| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chinmaya Panda, Clara Voelz, Pardes Habib, Christian Mevissen, Thomas Pufe, Cordian Beyer, Sharad Gupta, Alexander Slowi. Aggregated Tau-PHF6 (VQIVYK) Potentiates NLRP3 Inflammasome Expression and Autophagy in Human Microglial Cells. Cells. vol 10. issue 7. 2021-10-28. PMID:34209408. |
intra-neuronal misfolding of monomeric tau protein to toxic β-sheet rich neurofibrillary tangles is a hallmark of alzheimer's disease (ad). |
2021-10-28 |
2023-08-13 |
human |
| Kamlesh M Makwana, Matthew P Sarnowski, Jiayuan Miao, Yu-Shan Lin, Juan R Del Vall. N-Amination Converts Amyloidogenic Tau Peptides into Soluble Antagonists of Cellular Seeding. ACS chemical neuroscience. vol 12. issue 20. 2021-10-28. PMID:34609825. |
the spread of neurofibrillary tangles composed of tau protein aggregates is a hallmark of alzheimer's and related neurodegenerative diseases. |
2021-10-28 |
2023-08-13 |
Not clear |
| Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C Kim, Kun Ho Le. Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34627371. |
visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in alzheimer's continuum. |
2021-10-28 |
2023-08-13 |
Not clear |
| Eun Hyun Seo, Ho Jae Lim, Hyung-Jun Yoon, Kyu Yeong Choi, Jang Jae Lee, Jun Young Park, Seong Hye Choi, Hoowon Kim, Byeong C Kim, Kun Ho Le. Visuospatial memory impairment as a potential neurocognitive marker to predict tau pathology in Alzheimer's continuum. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34627371. |
given that tau accumulation, not amyloid-β (aβ) burden, is more closely connected with cognitive impairment in alzheimer's disease (ad), a detailed understanding of the tau-related characteristics of cognitive function is critical in both clinical and research settings. |
2021-10-28 |
2023-08-13 |
Not clear |
| Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntne. Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling. Alzheimer's research & therapy. vol 13. issue 1. 2021-10-28. PMID:34656177. |
to better understand the etiology and pathomechanisms of alzheimer's disease, several transgenic animal models that overexpress human tau or human amyloid-beta (aβ) have been developed. |
2021-10-28 |
2023-08-13 |
human |
| Rose Irwin, Ofrah Faust, Ivana Petrovic, Sharon Grayer Wolf, Hagen Hofmann, Rina Rosenzwei. Hsp40s play complementary roles in the prevention of tau amyloid formation. eLife. vol 10. 2021-10-27. PMID:34369377. |
the microtubule-associated protein, tau, is the major subunit of neurofibrillary tangles associated with neurodegenerative conditions, such as alzheimer's disease. |
2021-10-27 |
2023-08-13 |
Not clear |
| Gemin Zhu, Yuan Fang, Xiaoli Cui, Ruihua Jia, Xiaogang Kang, Rui Zha. Magnolol upregulates CHRM1 to attenuate Amyloid-β-triggered neuronal injury through regulating the cAMP/PKA/CREB pathway. Journal of natural medicines. 2021-10-27. PMID:34705126. |
alzheimer's disease (ad) is a common neurodegenerative disease characterized by neuronal degeneration and hyperphosphorylated tau. |
2021-10-27 |
2023-08-13 |
Not clear |
| Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D Louis Collins, Johannes Levin, Hiroshi Mori, Jae Hong Lee, Martin Rhys Farlow, Peter Schofield, Jasmeer P Chhatwal, Colin L Masters, Tammie Benzinger, John Morris, Randall Bateman, John Cs Breitner, Judes Poirier, Julie Gonneaud, Maxime Descoteaux, Sylvia Villeneuv. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease. eLife. vol 10. 2021-10-26. PMID:33983116. |
bundle-specific associations between white matter microstructure and aβ and tau pathology in preclinical alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Alexa Pichet Binette, Guillaume Theaud, François Rheault, Maggie Roy, D Louis Collins, Johannes Levin, Hiroshi Mori, Jae Hong Lee, Martin Rhys Farlow, Peter Schofield, Jasmeer P Chhatwal, Colin L Masters, Tammie Benzinger, John Morris, Randall Bateman, John Cs Breitner, Judes Poirier, Julie Gonneaud, Maxime Descoteaux, Sylvia Villeneuv. Bundle-specific associations between white matter microstructure and Aβ and tau pathology in preclinical Alzheimer's disease. eLife. vol 10. 2021-10-26. PMID:33983116. |
beta-amyloid (aβ) and tau proteins, the pathological hallmarks of alzheimer's disease (ad), are believed to spread through connected regions of the brain. |
2021-10-26 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. Corrigendum to: CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 9. 2021-10-26. PMID:34215872. |
corrigendum to: csf tau microtubule binding region identifies tau tangle and clinical stages of alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Jannatun Nayem Namme, Asim Kumar Bepari, Hirohide Takebayash. Cofilin Signaling in the CNS Physiology and Neurodegeneration. International journal of molecular sciences. vol 22. issue 19. 2021-10-26. PMID:34639067. |
