| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clifford R Jack, Terry M Therneau, Stephen D Weigand, Heather J Wiste, David S Knopman, Prashanthi Vemuri, Val J Lowe, Michelle M Mielke, Rosebud O Roberts, Mary M Machulda, Jonathan Graff-Radford, David T Jones, Christopher G Schwarz, Jeffrey L Gunter, Matthew L Senjem, Walter A Rocca, Ronald C Peterse. Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework. JAMA neurology. 2021-11-24. PMID:31305929. |
a national institute on aging-alzheimer's association (nia-aa) workgroup recently published a research framework in which alzheimer disease is defined by neuropathologic or biomarker evidence of β-amyloid plaques and tau tangles and not by clinical symptoms. |
2021-11-24 |
2023-08-13 |
Not clear |
| Yuancheng Li, Esther Lim, Travis Fields, Hui Wu, Yaolin Xu, Y Andrew Wang, Hui Ma. Improving Sensitivity and Specificity of Amyloid-β Peptides and Tau Protein Detection with Antibiofouling Magnetic Nanoparticles for Liquid Biopsy of Alzheimer's Disease. ACS biomaterials science & engineering. vol 5. issue 7. 2021-11-24. PMID:33405741. |
improving sensitivity and specificity of amyloid-β peptides and tau protein detection with antibiofouling magnetic nanoparticles for liquid biopsy of alzheimer's disease. |
2021-11-24 |
2023-08-13 |
Not clear |
| Jui-Heng Tseng, Aditi Ajit, Zarin Tabassum, Niyati Patel, Xu Tian, Youjun Chen, Alex W Prevatte, Karen Ling, Frank Rigo, Rick B Meeker, Laura E Herring, Todd J Cohe. Tau seeds are subject to aberrant modifications resulting in distinct signatures. Cell reports. vol 35. issue 4. 2021-11-24. PMID:33910013. |
the prion-like spread of tau pathology could underlie a spectrum of clinical syndromes including alzheimer's disease (ad). |
2021-11-24 |
2023-08-13 |
human |
| Amy F T Arnsten, Dibyadeep Datta, Todd M Preus. Studies of aging nonhuman primates illuminate the etiology of early-stage Alzheimer's-like neuropathology: An evolutionary perspective. American journal of primatology. vol 83. issue 11. 2021-11-24. PMID:33960505. |
tau pathology in alzheimer's disease (ad) preferentially afflicts the limbic and recently enlarged association cortices, causing a progression of mnemonic and cognitive deficits. |
2021-11-24 |
2023-08-13 |
mouse |
| Yun Chen, Marco Colonn. Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice? The Journal of experimental medicine. vol 218. issue 9. 2021-11-24. PMID:34292312. |
alzheimer's disease (ad) is characterized by extracellular aggregates of amyloid β peptides, intraneuronal tau aggregates, and neuronal death. |
2021-11-24 |
2023-08-13 |
mouse |
| Sazan Ismael, Ghadir Sindi, Robert A Colvin, Daewoo Le. Activity-dependent release of phosphorylated human tau from Drosophila neurons in primary culture. The Journal of biological chemistry. vol 297. issue 4. 2021-11-24. PMID:34473990. |
this activity-dependent tau release can be used to study the progression of tau pathology in alzheimer's disease (ad), as hyperphosphorylated tau is implicated in ad pathogenesis and related tauopathies. |
2021-11-24 |
2023-08-13 |
human |
| Nastaran Samimi, Govinda Sharma, Taeko Kimura, Tomoyasu Matsubara, Anni Huo, Kurumi Chiba, Yuko Saito, Shigeo Murayama, Hiroyasu Akatsu, Yoshio Hashizume, Masato Hasegawa, Mojtaba Farjam, Koorosh Shahpasand, Kanae Ando, Shin-Ichi Hisanag. Distinct phosphorylation profiles of tau in brains of patients with different tauopathies. Neurobiology of aging. vol 108. 2021-11-24. PMID:34536819. |
