| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
abnormally phosphorylated tau, an indicator of alzheimer's disease, accumulates in the first decades of life in the locus coeruleus (lc), the brain's main noradrenaline supply. |
2022-01-19 |
2023-08-13 |
human |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
our findings link lc degeneration to tau burden and memory in alzheimer's, and highlight a role of the noradrenergic system in this neurodegenerative disease. |
2022-01-19 |
2023-08-13 |
human |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
biomarkers with plasma amyloid β and tau protein assayed by immunomagnetic reduction in patients with amnestic mild cognitive impairment and alzheimer's disease. |
2022-01-18 |
2023-08-13 |
Not clear |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
this review addresses recent developments in the analyses of plasma amyloid beta (aβ) and total tau (t-tau) protein levels as biomarkers for discriminating amnestic mild cognitive impairment (amci) from alzheimer disease (ad), using immunomagnetic reduction (imr). |
2022-01-18 |
2023-08-13 |
Not clear |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
keywords: amyloid beta, plasma tau, alzheimer disease, biomarker, mild cognitive impairment. |
2022-01-18 |
2023-08-13 |
Not clear |
| Xiaohu iMa, Linlin Liu, Jing Men. Expression of concern: MicroRNA-125b promotes neurons cell apoptosis and tau phosphorylation in Alzheimer's disease. Neuroscience letters. vol 769. 2022-01-17. PMID:35034691. |
expression of concern: microrna-125b promotes neurons cell apoptosis and tau phosphorylation in alzheimer's disease. |
2022-01-17 |
2023-08-13 |
Not clear |
| Silvia Pelucchi, Fabrizio Gardoni, Monica Di Luca, Elena Marcell. Synaptic dysfunction in early phases of Alzheimer's Disease. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034752. |
moreover, the two main hallmarks of alzheimer's disease, i.e., amyloid-β and tau, act in concert to cause synaptic deficits. |
2022-01-17 |
2023-08-13 |
Not clear |
| Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue La. Zeaxanthin Attenuates the Vicious Circle Between Endoplasmic Reticulum Stress and Tau Phosphorylation: Involvement of GSK-3β Activation. Journal of Alzheimer's disease : JAD. 2022-01-17. PMID:35034906. |
alzheimer's disease (ad) characterized by neurofibrillary tangles caused by hyperphosphorylated tau is the most common cause of dementia. |
2022-01-17 |
2023-08-13 |
Not clear |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by excessive deposition of β amyloid (aβ), hyperphosphorylation of tau protein, and neuronal cell death. |
2022-01-17 |
2023-08-13 |
mouse |
| Claire J Ciampa, Jourdan H Parent, Theresa M Harrison, Rebekah M Fain, Matthew J Betts, Anne Maass, Joseph R Winer, Suzanne L Baker, Mustafa Janabi, Daniella J Furman, Mark D'Esposito, William J Jagust, Anne S Berr. Associations among locus coeruleus catecholamines, tau pathology, and memory in aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-01-16. PMID:35034099. |
the locus coeruleus (lc) is the brain's major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of alzheimer's disease (ad)-related tau pathology. |
2022-01-16 |
2023-08-13 |
Not clear |
| Prita R Asih, Kristie Stefanoska, Emmanuel Prikas, Arne Ittne. High level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged APP-transgenic alzheimer's mice. Neuroscience. 2022-01-15. PMID:35031398. |
high level forebrain expression of active tau kinase p38γ exacerbates cognitive dysfunction in aged app-transgenic alzheimer's mice. |
2022-01-15 |
2023-08-13 |
mouse |
| Steven G Fagan, Sibylle Bechet, Kumlesh K De. Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. Molecular neurobiology. 2022-01-15. PMID:35031916. |
therapeutic strategies for alzheimer's disease (ad) have largely focused on the regulation of amyloid pathology while those targeting tau pathology, and inflammatory mechanisms are less explored. |
