| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chijioke Akunwafo, Jeiran Choupan, Farshid Sepehrban. Premortem perivascular space morphology is a predictor of postmortem glia tau pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109135. |
premortem perivascular space morphology is a predictor of postmortem glia tau pathology in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Alexandre Henriques, Laura Rouvière, Anne Griesbeck, Ronny Schmidt, Christoph Schroeder, Clémence Farrugia, Philippe Poindron, Noelle Callizo. Neuroinflammation induced by amyloid beta 1-42 oligomers contributes to neuronal loss in an in vitro model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109142. |
alzheimer's disease is characterized by the extracellular accumulation of senile plaques composed of amyloid beta and the intracellular deposition of neurofibrillary tangles composed of hyperphosphorylated tau. |
2022-02-03 |
2023-08-13 |
human |
| Yu Hirota, Yasufumi Sakakibara, Kyoko Ibaraki, Kimi Takei, Koichi M Iijima, Michiko Sekiy. Localization of AD biomarker phospho-tau proteins in the brains of an App knock-in mouse model of Aβ amyloidosis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109150. |
amyloid-β (aβ) plaques, neurofibrillary tangles composed of hyper-phosphorylated tau proteins and neurodegeneration are neuropathological hallmarks of alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
mouse |
| Kirsten E J Wesenhagen, Charlotte E Teunissen, Johan Gobom, Stephanie J B Vos, Kaj Blennow, Henrik Zetterberg, Philip Scheltens, Betty M Tijms, Pieter Jelle Visse. Immune protein levels in cerebrospinal fluid: Associations with memory scores across the AD spectrum. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109166. |
alzheimer's disease (ad) is characterized by amyloid and tau aggregation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Allie N Greene, Matia B Solomon, Lisa M Privette Vinnedg. Elucidating a mechanism of tau hyperphosphorylation after DEK loss in vitro. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109167. |
the purpose of the current study is to elucidate the mechanism by which dek loss leads to tau pathology in vitro, with the goal of illuminating novel pathways of tauopathy in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Grant Kauwe, Kristeen Pareja-Navarro, Jackson Chen, Yaqiao Li, David Le, Yungui Zhou, Li Gan, Tara E Trac. Effect of KIBRA on tau-mediated synaptic and memory deficits. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109173. |
alzheimer's disease (ad) is characterized by an accumulation of tau in the brain and progressive memory decline. |
2022-02-03 |
2023-08-13 |
mouse |
| Rebecca Panitch, Junming Hu, Lindsay A Farrer, Gyungah R Ju. Multivariate analysis of blood and brain transcriptome in Alzheimer's reveals unique APOE ε4-related immune pathways. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109177. |
while alzheimer's disease (ad) is generally considered a brain disease, plasma levels of ad-related proteins including amyloid-β, phosphorylated tau, and neurofilament light chain are associated with neurodegeneration and neuroinflammation. |
2022-02-03 |
2023-08-13 |
Not clear |
| Gleb Bezgin, Tharick A Pascoal, Joseph Therriault, Firoza Z Lussier, Min Su Kang, Cécile Tissot, Stijn Servaes, Yi-Ting Wang, Peter Kunach, Jenna Stevenson, Serge Gauthier, Pedro Rosa-Net. Profiling tau accumulation with SPReAD: Sub-stages for propagation regions in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109182. |
profiling tau accumulation with spread: sub-stages for propagation regions in alzheimer's disease. |
2022-02-03 |
2023-08-13 |
Not clear |
| Prita Riana Asih, Kristie Stefanoska, Arne Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109187. |
hyperphosphorylation of the neuronal tau protein contributes to alzheimer's disease (ad) by promoting tau pathology and neuronal and cognitive deficits. |
2022-02-03 |
2023-08-13 |
mouse |
| Alexandre Henriques, Pierrick Jégo, Clémence Farrugia, Noelle Callizo. Intra-hippocampal injections of Aβ oligomers induce cognitive impairments associated with neurodegeneration and activation of microglia in senescent mice: Characterization of a novel animal model of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109200. |
