| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mar Cuadrado-Tejedor, Marta Pérez-González, Rocío Alfaro-Ruiz, Sara Badesso, Diego Sucunza, María Espelosin, Susana Ursúa, Mercedes Lachen-Montes, Joaquín Fernández-Irigoyen, Enrique Santamaria, Rafael Luján, Ana García-Ost. Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769380. |
despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the progression of alzheimer's disease, the interaction and specific contribution of each of them is not fully elucidated. |
2021-11-18 |
2023-08-13 |
human |
| Gaoping Lin, Feiyan Zhu, Nicholas M Kanaan, Rei Asano, Norimichi Shirafuji, Hirohito Sasaki, Tomohisa Yamaguchi, Soichi Enomoto, Yoshinori Endo, Asako Ueno, Masamichi Ikawa, Kouji Hayashi, Osamu Yamamura, Shu-Hui Yen, Yasunari Nakamoto, Tadanori Haman. Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein. International journal of molecular sciences. vol 22. issue 21. 2021-11-18. PMID:34769495. |
the neuropathological hallmarks of alzheimer's disease (ad) are senile plaques (sps), which are composed of amyloid β protein (aβ), and neurofibrillary tangles (nfts), which consist of highly phosphorylated tau protein. |
2021-11-18 |
2023-08-13 |
Not clear |
| Xue-Ning Shen, Yu-Yuan Huang, Shi-Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status. Translational psychiatry. vol 11. issue 1. 2021-11-18. PMID:34775468. |
plasma phosphorylated-tau181 as a predictive biomarker for alzheimer's amyloid, tau and fdg pet status. |
2021-11-18 |
2023-08-13 |
human |
| Xue-Ning Shen, Yu-Yuan Huang, Shi-Dong Chen, Yu Guo, Lan Tan, Qiang Dong, Jin-Tai Y. Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status. Translational psychiatry. vol 11. issue 1. 2021-11-18. PMID:34775468. |
we found plasma p-tau181 significantly correlated with brain amyloid (spearman ρ = 0.45, p < 0.0001), tau (0.25, p = 0.0003), and fdg pet uptakes (-0.37, p < 0.0001), and increased along the alzheimer's continuum. |
2021-11-18 |
2023-08-13 |
human |
| Keliang Pang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro, Johanna Mayer, Baogui Zhang, Man Li, Jiesi Wang, Hang Liu, Ailing Yang, Xi Chen, Jiazheng Liu, Bengt Winblad, Hua Han, Tianzi Jiang, Weiwen Wang, Per Nilsson, Wei Guo, Bai L. An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell research. 2021-11-18. PMID:34789895. |
an app knock-in rat model for alzheimer's disease exhibiting aβ and tau pathologies, neuronal death and cognitive impairments. |
2021-11-18 |
2023-08-13 |
mouse |
| Christine W Fung, Jia Guo, Hongjun Fu, Helen Y Figueroa, Elisa E Konofagou, Karen E Duf. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science advances. vol 6. issue 42. 2021-11-17. PMID:33067235. |
tau pathology in alzheimer's disease (ad) first develops in the entorhinal cortex (ec), then spreads to the hippocampus, followed by the neocortex. |
2021-11-17 |
2023-08-13 |
mouse |
| Lina Pan, Lanxia Meng, Mingyang He, Zhentao Zhan. Tau in the Pathophysiology of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 71. issue 11. 2021-11-17. PMID:33459970. |
however, accumulating evidence suggests that tau, which is associated with tauopathies such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and argyrophilic grain disease, is also involved in the pathophysiology of pd. |
2021-11-17 |
2023-08-13 |
Not clear |
| Pradeepkiran Jangampalli Adi, P Hemachandra Redd. Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 8. 2021-11-17. PMID:33940164. |
phosphorylated tau targeted small-molecule protacs for the treatment of alzheimer's disease and tauopathies. |
2021-11-17 |
2023-08-13 |
Not clear |
| Pradeepkiran Jangampalli Adi, P Hemachandra Redd. Phosphorylated tau targeted small-molecule PROTACs for the treatment of Alzheimer's disease and tauopathies. Biochimica et biophysica acta. Molecular basis of disease. vol 1867. issue 8. 2021-11-17. PMID:33940164. |
phosphorylated tau (p-tau) has received great attention in the field of alzheimer's disease (ad) as a potential therapeutic target due to its involvement with synaptic damage and neuronal dysfunction. |
2021-11-17 |
2023-08-13 |
Not clear |
| David J Ingham, Bryce R Blankenfeld, Shibin Chacko, Chamani Perera, Berl R Oakley, Truman Christopher Gambli. Fungally Derived Isoquinoline Demonstrates Inducer-Specific Tau Aggregation Inhibition. Biochemistry. vol 60. issue 21. 2021-11-17. PMID:34009955. |
in several neurodegenerative diseases, such as alzheimer's disease, tau has been found to dissociate from microtubules, leading to the formation of pathological aggregates that display an amyloid fibril-like structure. |
2021-11-17 |
2023-08-13 |
Not clear |
| Seyed Hani Hojjati, Farnia Feiz, Sindy Ozoria, Qolamreza R Razligh. Topographical Overlapping of the Amyloid-β and Tau Pathologies in the Default Mode Network Predicts Alzheimer's Disease with Higher Specificity. Journal of Alzheimer's disease : JAD. vol 83. issue 1. 2021-11-17. PMID:34219729. |
