All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Juliana C Silva, Lucy Vivash, Charles B Malpas, Yong Hao, Catriona McLean, Zhibin Chen, Terence J O'Brien, Nigel C Jones, Patrick Kwa. Low prevalence of amyloid and tau pathology in drug-resistant temporal lobe epilepsy. Epilepsia. vol 62. issue 12. 2021-12-01. PMID:34595752. hyperphosphorylated tau (ptau) and amyloid-β (aβ) plaques, pathological hallmarks of alzheimer disease, have been hypothesized to play a mechanistic role. 2021-12-01 2023-08-13 Not clear
Sandhitsu R Das, Xueying Lyu, Michael Tran Duong, Long Xie, Lauren McCollum, Robin de Flores, Michael DiCalogero, David J Irwin, Bradford C Dickerson, Ilya M Nasrallah, Paul A Yushkevich, David A Wol. Tau-Atrophy Variability Reveals Phenotypic Heterogeneity in Alzheimer's Disease. Annals of neurology. vol 90. issue 5. 2021-12-01. PMID:34617306. tau neurofibrillary tangles (t) are the primary driver of downstream neurodegeneration (n) and subsequent cognitive impairment in alzheimer's disease (ad). 2021-12-01 2023-08-13 Not clear
Xue Wu, Zhenxu Xiao, Jingwei Yi, Saineng Ding, Hongchen Gu, Wanqing Wu, Jianfeng Luo, Xiaoniu Liang, Li Zheng, Hong Xu, Qianhua Zhao, Ding Din. Development of a Plasma Biomarker Diagnostic Model Incorporating Ultrasensitive Digital Immunoassay as a Screening Strategy for Alzheimer Disease in a Chinese Population. Clinical chemistry. vol 67. issue 12. 2021-12-01. PMID:34662373. the ultrasensitive detection of blood-based biomarkers such as amyloid β (aβ), tau, and neurofilament light (nfl) has drawn much attention in alzheimer disease (ad) diagnosis. 2021-12-01 2023-08-13 Not clear
Zeba Mueed, Pankaj Kumar Rai, Mohammad Amjad Kamal, Nitesh Kumar Podda. Decoding the Inter-Relationship between Sleep Disorders and Alzheimer's Disease Pathogenesis. CNS & neurological disorders drug targets. vol 20. issue 8. 2021-11-30. PMID:32885762. alzheimer's disease (ad), characterized by abnormally phosphorylated tau, paired helical filaments (phfs), neurofibrillary tangles (nfts), deregulated mammalian target of rapamycin (mtor), and aβ deposits, is a multifactorial disease with sleep disorders being one of the causative agents. 2021-11-30 2023-08-13 Not clear
David S Knopman, Emily S Lundt, Terry M Therneau, Sabrina M Albertson, Jeffrey L Gunter, Matthew L Senjem, Christopher G Schwarz, Michelle M Mielke, Mary M Machulda, Bradley F Boeve, David T Jones, Jon Graff-Radford, Prashanthi Vemuri, Kejal Kantarci, Val J Lowe, Ronald C Petersen, Clifford R Jac. Association of Initial β-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment. JAMA neurology. vol 78. issue 2. 2021-11-30. PMID:33074304. tau accumulation in alzheimer disease (ad) is closely associated with cognitive impairment. 2021-11-30 2023-08-13 Not clear
Vijay K Ramanan, Xuewei Wang, Scott A Przybelski, Sheelakumari Raghavan, Michael G Heckman, Anthony Batzler, Matthew L Kosel, Timothy J Hohman, David S Knopman, Jonathan Graff-Radford, Val J Lowe, Michelle M Mielke, Clifford R Jack, Ronald C Petersen, Owen A Ross, Prashanthi Vemur. Variants in Brain communications. vol 2. issue 2. 2021-11-30. PMID:33426524. variants in tau deposition is a key biological feature of alzheimer's disease that is closely related to cognitive impairment. 2021-11-30 2023-08-13 Not clear
Vijay Krishna Medala, Buchaiah Gollapelli, Saikat Dewanjee, Gilbert Ogunmokun, Ramesh Kandimalla, Jayalakshmi Vallamkond. Mitochondrial dysfunction, mitophagy, and role of dynamin-related protein 1 in Alzheimer's disease. Journal of neuroscience research. vol 99. issue 4. 2021-11-30. PMID:33465841. therefore, targeting mitochondria and associated mitochondrial proteins seems to be a promising alternative instead of targeting aβ and tau in the prevention of alzheimer's disease. 2021-11-30 2023-08-13 mouse
Elijah Mak, Nicolas Nicastro, Maura Malpetti, George Savulich, Ajenthan Surendranathan, Negin Holland, Luca Passamonti, P Simon Jones, Stephen F Carter, Li Su, Young T Hong, Tim D Fryer, Guy B Williams, Franklin Aigbirhio, James B Rowe, John T O'Brie. Imaging tau burden in dementia with Lewy bodies using [ Neurobiology of aging. vol 101. 2021-11-30. PMID:33631469. imaging tau burden in dementia with lewy bodies using [ alzheimer's disease (ad) pathology is frequently observed as a comorbidity in people with dementia with lewy bodies (dlb). 2021-11-30 2023-08-13 Not clear
Yiyuan Xia, Zhi-Hao Wang, Zhentao Zhang, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Xiao-Chuan Wang, Keqiang Y. Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease. Progress in neurobiology. vol 204. 2021-11-30. PMID:34166772. asparagine endopeptidase (aep), a newly identified delta-secretase, simultaneously cleaves both app and tau, promoting alzheimer's disease (ad) pathologies. 2021-11-30 2023-08-13 mouse
Yin Xu, Nicholas E Propson, Shuqi Du, Wen Xiong, Hui Zhen. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 27. 2021-11-30. PMID:34187889. while neuronal autophagy is known to participate in the degradation of neurofibrillary tangles composed of hyperphosphorylated and misfolded tau protein in alzheimer's disease and other tauopathies, how microglial-specific autophagy regulates microglial intrinsic properties and neuronal tau pathology is not well understood. 2021-11-30 2023-08-13 Not clear