for instance, oxidative stress-induced increase in cofilin dephosphorylation is linked to the accumulation of tau tangles and amyloid-beta plaques in alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Douglas H Kelle. Brain cerebrospinal fluid flow. Physical review fluids. vol 6. issue 7. 2021-10-26. PMID:34671708. |
according to the glymphatic hypothesis, in physiological conditions, cerebrospinal fluid flows primarily during sleep and serves to remove metabolic wastes like the amyloid-beta and tau proteins whose accumulation is believed to cause alzheimer's disease. |
2021-10-26 |
2023-08-13 |
human |
| Ines Moreno-Gonzalez, George A Edwards, Omar Hasan, Nazaret Gamez, Jonathan E Schulz, Juan Jose Fernandez-Valenzuela, Antonia Gutierrez, Claudio Soto, Paul E Schul. Longitudinal Assessment of Tau-Associated Pathology by Diagnostics (Basel, Switzerland). vol 11. issue 10. 2021-10-26. PMID:34679572. |
in alzheimer's disease (ad), nfts are accompanied by extracellular amyloid-beta (aβ), but primary tauopathy disorders are marked by the accumulation of tau protein alone, including forms of frontotemporal dementia (ftd), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), among others. |
2021-10-26 |
2023-08-13 |
Not clear |
| Trae Carroll, Sanjib Guha, Keith Nehrke, Gail V W Johnso. Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer's Disease. Biology. vol 10. issue 10. 2021-10-26. PMID:34681146. |
tau post-translational modifications: potentiators of selective vulnerability in sporadic alzheimer's disease. |
2021-10-26 |
2023-08-13 |
Not clear |
| Trae Carroll, Sanjib Guha, Keith Nehrke, Gail V W Johnso. Tau Post-Translational Modifications: Potentiators of Selective Vulnerability in Sporadic Alzheimer's Disease. Biology. vol 10. issue 10. 2021-10-26. PMID:34681146. |
sporadic alzheimer's disease (ad) is the most common form of dementia, and its severity is characterized by the progressive formation of tau neurofibrillary tangles along a well-described path through the brain. |
2021-10-26 |
2023-08-13 |
Not clear |
| Nasim Rezaee, W M A D Binosha Fernando, Eugene Hone, Hamid R Sohrabi, Stuart K Johnson, Stuart Gunzburg, Ralph N Martin. Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article. Frontiers in aging neuroscience. vol 13. 2021-10-26. PMID:34690742. |
alzheimer's disease (ad) is characterized by the excessive deposition of extracellular amyloid-beta peptide (aβ) and the build-up of intracellular neurofibrillary tangles containing hyperphosphorylated tau proteins. |
2021-10-26 |
2023-08-13 |
human |
| Alexandra L Clark, Alexandra J Weigand, Katherine J Bangen, Kelsey R Thomas, Graham M L Eglit, Mark W Bondi, Lisa Delano-Woo. Higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in Vietnam-era veterans: A Department of Defense Alzheimer's Disease Neuroimaging Initiative (DOD-ADNI) study. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-10-26. PMID:34692979. |
higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in vietnam-era veterans: a department of defense alzheimer's disease neuroimaging initiative (dod-adni) study. |
2021-10-26 |
2023-08-13 |
Not clear |
| Z Jaunmuktane, S Brandne. Invited Review: The role of prion-like mechanisms in neurodegenerative diseases. Neuropathology and applied neurobiology. vol 46. issue 6. 2021-10-25. PMID:31868945. |
there is increasing evidence that other neurodegenerative diseases, most notably alzheimer's disease (aβ and tau), parkinson's disease (α-synuclein), frontotemporal dementia (tdp43, tau or fus) and motor neurone disease (tdp43), exhibit at least some of the misfolded prion protein properties. |
2021-10-25 |
2023-08-13 |
Not clear |
| Richelle Sopko, Olga Golonzhka, Joseph Arndt, Chao Quan, Julie Czerkowicz, Andrew Cameron, Benjamin Smith, Yogapriya Murugesan, Garrett Gibbons, Soo-Jung Kim, John Q Trojanowski, Virginia M Y Lee, Kurt R Brunden, Danielle L Graham, Paul H Weinreb, Heike Herin. Characterization of tau binding by gosuranemab. Neurobiology of disease. vol 146. 2021-10-25. PMID:32991997. |
deposition of tau aggregates in the brain is a pathological hallmark of several neurodegenerative diseases, termed tauopathies, such as alzheimer's disease (ad), corticobasal degeneration, and progressive supranuclear palsy (psp). |
2021-10-25 |
2023-08-13 |
mouse |
| Mauro Montalbano, Salome McAllen, Filippa Lo Cascio, Urmi Sengupta, Stephanie Garcia, Nemil Bhatt, Anna Ellsworth, Eric A Heidelman, Omar D Johnson, Samantha Doskocil, Rakez Kaye. TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia. Neurobiology of disease. vol 146. 2021-10-25. PMID:33065281. |
tdp-43 and tau oligomers in alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. |
2021-10-25 |
2023-08-13 |
human |