modifiable) environmental factors in the onset of alzheimer's disease pathological processes, which may be of interest for future prevention strategies. 2022-01-13 2023-08-13 human
Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Kwan, David J Margolis, Peng Jiang, Alexander Kusnecov, Qian Ca. Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy. Brain : a journal of neurology. 2022-01-13. PMID:35022692. mitochondrial defects are a hallmark of early pathophysiology in alzheimer's disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity. 2022-01-13 2023-08-13 mouse
Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Li. Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease. Molecular therapy. Nucleic acids. vol 27. 2022-01-13. PMID:35024240. implications of mir-148a-3p/p35/pten signaling in tau hyperphosphorylation and autoregulatory feedforward of akt/creb in alzheimer's disease. 2022-01-13 2023-08-13 mouse
Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. a hallmark of alzheimer's disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. 2022-01-13 2023-08-13 Not clear
Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. we apply this approach to a six-stage 'braak pattern' of tau proteins, in alzheimer's disease, motivated by a recent observation that seed-competent tau precedes tau aggregation. 2022-01-13 2023-08-13 Not clear
Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P De Deyn, Maria Bjerke, Guy Nagels, Charlotte E Teunissen, Sebastiaan Engelborgh. Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers. Brain : a journal of neurology. 2022-01-13. PMID:35026840. alzheimer's disease cerebrospinal fluid (csf) biomarkers 42 amino acid long amyloid-β peptide (aβ1-42), total tau protein (t-tau), and tau protein phosphorylated at threonine 181 (p-tau181) are considered surrogate biomarkers of alzheimer's disease pathology, and significantly improve diagnostic accuracy. 2022-01-13 2023-08-13 Not clear
Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P De Deyn, Maria Bjerke, Guy Nagels, Charlotte E Teunissen, Sebastiaan Engelborgh. Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers. Brain : a journal of neurology. 2022-01-13. PMID:35026840. our data suggest that similarly to what has been reported for aβ1-42, plateau levels of p-tau181 and t-tau are reached during the disease course, albeit at later disease stages, reducing the potential of tau biomarkers to monitor alzheimer's disease pathology as the disease progresses. 2022-01-13 2023-08-13 Not clear
Francesca Parolini, Roberto Tira, Carlo Giorgio Barracchia, Francesca Munari, Stefano Capaldi, Mariapina D'Onofrio, Michael Assfal. Ubiquitination of Alzheimer's-related tau protein affects liquid-liquid phase separation in a site- and cofactor-dependent manner. International journal of biological macromolecules. 2022-01-12. PMID:35016968. phase separation of the alzheimer's related protein tau into liquid condensates is facilitated by polyanions and is regulated by post-translational modifications. 2022-01-12 2023-08-13 Not clear
Angie K Torres, Bastián I Rivera, Catalina M Polanco, Claudia Jara, Cheril Tapia-Roja. Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017410. phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and alzheimer's disease. 2022-01-12 2023-08-13 Not clear
Angie K Torres, Bastián I Rivera, Catalina M Polanco, Claudia Jara, Cheril Tapia-Roja. Phosphorylated tau as a toxic agent in synaptic mitochondria: implications in aging and Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017410. finally, we show evidence and argue about the presence of phosphorylated tau phf-1 inside mitochondria in alzheimer's disease, which could be considered as an early event in the neurodegenerative process. 2022-01-12 2023-08-13 Not clear
Alejandro R Roda, Gabriel Serra-Mir, Laia Montoliu-Gaya, Lidia Tiessler, Sandra Villega. Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017413. amyloid-beta peptide and tau protein crosstalk in alzheimer's disease. 2022-01-12 2023-08-13 Not clear
Xi-Chen Zhu, Lu Liu, Wen-Zhuo Dai, Tao M. Crry silencing alleviates Alzheimer's disease injury by regulating neuroinflammatory cytokines and the complement system. Neural regeneration research. vol 17. issue 8. 2022-01-12. PMID:35017447. complement component (3b/4b) receptor 1 (cr1) expression is positively related to the abundance of phosphorylated microtubule-associated protein tau (tau), and cr1 expression is associated with susceptibility to alzheimer's disease. 2022-01-12 2023-08-13 mouse
Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Patricia Villanueva-Anguita, Isabel Ubeda-Banon, Alicia Flores-Cuadrado, Alino Martinez-Marcos, Daniel Saiz-Sanche. Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008592. alzheimer's disease (ad), the most prevalent neurodegenerative disorder, is characterized by executive dysfunction and memory impairment mediated by the accumulation of extracellular amyloid-β peptide (aβ) and intracellular hyperphosphorylated tau protein. 2022-01-11 2023-08-13 human
Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Post-Ischemic Neurodegeneration of the Hippocampus Resembling Alzheimer's Disease Proteinopathy. International journal of molecular sciences. vol 23. issue 1. 2022-01-11. PMID:35008731. in the hippocampus, studies have revealed dysregulation of the genes for the amyloid protein precursor metabolism and tau protein that is identical in nature to alzheimer's disease. 2022-01-11 2023-08-13 Not clear