| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murat Bilgel, Alisa Bannerjee, Andrea Shafer, Yang An, Susan M Resnic. Vascular risk is not associated with PET measures of Alzheimer's disease neuropathology among cognitively normal older adults. Neuroimage. Reports. vol 1. issue 4. 2021-12-20. PMID:34927122. |
studies have found that vascular risk factors are associated with greater amyloid-β (aβ) and tau burden, which are hallmark neuropathologies of alzheimer's disease (ad). |
2021-12-20 |
2023-08-13 |
human |
| Antoine Leuzy, Ruben Smith, Nicholas C Cullen, Olof Strandberg, Jacob W Vogel, Alexa Pichet Binette, Edilio Borroni, Shorena Janelidze, Tomas Ohlsson, Jonas Jögi, Rik Ossenkoppele, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Erik Stomrud, Oskar Hansso. Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease. JAMA neurology. 2021-12-20. PMID:34928318. |
biomarker-based prediction of longitudinal tau positron emission tomography in alzheimer disease. |
2021-12-20 |
2023-08-13 |
Not clear |
| Antoine Leuzy, Ruben Smith, Nicholas C Cullen, Olof Strandberg, Jacob W Vogel, Alexa Pichet Binette, Edilio Borroni, Shorena Janelidze, Tomas Ohlsson, Jonas Jögi, Rik Ossenkoppele, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Gregory Klein, Erik Stomrud, Oskar Hansso. Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease. JAMA neurology. 2021-12-20. PMID:34928318. |
there is currently no consensus as to which biomarkers best predict longitudinal tau accumulation at different clinical stages of alzheimer disease (ad). |
2021-12-20 |
2023-08-13 |
Not clear |
| Margaret Hayne, Aaron DiAntoni. Protein phosphatase 2A restrains DLK signaling to promote proper Drosophila synaptic development and mammalian cortical neuron survival. Neurobiology of disease. 2021-12-19. PMID:34923110. |
in post-mitotic neurons, the microtubule associated protein tau is a particularly well-studied pp2a substrate as hyperphosphorylation of tau is a hallmark of alzheimer's disease. |
2021-12-19 |
2023-08-13 |
drosophila_melanogaster |
| Lenka Hruba, Pavel Polishchuk, Viswanath Das, Marian Hajduch, Petr Dzuba. An identification of MARK inhibitors using high throughput MALDI-TOF mass spectrometry. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 146. 2021-12-19. PMID:34923338. |
map/microtubule affinity-regulating kinases (marks) were recently identified as potential drug targets for alzheimer's disease (ad) due to their role in pathological hyperphosphorylation of tau protein. |
2021-12-19 |
2023-08-13 |
Not clear |
| Enrique Luengo, Paula Trigo-Alonso, Cristina Fernández-Mendívil, Ángel Nuñez, Marta Del Campo, César Porrero, Nuria García-Magro, Pilar Negredo, Sergio Senar, Cristina Sánchez-Ramos, Juan A Bernal, Alberto Rábano, Jeroen Hoozemans, Ana I Casas, Harald H H W Schmidt, Manuela G Lópe. Implication of type 4 NADPH oxidase (NOX4) in tauopathy. Redox biology. vol 49. 2021-12-18. PMID:34922273. |
aggregates of the microtubule-associated protein tau are a common marker of neurodegenerative diseases collectively termed as tauopathies, such as alzheimer's disease (ad) and frontotemporal dementia. |
2021-12-18 |
2023-08-13 |
mouse |
| Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobo. Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease. Clinical mass spectrometry (Del Mar, Calif.). vol 14 Pt B. 2021-12-17. PMID:34917763. |
use of the tau protein-to-peptide ratio in csf to improve diagnostic classification of alzheimer's disease. |
2021-12-17 |
2023-08-13 |
Not clear |
| Karl Hansson, Rahil Dahlén, Oskar Hansson, Elin Pernevik, Ross Paterson, Jonathan M Schott, Nadia Magdalinou, Henrik Zetterberg, Kaj Blennow, Johan Gobo. Use of the tau protein-to-peptide ratio in CSF to improve diagnostic classification of Alzheimer's disease. Clinical mass spectrometry (Del Mar, Calif.). vol 14 Pt B. 2021-12-17. PMID:34917763. |
cerebrospinal fluid (csf) tau and phospho-tau are well established biomarkers of alzheimer's disease. |
2021-12-17 |
2023-08-13 |
Not clear |
| Kurt A Jellinge. Recent update on the heterogeneity of the Alzheimer's disease spectrum. Journal of neural transmission (Vienna, Austria : 1996). 2021-12-17. PMID:34919190. |
alzheimer's disease (ad), the most common form of dementia worldwide, is a mixed proteinopathy (β-amyloid, tau and other proteins). |
2021-12-17 |
2023-08-13 |
Not clear |
| Allan I Levey, Deqiang Qiu, Liping Zhao, William T Hu, Duc M Duong, Lenora Higginbotham, Eric B Dammer, Nicholas T Seyfried, Thomas S Wingo, Chadwick M Hales, Malú Gámez Tansey, David S Goldstein, Anees Abrol, Vince D Calhoun, Felicia C Goldstein, Ihab Hajjar, Anne M Fagan, Doug Galasko, Steven D Edland, John Hanfelt, James J Lah, David Weinshenke. A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment. Brain : a journal of neurology. 2021-12-17. PMID:34919634. |
the locus coeruleus (lc) is the initial site of alzheimer's disease neuropathology, with hyperphosphorylated tau appearing in early adulthood followed by neurodegeneration in dementia. |
2021-12-17 |
2023-08-13 |
human |
