All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Pia Kivisäkk, Hadia A Fatima, Danielle S Cahoon, Brunah Otieno, Leena Chacko, Farnaz Minooei, Catherine Demos, Martin Stengelin, George Sigal, Jacob Wohlstadter, Steven E Arnol. Clinical evaluation of a novel plasma pTau217 electrochemiluminescence immunoassay in Alzheimer's disease. Scientific reports. vol 14. issue 1. 2024-01-05. PMID:38182740. a growing literature suggests that plasma levels of tau phosphorylated at amino acid 217 (ptau217) performs similarly to cerebrospinal fluid (csf) biomarkers and pet imaging to detect amyloid pathology and to provide diagnostic and prognostic information in alzheimer's disease (ad), but a significant limiting factor thus far has been a lack of widely available immunoassays. 2024-01-05 2024-01-08 Not clear
Muhammad Ayaz, Osama F Mosa, Asif Nawaz, Alashary Adam Eisa Hamdoon, Modawy Elnour Modawy Elkhalifa, Abdul Sadiq, Farhat Ullah, Alshebli Ahmed, Atul Kabra, Haroon Khan, H C Ananda Murth. Neuroprotective potentials of Lead phytochemicals against Alzheimer's disease with focus on oxidative stress-mediated signaling pathways: Pharmacokinetic challenges, target specificity, clinical trials and future perspectives. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 124. 2024-01-05. PMID:38181530. alzheimer's diseases (ad) and dementia are among the highly prevalent neurological disorders characterized by deposition of beta amyloid (aβ) plaques, dense deposits of highly phosphorylated tau proteins, insufficiency of acetylcholine (ach) and imbalance in glutamatergic system. 2024-01-05 2024-01-08 Not clear
Daniel Ruiz-Gabarre, Laura Vallés-Saiz, Almudena Carnero-Espejo, Isidro Ferrer, Félix Hernández, Ramon Garcia-Escudero, Jesús Ávila, Vega García-Escuder. Intron retention as a productive mechanism in human MAPT: RNA species generated by retention of intron 3. EBioMedicine. vol 100. 2024-01-05. PMID:38181704. tau is essential for several physiological functions and associated with pathological processes, including alzheimer's disease (ad). 2024-01-05 2024-01-08 human
George Anderso. A More Holistic Perspective of Alzheimer's Disease: Roles of Gut Microbiome, Adipocytes, HPA Axis, Melatonergic Pathway and Astrocyte Mitochondria in the Emergence of Autoimmunity. Frontiers in bioscience (Landmark edition). vol 28. issue 12. 2024-01-05. PMID:38179773. for 40 years, alzheimer's disease pathophysiology has focused on two culprits, amyloid-β induced plaques and hyperphosphorylated tau associated tangles, with no significant treatment advance. 2024-01-05 2024-01-07 Not clear
Mónica Rosselli, Idaly Vélez Uribe, Emily Ahne, Layaly Shihade. Culture, Ethnicity, and Level of Education in Alzheimer's Disease. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 19. issue 1. 2024-01-04. PMID:38176794. alzheimer's disease (ad) is the most frequent cause of dementia, where the abnormal accumulation of beta-amyloid (aβ) and tau lead to neurodegeneration as well as loss of cognitive, behavioral, and functional abilities. 2024-01-04 2024-01-07 Not clear
Todd E Gold. Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 19. issue 1. 2024-01-04. PMID:38176791. scientific advances over the last four decades have steadily infused the alzheimer's disease (ad) field with great optimism that therapies targeting aβ, amyloid, tau, and innate immune activation states in the brain would provide disease modification. 2024-01-04 2024-01-07 Not clear