Sumire Matsumoto, Tomomi Tsunemats. Association between Sleep, Alzheimer's, and Parkinson's Disease. Biology. vol 10. issue 11. 2021-11-30. PMID:34827122. alzheimer's disease (ad) is a type of dementia that slowly affects memory and cognitive function, and is characterized by the aggregation of the β-amyloid protein and tau neurofibrillary tangles in the brain. 2021-11-30 2023-08-13 Not clear
Laura Ibanez, Justin B Mille. Editorial for the Genetics of Alzheimer's Disease Special Issue: October 2021. Genes. vol 12. issue 11. 2021-11-30. PMID:34828400. alzheimer's disease is a complex and multifactorial condition regulated by both genetics and lifestyle, which ultimately results in the accumulation of β-amyloid (aβ) and tau proteins in the brain, loss of gray matter, and neuronal death [...]. 2021-11-30 2023-08-13 Not clear
Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell'Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amador. Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer's Disease (sAD) Mouse Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830036. tau cleavage contributes to cognitive dysfunction in strepto-zotocin-induced sporadic alzheimer's disease (sad) mouse model. 2021-11-30 2023-08-13 mouse
Valentina Latina, Giacomo Giacovazzo, Pietro Calissano, Anna Atlante, Federico La Regina, Francesca Malerba, Marco Dell'Aquila, Egidio Stigliano, Bijorn Omar Balzamino, Alessandra Micera, Roberto Coccurello, Giuseppina Amador. Tau Cleavage Contributes to Cognitive Dysfunction in Strepto-Zotocin-Induced Sporadic Alzheimer's Disease (sAD) Mouse Model. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830036. tau cleavage plays a crucial role in the onset and progression of alzheimer's disease (ad), a widespread neurodegenerative disease whose incidence is expected to increase in the next years. 2021-11-30 2023-08-13 mouse
Frank Y Shan, Kar-Ming Fung, Tarek Zieneldien, Janice Kim, Chuanhai Cao, Jason H Huan. Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders. Life (Basel, Switzerland). vol 11. issue 11. 2021-11-30. PMID:34833002. furthermore, α-synuclein also appears to contribute to the fibrilization of tau and amyloid beta, which are crucial proteins in alzheimer's disease, advocating for α-synuclein's preeminent role in neurodegeneration. 2021-11-30 2023-08-13 Not clear
Heiko Kroth, Felix Oden, Andreia Monica Serra, Jerome Molette, Andre Mueller, Mathias Berndt, Francesca Capotosti, Emanuele Gabellieri, Heribert Schmitt-Willich, David Hickman, Andrea Pfeifer, Ludger Dinkelborg, Andrew Stephen. Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core. Bioorganic & medicinal chemistry. vol 52. 2021-11-30. PMID:34839158. tau aggregates represent a critical pathology in alzheimer's disease (ad) and other forms of dementia. 2021-11-30 2023-08-13 human
Supriyo Saha, Dilipkumar Pal, Satish B Nims. Recent Advances in the Discovery of GSK-3 Inhibitors from Synthetic Origin in the Treatment of Neurological Disorders. Current drug targets. vol 22. issue 12. 2021-11-29. PMID:33494672. this enzyme mainly phosphorylates tau protein with the increased amount in neuronal fibres together with beta-amyloid plaques that cause neuronal diseases like alzheimer's, parkinson's and many more. 2021-11-29 2023-08-13 mouse
Eleni Gkanatsiou, Charlotte Sahlin, Erik Portelius, Malin Johannesson, Linda Söderberg, Johanna Fälting, Hans Basun, Christer Möller, Tomas Odergren, Henrik Zetterberg, Kaj Blennow, Lars Lannfelt, Gunnar Brinkmal. Characterization of monomeric and soluble aggregated Aβ in Down's syndrome and Alzheimer's disease brains. Neuroscience letters. vol 754. 2021-11-29. PMID:33848613. the major characteristics of alzheimer's disease (ad) are amyloid plaques, consisting of aggregated beta amyloid (aβ) peptides, together with tau pathology (tangles, neuropil treads and dystrophic neurites surrounding the plaques), in the brain. 2021-11-29 2023-08-13 human
Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Y. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease. The EMBO journal. vol 40. issue 17. 2021-11-29. PMID:34260075. gut inflammation triggers c/ebpβ/δ-secretase-dependent gut-to-brain propagation of aβ and tau fibrils in alzheimer's disease. 2021-11-29 2023-08-13 mouse
Mar Pacheco-Herrero, Luis O Soto-Rojas, Heidy Reyes-Sabater, Linda Garcés-Ramirez, Fidel de la Cruz López, Ignacio Villanueva-Fierro, José Luna-Muño. Current Status and Challenges of Stem Cell Treatment for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 84. issue 3. 2021-11-29. PMID:34633316. neurodegenerative diseases called tauopathies, such as alzheimer's disease (ad), frontotemporal dementia, progressive supranuclear palsy, and parkinson's disease, among others, are characterized by the pathological processing and accumulation of tau protein. 2021-11-29 2023-08-13 Not clear