here, we investigated the phosphorylation states of tau in several tauopathies, including corticobasal degeneration, pick's disease, progressive supranuclear palsy (psp), argyrophilic grain dementia (agd) and alzheimer's disease (ad). |
2021-11-24 |
2023-08-13 |
Not clear |
| Gabriella King, Kaliana M Veros, Duncan Archibald Allan MacLaren, Martin Peter Konrad Leigh, Joseph A Spernyak, Stewart D Clar. Human wildtype tau expression in cholinergic pedunculopontine tegmental neurons is sufficient to produce PSP-like behavioural deficits and neuropathology. The European journal of neuroscience. vol 54. issue 10. 2021-11-24. PMID:34668254. |
in contrast to parkinson's disease, the underlying pathology displays aggregation of the protein tau, which is also seen in disorders such as alzheimer's disease. |
2021-11-24 |
2023-08-13 |
human |
| Somayeh Meysami, Cyrus A Raji, David A Merrill, Verna R Porter, Mario F Mende. Quantitative MRI Differences Between Early versus Late Onset Alzheimer's Disease. American journal of Alzheimer's disease and other dementias. vol 36. 2021-11-24. PMID:34814740. |
investigators report greater parietal tau deposition and alternate frontoparietal network involvement in early onset alzheimer's disease (eoad) with onset <65 years as compared with typical late onset ad (load). |
2021-11-24 |
2023-08-13 |
Not clear |
| Giovanni B Frisoni, Daniele Altomare, Dietmar Rudolf Thal, Federica Ribaldi, Rik van der Kant, Rik Ossenkoppele, Kaj Blennow, Jeffrey Cummings, Cornelia van Duijn, Peter M Nilsson, Pierre-Yves Dietrich, Philip Scheltens, Bruno Duboi. The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. Nature reviews. Neuroscience. 2021-11-24. PMID:34815562. |
the current conceptualization of alzheimer disease (ad) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid deposition and then tau deposition to neurodegeneration and progressive cognitive impairment. |
2021-11-24 |
2023-08-13 |
Not clear |
| Evan E Hubbard, Lilian R Heil, Gennifer E Merrihew, Jasmeer P Chhatwal, Martin R Farlow, Catriona A McLean, Bernardino Ghetti, Kathy L Newell, Matthew P Frosch, Randall J Bateman, Eric B Larson, C Dirk Keene, Richard J Perrin, Thomas J Montine, Michael J MacCoss, Ryan R Julia. Does Data-Independent Acquisition Data Contain Hidden Gems? A Case Study Related to Alzheimer's Disease. Journal of proteome research. 2021-11-24. PMID:34818016. |
examination of a large set of human brain samples revealed a striking relationship between alzheimer's disease (ad) status and isomerization of aspartic acid in a peptide from tau. |
2021-11-24 |
2023-08-13 |
human |
| Ana Baena, Yamile Bocanegra, Valeria Torres, Clara Vila-Castelar, Edmarie Guzmán-Vélez, Joshua T Fox-Fuller, Jennifer R Gatchel, Justin Sánchez, Celina F Pluim, Liliana Ramirez-Gómez, Jairo Martínez, David Pineda, Francisco Lopera, Yakeel T Quiro. Neuroticism Is Associated with Tau Pathology in Cognitively Unimpaired Individuals with Autosomal Dominant Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 82. issue 4. 2021-11-23. PMID:34219716. |
neuroticism is associated with tau pathology in cognitively unimpaired individuals with autosomal dominant alzheimer's disease. |
2021-11-23 |
2023-08-13 |
Not clear |
| Marwa Malhis, Senthilvelrajan Kaniyappan, Isabelle Aillaud, Ram Reddy Chandupatla, Lisa Marie Ramirez, Markus Zweckstetter, Anselm H C Horn, Eckhard Mandelkow, Heinrich Sticht, Susanne Aileen Funk. Potent Tau Aggregation Inhibitor D-Peptides Selected against Tau-Repeat 2 Using Mirror Image Phage Display. Chembiochem : a European journal of chemical biology. vol 22. issue 21. 2021-11-23. PMID:34375027. |