topographical overlapping of the amyloid-β and tau pathologies in the default mode network predicts alzheimer's disease with higher specificity. |
2021-11-17 |
2023-08-13 |
Not clear |
| Seyed Hani Hojjati, Farnia Feiz, Sindy Ozoria, Qolamreza R Razligh. Topographical Overlapping of the Amyloid-β and Tau Pathologies in the Default Mode Network Predicts Alzheimer's Disease with Higher Specificity. Journal of Alzheimer's disease : JAD. vol 83. issue 1. 2021-11-17. PMID:34219729. |
while amyloid-β (aβ) plaques and tau tangles are the well-recognized pathologies of alzheimer's disease (ad), they are more often observed in healthy individuals than in ad patients. |
2021-11-17 |
2023-08-13 |
Not clear |
| Yulin Luo, Li Tan, Joseph Therriault, Hua Zhang, Ying Ga. The Role of Apolipoprotein E ε4 in Early and Late Mild Cognitive Impairment. European neurology. vol 84. issue 6. 2021-11-17. PMID:34340229. |
our goal was to evaluate the association of apoe ε4 with cerebrospinal fluid (csf) tau levels and cognition in emci and lmci patients in the alzheimer's disease neuroimaging initiative database, and whether this association was mediated by amyloid-β (aβ). |
2021-11-17 |
2023-08-13 |
Not clear |
| Somayra S A Mamsa, Bruno P Melon. Arginine and Arginine-Rich Peptides as Modulators of Protein Aggregation and Cytotoxicity Associated With Alzheimer's Disease. Frontiers in molecular neuroscience. vol 14. 2021-11-17. PMID:34776866. |
the putative role of proteopathies in chronic neurodegenerative diseases such as alzheimer's disease (ad) warrants investigation into whether carps could also prevent the aggregation and cytotoxicity of amyloidogenic proteins, particularly amyloid-beta and tau. |
2021-11-17 |
2023-08-13 |
Not clear |
| Bin Jiao, Hui Liu, Lina Guo, Xinxin Liao, Yafang Zhou, Ling Weng, Xuewen Xiao, Lu Zhou, Xin Wang, Yaling Jiang, Qijie Yang, Yuan Zhu, Lin Zhou, Weiwei Zhang, Junling Wang, Xinxiang Yan, Beisha Tang, Lu She. Performance of Plasma Amyloid β, Total Tau, and Neurofilament Light Chain in the Identification of Probable Alzheimer's Disease in South China. Frontiers in aging neuroscience. vol 13. 2021-11-17. PMID:34776933. |
performance of plasma amyloid β, total tau, and neurofilament light chain in the identification of probable alzheimer's disease in south china. |
2021-11-17 |
2023-08-13 |
Not clear |
| Billie J Matchett, Lea T Grinberg, Panos Theofilas, Melissa E Murra. The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33427939. |
alzheimer's disease (ad) is neuropathologically characterized by the intracellular accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β plaques, which affect certain brain regions in a progressive manner. |
2021-11-16 |
2023-08-13 |
Not clear |
| Jiaqian Wan, Yehong Gong, Zhengdong Xu, Xuewei Dong, Guanghong Wei, Qingwen Zhan. Molecular dynamics simulations reveal the destabilization mechanism of Alzheimer's disease-related tau R3-R4 Protofilament by norepinephrine. Biophysical chemistry. vol 271. 2021-11-16. PMID:33515860. |
molecular dynamics simulations reveal the destabilization mechanism of alzheimer's disease-related tau r3-r4 protofilament by norepinephrine. |
2021-11-16 |
2023-08-13 |
Not clear |
| Jiaqian Wan, Yehong Gong, Zhengdong Xu, Xuewei Dong, Guanghong Wei, Qingwen Zhan. Molecular dynamics simulations reveal the destabilization mechanism of Alzheimer's disease-related tau R3-R4 Protofilament by norepinephrine. Biophysical chemistry. vol 271. 2021-11-16. PMID:33515860. |
aggregation of tau protein into neurofibrillary tangles is associated with the pathogenesis of alzheimer's disease (ad) which has no cure yet. |
2021-11-16 |
2023-08-13 |
Not clear |
| Nicholas J Ashton, Tharick A Pascoal, Thomas K Karikari, Andréa L Benedet, Juan Lantero-Rodriguez, Gunnar Brinkmalm, Anniina Snellman, Michael Schöll, Claire Troakes, Abdul Hye, Serge Gauthier, Eugeen Vanmechelen, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blenno. Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33585983. |
the quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (csf) or plasma, has shown great promise in detecting alzheimer's disease (ad) pathophysiology. |
2021-11-16 |
2023-08-13 |
Not clear |
| Emma Gerrits, Nieske Brouwer, Susanne M Kooistra, Maya E Woodbury, Yannick Vermeiren, Mirjam Lambourne, Jan Mulder, Markus Kummer, Thomas Möller, Knut Biber, Wilfred F A den Dunnen, Peter P De Deyn, Bart J L Eggen, Erik W G M Boddek. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta neuropathologica. vol 141. issue 5. 2021-11-16. PMID:33609158. |
alzheimer's disease (ad) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-β and intraneuronal hyperphosphorylated tau tangles and neuropil threads. |
2021-11-16 |
2023-08-13 |
mouse |