All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. tau phosphorylation and opa1 proteolysis are unrelated events: implications for alzheimer's disease. 2021-10-22 2023-08-13 mouse
Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. this study focuses on one particular aspect of this question by investigating the functional interaction between the microtubule-associated protein tau and the mitochondrial inner membrane fusion machinery, which shows alterations in alzheimer's brains. 2021-10-22 2023-08-13 mouse
Marcel V Alav. Tau phosphorylation and OPA1 proteolysis are unrelated events: Implications for Alzheimer's Disease. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 12. 2021-10-22. PMID:34400172. these results irrefutably demonstrate that there is no direct functional interaction between posttranslational tau modifications and the regulation of the oma1-opa1 pathway, which implies a common root cause modulating both pathways in alzheimer's. 2021-10-22 2023-08-13 mouse
D G Garbuz, O G Zatsepina, M B Evgen'e. [Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer's Disease Pathogenesis]. Molekuliarnaia biologiia. vol 55. issue 5. 2021-10-22. PMID:34671002. [beta amyloid, tau protein, and neuroinflammation: an attempt to integrate different hypotheses of alzheimer's disease pathogenesis]. 2021-10-22 2023-08-13 Not clear
Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. soluble forms of tau are toxic in alzheimer's disease. 2021-10-21 2023-08-12 Not clear
Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. accumulation of neurofibrillary tangles (nft), intracellular inclusions of fibrillar forms of tau, is a hallmark of alzheimer disease. 2021-10-21 2023-08-12 Not clear
Katherine J Kopeikina, Bradley T Hyman, Tara L Spires-Jone. Soluble forms of tau are toxic in Alzheimer's disease. Translational neuroscience. vol 3. issue 3. 2021-10-21. PMID:23029602. here we review the data supporting soluble tau as toxic to neurons and synapses in the brain and the implications of these data for development of therapeutic strategies for alzheimer's disease and other tauopathies. 2021-10-21 2023-08-12 Not clear
Ehren L Newman, Christopher F Shay, Michael E Hasselm. Malignant synaptic growth and Alzheimer's disease. Future neurology. vol 7. issue 5. 2021-10-21. PMID:23420180. we will include discussion of its relationship, in terms of points of alignment and points of contention, to other models of alzheimer's disease, including the cholinergic hypothesis and the tau and β-amyloid models of alzheimer's disease. 2021-10-21 2023-08-12 Not clear
Umesh K Jinwal, John Koren, Chad A Dicke. Reconstructing the Hsp90/Tau Machine. Current enzyme inhibition. vol 9. issue 1. 2021-10-21. PMID:23798910. recent work demonstrates that age-related changes to the cellular chaperone repertoire contributes to abnormal buildup of the microtubule-associated protein tau that accumulates in a group of diseases termed tauopathies, the most common being alzheimer's disease (ad). 2021-10-21 2023-08-12 Not clear
Yu Wang, Yu Feng, Qunying Fu, Lei L. Panax notoginsenoside Rb1 ameliorates Alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating Tau protein expression. Experimental and therapeutic medicine. vol 6. issue 3. 2021-10-21. PMID:24137274. panax notoginsenoside rb1 ameliorates alzheimer's disease by upregulating brain-derived neurotrophic factor and downregulating tau protein expression. 2021-10-21 2023-08-12 Not clear
Fiona J Baird, Craig L Bennet. Microtubule defects & Neurodegeneration. Journal of genetic syndromes & gene therapy. vol 4. 2021-10-21. PMID:24563812. the importance of mt dynamics and stability is underscored by the critical role tau protein plays in mt-associated stabilization versus the dysfunction seen in alzheimer's disease, frontotemporal dementia and other tauopathies. 2021-10-21 2023-08-12 mouse
