| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francisca Randez-Gil, Lino Bojunga, Francisco Estruch, Joris Winderickx, Maurizio Del Poeta, Jose A Priet. Sphingolipids and Inositol Phosphates Regulate the Tau Protein Phosphorylation Status in Humanized Yeast. Frontiers in cell and developmental biology. vol 8. 2021-11-13. PMID:33282871. |
hyperphosphorylation of protein tau is a hallmark of alzheimer's disease (ad). |
2021-11-13 |
2023-08-13 |
Not clear |
| Benjamin Combs, Kyle R Christensen, Collin Richards, Andrew Kneynsberg, Rebecca L Mueller, Sarah L Morris, Gerardo A Morfini, Scott T Brady, Nicholas M Kanaa. Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 45. 2021-11-13. PMID:34607969. |
pathologic tau modifications are characteristic of alzheimer's disease and related dementias, but mechanisms of tau toxicity continue to be debated. |
2021-11-13 |
2023-08-13 |
rat |
| Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Li. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases. Translational neurodegeneration. vol 10. issue 1. 2021-11-13. PMID:34753506. |
the role of pathological tau in synaptic dysfunction in alzheimer's diseases. |
2021-11-13 |
2023-08-13 |
Not clear |
| Moxin Wu, Manqing Zhang, Xiaoping Yin, Kai Chen, Zhijian Hu, Qin Zhou, Xianming Cao, Zhiying Chen, Dan Li. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases. Translational neurodegeneration. vol 10. issue 1. 2021-11-13. PMID:34753506. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (aβ) overload and hyperphosphorylated tau accumulation in the brain. |
2021-11-13 |
2023-08-13 |
Not clear |
| Johan Gobom, Lucilla Parnetti, Pedro Rosa-Neto, Martin Vyhnalek, Serge Gauthier, Samuela Cataldi, Ondrej Lerch, Jan Laczo, Katerina Cechova, Marcus Clarin, Andrea I Benet, Tharick A Pascoal, Neserine Rahmouni, Manu Vandijck, Else Huyck, Nathalie Le Bastard, Jenna Stevenson, Mira Chamoun, Daniel Alcolea, Alberto Lleó, Ulf Andreasson, Marcel M Verbeek, Giovanni Bellomo, Roberta Rinaldi, Nicholas Ashton, Henrik Zetterberg, Katerina Sheardova, Jakub Hort, Kaj Blenno. Validation of the LUMIPULSE automated immunoassay for the measurement of core AD biomarkers in cerebrospinal fluid. Clinical chemistry and laboratory medicine. 2021-11-13. PMID:34773730. |
the core cerebrospinal fluid (csf) biomarkers; total tau (ttau), phospho-tau (ptau), amyloid β 1-42 (aβ 1-42), and the aβ 1-42/aβ 1-40 ratio have transformed alzheimer's disease (ad) research and are today increasingly used in clinical routine laboratories as diagnostic tools. |
2021-11-13 |
2023-08-13 |
Not clear |
| Nicholas M Kanaan, Tessa Grabinsk. Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey. Frontiers in molecular neuroscience. vol 14. 2021-11-12. PMID:33986642. |
additionally, tau is a central player in the pathogenesis of several diseases such as alzheimer's disease and several frontotemporal dementias. |
2021-11-12 |
2023-08-13 |
rat |
| Jennifer Grundman, Brian Spencer, Floyd Sarsoza, Robert A Rissma. Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression. PloS one. vol 16. issue 9. 2021-11-12. PMID:34587152. |
our analyses show overexpression of different tau isoforms and their interactions with amyloid-beta in sh-sy5y cells result in isoform-specific changes in the transcriptome, with locus-specific transposable element dysregulation patterns paralleling those seen in patients with alzheimer's disease and progressive supranuclear palsy. |
2021-11-12 |
2023-08-13 |
human |
| Elena Moreno-Castillo, Yoanna M Álvarez-Ginarte, Mario E Valdés-Tresanco, Luis A Montero-Cabrera, Ernesto Moreno, Pedro A Valient. Understanding the disrupting mechanism of the Tau aggregation motif " Journal of molecular recognition : JMR. vol 33. issue 9. 2021-11-11. PMID:32227525. |
understanding the disrupting mechanism of the tau aggregation motif " alzheimer's disease is a progressive neurodegenerative disorder characterized by the abnormal processing of the tau and the amyloid precursor proteins. |
2021-11-11 |
2023-08-13 |
Not clear |
| Angela Marie Jablonski, Lee Warren, Marija Usenovic, Heather Zhou, Jonathan Sugam, Sophie Parmentier-Batteur, Bhavya Volet. Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models. Scientific reports. vol 11. issue 1. 2021-11-11. PMID:33564035. |
astrocytic expression of the alzheimer's disease risk allele, apoeε4, potentiates neuronal tau pathology in multiple preclinical models. |
2021-11-11 |
2023-08-13 |
mouse |
| Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology. vol 203. 2021-11-11. PMID:34004220. |
plexin-a4 mediates amyloid-β-induced tau pathology in alzheimer's disease animal model. |
2021-11-11 |
2023-08-13 |
mouse |
| Sunwoo Chung, Jinhee Yang, Haeng Jun Kim, Eun Mi Hwang, Wonik Lee, Kyujin Suh, Hayoung Choi, Inhee Mook-Jun. Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Progress in neurobiology. vol 203. 2021-11-11. PMID:34004220. |