Ana Rita Agra Almeida Quadros, Zhaozhi Li, Xue Wang, I Sandra Ndayambaje, Sandeep Aryal, Nandini Ramesh, Matthew Nolan, Rojashree Jayakumar, Yi Han, Hannah Stillman, Corey Aguilar, Hayden J Wheeler, Theresa Connors, Jone Lopez-Erauskin, Michael W Baughn, Ze'ev Melamed, Melinda S Beccari, Laura Olmedo Martínez, Michael Canori, Chao-Zong Lee, Laura Moran, Isabelle Draper, Alan S Kopin, Derek H Oakley, Dennis W Dickson, Don W Cleveland, Bradley T Hyman, Sudeshna Das, Nilüfer Ertekin-Taner, Clotilde Lagier-Tourenn. Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease. Acta neuropathologica. vol 147. issue 1. 2024-01-04. PMID:38175301. here, we identify both stmn2 and unc13a cryptic exons in alzheimer's disease patients, that correlate with tdp-43 pathology burden, but not with amyloid-β or tau deposits. 2024-01-04 2024-01-06 Not clear
Daniel C Xu, Hanna Sas-Nowosielska, Greg Donahue, Hua Huang, Naemeh Pourshafie, Charly R Good, Shelley L Berge. Histone acetylation in an Alzheimer's disease cell model promotes homeostatic amyloid-reducing pathways. Acta neuropathologica communications. vol 12. issue 1. 2024-01-03. PMID:38167174. alzheimer's disease (ad) is a disorder characterized by cognitive decline, neurodegeneration, and accumulation of amyloid plaques and tau neurofibrillary tangles in the brain. 2024-01-03 2024-01-06 Not clear
Qinggang Fu, Bixiang Zhang, Xiaoping Chen, Liang Ch. Liquid-liquid phase separation in Alzheimer's disease. Journal of molecular medicine (Berlin, Germany). 2024-01-03. PMID:38167731. the pathological aggregation and misfolding of tau and amyloid-β play a key role in alzheimer's disease (ad). 2024-01-03 2024-01-06 human
Valeria Melissa García-Cruz, Clorinda Aria. Palmitic Acid Induces Posttranslational Modifications of Tau Protein in Alzheimer's Disease-Related Epitopes and Increases Intraneuronal Tau Levels. Molecular neurobiology. 2024-01-03. PMID:38167971. palmitic acid induces posttranslational modifications of tau protein in alzheimer's disease-related epitopes and increases intraneuronal tau levels. 2024-01-03 2024-01-06 human
Pallabi Sil Paul, Tark Patel, Jae-Young Cho, Allan Yarahmady, Aria Khalili, Valentyna Semenchenko, Holger Wille, Marianna Kulka, Sue-Ann Mok, Satyabrata Ka. Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167993. native plga nanoparticles attenuate aβ-seed induced tau aggregation under in vitro conditions: potential implication in alzheimer's disease pathology. 2024-01-03 2024-01-06 Not clear
Pallabi Sil Paul, Tark Patel, Jae-Young Cho, Allan Yarahmady, Aria Khalili, Valentyna Semenchenko, Holger Wille, Marianna Kulka, Sue-Ann Mok, Satyabrata Ka. Native PLGA nanoparticles attenuate Aβ-seed induced tau aggregation under in vitro conditions: potential implication in Alzheimer's disease pathology. Scientific reports. vol 14. issue 1. 2024-01-03. PMID:38167993. evidence suggests that beta-amyloid (aβ)-induced phosphorylation/aggregation of tau protein plays a critical role in the degeneration of neurons and development of alzheimer's disease (ad), the most common cause of dementia affecting the elderly population. 2024-01-03 2024-01-06 Not clear
Przemysław R Kac, Fernando González-Ortiz, Andreja Emeršič, Maciej Dulewicz, Srinivas Koutarapu, Michael Turton, Yang An, Denis Smirnov, Agnieszka Kulczyńska-Przybik, Vijay Varma, Nicholas J Ashton, Laia Montoliu-Gaya, Elena Camporesi, Izabela Winkel, Bogusław Paradowski, Abhay Moghekar, Juan C Troncoso, Gunnar Brinkmalm, Susan M Resnick, Barbara Mroczko, Hlin Kvartsberg, Milica Gregorič Kramberger, Jörg Hanrieder, Saša Čučnik, Peter Harrison, Henrik Zetterberg, Piotr Lewczuk, Madhav Thambisetty, Uroš Rot, Douglas Galasko, Kaj Blennow, Thomas K Karikar. Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer's disease neuropathology. medRxiv : the preprint server for health sciences. 2024-01-03. PMID:38168323. blood phosphorylated tau (p-tau) biomarkers, including p-tau217, show high associations with alzheimer's disease (ad) neuropathologic change and clinical stage. 2024-01-03 2024-01-06 human
