| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nilesh Gajanan Bajad, Rayala Swetha, Gopichand Gutti, Meenakshi Singh, Ashok Kumar, Sushil Kumar Sing. A systematic review of carbohydrate-based bioactive molecules for Alzheimer's disease. Future medicinal chemistry. vol 13. issue 19. 2021-11-03. PMID:34472382. |
most importantly, several reported carbohydrate-based molecules for alzheimer's disease act on β-amyloid aggregation, tau protein, cholinesterase and oxidative stress, with enhanced pharmacokinetic and mechanistic properties. |
2021-11-03 |
2023-08-13 |
Not clear |
| Yogesh Todarwal, Camilla Gustafsson, Nghia Nguyen Thi Minh, Ingrid Ertzgaard, Therése Klingstedt, Bernardino Ghetti, Ruben Vidal, Carolin König, Mikael Lindgren, K Peter R Nilsson, Mathieu Linares, Patrick Norma. Tau Protein Binding Modes in Alzheimer's Disease for Cationic Luminescent Ligands. The journal of physical chemistry. B. vol 125. issue 42. 2021-11-03. PMID:34643404. |
tau protein binding modes in alzheimer's disease for cationic luminescent ligands. |
2021-11-03 |
2023-08-13 |
Not clear |
| Yogesh Todarwal, Camilla Gustafsson, Nghia Nguyen Thi Minh, Ingrid Ertzgaard, Therése Klingstedt, Bernardino Ghetti, Ruben Vidal, Carolin König, Mikael Lindgren, K Peter R Nilsson, Mathieu Linares, Patrick Norma. Tau Protein Binding Modes in Alzheimer's Disease for Cationic Luminescent Ligands. The journal of physical chemistry. B. vol 125. issue 42. 2021-11-03. PMID:34643404. |
the bi-thiophene-vinylene-benzothiazole (btvbt4) ligand developed for alzheimer's disease (ad)-specific detection of amyloid tau has been studied by a combination of several theoretical methods and experimental spectroscopies. |
2021-11-03 |
2023-08-13 |
Not clear |
| Amy L Hobday, Mayur S Parma. The Link Between Diabetes Mellitus and Tau Hyperphosphorylation: Implications for Risk of Alzheimer's Disease. Cureus. vol 13. issue 9. 2021-11-03. PMID:34725612. |
the link between diabetes mellitus and tau hyperphosphorylation: implications for risk of alzheimer's disease. |
2021-11-03 |
2023-08-13 |
Not clear |
| Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R Strickland, Javier Remolina Serrano, Marco Colonna, Jason D Ulrich, David M Holtzma. Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of experimental medicine. vol 218. issue 8. 2021-11-02. PMID:34100905. |
in alzheimer's disease (ad) models, ad risk variants in the microglial-expressed trem2 gene decrease aβ plaque-associated microgliosis and increase neuritic dystrophy as well as plaque-associated seeding and spreading of tau aggregates. |
2021-11-02 |
2023-08-13 |
mouse |
| Taxiarchis Katsinelos, William A McEwan, Thomas R Jahn, Walter Nicke. Identification of cis-acting determinants mediating the unconventional secretion of tau. Scientific reports. vol 11. issue 1. 2021-11-02. PMID:34155306. |
the deposition of tau aggregates throughout the brain is a pathological characteristic within a group of neurodegenerative diseases collectively termed tauopathies, which includes alzheimer's disease. |
2021-11-02 |
2023-08-13 |
drosophila_melanogaster |
| Yaojun Ju, Kin Yip Ta. Pathological mechanisms and therapeutic strategies for Alzheimer's disease. Neural regeneration research. vol 17. issue 3. 2021-11-02. PMID:34380884. |
neurofibrillary tangles assembled by microtubule-associated protein tau are other important histopathological characteristics in alzheimer's disease brains. |
2021-11-02 |
2023-08-13 |
Not clear |
| Satoshi Muraoka, Annina M DeLeo, Zijian Yang, Harutsugu Tatebe, Kayo Yukawa-Takamatsu, Seiko Ikezu, Takahiko Tokuda, David Issadore, Robert A Stern, Tsuneya Ikez. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging and disease. vol 12. issue 6. 2021-11-02. PMID:34527415. |
extracellular vesicles (evs) are known to carry tau in alzheimer's disease and other tauopathies. |
2021-11-02 |
2023-08-13 |
Not clear |
| Elodie Leroux, Romain Perbet, Raphaëlle Caillierez, Kevin Richetin, Sarah Lieger, Jeanne Espourteille, Thomas Bouillet, Séverine Bégard, Clément Danis, Anne Loyens, Nicolas Toni, Nicole Déglon, Vincent Deramecourt, Susanna Schraen-Maschke, Luc Buée, Morvane Coli. Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies. Molecular therapy : the journal of the American Society of Gene Therapy. 2021-11-02. PMID:34563677. |
the most striking evidence was coming mainly from alzheimer's disease where the bd-evs clearly contain pathological species that can induce tau lesions in vivo. |
2021-11-02 |
2023-08-13 |
human |
| Tammaryn Lashley, Maria-Armineh Tossounian, Neve Costello Heaven, Samantha Wallworth, Sew Peak-Chew, Aaron Bradshaw, J Mark Cooper, Rohan de Silva, Surjit Kaila Srai, Oksana Malanchuk, Valeriy Filonenko, Margreet B Koopman, Stefan G D Rüdiger, Mark Skehel, Ivan Gou. Extensive Anti-CoA Immunostaining in Alzheimer's Disease and Covalent Modification of Tau by a Key Cellular Metabolite Coenzyme A. Frontiers in cellular neuroscience. vol 15. 2021-11-02. PMID:34720880. |
extensive anti-coa immunostaining in alzheimer's disease and covalent modification of tau by a key cellular metabolite coenzyme a. alzheimer's disease (ad) is a neurodegenerative disorder, accounting for at least two-thirds of dementia cases. |
