| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månber. CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration. Molecular neurodegeneration. vol 19. issue 1. 2024-02-13. PMID:38350954. |
amyloid and tau aggregates are considered to cause neurodegeneration and consequently cognitive decline in individuals with alzheimer's disease (ad). |
2024-02-13 |
2024-02-16 |
Not clear |
| Aaron T Balana, Anne-Laure Mahul-Mellier, Binh A Nguyen, Mian Horvath, Afraah Javed, Eldon R Hard, Yllza Jasiqi, Preeti Singh, Shumaila Afrin, Rose Pedretti, Virender Singh, Virginia M-Y Lee, Kelvin C Luk, Lorena Saelices, Hilal A Lashuel, Matthew R Prat. O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology. Nature chemical biology. 2024-02-12. PMID:38347213. |
amyloid-forming proteins such α-synuclein and tau, which are implicated in alzheimer's and parkinson's disease, can form different fibril structures or strains with distinct toxic properties, seeding activities and pathology. |
2024-02-12 |
2024-02-15 |
Not clear |
| Pranesh Padmanabhan, Andrew Kneynsberg, Esteban Cruz, Adam Briner, Jürgen Göt. Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular brain. vol 17. issue 1. 2024-02-12. PMID:38347594. |
the most studied of these modifications is phosphorylation, which affects tau's aggregation and loss- and gain-of-functions, including the interaction with microtubules, in alzheimer's disease and primary tauopathies. |
2024-02-12 |
2024-02-15 |
Not clear |
| Wei Li, Hong-Lian Li, Jian-Zhi Wang, Rong Liu, Xiaochuan Wan. Abnormal protein post-translational modifications induces aggregation and abnormal deposition of protein, mediating neurodegenerative diseases. Cell & bioscience. vol 14. issue 1. 2024-02-12. PMID:38347638. |
for example, the main pathological features of alzheimer's disease are the aggregation of beta-amyloid protein and abnormal phosphorylation of tau protein. |
2024-02-12 |
2024-02-15 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
impaired sleep is associated with tau deposition on impaired sleep is commonly associated with alzheimer's disease (ad), although the underlying mechanisms remain unclear. |
2024-02-11 |
2024-02-14 |
Not clear |
| Ryan T Kim, Liangdong Zhou, Yi Li, Ana C Krieger, Anna S Nordvig, Tracy Butler, Mony J de Leon, Gloria C Chian. Impaired sleep is associated with tau deposition on Journal of the neurological sciences. vol 458. 2024-02-11. PMID:38341949. |
using data from the alzheimer's disease neuroimaging initiative, we investigated whether a medical history of impaired sleep, informant-reported nighttime behaviors, and sleep-affecting medications are associated with beta-amyloid and tau deposition on pet and cognitive change, cross-sectionally and longitudinally. |
2024-02-11 |
2024-02-14 |
Not clear |
| D M Sithara Dissanayaka, Vijay Jayasena, Stephanie R Rainey-Smith, Ralph N Martins, W M A D Binosha Fernand. The Role of Diet and Gut Microbiota in Alzheimer's Disease. Nutrients. vol 16. issue 3. 2024-02-10. PMID:38337696. |
alzheimer's disease (ad), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (aβ) plaques and hyperphosphorylated tau tangles. |
2024-02-10 |
2024-02-12 |
Not clear |
| Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H Chen. Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases. Molecules (Basel, Switzerland). vol 29. issue 3. 2024-02-10. PMID:38338484. |
the molecular events of protein misfolding and self-aggregation of tau and amylin are associated with the progression of alzheimer's and diabetes, respectively. |
2024-02-10 |
2024-02-12 |
Not clear |
| Tânia Soares Martins, Steven Pelech, Maria Ferreira, Beatriz Pinho, Kevin Leandro, Luís Pereira de Almeida, Benedict Breitling, Niels Hansen, Hermann Esselmann, Jens Wiltfang, Odete A B da Cruz E Silva, Ana Gabriela Henrique. Phosphoproteome Microarray Analysis of Extracellular Particles as a Tool to Explore Novel Biomarker Candidates for Alzheimer's Disease. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338863. |
phosphorylation plays a key role in alzheimer's disease (ad) pathogenesis, impacting distinct processes such as amyloid-beta (aβ) peptide production and tau phosphorylation. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
the associations of phosphorylated tau 181 and tau 231 levels in plasma and cerebrospinal fluid with cognitive function in alzheimer's disease: a systematic review and meta-analysis. |
2024-02-10 |
2024-02-12 |
Not clear |
