| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tomohiro Tsuchida, Kouki Susa, Tomohiro Kibiki, Takahiro Tsuchiya, Katsushiro Miyamoto, Yasuko In, Katsuhiko Minoura, Taizo Taniguchi, Toshimasa Ishida, Koji Tomo. Structural study of the recognition mechanism of tau antibody Tau2r3 with the key sequence (VQIINK) in tau aggregation. Biochemical and biophysical research communications. vol 585. 2021-11-29. PMID:34784549. |
one of the histopathological features of alzheimer's disease (ad) is higher order neurofibrillary tangles formed by abnormally aggregated tau protein. |
2021-11-29 |
2023-08-13 |
Not clear |
| Diana M Acosta, Chiara Mancinelli, Clay Bracken, David Elieze. Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation. The Journal of biological chemistry. 2021-11-28. PMID:34838590. |
post-translationally modified tau is the primary component of tau neurofibrillary tangles, a pathological hallmark of alzheimer's disease and other tauopathies. |
2021-11-28 |
2023-08-13 |
Not clear |
| Ashif Iqubal, Syed Obaidur Rahman, Musheer Ahmed, Pratichi Bansal, Md Rafi Haider, Mohammad Kashif Iqubal, Abul Kalam Najmi, Faheem Hyder Pottoo, Syed Ehtaishamul Haqu. Current Quest in Natural Bioactive Compounds for Alzheimer's Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence. Current drug targets. vol 22. issue 6. 2021-11-26. PMID:33302832. |
pathologically, alzheimer's disease (ad) is characterized by the presence of β-amyloid (aβ) plaques, hyper-phosphorylated tau proteins, and neurofibrillary tangles, however, persistence oxidative-nitrative stress, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, pro-apoptotic proteins along with altered neurotransmitters level are common etiological attributes in its pathogenesis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Joseph R Winer, Allison Morehouse, Laura Fenton, Theresa M Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L Baker, William J Jagust, Matthew P Walke. Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 36. 2021-11-26. PMID:34290080. |
alzheimer's disease is associated with poor sleep, but the impact of tau and β-amyloid (aβ) pathology on sleep remains largely unknown. |
2021-11-26 |
2023-08-13 |
human |
| Yaochen Chuang, Iatkio Van, Yonghua Zhao, Youhua X. Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34407393. |
the mechanism of alzheimer's disease is closely associated with the aggregation of amyloid-β protein and causes neurotoxicity and extracellular accumulation in the brain and to intracellular neurofibrillary tangles caused by tau protein hyperphosphorylation in the brain tissue. |
2021-11-26 |
2023-08-13 |
Not clear |
| Yaochen Chuang, Iatkio Van, Yonghua Zhao, Youhua X. Icariin ameliorate Alzheimer's disease by influencing SIRT1 and inhibiting Aβ cascade pathogenesis. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34407393. |
the decrease of sirtuin1 level would cause alzheimer's disease by means of promoting the amyloidogenic pathway to generate amyloid-β species and thereby triggering amyloid-β cascade reaction, such as tau protein hyperphosphorylation, neuron autophagy, neuroinflammation, oxidative stress, and neuron apoptosis. |
2021-11-26 |
2023-08-13 |
Not clear |
| Henika Patel, Pablo Martinez, Abigail Perkins, Xavier Taylor, Nur Jury, David McKinzie, Cristian A Lasagna-Reeve. Pathological tau and reactive astrogliosis are associated with distinct functional deficits in a mouse model of tauopathy. Neurobiology of aging. vol 109. 2021-11-26. PMID:34655981. |
pathological aggregation of tau and neuroinflammatory changes mark the clinical course of alzheimer's disease and related tauopathies. |
2021-11-26 |
2023-08-13 |
mouse |
| Erica Barini, Gudrun Plotzky, Yulia Mordashova, Jonas Hoppe, Esther Rodriguez-Correa, Sonja Julier, Florie LePrieult, Ina Mairhofer, Mario Mezler, Sandra Biesinger, Miroslav Cik, Marcus W Meinhardt, Ebru Ercan-Herbst, Dagmar E Ehrnhoefer, Andreas Striebinger, Karen Bodie, Corinna Klein, Laura Gasparini, Kerstin Schlege. Tau in the brain interstitial fluid is fragmented and seeding-competent. Neurobiology of aging. vol 109. 2021-11-26. PMID:34655982. |
in alzheimer disease, tau pathology is thought to propagate from cell to cell throughout interconnected brain areas. |
2021-11-26 |
2023-08-13 |
mouse |
| Bora Yoon, Tengfei Guo, Karine Provost, Deniz Korman, Tyler J Ward, Susan M Landau, William J Jagus. Abnormal tau in amyloid PET negative individuals. Neurobiology of aging. vol 109. 2021-11-26. PMID:34715443. |
we included 561 participants with aβ and tau pet from the alzheimer's disease neuroimaging initiative (adni). |
2021-11-26 |
2023-08-13 |
human |