Zhongcong Xie, Celeste A Swain, Sarah A P Ward, Hui Zheng, Yuanlin Dong, Neelakantan Sunder, Dennis W Burke, Diana Escobar, Yiying Zhang, Edward R Marcantoni. Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. Annals of clinical and translational neurology. vol 1. issue 5. 2021-10-21. PMID:24860840. low cerebrospinal fluid (csf) βamyloid protein (aβ) and high csf tau levels are associated with alzheimer's disease. 2021-10-21 2023-08-13 Not clear
Doris Lambracht-Washington, Roger N Rosenber. Anti-amyloid beta to tau - based immunization: Developments in immunotherapy for Alzheimer disease. ImmunoTargets and therapy. vol 2013. issue 2. 2021-10-21. PMID:24926455. anti-amyloid beta to tau - based immunization: developments in immunotherapy for alzheimer disease. 2021-10-21 2023-08-13 mouse
Yin Luo, Buyong Ma, Ruth Nussinov, Guanghong We. Structural Insight into Tau Protein's Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and Aggregation. The journal of physical chemistry letters. vol 5. issue 17. 2021-10-21. PMID:25206938. tau is an intrinsically disordered protein (idp) implicated in alzheimer's disease. 2021-10-21 2023-08-13 Not clear
Aaron Carman, Sarah Kishinevsky, John Koren, Wenjie Lou, Gabriela Chiosi. Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention. Journal of Alzheimer's disease & Parkinsonism. vol 2013. issue Suppl 10. 2021-10-21. PMID:25258700. these aberrant proteins, known as "clients," have major roles in the pathogenesis of numerous neurological disorders, including tau in alzheimer's disease, α-synuclein and lrrk2 in parkinson's disease, sod-1, tdp-43 and fus in amyotrophic lateral sclerosis, and polyq-expanded proteins such as huntingtin in huntington's disease. 2021-10-21 2023-08-13 Not clear
Xiaohua Deng, Meili Li, Weiming Ai, Lixin He, Dahua Lu, Peter R Patrylo, Huaibin Cai, Xuegang Luo, Zhiyuan Li, Xiaoxin Ya. Lipolysaccharide-Induced Neuroinflammation Is Associated with Alzheimer-Like Amyloidogenic Axonal Pathology and Dendritic Degeneration in Rats. Advances in Alzheimer's disease. vol 3. issue 2. 2021-10-21. PMID:25360394. chronic neuroinflammation is thought to play an etiological role in alzheimer's disease (ad), which is characterized pathologically by amyloid and tau formation, as well as neuritic dystrophy and synaptic degeneration. 2021-10-21 2023-08-13 rat
Kai Sin Chin, Nawaf Yassi, Leonid Churilov, Colin Louis Masters, Rosie Watso. Prevalence and clinical associations of tau in Lewy body dementias: A systematic review and meta-analysis. Parkinsonism & related disorders. vol 80. 2021-10-21. PMID:33260030. alzheimer's disease neuropathologies (amyloid-β and tau) frequently co-exist to varying degrees in lewy body dementias (lbd), which include dementia with lewy bodies (dlb) and parkinson's disease dementia (pdd). 2021-10-21 2023-08-13 Not clear
Carmen Laura Sayas, Jesús Ávil. GSK-3 and Tau: A Key Duet in Alzheimer's Disease. Cells. vol 10. issue 4. 2021-10-21. PMID:33804962. gsk-3 and tau: a key duet in alzheimer's disease. 2021-10-21 2023-08-13 human
Altmash Khan, Gifty Kuriachan, Radhakrishnan Mahalakshm. Cellular Interactome of Mitochondrial Voltage-Dependent Anion Channels: Oligomerization and Channel (Mis)Regulation. ACS chemical neuroscience. vol 12. issue 19. 2021-10-21. PMID:34503333. additionally, human vdacs are now implicated in interaction with aggregation-prone cytosolic proteins, including aβ, tau, and α-synuclein, contributing directly to the onset of alzheimer's and parkinson's diseases. 2021-10-21 2023-08-13 human
Umesh K Jinwal, John Koren, John C O'Leary, Jeffrey R Jones, Jose F Abisambra, Chad A Dicke. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Molecular and cellular pharmacology. vol 2. issue 2. 2021-10-20. PMID:20523917. the most devastating tau related disorder is alzheimer's disease (ad). 2021-10-20 2023-08-12 Not clear