| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James R Hall, Melissa Petersen, Leigh Johnson, Sid E O'Bryan. Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults. Frontiers in psychology. vol 12. 2021-11-23. PMID:34803857. |
the presence of higher levels of plasma tau and elevated neurobehavioral symptoms may be an early indicator of cognitive decline and prodromal alzheimer's disease. |
2021-11-23 |
2023-08-13 |
human |
| Cinzia Severini, Christian Barbato, Maria Grazia Di Certo, Francesca Gabanella, Carla Petrella, Arianna Di Stadio, Marco de Vincentiis, Antonella Polimeni, Massimo Ralli, Antonio Grec. Alzheimer's Disease: New Concepts on the Role of Autoimmunity and NLRP3 Inflammasome in the Pathogenesis of the Disease. Current neuropharmacology. vol 19. issue 4. 2021-11-22. PMID:32564756. |
alzheimer's disease (ad), recognized as the most common neurodegenerative disorder, is clinically characterized by the presence of extracellular beta-amyloid (aβ) plaques and by intracellular neurofibrillary tau tangles, accompanied by glial activation and neuroinflammation. |
2021-11-22 |
2023-08-13 |
Not clear |
| Vasilios C Constantinides, George P Paraskevas, Fotini Boufidou, Mara Bourbouli, Leonidas Stefanis, Elisabeth Kapak. Cerebrospinal fluid biomarker profiling in corticobasal degeneration: Application of the AT(N) and other classification systems. Parkinsonism & related disorders. vol 82. 2021-11-22. PMID:33246219. |
total tau (τt), phosphorylated tau (τp-181) and amyloid beta (aβ42) are cerebrospinal fluid (csf) biomarkers of alzheimer's disease (ad). |
2021-11-22 |
2023-08-13 |
Not clear |
| Mina Eftekharzadeh, Sara Simorgh, Maryam Doshmanziari, Leila Hassanzadeh, Marjan Shariatpanah. Human adipose-derived stem cells reduce receptor-interacting protein 1, receptor-interacting protein 3, and mixed lineage kinase domain-like pseudokinase as necroptotic markers in rat model of Alzheimer's disease. Indian journal of pharmacology. vol 52. issue 5. 2021-11-22. PMID:33283771. |
alzheimer's disease (ad) is a constant, developing brain impairment that is described as the aggregation of misfolded amyloid-beta-peptide (ab) and abnormal tau protein in the brain. |
2021-11-22 |
2023-08-13 |
human |
| Boris Guennewig, Julia Lim, Lee Marshall, Andrew N McCorkindale, Patrick J Paasila, Ellis Patrick, Jillian J Kril, Glenda M Halliday, Antony A Cooper, Greg T Sutherlan. Defining early changes in Alzheimer's disease from RNA sequencing of brain regions differentially affected by pathology. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33649380. |
tau pathology in alzheimer's disease (ad) spreads in a predictable pattern that corresponds with disease symptoms and severity. |
2021-11-22 |
2023-08-13 |
Not clear |
| Jaeho Kim, Yuhyun Park, Seongbeom Park, Hyemin Jang, Hee Jin Kim, Duk L Na, Hyejoo Lee, Sang Won Se. Prediction of tau accumulation in prodromal Alzheimer's disease using an ensemble machine learning approach. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33707488. |
prediction of tau accumulation in prodromal alzheimer's disease using an ensemble machine learning approach. |
2021-11-22 |
2023-08-13 |
human |
| Derek H Oakley, Naomi Klickstein, Caitlin Commins, Mirra Chung, Simon Dujardin, Rachel E Bennett, Bradley T Hyman, Matthew P Frosc. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 19. 2021-11-22. PMID:33893219. |
tau aggregation within neurons is a critical feature of alzheimer's disease (ad) and related tauopathies. |
2021-11-22 |
2023-08-13 |
human |
| Deepthi Rapaka, Veera Raghavulu Bitra, Siva Reddy Challa, Paul C Adiukw. Potentiation of microglial endocannabinoid signaling alleviates neuroinflammation in Alzheimer's disease. Neuropeptides. vol 90. 2021-11-22. PMID:34508923. |
alzheimer's disease (ad) isaprogressive neurodegenerative disorder characterized by chronic inflammation due to the presence of neurotoxic aβ and tau proteins. |
2021-11-22 |
2023-08-13 |
Not clear |
| Bhanwar Singh Choudhary, Sukanya, Pakhuri Mehta, Stephane Bach, Sandrine Ruchaud, Thomas Robert, Beatrice Josselin, Slawomir Filipek, Ruchi Mali. Discovery of thiazolidin-4-one analogue as selective GSK-3β inhibitor through structure based virtual screening. Bioorganic & medicinal chemistry letters. vol 52. 2021-11-22. PMID:34560262. |
gsk-3β directly phosphorylate tubulin binding site of tau protein, indicating its importance in tau aggregation and, therefore, in alzheimer's disease pathology. |
2021-11-22 |
2023-08-13 |
Not clear |
| Alireza Moein Alsadat, Farnaz Nikbakht, Hadiseh Hossein Nia, Fereshteh Golab, Yasaman Khadem, Mahmoud Barati, Somayeh Vazifekha. GSK-3β as a target for apigenin-induced neuroprotection against Aβ 25-35 in a rat model of Alzheimer's disease. Neuropeptides. vol 90. 2021-11-22. PMID:34597878. |