2022-01-15 |
2023-08-13 |
mouse |
| Alberto Fernando Oliveira Justo, Claudia Kimie Suemot. The modulation of neuroinflammation by inducible nitric oxide synthase. Journal of cell communication and signaling. 2022-01-15. PMID:35031946. |
the accumulation and propagation of misfolded proteins in the brain is a pathological hallmark shared by many neurodegenerative diseases, such as the depositions of β-amyloid and hyperphosphorylated tau proteins in alzheimer's disease. |
2022-01-15 |
2023-08-13 |
mouse |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twins show comparable tau PET load and spatial distribution. Brain : a journal of neurology. 2022-01-13. PMID:35022652. |
tau accumulation starts during the preclinical phase of alzheimer's disease and is closely associated with cognitive decline. |
2022-01-13 |
2023-08-13 |
human |
| Emma M Coomans, Jori Tomassen, Rik Ossenkoppele, Sandeep S V Golla, Marijke den Hollander, Lyduine E Collij, Emma Weltings, Sophie van der Landen, Emma E Wolters, Albert D Windhorst, Frederik Barkhof, Eco J C de Geus, Philip Scheltens, Pieter Jelle Visser, Bart N M van Berckel, Anouk den Brabe. Genetically identical twins show comparable tau PET load and spatial distribution. Brain : a journal of neurology. 2022-01-13. PMID:35022652. |
considering also the presence of dissimilarities in tau pathology in identical twin-pairs, our results additionally support a role for (potentially modifiable) environmental factors in the onset of alzheimer's disease pathological processes, which may be of interest for future prevention strategies. |
2022-01-13 |
2023-08-13 |
human |
| Yu Young Jeong, Sinsuk Han, Nuo Jia, Mingyang Zhang, Preethi Sheshadri, Prasad Tammineni, Jasmine Cheung, Marialaina Nissenbaum, Sindhuja S Baskar, Kelvin Kwan, David J Margolis, Peng Jiang, Alexander Kusnecov, Qian Ca. Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy. Brain : a journal of neurology. 2022-01-13. PMID:35022692. |
mitochondrial defects are a hallmark of early pathophysiology in alzheimer's disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity. |
2022-01-13 |
2023-08-13 |
mouse |
| Li Zeng, Hailun Jiang, Ghulam Md Ashraf, Jianghong Liu, Linlin Wang, Kaiyue Zhao, Mimin Liu, Zhuorong Li, Rui Li. Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease. Molecular therapy. Nucleic acids. vol 27. 2022-01-13. PMID:35024240. |
implications of mir-148a-3p/p35/pten signaling in tau hyperphosphorylation and autoregulatory feedforward of akt/creb in alzheimer's disease. |
2022-01-13 |
2023-08-13 |
mouse |
| Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. |
a hallmark of alzheimer's disease is the aggregation of insoluble amyloid-beta plaques and tau protein neurofibrillary tangles. |
2022-01-13 |
2023-08-13 |
Not clear |
| Prama Putra, Travis B Thompson, Pavanjit Chaggar, Alain Goriel. Braiding Braak and Braak: Staging patterns and model selection in network neurodegeneration. Network neuroscience (Cambridge, Mass.). vol 5. issue 4. 2022-01-13. PMID:35024537. |
we apply this approach to a six-stage 'braak pattern' of tau proteins, in alzheimer's disease, motivated by a recent observation that seed-competent tau precedes tau aggregation. |
2022-01-13 |
2023-08-13 |
Not clear |
| Claire Bridel, Charisse Somers, Anne Sieben, Annemieke Rozemuller, Ellis Niemantsverdriet, Hanne Struyfs, Yannick Vermeiren, Christine Van Broeckhoven, Peter P De Deyn, Maria Bjerke, Guy Nagels, Charlotte E Teunissen, Sebastiaan Engelborgh. Associating Alzheimer's disease pathology with its cerebrospinal fluid biomarkers. Brain : a journal of neurology. 2022-01-13. PMID:35026840. |
alzheimer's disease cerebrospinal fluid (csf) biomarkers 42 amino acid long amyloid-β peptide (aβ1-42), total tau protein (t-tau), and tau protein phosphorylated at threonine 181 (p-tau181) are considered surrogate biomarkers of alzheimer's disease pathology, and significantly improve diagnostic accuracy. |
2022-01-13 |
2023-08-13 |
Not clear |