| M Jahanshahi, E Nikmahzar, S Gorgan. Taurine can Decrease Phosphorylated Tau Protein Levels in Alzheimer's Model Rats' Brains. Kathmandu University medical journal (KUMJ). vol 19. issue 74. 2021-11-26. PMID:34819436. |
taurine can decrease phosphorylated tau protein levels in alzheimer's model rats' brains. |
2021-11-26 |
2023-08-13 |
rat |
| Annie G Bryant, Mary K Manhard, David H Salat, Bruce R Rosen, Bradley T Hyman, Keith A Johnson, Susie Huang, Rachel E Bennett, Yi-Fen Ye. Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Current Alzheimer research. 2021-11-26. PMID:34825871. |
reduced cerebrovascular function and accumulation of tau pathology are key components of cognitive decline in alzheimer's disease (ad). |
2021-11-26 |
2023-08-13 |
Not clear |
| Jayanti Mishra, Bhumika Kumar, Mukesh Pandey, Faheem H Pottoo, Faizana Fayaz, Firdos Alam Khan, Pravat K Saho. Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer's Disease. Combinatorial chemistry & high throughput screening. vol 24. issue 10. 2021-11-25. PMID:32957874. |
neurodegeneration in alzheimer's disease is the result of the deposition of protein beta-amyloid that forms plaques and another protein called tau, forming tangles that prevent the proper functioning of nerve cells in the brain. |
2021-11-25 |
2023-08-13 |
Not clear |
| Emily Miyoshi, Tina Bilousova, Mikhail Melnik, Danyl Fakhrutdinov, Wayne W Poon, Harry V Vinters, Carol A Miller, Maria Corrada, Claudia Kawas, Ryan Bohannan, Chad Caraway, Chris Elias, Katherine N Maina, Jesus J Campagna, Varghese John, Karen Hoppens Gyly. Exosomal tau with seeding activity is released from Alzheimer's disease synapses, and seeding potential is associated with amyloid beta. Laboratory investigation; a journal of technical methods and pathology. vol 101. issue 12. 2021-11-25. PMID:34462532. |
exosomal tau with seeding activity is released from alzheimer's disease synapses, and seeding potential is associated with amyloid beta. |
2021-11-25 |
2023-08-13 |
mouse |
| Sarah Helena Nies, Hideyuki Takahashi, Charlotte S Herber, Anita Huttner, Alison Chase, Stephen M Strittmatte. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. The Journal of biological chemistry. vol 297. issue 4. 2021-11-25. PMID:34480901. |
spreading of alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. |
2021-11-25 |
2023-08-13 |
mouse |
| Sarah Helena Nies, Hideyuki Takahashi, Charlotte S Herber, Anita Huttner, Alison Chase, Stephen M Strittmatte. Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β. The Journal of biological chemistry. vol 297. issue 4. 2021-11-25. PMID:34480901. |
in alzheimer's disease (ad), deposition of pathological tau and amyloid-β (aβ) drive synaptic loss and cognitive decline. |
2021-11-25 |
2023-08-13 |
mouse |
| Samantha M Rossano, William Charles Kreis. Untangling the relationship between microglia and tau in Alzheimer's disease. Trends in neurosciences. vol 44. issue 12. 2021-11-25. PMID:34674877. |
untangling the relationship between microglia and tau in alzheimer's disease. |
2021-11-25 |
2023-08-13 |
Not clear |
| Samantha M Rossano, William Charles Kreis. Untangling the relationship between microglia and tau in Alzheimer's disease. Trends in neurosciences. vol 44. issue 12. 2021-11-25. PMID:34674877. |
autopsy and imaging studies have demonstrated a typical pattern of tau progression in alzheimer's disease (ad), spreading to previously unaffected regions in an anatomical sequence of 'braak' stages. |
2021-11-25 |
2023-08-13 |
Not clear |
| Laura Owlett, Elizabeth K Belcher, Dawling A Dionisio-Santos, Jacqueline P Williams, John A Olschowka, M Kerry O'Banio. Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease. Life sciences in space research. vol 27. 2021-11-25. PMID:34756235. |
space radiation does not alter amyloid or tau pathology in the 3xtg mouse model of alzheimer's disease. |
2021-11-25 |
2023-08-13 |
mouse |
| Laura Owlett, Elizabeth K Belcher, Dawling A Dionisio-Santos, Jacqueline P Williams, John A Olschowka, M Kerry O'Banio. Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease. Life sciences in space research. vol 27. 2021-11-25. PMID:34756235. |
previous work demonstrated a worsening of alzheimer's disease pathology in the app/ps1 transgenic mouse model, however effects of space radiation on tau pathology have not been studied. |
2021-11-25 |
2023-08-13 |
mouse |
| Diana Kindler, Cinzia Maschio, Ruiqing Ni, Valerio Zerbi, Daniel Razansky, Jan Kloh. Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2021-11-25. PMID:34822744. |
while perfusion deficits have been observed in patients with alzheimer's disease and tauopaties, little is known about the role of tau in vascular dysfunction. |
2021-11-25 |
2023-08-13 |
mouse |