amyloid-β (aβ) and tau are major pathological hallmarks of alzheimer's disease (ad). |
2021-11-11 |
2023-08-13 |
mouse |
| Nada H Ashour, Dalia M El-Tanbouly, Nesrine S El Sayed, Mahmoud M Khatta. Roflumilast ameliorates cognitive deficits in a mouse model of amyloidogenesis and tauopathy: Involvement of nitric oxide status, Aβ extrusion transporter ABCB1, and reversal by PKA inhibitor H89. Progress in neuro-psychopharmacology & biological psychiatry. vol 111. 2021-11-11. PMID:34051306. |
in conclusion, boosting pka, by rof, modulated pxr/abcb1 expression and arginase/nos activities to restrict the main post-translational modifications of tau, aβ deposition and, accordingly, cognitive deterioration of sporadic alzheimer's disease. |
2021-11-11 |
2023-08-13 |
mouse |
| Tuan D Samdin, Adam G Kreutzer, James S Nowic. Exploring amyloid oligomers with peptide model systems. Current opinion in chemical biology. vol 64. 2021-11-11. PMID:34229162. |
the assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as alzheimer's, parkinson's, and huntington's diseases, frontotemporal dementias, and type ii diabetes. |
2021-11-11 |
2023-08-13 |
Not clear |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
alzheimer's disease is the most common form of dementia characterized by intracellular aggregates of hyperphosphorylated tau protein and extracellular accumulation of amyloid β (aβ) peptides. |
2021-11-11 |
2023-08-13 |
mouse |
| Kevin Carvalho, Elodie Martin, Aurélia Ces, Nadège Sarrazin, Pauline Lagouge-Roussey, Caroline Nous, Leyna Boucherit, Ihsen Youssef, Annick Prigent, Emilie Faivre, Sabiha Eddarkaoui, Thibaut Gauvrit, Didier Vieau, Susana Boluda, Vincent Huin, Bertrand Fontaine, Luc Buée, Benoît Delatour, Patrick Dutar, Florian Sennlaub, Xavier Guillonneau, David Blum, Cécile Delarass. P2X7-deficiency improves plasticity and cognitive abilities in a mouse model of Tauopathy. Progress in neurobiology. vol 206. 2021-11-11. PMID:34391810. |
due to the convergent role of p2x7 blockade in both aβ and tau background, p2x7 inhibitors might prove to be ideal candidate drugs to curb the devastating cognitive decline in alzheimer's disease and tauopathies. |
2021-11-11 |
2023-08-13 |
mouse |
| Yuan Hu, Danjing Yang, Ying Tu, Keke Chai, Lei Chu, Shuo Shi, Tianming Ya. Dynamic-Inspired Perspective on the Molecular Inhibitor of Tau Aggregation by Glucose Gallates Based on Human Neurons. ACS chemical neuroscience. vol 12. issue 21. 2021-11-11. PMID:34649422. |
a molecular inhibitor of tau protein aggregation offers an attractive therapeutic possibility as disease-modifying treatment of alzheimer's disease. |
2021-11-11 |
2023-08-13 |
human |
| Thomas K Karikari, Andreja Emeršič, Agathe Vrillon, Juan Lantero-Rodriguez, Nicholas J Ashton, Milica Gregorič Kramberger, Julien Dumurgier, Claire Hourregue, Saša Čučnik, Gunnar Brinkmalm, Uroš Rot, Henrik Zetterberg, Claire Paquet, Kaj Blenno. Head-to-head comparison of clinical performance of CSF phospho-tau T181 and T217 biomarkers for Alzheimer's disease diagnosis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 5. 2021-11-10. PMID:33252199. |
phosphorylated tau (p-tau) in cerebrospinal fluid (csf) is an established alzheimer's disease (ad) biomarker. |
2021-11-10 |
2023-08-13 |
Not clear |
| Marangelie Criado-Marrero, Niat T Gebru, Danielle M Blazier, Lauren A Gould, Jeremy D Baker, David Beaulieu-Abdelahad, Laura J Blai. Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832539. |
the microtubule associated protein tau is an intrinsically disordered phosphoprotein that accumulates under pathological conditions leading to formation of neurofibrillary tangles, a hallmark of alzheimer's disease (ad). |
2021-11-10 |
2023-08-13 |
mouse |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
as we have previously demonstrated the presence of α-synuclein deposits in the pancreas of patients with synucleinopathies, as well as tau and aβ deposits in the pancreatic tissue of alzheimer's disease patients, we studied the immunoreactivity of amylin, tau and α-synuclein in the pancreas of 138 subjects with neurodegenerative diseases or type two diabetes and assessed whether the pancreatic β-cells of these subjects present cooccurrence of misfolded proteins. |
2021-11-10 |
2023-08-13 |
human |
| Ivan Martinez-Valbuena, Rafael Valenti-Azcarate, Irene Amat-Villegas, Irene Marcilla, Gloria Marti-Andres, Maria-Cristina Caballero, Mario Riverol, María-Teresa Tuñon, Paul E Fraser, María-Rosario Luqui. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta neuropathologica communications. vol 9. issue 1. 2021-11-10. PMID:33832546. |
our study shows, for the first time, that along with amylin, pancreatic α-synuclein, aβ, prp and tau may contribute together to the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in alzheimer's and parkinson's disease. |
2021-11-10 |
2023-08-13 |
human |