alzheimer's disease and other tauopathies are associated with neurofibrillary tangles composed of tau protein, as well as toxic tau oligomers. |
2021-11-23 |
2023-08-13 |
Not clear |
| Jacob Ziontz, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Hippocampal Connectivity with Retrosplenial Cortex is Linked to Neocortical Tau Accumulation and Memory Function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 42. 2021-11-23. PMID:34531286. |
the mechanisms underlying accumulation of alzheimer's disease (ad)-related tau pathology outside of the medial temporal lobe (mtl) in older adults are unknown but crucial to understanding cognitive decline. |
2021-11-23 |
2023-08-13 |
human |
| Bin Dai, Tao Zhong, Zhi-Xian Chen, Wang Chen, Na Zhang, Xiao-Ling Liu, Li-Qiang Wang, Jie Chen, Yi Lian. Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34560101. |
intraneuronal neurofibrillary tangles composed of tau aggregates have been widely accepted as an important pathological hallmark of alzheimer's disease. |
2021-11-23 |
2023-08-13 |
human |
| Bin Dai, Tao Zhong, Zhi-Xian Chen, Wang Chen, Na Zhang, Xiao-Ling Liu, Li-Qiang Wang, Jie Chen, Yi Lian. Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34560101. |
a current therapeutic avenue for treating alzheimer's disease is aimed at inhibiting tau accumulation with small molecules such as natural flavonoids. |
2021-11-23 |
2023-08-13 |
human |
| Bin Dai, Tao Zhong, Zhi-Xian Chen, Wang Chen, Na Zhang, Xiao-Ling Liu, Li-Qiang Wang, Jie Chen, Yi Lian. Myricetin slows liquid-liquid phase separation of Tau and activates ATG5-dependent autophagy to suppress Tau toxicity. The Journal of biological chemistry. vol 297. issue 4. 2021-11-23. PMID:34560101. |
collectively, these results demonstrate how llps and abnormal aggregation of tau are inhibited by natural flavonoids, bridging the gap between tau llps and aggregation in neuronal cells, and also establish that myricetin could act as an atg5-dependent autophagic activator to ameliorate the pathogenesis of alzheimer's disease. |
2021-11-23 |
2023-08-13 |
human |
| Hao Li, Eunjung Joo, Jin Yong Le. Theoretical Insights into Mutation and Histidine Tautomerism Effects on Tau Proteins. ACS chemical neuroscience. vol 12. issue 22. 2021-11-23. PMID:34735109. |
research on misfolding of tau proteins will help to better understand the formation process of neurofibrillary tangles, a hallmark of alzheimer's disease. |
2021-11-23 |
2023-08-13 |
Not clear |
| Narendran Annadurai, Lukáš Malina, Mario Salmona, Luisa Diomede, Antonio Bastone, Alfredo Cagnotto, Margherita Romeo, Martin Šrejber, Karel Berka, Michal Otyepka, Marián Hajdúch, Viswanath Da. Antitumour drugs targeting tau R3 VQIVYK and Cys322 prevent seeding of endogenous tau aggregates by exogenous seeds. The FEBS journal. 2021-11-23. PMID:34743390. |
emerging experimental evidence suggests tau pathology spreads between neuroanatomically connected brain regions in a prion-like manner in alzheimer's disease (ad). |
2021-11-23 |
2023-08-13 |
human |
| Longfei Jia, Min Zhu, Jianwei Yang, Yana Pang, Qi Wang, Ying Li, Tingting Li, Fangyu Li, Qigeng Wang, Yan Li, Yiping We. Prediction of P-tau/Aβ42 in the cerebrospinal fluid with blood microRNAs in Alzheimer's disease. BMC medicine. vol 19. issue 1. 2021-11-23. PMID:34775974. |
the most common biomarkers of alzheimer's disease (ad) are amyloid β (aβ) and tau, detected in cerebrospinal fluid (csf) or with positron emission tomography imaging. |
2021-11-23 |
2023-08-13 |
Not clear |