| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacopo Meldoles. Extracellular vesicles (exosomes and ectosomes) play key roles in the pathology of brain diseases. Molecular biomedicine. vol 2. issue 1. 2022-01-10. PMID:35006460. |
in alzheimer's disease the vesicles can affect the brain by changing their generation and inducing co-release of effective proteins, such aβ and tau, from neurons and astrocytes. |
2022-01-10 |
2023-08-13 |
Not clear |
| Juan R Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M McManus, Michael T Heneka, Jesús Avil. p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. Molecular neurobiology. 2022-01-10. PMID:35006531. |
alzheimer's disease (ad) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. |
2022-01-10 |
2023-08-13 |
Not clear |
| Perla H Horta-López, Graciela Mendoza-Franco, Fanny Rodríguez-Cruz, Francisco M Torres-Cruz, Elizabeth Hernández-Echeagaray, Jose J Jarero-Basulto, Jan Rícny, Benjamín Florán Garduño, Francisco Garcia-Sierr. Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer's disease brain. Neuroscience. 2022-01-10. PMID:35007692. |
association of α-1-antichymotrypsin expression with the development of conformational changes of tau protein in alzheimer's disease brain. |
2022-01-10 |
2023-08-13 |
Not clear |
| Perla H Horta-López, Graciela Mendoza-Franco, Fanny Rodríguez-Cruz, Francisco M Torres-Cruz, Elizabeth Hernández-Echeagaray, Jose J Jarero-Basulto, Jan Rícny, Benjamín Florán Garduño, Francisco Garcia-Sierr. Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer's disease brain. Neuroscience. 2022-01-10. PMID:35007692. |
in alzheimer's disease (ad), two mutually exclusive amino-terminal-dependent conformations have been reported to occur during the aggregation of tau protein into neurofibrillary tangles (nfts). |
2022-01-10 |
2023-08-13 |
Not clear |
| Clément Danis, Elian Dupré, Orgeta Zejneli, Raphaëlle Caillierez, Alexis Arrial, Séverine Bégard, Justine Mortelecque, Sabiha Eddarkaoui, Anne Loyens, François-Xavier Cantrelle, Xavier Hanoulle, Jean-Christophe Rain, Morvane Colin, Luc Buée, Isabelle Landrie. Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment. Molecular therapy : the journal of the American Society of Gene Therapy. 2022-01-10. PMID:35007758. |
tau proteins aggregate into filaments in brain cells in alzheimer's disease and related disorders referred to as tauopathies. |
2022-01-10 |
2023-08-13 |
mouse |
| Denise Visser, Sander C J Verfaillie, Emma E Wolters, Emma M Coomans, Tessa Timmers, Hayel Tuncel, Ronald Boellaard, Sandeep S V Golla, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Bart N M van Berckel, Rik Ossenkoppel. Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease. European journal of nuclear medicine and molecular imaging. 2022-01-08. PMID:34997294. |
differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset alzheimer's disease. |
2022-01-08 |
2023-08-13 |
Not clear |
| Yi Chen, Joseph Therriault, Jing Luo, Maowen Ba, Hua Zhang, Alzheimer's Disease Neuroimaging Initiativ. Neurofilament light as a biomarker of axonal degeneration in patients with mild cognitive impairment and Alzheimer's disease. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997710. |
in addition, the diagnostic accuracy of cerebrospinal fluid and plasma neurofilament light for progressive mild cognitive impairment and alzheimer's disease was almost the same as that of cerebrospinal fluid total tau (t-tau). |
2022-01-08 |
2023-08-13 |
human |
| Malin Wennström, Shorena Janelidze, K Peter R Nilsson, Geidy E Serrano, Thomas G Beach, Jeffrey L Dage, Oskar Hansso. Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels. Acta neuropathologica communications. vol 10. issue 1. 2022-01-07. PMID:34991721. |
recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in alzheimer's disease (ad), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. |
2022-01-07 |
2023-08-13 |
Not clear |
| Likui Lu, Xi Yu, Yongle Cai, Miao Sun, Hao Yan. Application of CRISPR/Cas9 in Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2022-01-07. PMID:34992519. |
alzheimer's disease (ad) is a progressive and irreversible neurodegenerative disorder clinically characterized by cognitive impairment, abnormal behavior, and social deficits, which is intimately linked with excessive β-amyloid (aβ) protein deposition along with many other misfolded proteins, neurofibrillary tangles formed by hyperphosphorylated tau protein aggregates, and mitochondrial damage in neurons, leading to neuron loss. |
2022-01-07 |
2023-08-13 |
Not clear |
| Qi Wang, Kewei Chen, Yi Su, Eric M Reiman, Joel T Dudley, Benjamin Readhea. Deep learning-based brain transcriptomic signatures associated with the neuropathological and clinical severity of Alzheimer's disease. Brain communications. vol 4. issue 1. 2022-01-07. PMID:34993477. |
here, we use a deep learning method to analyse rna-seq data from 1114 brain donors from the accelerating medicines project for alzheimer's disease consortium to characterize post-mortem brain transcriptome signatures associated with amyloid-β plaque, tau neurofibrillary tangles and clinical severity in multiple alzheimer's disease dementia populations. |