| Zhirui Li, Zixuan Fan, Qian Zhan. The Associations of Phosphorylated Tau 181 and Tau 231 Levels in Plasma and Cerebrospinal Fluid with Cognitive Function in Alzheimer's Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's disease : JAD. 2024-02-10. PMID:38339929. |
cerebrospinal fluid (csf) or blood biomarkers like phosphorylated tau proteins (p-tau) are used to detect alzheimer's disease (ad) early. |
2024-02-10 |
2024-02-12 |
Not clear |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
generation of tau dephosphorylation-targeting chimeras for the treatment of alzheimer's disease and related tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jingfen Su, Yue Xiao, Linyu Wei, Huiyang Lei, Fei Sun, Weixia Wang, Jun Yin, Rui Xiong, Shihong Li, Pei Zhang, Ying Zhou, Xiaochuan Wang, Jie Zheng, Jian-Zhi Wan. Generation of tau dephosphorylation-targeting chimeras for the treatment of Alzheimer's disease and related tauopathies. Science bulletin. 2024-02-10. PMID:38341350. |
abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in alzheimer's disease (ad) and many other tauopathies. |
2024-02-10 |
2024-02-14 |
mouse |
| Jung-Min Pyun, Young Ho Park, Young Chul Youn, Min Ju Kang, Kyu Hwan Shim, Jae-Won Jang, Jihwan You, Kwangsik Nho, SangYun Ki. Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity. Translational psychiatry. vol 14. issue 1. 2024-02-10. PMID:38341444. |
we compared tau burden measured by pet, brain volume assessed by mri, cross-sectional cognitive function, longitudinal cognitive decline and polygenic risk score (prs) between pet/plasma groups (pet-/plasma-, pet-/plasma+, pet+/plasma-, pet+/plasma+) using alzheimer's disease neuroimaging initiative database. |
2024-02-10 |
2024-02-14 |
human |
| Corrina S Fonseca, Suzanne L Baker, Lindsey Dobyns, Mustafa Janabi, William J Jagust, Theresa M Harriso. Tau accumulation and atrophy predict amyloid independent cognitive decline in aging. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2024-02-09. PMID:38334195. |
amyloid beta (aβ) and tau pathology are cross-sectionally associated with atrophy and cognitive decline in aging and alzheimer's disease (ad). |
2024-02-09 |
2024-02-11 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
impact of apoe on amyloid and tau accumulation in argyrophilic grain disease and alzheimer's disease. |
2024-02-09 |
2024-02-12 |
Not clear |
| Ana-Caroline Raulin, Sydney V Doss, Michael G Heckman, Emily C Craver, Zonghua Li, Tadafumi C Ikezu, Hiroaki Sekiya, Chia-Chen Liu, Yuka A Martens, Cassandra L Rosenberg, Lindsey A Kuchenbecker, Michael DeTure, R Ross Reichard, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Emmaline K Kounaves, Melissa E Murray, Dennis W Dickson, Ronald C Petersen, Guojun Bu, Takahisa Kanekiy. Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease. Acta neuropathologica communications. vol 12. issue 1. 2024-02-09. PMID:38336940. |
alzheimer's disease (ad), characterized by the deposition of amyloid-β (aβ) in senile plaques and neurofibrillary tangles of phosphorylated tau (ptau), is increasingly recognized as a complex disease with multiple pathologies. |
2024-02-09 |
2024-02-12 |
Not clear |
| Belfin Robinson, Shankar Bhamidi, Eran Daya. The spatial distribution of coupling between tau and neurodegeneration in amyloid-β positive mild cognitive impairment. Neurobiology of aging. vol 136. 2024-02-08. PMID:38330641. |
synergies between amyloid-β (aβ), tau, and neurodegeneration persist along the alzheimer's disease (ad) continuum. |
2024-02-08 |
2024-02-11 |
human |
| Ahmed A Elbatrawy, Taiwo A Ademoye, Heba Alnakhala, Arati Tripathi, Ashique Zami, Raluca Ostafe, Ulf Dettmer, Jessica S Forti. Discovery of small molecule benzothiazole and indole derivatives tackling tau 2N4R and α-synuclein fibrils. Bioorganic & medicinal chemistry. vol 100. 2024-02-08. PMID:38330847. |
tau and α-synuclein aggregates are the main histopathological hallmarks present in alzheimer's disease (ad), parkinson's disease (pd), and other neurodegenerative disorders. |
2024-02-08 |
2024-02-11 |
Not clear |
| Mo Chen, Xuejian Feng, Jiaxin Liu, Jianan Wang, Xu Yang, Xianghui Yu, Wei Kong, Bo Sun, Hui W. Prokaryote-derived phosphorylated Tau epitope vaccine is immunogenic and non-T-cell activated in the mice model. Vaccine. 2024-02-08. PMID:38331660. |
accumulation of phosphorylated tau protein is a prominent pathological hallmark of alzheimer's disease (ad). |
2024-02-08 |
2024-02-11 |
mouse |