2021-11-02 |
2023-08-13 |
human |
| Liping Fu, Zhi Zhou, Linwen Liu, Jinming Zhang, Hengge Xie, Xiaojun Zhang, Mingwei Zhu, Ruimin Wan. Functional Abnormality Associated With Tau Deposition in Alzheimer's Disease - A Hybrid Positron Emission Tomography/MRI Study. Frontiers in aging neuroscience. vol 13. 2021-11-02. PMID:34721001. |
functional abnormality associated with tau deposition in alzheimer's disease - a hybrid positron emission tomography/mri study. |
2021-11-02 |
2023-08-13 |
Not clear |
| Aqilah Hambali, Jaya Kumar, Nur Fariesha Md Hashim, Sandra Maniam, Muhammad Zulfadli Mehat, Manraj Singh Cheema, Muzaimi Mustapha, Mohd Ilham Adenan, Johnson Stanslas, Hafizah Abdul Hami. Hypoxia-Induced Neuroinflammation in Alzheimer's Disease: Potential Neuroprotective Effects of Frontiers in physiology. vol 12. 2021-11-02. PMID:34721056. |
hypoxia-induced neuroinflammation in alzheimer's disease: potential neuroprotective effects of alzheimer's disease (ad) is a neurodegenerative disorder that is characterised by the presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau tangles in the brain. |
2021-11-02 |
2023-08-13 |
Not clear |
| Charles D Chen, Timothy R Holden, Brian A Gordon, Erin E Franklin, Yan Li, Dean W Coble, Hongbo Luo, Randall J Bateman, Beau M Ances, Richard J Perrin, Tammie L S Benzinger, Nigel J Cairns, John C Morri. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 12. 2021-11-01. PMID:33150749. |
ante- and postmortem tau in autosomal dominant and late-onset alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Charles D Chen, Timothy R Holden, Brian A Gordon, Erin E Franklin, Yan Li, Dean W Coble, Hongbo Luo, Randall J Bateman, Beau M Ances, Richard J Perrin, Tammie L S Benzinger, Nigel J Cairns, John C Morri. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 12. 2021-11-01. PMID:33150749. |
antemortem tau positron emission tomography imaging suggests elevated tau pathology in autosomal dominant versus late-onset alzheimer's disease at equivalent clinical stages, but does not implicate the specific tau pathologies responsible. |
2021-11-01 |
2023-08-13 |
Not clear |
| Charles D Chen, Timothy R Holden, Brian A Gordon, Erin E Franklin, Yan Li, Dean W Coble, Hongbo Luo, Randall J Bateman, Beau M Ances, Richard J Perrin, Tammie L S Benzinger, Nigel J Cairns, John C Morri. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 12. 2021-11-01. PMID:33150749. |
here we made stereological measurements of tau neurofibrillary tangles, neuritic plaques, and neuropil threads and found compared to late-onset alzheimer's disease, autosomal dominant alzheimer's disease showed even greater tangle and thread burdens. |
2021-11-01 |
2023-08-13 |
Not clear |
| Charles D Chen, Timothy R Holden, Brian A Gordon, Erin E Franklin, Yan Li, Dean W Coble, Hongbo Luo, Randall J Bateman, Beau M Ances, Richard J Perrin, Tammie L S Benzinger, Nigel J Cairns, John C Morri. Ante- and postmortem tau in autosomal dominant and late-onset Alzheimer's disease. Annals of clinical and translational neurology. vol 7. issue 12. 2021-11-01. PMID:33150749. |
finally, our results suggest tau imaging measures total tau burden in alzheimer's disease, composed predominantly of tangle and thread pathology. |
2021-11-01 |
2023-08-13 |
Not clear |
| Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of disease. vol 147. 2021-11-01. PMID:33184027. |
aging drives pathological accumulation of proteins such as tau, causing neurodegenerative dementia disorders like alzheimer's disease. |
2021-11-01 |
2023-08-13 |
mouse |
| Rebecca L Kow, Timothy J Strovas, Pamela J McMillan, Ashley M Jacobi, Mark A Behlke, Aleen D Saxton, Caitlin S Latimer, C Dirk Keene, Brian C Kraeme. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of disease. vol 147. 2021-11-01. PMID:33184027. |
alzheimer's disease patients with low toe1 levels exhibited significantly increased pathological tau deposition and loss of neun staining. |
2021-11-01 |
2023-08-13 |
mouse |
| Anna Siegert, Marija Rankovic, Filippo Favretto, Tina Ukmar-Godec, Timo Strohäker, Stefan Becker, Markus Zweckstette. Interplay between tau and α-synuclein liquid-liquid phase separation. Protein science : a publication of the Protein Society. vol 30. issue 7. 2021-11-01. PMID:33452693. |
liquid-liquid phase separation (llps) of proteins has recently been shown to be important for protein aggregation involved in amyotrophic lateral sclerosis, whereas tau phase separation has been linked to alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |
| Saeed Najafi, Yanxian Lin, Andrew P Longhini, Xuemei Zhang, Kris T Delaney, Kenneth S Kosik, Glenn H Fredrickson, Joan-Emma Shea, Songi Ha. Liquid-liquid phase separation of Tau by self and complex coacervation. Protein science : a publication of the Protein Society. vol 30. issue 7. 2021-11-01. PMID:33955104. |
the liquid-liquid phase separation (llps) of tau has been postulated to play a role in modulating the aggregation property of tau, a process known to be critically associated with the pathology of a broad range of neurodegenerative diseases including alzheimer's disease. |
2021-11-01 |
2023-08-13 |
Not clear |