Celia Painous, Manel Fernández, Jesica Pérez, Lorena de Mena, Ana Cámara, Yaroslau Compt. Fluid and tissue biomarkers in Parkinson's disease: Immunodetection or seed amplification? Central or peripheral? Parkinsonism & related disorders. 2024-01-03. PMID:38168618. accordingly, in alzheimer's disease determination of levels of total and phosphorylated tau (τ and p-τ, usually p-τ181) along with amyloid-beta1-42 (aβ1-42) by immunodetection in cerebrospinal fluid (csf) and currently even in peripheral blood, have been widely accepted and introduced to routine diagnosis. 2024-01-03 2024-01-06 Not clear
Nicolai Franzmeier, Amir Dehsarvi, Anna Steward, Davina Biel, Anna Dewenter, Sebastian Niclas Roemer, Fabian Wagner, Mattes Groß, Matthias Brendel, Alexis Moscoso, Prithvi Arunachalam, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Michael Schöl. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-01-03. PMID:38172114. elevated csf gap-43 is associated with accelerated tau accumulation and spread in alzheimer's disease. 2024-01-03 2024-01-06 Not clear
Nicolai Franzmeier, Amir Dehsarvi, Anna Steward, Davina Biel, Anna Dewenter, Sebastian Niclas Roemer, Fabian Wagner, Mattes Groß, Matthias Brendel, Alexis Moscoso, Prithvi Arunachalam, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Michael Schöl. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-01-03. PMID:38172114. in alzheimer's disease, amyloid-beta (aβ) triggers the trans-synaptic spread of tau pathology, and aberrant synaptic activity has been shown to promote tau spreading. 2024-01-03 2024-01-06 Not clear
Nicolai Franzmeier, Amir Dehsarvi, Anna Steward, Davina Biel, Anna Dewenter, Sebastian Niclas Roemer, Fabian Wagner, Mattes Groß, Matthias Brendel, Alexis Moscoso, Prithvi Arunachalam, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Michael Schöl. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-01-03. PMID:38172114. we therefore tested whether aβ-related gap-43 increases, as a marker of synaptic changes, drive tau spreading in 93 patients across the aging and alzheimer's spectrum with available csf gap-43, amyloid-pet and longitudinal tau-pet assessments. 2024-01-03 2024-01-06 Not clear
Nicolai Franzmeier, Amir Dehsarvi, Anna Steward, Davina Biel, Anna Dewenter, Sebastian Niclas Roemer, Fabian Wagner, Mattes Groß, Matthias Brendel, Alexis Moscoso, Prithvi Arunachalam, Kaj Blennow, Henrik Zetterberg, Michael Ewers, Michael Schöl. Elevated CSF GAP-43 is associated with accelerated tau accumulation and spread in Alzheimer's disease. Nature communications. vol 15. issue 1. 2024-01-03. PMID:38172114. this suggests that gap-43-related synaptic changes are linked to faster aβ-related tau spread across connected regions and that synapses could be key targets for preventing tau spreading in alzheimer's disease. 2024-01-03 2024-01-06 Not clear
Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. the fluorescent ligand btvbt2 reveals increased p-tau uptake by retinal microglia in alzheimer's disease patients and app amyloid beta (aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of alzheimer's disease (ad) patients and transgenic ad mice. 2024-01-03 2024-01-06 mouse
Gérard N Bischof, Elena Jaeger, Kathrin Giehl, Merle C Hönig, Peter H Weiss, Alexander Drzezg. Affection of Motor Network Regions by Tau Pathology Across the Alzheimer's Disease Spectrum. eNeuro. 2024-01-02. PMID:38164539. affection of motor network regions by tau pathology across the alzheimer's disease spectrum. 2024-01-02 2024-01-05 Not clear