alzheimer's disease is characterized by the extracellular accumulation of senile plaques composed of amyloid beta and the intracellular deposition of neurofibrillary tangles composed of hyperphosphorylated tau. |
2022-02-03 |
2023-08-13 |
mouse |
| Alexandra J Weigand, Kelsey R Thomas, Katherine J Bangen, Graham M L Eglit, Adam M Brickman, Mark W Bond. Evidence for the progression of tau and neurodegeneration beyond the medial temporal lobe in amyloid-negative older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109203. |
despite the important role of tau in alzheimer's disease (ad), tau in the absence of amyloid (aβ) is typically considered as separable from the ad continuum. |
2022-02-03 |
2023-08-13 |
Not clear |
| Michael Kelberman, David Weinshenke. Altered locus coeruleus activity and neurochemistry in the presence of Alzheimer's disease-like hyperphosphorylated tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109220. |
altered locus coeruleus activity and neurochemistry in the presence of alzheimer's disease-like hyperphosphorylated tau pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Michael Kelberman, David Weinshenke. Altered locus coeruleus activity and neurochemistry in the presence of Alzheimer's disease-like hyperphosphorylated tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109220. |
the locus coeruleus (lc), the main source of norepinephrine (ne) in the brain, develops tau pathology prior to other brain regions and later degenerates in alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |
| Michela Marcatti, Anna Fracassi, Nemil Bhatt, Chandramouli Natarajan, Balaji Krishnan, Rakez Kayed, Giulio Taglialatel. AD- and PSP-specific brain-derived tau oligomers engage synapses with different dynamic. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109245. |
alzheimer's disease (ad) is characterized by gradual cognitive decline driven by the targeting of synapses by small oligomers of both aβ (aβo) and tau (tauo), which results in synaptic dysfunction that ultimately underscores disease progression. |
2022-02-03 |
2023-08-13 |
human |
| Timothy Wu, Caiwei Guo, Joshua M Shulma. Elucidating cellular contributions to tau-mediated neurodegeneration using drosophila and single-cell transcriptomics. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109262. |
alzheimer's dementia (ad) is neuropathologically defined by aggregations of amyloid-beta plaques and tau neurofibrillary tangles in the brain, with tau pathology being most strongly correlated with cognitive decline. |
2022-02-03 |
2023-08-13 |
human |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of alzheimer's tau pathology. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
alzheimer's disease involves widespread and progressive deposition of misfolded protein tau, likely via "prion-like" trans-neuronal transmission along the brain's structural connectome. |
2022-02-03 |
2023-08-13 |
Not clear |
| Ashish Raj, Veronica Tora, Bruno Franch. Combining network spread with protein aggregation correctly recapitulates empirical spatio-temporal progression of Alzheimer's tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109265. |
it is not well understood how tau aggregation and spread leads to stereotypical progression in the alzheimer brain. |
2022-02-03 |
2023-08-13 |
Not clear |
| Neil R Cashman, Ebrima Gibbs, Andrei Roman, Clay Shyu, Eugene M Williams, Xubiao Peng, Shawn Ching-Chung Hsueh, Aina Adekunle, Steven S Plotkin, Johanne Kapla. Conformational epitopes exposed on misfolded toxic forms of amyloid-beta, tau and alpha-synuclein directly contribute to their seeding activity. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109274. |
for example, toxic oligomers of amyloid-beta (abeta) as well as oligomers and small soluble fibrils of tau and alpha-synuclein (asyn) have been reported to contribute to neuronal damage and progression of alzheimer's disease as well as various tauopathies (e.g. |
2022-02-03 |
2023-08-13 |
Not clear |
| Annie G Bryant, Rachel E Bennett, David H Salat, Bruce R Rosen, Bradley T Hyman, Keith A Johnson, Susie Huang, Yi-Fen Ye. Heterogeneity of tau deposition and microvascular involvement in MCI and AD. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109281. |
recent preclinical and clinical studies have highlighted the role of tau pathology in the impaired cerebrovascular function frequently observed in mild cognitive impairment (mci) and alzheimer's disease (ad). |
2022-02-03 |
2023-08-13 |
Not clear |