All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Nasim Rezaee, W M A D Binosha Fernando, Eugene Hone, Hamid R Sohrabi, Stuart K Johnson, Stuart Gunzburg, Ralph N Martin. Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article. Frontiers in aging neuroscience. vol 13. 2021-10-26. PMID:34690742. alzheimer's disease (ad) is characterized by the excessive deposition of extracellular amyloid-beta peptide (aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. 2021-10-26 2023-08-13 human
Alexandra L Clark, Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Graham M L Eglit, Mark W Bondi, Lisa Delano-Woo. Higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in Vietnam-era veterans: A Department of Defense Alzheimer's Disease Neuroimaging Initiative (DOD-ADNI) study. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-26. PMID:34692979. higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in vietnam-era veterans: a department of defense alzheimer's disease neuroimaging initiative (dod-adni) study. 2021-10-26 2023-08-13 Not clear
Z Jaunmuktane, S Brandne. Invited Review: The role of prion-like mechanisms in neurodegenerative diseases. Neuropathology and applied neurobiology. vol 46. issue 6. 2021-10-25. PMID:31868945. there is increasing evidence that other neurodegenerative diseases, most notably alzheimer's disease (aβ and tau), parkinson's disease (α-synuclein), frontotemporal dementia (tdp43, tau or fus) and motor neurone disease (tdp43), exhibit at least some of the misfolded prion protein properties. 2021-10-25 2023-08-13 Not clear
Richelle Sopko, Olga Golonzhka, Joseph Arndt, Chao Quan, Julie Czerkowicz, Andrew Cameron, Benjamin Smith, Yogapriya Murugesan, Garrett Gibbons, Soo-Jung Kim, John Q Trojanowski, Virginia M Y Lee, Kurt R Brunden, Danielle L Graham, Paul H Weinreb, Heike Herin. Characterization of tau binding by gosuranemab. Neurobiology of disease. vol 146. 2021-10-25. PMID:32991997. deposition of tau aggregates in the brain is a pathological hallmark of several neurodegenerative diseases, termed tauopathies, such as alzheimer's disease (ad), corticobasal degeneration, and progressive supranuclear palsy (psp). 2021-10-25 2023-08-13 mouse
Mauro Montalbano, Salome McAllen, Filippa Lo Cascio, Urmi Sengupta, Stephanie Garcia, Nemil Bhatt, Anna Ellsworth, Eric A Heidelman, Omar D Johnson, Samantha Doskocil, Rakez Kaye. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiology of disease. vol 146. 2021-10-25. PMID:33065281. tdp-43 and tau oligomers in alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. 2021-10-25 2023-08-13 human
Amy F T Arnsten, Dibyadeep Datta, Kelly Del Tredici, Heiko Braa. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 1. 2021-10-25. PMID:33075193. hypothesis: tau pathology is an initiating factor in sporadic alzheimer's disease. 2021-10-25 2023-08-13 human
Hong Xu, Mia O'Reilly, Garrett S Gibbons, Lakshmi Changolkar, Jennifer D McBride, Dawn M Riddle, Bin Zhang, Anna Stieber, Jeffrey Nirschl, Soo-Jung Kim, Kevt-Her Hoxha, Kurt R Brunden, Gerard D Schellenberg, John Q Trojanowski, Virginia M-Y Le. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta neuropathologica. vol 141. issue 2. 2021-10-25. PMID:33385254. here, we used biochemically enriched brain-derived tau seeds from alzheimer's disease (ad), corticobasal degeneration (cbd) and progressive supranuclear palsy (psp) patient brains with a modified seeding protocol to template the recruitment of recombinant 2n4r (t40) tau in vitro. 2021-10-25 2023-08-13 human
Juan Carlos Polanco, Gabriel Rhys Hand, Adam Briner, Chuanzhou Li, Jürgen Göt. Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol. Acta neuropathologica. vol 141. issue 2. 2021-10-25. PMID:33417012. the microtubule-associated protein tau has a critical role in alzheimer's disease and other tauopathies. 2021-10-25 2023-08-13 mouse
Niklas Mattsson-Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansso. Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau. EMBO molecular medicine. vol 13. issue 6. 2021-10-25. PMID:33949133. alzheimer's disease is characterized by β-amyloid plaques and tau tangles. 2021-10-25 2023-08-13 Not clear
Niklas Mattsson-Carlgren, Shorena Janelidze, Randall J Bateman, Ruben Smith, Erik Stomrud, Geidy E Serrano, Eric M Reiman, Sebastian Palmqvist, Jeffrey L Dage, Thomas G Beach, Oskar Hansso. Soluble P-tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau. EMBO molecular medicine. vol 13. issue 6. 2021-10-25. PMID:33949133. plasma levels of phospho-tau217 (p-tau217) accurately differentiate alzheimer's disease dementia from other dementias, but it is unclear to what degree this reflects β-amyloid plaque accumulation, tau tangle accumulation, or both. 2021-10-25 2023-08-13 Not clear
Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Oskar Hansso. Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers. EMBO molecular medicine. vol 13. issue 8. 2021-10-25. PMID:34254442. tau pet correlates with different alzheimer's disease-related features compared to csf and plasma p-tau biomarkers. 2021-10-25 2023-08-13 human
Rik Ossenkoppele, Juhan Reimand, Ruben Smith, Antoine Leuzy, Olof Strandberg, Sebastian Palmqvist, Erik Stomrud, Henrik Zetterberg, Philip Scheltens, Jeffrey L Dage, Femke Bouwman, Kaj Blennow, Niklas Mattsson-Carlgren, Shorena Janelidze, Oskar Hansso. Tau PET correlates with different Alzheimer's disease-related features compared to CSF and plasma p-tau biomarkers. EMBO molecular medicine. vol 13. issue 8. 2021-10-25. PMID:34254442. pet, csf and plasma biomarkers of tau pathology may be differentially associated with alzheimer's disease (ad)-related demographic, cognitive, genetic and neuroimaging markers. 2021-10-25 2023-08-13 human
Zirong Chen, FeiFan Chang, Linyin Yao, Fan Yuan, Junsheng Hong, Dawei Wu, Yongxiang We. Clinical significance of the cognition-related pathogenic proteins in plasma neuronal-derived exosomes among normal cognitive adults over 45 years old with olfactory dysfunction. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2021-10-25. PMID:34693486. exosomal phospho-tau-181(p-t181-tau), total tau (t-tau), and amyloid-β peptide 42 (aβ42) have been proved the capacity for the amnestic mild cognitive impairment (mci) and the diagnosis of alzheimer's disease (ad). 2021-10-25 2023-08-13 Not clear
Kamalini G Ranasinghe, Cathrine Petersen, Kiwamu Kudo, Danielle Mizuiri, Katherine P Rankin, Gil D Rabinovici, Maria Luisa Gorno-Tempini, William W Seeley, Salvatore Spina, Bruce L Miller, Keith Vossel, Lea T Grinberg, Srikantan S Nagaraja. Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-10-22. PMID:33884753. neurophysiological manifestations selectively associated with amyloid beta and tau depositions in alzheimer's disease (ad) are useful network biomarkers to identify peptide specific pathological processes. 2021-10-22 2023-08-13 Not clear
Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. csf metabolites associate with csf tau and improve prediction of alzheimer's disease status. 2021-10-22 2023-08-13 Not clear
Ruocheng Dong, Burcu F Darst, Yuetiva Deming, Yue Ma, Qiongshi Lu, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Corinne D Engelma. CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-22. PMID:33969169. cerebrospinal fluid (csf) total tau (t-tau) and phosphorylated tau (p-tau) are biomarkers of alzheimer's disease (ad), yet much is unknown about ad-associated changes in tau metabolism and tau tangle etiology. 2021-10-22 2023-08-13 Not clear
Heidi Strand, Lamya Garabet, Börje Bjelke, Cindhya Sithiravel, Ingrid Marie Hardang, Morten K Mo. β-Amyloid in Cerebrospinal Fluid: How to Keep It Floating (Not Sticking) by Standardization of Preanalytic Processes and Collection Tubes. The journal of applied laboratory medicine. vol 6. issue 5. 2021-10-22. PMID:34059876. phosphorylated tau (ptau), total tau (ttau), and β-amyloid (aβ) are established cerebrospinal fluid (csf) biomarkers used to help diagnose alzheimer disease. 2021-10-22 2023-08-13 Not clear
He-Ao Zhang, Chun-Xu Yuan, Ke-Fu Liu, Qi-Fan Yang, Juan Zhao, Hui Li, Qing-Hu Yang, Da Song, Zhen-Zhen Quan, Hong Qin. Neural stem cell transplantation alleviates functional cognitive deficits in a mouse model of tauopathy. Neural regeneration research. vol 17. issue 1. 2021-10-22. PMID:34100451. in this study, nscs were transplanted into the hippocampal ca1 region of the rtg (tau p301l) 4510 mouse model, a tauopathy model that is thought to reflect the tau pathology associated with alzheimer's disease. 2021-10-22 2023-08-13 mouse
Zhi Rua. Extracellular vesicles drive tau spreading in Alzheimer's disease. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269203. extracellular vesicles drive tau spreading in alzheimer's disease. 2021-10-22 2023-08-13 Not clear
Yi-Tong Lin, Qing-Qing Shi, Lei Zhang, Cai-Ping Yue, Zhi-Jun He, Xue-Xia Li, Qian-Jun He, Qiong Liu, Xiu-Bo D. Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota. Neural regeneration research. vol 17. issue 2. 2021-10-22. PMID:34269217. the results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×tg alzheimer's disease mice. 2021-10-22 2023-08-13 mouse