2022-01-07 |
2023-08-13 |
Not clear |
| Lucy Vivash, Charles B Malpas, Christopher M Hovens, Amy Brodtmann, Steven Collins, Stephen Macfarlane, Dennis Velakoulis, Terence J O'Brie. Sodium selenate as a disease-modifying treatment for mild-moderate Alzheimer's disease: an open-label extension study. BMJ neurology open. vol 3. issue 2. 2022-01-06. PMID:34988458. |
sodium selenate is a potential disease-modifying treatment for alzheimer's disease (ad) which reduces hyperphosphorylated tau through activation of the protein phosphatase 2a enzyme. |
2022-01-06 |
2023-08-13 |
Not clear |
| Ashwani K Dhingra, Bhawna Chopra, Akash Jain, Jasmine Chaudhar. Imidazole: Multi-targeted Therapeutic Leads for the Management of Alzheimer's Disease. Mini reviews in medicinal chemistry. 2022-01-05. PMID:34983347. |
alzheimer's disease (ad) is a multifactorial disorder coupled with an array of neuropathological mechanisms, including tau phosphorylation, aβ aggregation, metal ion deregulation, and oxidative stress, along with neuro-inflammation. |
2022-01-05 |
2023-08-13 |
Not clear |
| Chae Kim, Tracy Haldiman, Sang-Gyun Kang, Lenka Hromadkova, Zhuang Zhuang Han, Wei Chen, Frances Lissemore, Alan Lerner, Rohan de Silva, Mark L Cohen, David Westaway, Jiri G Safa. Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer's disease. Science translational medicine. vol 14. issue 626. 2022-01-05. PMID:34985969. |
distinct populations of highly potent tau seed conformers in rapidly progressing alzheimer's disease. |
2022-01-05 |
2023-08-13 |
Not clear |
| Ni-Ni Chiang, Te-Hsien Lin, Yu-Shan Teng, Ying-Chieh Sun, Kuo-Hsuan Chang, Chung-Yin Lin, Hsiu Mei Hsieh-Li, Ming-Tsan Su, Chiung-Mei Chen, Guey-Jen Lee-Che. Flavones 7,8-DHF, Quercetin, and Apigenin Against Tau Toxicity Frontiers in aging neuroscience. vol 13. 2022-01-03. PMID:34975454. |
flavones 7,8-dhf, quercetin, and apigenin against tau toxicity alzheimer's disease (ad) is a progressive neurodegenerative disease with memory loss and cognitive decline. |
2022-01-03 |
2023-08-13 |
Not clear |
| Yulian Zou, Chen-Ling Gan, Zhiming Xin, Hai-Tao Zhang, Qi Zhang, Tae Ho Lee, Xiaodong Pan, Zhou Che. Programmed Cell Death Protein 1 Blockade Reduces Glycogen Synthase Kinase 3β Activity and Tau Hyperphosphorylation in Alzheimer's Disease Mouse Models. Frontiers in cell and developmental biology. vol 9. 2022-01-03. PMID:34977020. |
programmed cell death protein 1 blockade reduces glycogen synthase kinase 3β activity and tau hyperphosphorylation in alzheimer's disease mouse models. |
2022-01-03 |
2023-08-13 |
mouse |
| Vérane Achard, Kelly Ceyzériat, Benjamin B Tournier, Giovanni B Frisoni, Valentina Garibotto, Thomas Zill. Biomarkers to Evaluate Androgen Deprivation Therapy for Prostate Cancer and Risk of Alzheimer's Disease and Neurodegeneration: Old Drugs, New Concerns. Frontiers in oncology. vol 11. 2021-12-31. PMID:34970480. |
importantly, no study investigated yet biomarkers of alzheimer's disease pathology, namely amyloid and tau. |
2021-12-31 |
2023-08-13 |
Not clear |
| Samuel Walter Hersh, Yang You, Roshanak Aslebagh, Scott A Shaffer, Seiko Ikezu, Jesse Mez, Kathryn L Lunetta, Mark W Logue, Lindsay A Farrer, Tsuneya Ikez. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971140. |
alzheimer's disease associated akap9 i2558m mutation alters posttranslational modification and interactome of tau and cellular functions in crispr-edited human neuronal cells. |
2021-12-31 |
2023-08-13 |
human |
| Ankita Srivastav, Sahabudeen Sheik Mohidee. Intestinal microbial dysbiosis induced tau accumulation establishes a gut-brain correlation for pathology Alzheimer's disease in Drosophila melanogaster. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971141. |
intestinal microbial dysbiosis induced tau accumulation establishes a gut-brain correlation for pathology alzheimer's disease in drosophila melanogaster. |
2021-12-31 |
2023-08-13 |
drosophila_melanogaster |
| Ankita Srivastav, Sahabudeen Sheik Mohidee. Intestinal microbial dysbiosis induced tau accumulation establishes a gut-brain correlation for pathology Alzheimer's disease in Drosophila melanogaster. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971141. |
to study how the exposure of pseudomonas sp., a gram-negative bacteria, influences tau accumulation and neurodegeneration thereby understanding the gut-brain correlation for the pathology of alzheimer's disease. |
2021-12-31 |
2023-08-13 |
drosophila_melanogaster |
| Juliet V Santiago, Sruti Rayaprolu, Hailian Xiao, Nicholas T Seyfried, Srikant Rangaraj. Identification of state-specific proteomic characteristics of microglia-derived exosomes. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971151. |
alzheimer's disease (ad) is the most common neurodegenerative disorder defined by progressive pathological protein aggregation (amyloid-beta and tau) and deterioration of cognitive function. |
2021-12-31 |
2023-08-13 |
Not clear |