| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bryan Ng, Jane Vowles, Féodora Bertherat, Ajantha Abey, Peter Kilfeather, Dayne Beccano-Kelly, M Irina Stefana, Darragh P O'Brien, Nora Bengoa-Vergniory, Phillippa J Carling, John A Todd, Tara M Caffrey, Natalie Connor-Robson, Sally A Cowley, Richard Wade-Martin. Tau depletion in human neurons mitigates Aβ-driven toxicity. Molecular psychiatry. 2024-02-16. PMID:38361127. |
alzheimer's disease (ad) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (aβ) and hyperphosphorylated tau aggregates, respectively. |
2024-02-16 |
2024-02-18 |
mouse |
| Nicolas De Leiris, Pascale Perret, Charlotte Lombardi, Bülent Gözel, Sabine Chierici, Philippe Millet, Marlène Debiossat, Sandrine Bacot, Benjamin B Tournier, Patrick Chames, Jean-Luc Lenormand, Catherine Ghezzi, Daniel Fagret, Marcelle Mouli. A single-domain antibody for the detection of pathological Tau protein in the early stages of oligomerization. Journal of translational medicine. vol 22. issue 1. 2024-02-16. PMID:38365700. |
soluble oligomeric forms of tau protein have emerged as crucial players in the propagation of tau pathology in alzheimer's disease (ad). |
2024-02-16 |
2024-02-19 |
human |
| Juan Lantero-Rodriguez, Gemma Salvadó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S Brum, Andrea L Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease. Molecular neurodegeneration. vol 19. issue 1. 2024-02-16. PMID:38365825. |
plasma n-terminal containing tau fragments (nta-tau): a biomarker of tau deposition in alzheimer's disease. |
2024-02-16 |
2024-02-19 |
Not clear |
| Juan Lantero-Rodriguez, Gemma Salvadó, Anniina Snellman, Laia Montoliu-Gaya, Wagner S Brum, Andrea L Benedet, Niklas Mattsson-Carlgren, Pontus Tideman, Shorena Janelidze, Sebastian Palmqvist, Erik Stomrud, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer's Disease. Molecular neurodegeneration. vol 19. issue 1. 2024-02-16. PMID:38365825. |
novel phosphorylated-tau (p-tau) blood biomarkers (e.g., p-tau181, p-tau217 or p-tau231), are highly specific for alzheimer's disease (ad), and can track amyloid-β (aβ) and tau pathology. |
2024-02-16 |
2024-02-19 |
Not clear |
| Bianca A Trombetta, Chao-Yi Wu, Evan Kuo, Matthijs B de Geus, Hiroko H Dodge, Becky C Carlyle, Pia Kivisäkk, Steven E Arnol. Cerebrospinal fluid biomarker profiling of diverse pathophysiological domains in Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 1. 2024-02-15. PMID:38356471. |
while alzheimer's disease (ad) is defined by amyloid-β plaques and tau tangles in the brain, it is evident that many other pathophysiological processes such as inflammation, neurovascular dysfunction, oxidative stress, and metabolic derangements also contribute to the disease process and that varying contributions of these pathways may reflect the heterogeneity of ad. |
2024-02-15 |
2024-02-17 |
Not clear |
| Pranitha Y Premnath, Joseph J Locascio, Kayden J Mimmack, Christopher Gonzalez, Michael J Properzi, Onyinye Udeogu, Paul B Rosenberg, Gad A Marshall, Jennifer R Gatche. Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 1. 2024-02-15. PMID:38356477. |
longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: findings from the alzheimer's disease neuroimaging initiative. |
2024-02-15 |
2024-02-17 |
Not clear |
| Pranitha Y Premnath, Joseph J Locascio, Kayden J Mimmack, Christopher Gonzalez, Michael J Properzi, Onyinye Udeogu, Paul B Rosenberg, Gad A Marshall, Jennifer R Gatche. Longitudinal associations of apathy and regional tau in mild cognitive impairment and dementia: Findings from the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & dementia (New York, N. Y.). vol 10. issue 1. 2024-02-15. PMID:38356477. |
in the current study, we sought to examine the relationships between longitudinal apathy and regional tau burden in cognitively impaired older adults from the alzheimer's disease neuroimaging initiative (adni) database. |
2024-02-15 |
2024-02-17 |
Not clear |
| Ellie I James, David W Baggett, Edcon Chang, Joel Schachter, Thomas Nixey, Karoline Choi, Miklos Guttman, Abhinav Nat. Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation. bioRxiv : the preprint server for biology. 2024-02-14. PMID:38352474. |
microtubule-associated protein tau is an intrinsically disordered protein (idp) that forms characteristic fibrillar aggregates in several diseases, the most well-known of which is alzheimer's disease (ad). |
2024-02-14 |
2024-02-16 |
Not clear |
| Emma L Twait, Lotte Gerritsen, Justine E F Moonen, Inge M W Verberk, Charlotte E Teunissen, Pieter Jelle Visser, Wiesje M van der Flier, Mirjam I Geerling. Plasma Markers of Alzheimer's Disease Pathology, Neuronal Injury, and Astrocytic Activation and MRI Load of Vascular Pathology and Neurodegeneration: The SMART-MR Study. Journal of the American Heart Association. 2024-02-14. PMID:38353228. |