| Ramesh Kandimalla, Maria Manczak, Jangampalli Adi Pradeepkiran, Hallie Morton, P Hemachandra Redd. A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of Alzheimer disease. Human molecular genetics. 2021-12-17. PMID:34919689. |
a partial reduction of drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of alzheimer disease. |
2021-12-17 |
2023-08-13 |
mouse |
| Ramesh Kandimalla, Maria Manczak, Jangampalli Adi Pradeepkiran, Hallie Morton, P Hemachandra Redd. A partial reduction of Drp1 improves cognitive behavior and enhances mitophagy, autophagy and dendritic spines in a transgenic tau mouse model of Alzheimer disease. Human molecular genetics. 2021-12-17. PMID:34919689. |
the purpose of our study is to understand the impact of a partial dynamin-related protein 1 (drp1) on cognitive behavior, mitophagy, autophagy, and mitochondrial and synaptic activities in transgenic tau mice in alzheimer's disease (ad). |
2021-12-17 |
2023-08-13 |
mouse |
| Stephen L P Lippi, Caroline L C Neely, Anthony L Amay. Trace concentrations, heavy implications: Influences of biometals on major brain pathologies of Alzheimer's disease. The international journal of biochemistry & cell biology. 2021-12-15. PMID:34906694. |
alzheimer's disease (ad) is a neurodegenerative condition that involves accumulation of toxic protein species, notably amyloid-β plaques and neurofibrillary tau tangles that are associated with cognitive decline. |
2021-12-15 |
2023-08-13 |
Not clear |
| Thanaphong Phongpreecha, Chandresh R Gajera, Candace C Liu, Kausalia Vijayaragavan, Alan L Chang, Martin Becker, Ramin Fallahzadeh, Rosemary Fernandez, Nadia Postupna, Emily Sherfield, Dmitry Tebaykin, Caitlin Latimer, Carol A Shively, Thomas C Register, Suzanne Craft, Kathleen S Montine, Edward J Fox, Kathleen L Poston, C Dirk Keene, Michael Angelo, Sean C Bendall, Nima Aghaeepour, Thomas J Montin. Single-synapse analyses of Alzheimer's disease implicate pathologic tau, DJ1, CD47, and ApoE. Science advances. vol 7. issue 51. 2021-12-15. PMID:34910503. |
single-synapse analyses of alzheimer's disease implicate pathologic tau, dj1, cd47, and apoe. |
2021-12-15 |
2023-08-13 |
Not clear |
| Erin E Congdon, Yixiang Jiang, Einar M Sigurdsso. Targeting tau only extracellularly is likely to be less efficacious than targeting it both intra- and extracellularly. Seminars in cell & developmental biology. 2021-12-13. PMID:34896021. |
alzheimer's disease is the most common tauopathy, but the group consists of over 20 different diseases, many of which have tau pathology as their primary feature. |
2021-12-13 |
2023-08-13 |
Not clear |
| Nikoleta Csicsatkova, Peter Szalay, Katarina Matyasova, Veronika Mate, Martin Cente, Tomas Smolek, Veronika Brezovakova, Lucie Kawecka, Norbert Zilka, Santosh Jadha. Transcriptomic signature of Alzheimer's disease tau seed-induced pathology. General physiology and biophysics. vol 40. issue 6. 2021-12-13. PMID:34897025. |
transcriptomic signature of alzheimer's disease tau seed-induced pathology. |
2021-12-13 |
2023-08-13 |
Not clear |
| Nikoleta Csicsatkova, Peter Szalay, Katarina Matyasova, Veronika Mate, Martin Cente, Tomas Smolek, Veronika Brezovakova, Lucie Kawecka, Norbert Zilka, Santosh Jadha. Transcriptomic signature of Alzheimer's disease tau seed-induced pathology. General physiology and biophysics. vol 40. issue 6. 2021-12-13. PMID:34897025. |
spreading of tau pathology to anatomical distinct regions in alzheimer's disease (ad) is associated with progression of the disease. |
2021-12-13 |
2023-08-13 |
Not clear |
| Aviva M Tolkovsky, Maria Grazia Spillantin. Tau aggregation and its relation to selected forms of neuronal cell death. Essays in biochemistry. 2021-12-13. PMID:34897457. |
although alzheimer's disease (ad) is the most prevalent tauopathy, tauopathies comprise an array of over 30 diseases in which the cytoplasmic protein tau aggregates in neurons, and also, in some diseases, in glia. |
2021-12-13 |
2023-08-13 |
Not clear |
| Jianfeng Wu, Qunxi Dong, Jie Zhang, Yi Su, Teresa Wu, Richard J Caselli, Eric M Reiman, Jieping Ye, Natasha Lepore, Kewei Chen, Paul M Thompson, Yalin Wan. Federated Morphometry Feature Selection for Hippocampal Morphometry Associated Beta-Amyloid and Tau Pathology. Frontiers in neuroscience. vol 15. 2021-12-13. PMID:34899166. |
amyloid-β (aβ) plaques and tau protein tangles in the brain are now widely recognized as the defining hallmarks of alzheimer's disease (ad), followed by structural atrophy detectable on brain magnetic resonance imaging (mri) scans. |
2021-12-13 |
2023-08-13 |
human |
| Chanting He, Xiaoyan Zhao, Yang Lei, Jisheng Nie, Xiaoting Lu, Jing Song, Linping Wang, Huan Li, Fangqu Liu, Yidan Zhang, Qiao Ni. Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al. Molecular therapy. Nucleic acids. vol 26. 2021-12-13. PMID:34900398. |
aluminum is a known neurotoxin that can induce aβ deposition and abnormal phosphorylation of tau protein, leading to alzheimer disease (ad)-like damages such as neuronal damage and decreased learning and memory functions. |
2021-12-13 |
2023-08-13 |
rat |