glycogen synthase kinase-3 (gsk-3) is a critical molecule in alzheimer's disease (ad) that modulates two histopathological hallmarks of ad: amyloid beta (aβ) plaques and neurofibrillary tangles composed of aberrant hyper-phosphorylation of tau protein. |
2021-11-22 |
2023-08-13 |
rat |
| Anand Kumar, Charles B Nemeroff, Joseph J Cooper, Alik Widge, Carolyn Rodriguez, Linda Carpenter, William M McDonal. Amyloid and Tau in Alzheimer's Disease: Biomarkers or Molecular Targets for Therapy? Are We Shooting the Messenger? The American journal of psychiatry. vol 178. issue 11. 2021-11-22. PMID:34734743. |
amyloid and tau in alzheimer's disease: biomarkers or molecular targets for therapy? |
2021-11-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Balazs Toth, Paul T Manser, Sandra Sanabria-Bohórquez, Edmond Teng, Michael Keeley, Randall J Bateman, Robby M Weimer, Kristin R Wildsmit. Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated. Journal of Alzheimer's disease : JAD. 2021-11-22. PMID:34806603. |
site-specific cerebrospinal fluid tau hyperphosphorylation in response to alzheimer's disease brain pathology: not all tau phospho-sites are hyperphosphorylated. |
2021-11-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Balazs Toth, Paul T Manser, Sandra Sanabria-Bohórquez, Edmond Teng, Michael Keeley, Randall J Bateman, Robby M Weimer, Kristin R Wildsmit. Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated. Journal of Alzheimer's disease : JAD. 2021-11-22. PMID:34806603. |
understanding patterns of association between csf phosphorylated tau (p-tau) species and clinical disease severity will aid alzheimer's disease (ad) diagnosis and treatment. |
2021-11-22 |
2023-08-13 |
Not clear |
| Erden Eren, Jack F V Hunt, Michelle Shardell, Sahil Chawla, Joyce Tran, Jeffrey Gu, Nick M Vogt, Sterling C Johnson, Barbara B Bendlin, Dimitrios Kapogianni. Extracellular vesicle biomarkers of Alzheimer's disease associated with sub-clinical cognitive decline in late middle age. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32588967. |
neuronal extracellular vesicle (nev) tau and insulin signaling biomarkers may detect preclinical alzheimer's disease and age-associated cognitive decline. |
2021-11-19 |
2023-08-13 |
Not clear |
| Mitchel A Kling, Dayan B Goodenowe, Vijitha Senanayake, Siamak MahmoudianDehkordi, Matthias Arnold, Tyler J Massaro, Rebecca Baillie, Xianlin Han, Yuk-Yee Leung, Andrew J Saykin, Kwangsik Nho, Alexandra Kueider-Paisley, Jessica D Tenenbaum, Li-San Wang, Leslie M Shaw, John Q Trojanowski, Rima F Kaddurah-Daou. Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 9. 2021-11-19. PMID:32715599. |
circulating ethanolamine plasmalogen indices in alzheimer's disease: relation to diagnosis, cognition, and csf tau. |
2021-11-19 |
2023-08-13 |
Not clear |
| Mette Habekost, Per Qvist, Mark Denham, Ida E Holm, Arne Lund Jørgense. Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration. Molecular neurobiology. vol 58. issue 5. 2021-11-19. PMID:33415685. |
to model alzheimer's disease and other tauopathies, it is essential that alternative splicing of the mapt transcript in these neurons produces the relevant tau isoforms. |
2021-11-19 |
2023-08-13 |
human |
| Charles Arber, Argyro Alatza, Claire A Leckey, Ross W Paterson, Henrik Zetterberg, Selina Wra. Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia. Journal of neurochemistry. vol 159. issue 2. 2021-11-19. PMID:33539581. |
mass spectrometry analysis of tau and amyloid-beta in ipsc-derived models of alzheimer's disease and dementia. |
2021-11-19 |
2023-08-13 |
human |
| Jenna N Adams, Anne Maass, David Berron, Theresa M Harrison, Suzanne L Baker, Wesley P Thomas, Morgan Stanfill, William J Jagus. Reduced Repetition Suppression in Aging is Driven by Tau-Related Hyperactivity in Medial Temporal Lobe. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 17. 2021-11-19. PMID:33731446. |
tau deposition begins in the medial temporal lobe (mtl) in aging and alzheimer's disease (ad), and mtl neural dysfunction is commonly observed in these groups. |
2021-11-19 |
2023-08-13 |
human |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
the many faces of post-ischemic tau protein in brain neurodegeneration of the alzheimer's disease type. |
2021-11-19 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Stanisław J Czuczwar, Sławomir Januszewski, Mirosław Jabłońsk. The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. Cells. vol 10. issue 9. 2021-11-19. PMID:34571862. |
recent data suggest that post-ischemic brain neurodegeneration in humans and animals is associated with the modified tau protein in a manner typical of alzheimer's disease neuropathology. |
2021-11-19 |
2023-08-13 |
Not clear |