plasma biomarkers for alzheimer's disease-related pathology have recently emerged, including aβ (amyloid-beta), p-tau (phosphorylated tau), nfl (neurofilament light), and gfap (glial fibrillary acidic protein). |
2024-02-14 |
2024-02-16 |
Not clear |
| Nauman Malik, Mohi-Uddin Miah, Alessandro Galgani, Kirsty McAleese, Lauren Walker, Fiona E LeBeau, Johannes Attems, Tiago F Outeiro, Alan Thomas, David J Kos. Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change. Acta neuropathologica. vol 147. issue 1. 2024-02-14. PMID:38353753. |
employing frozen and fixed frontal cortex grey and white matter tissue from non-ad controls (con; n = 39) and alzheimer's disease (ad) cases (n = 21), biochemical and immunohistochemical (ihc) measures of aβ and at-8 phosphorylated tau were assessed. |
2024-02-14 |
2024-02-16 |
Not clear |
| Benjamin S Zide, Nancy J Donovan, Soyoung Lee, Sukriti Nag, David A Bennett, Heidi I L Jacob. Social activity mediates locus coeruleus tangle-related cognition in older adults. Molecular psychiatry. 2024-02-14. PMID:38355788. |
conversely, accumulation of tau tangles in the brainstem locus coeruleus nuclei is recently studied as a very early marker of alzheimer's disease (ad) pathogenesis and cognitive vulnerability, even among older adults without cognitive impairment or significant cerebral ad pathologies. |
2024-02-14 |
2024-02-17 |
Not clear |
| Aditya Singh, Vaseem Ahamad Ansari, Tarique Mahmood, Syed Misbahul Hasan, Rufaida Wasim, Shubhrat Maheshwari, Juber Akhtar, Suvaiv Sheikh, Vishal Kumar Vishwakarm. Targeting Abnormal Tau Phosphorylation for Alzheimer's Therapeutics. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2024-02-13. PMID:38350636. |
targeting abnormal tau phosphorylation for alzheimer's therapeutics. |
2024-02-13 |
2024-02-16 |
Not clear |
| Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månber. CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration. Molecular neurodegeneration. vol 19. issue 1. 2024-02-13. PMID:38350954. |
amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with alzheimer's disease (ad). |
2024-02-13 |
2024-02-16 |
Not clear |
| Aaron T Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Prat. O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology. 2024-02-12. PMID:38347213. |
amyloid-forming proteins such α-synuclein and tau, which are implicated in alzheimer's and parkinson's disease, can form different fibril structures or strains with distinct toxic properties, seeding activities and pathology. |
2024-02-12 |
2024-02-15 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Göt. Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular brain. vol 17. issue 1. 2024-02-12. PMID:38347594. |
the most studied of these modifications is phosphorylation, which affects tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in alzheimer's disease and primary tauopathies. |
2024-02-12 |
2024-02-15 |
Not clear |
| Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases. Cell & bioscience. vol 14. issue 1. 2024-02-12. PMID:38347638. |
for example, the main pathological features of alzheimer's disease are the aggregation of beta-amyloid protein and abnormal phosphorylation of tau protein. |
2024-02-12 |
2024-02-15 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
impaired sleep is associated with tau deposition on impaired sleep is commonly associated with alzheimer's disease (ad), although the underlying mechanisms remain unclear. |
2024-02-11 |
2024-02-14 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
using data from the alzheimer's disease neuroimaging initiative, we investigated whether a medical history of impaired sleep, informant-reported nighttime behaviors, and sleep-affecting medications are associated with beta-amyloid and tau deposition on pet and cognitive change, cross-sectionally and longitudinally. |
2024-02-11 |
2024-02-14 |
Not clear |
| D M Sithara Dissanayaka, Vijay Jayasena, Stephanie R Rainey-Smith, Ralph N Martins, W M A D Binosha Fernand. The Role of Diet and Gut Microbiota in Alzheimer's Disease. Nutrients. vol 16. issue 3. 2024-02-10. PMID:38337696. |
alzheimer's disease (ad), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (aβ) plaques and hyperphosphorylated tau tangles. |
2024-02-10 |
2024-02-12 |
Not clear |
| Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H Chen. Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338484. |
the molecular events of protein misfolding and self-aggregation of tau and amylin are associated with the progression of alzheimer's and diabetes, respectively. |
2024-02-10 |
2024-02-12 |
Not clear |