| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joyce R Chong, Nicholas J Ashton, Thomas K Karikari, Tomotaka Tanaka, Michael Schöll, Henrik Zetterberg, Kaj Blennow, Christopher P Chen, Mitchell K P La. Blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of Alzheimer's disease: a focused review on recent advances. Journal of neurology, neurosurgery, and psychiatry. vol 92. issue 11. 2021-10-14. PMID:34510001. |
blood-based high sensitivity measurements of beta-amyloid and phosphorylated tau as biomarkers of alzheimer's disease: a focused review on recent advances. |
2021-10-14 |
2023-08-13 |
Not clear |
| Duygu Tosun, Zeynep Demir, Dallas P Veitch, Daniel Weintraub, Paul Aisen, Clifford R Jack, William J Jagust, Ronald C Petersen, Andrew J Saykin, Leslie M Shaw, John Q Trojanowski, Michael W Weine. Contribution of Alzheimer's biomarkers and risk factors to cognitive impairment and decline across the Alzheimer's disease continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-10-14. PMID:34647694. |
amyloid beta (aβ), tau, and neurodegeneration jointly with the alzheimer's disease (ad) risk factors affect the severity of clinical symptoms and disease progression. |
2021-10-14 |
2023-08-13 |
Not clear |
| Oskar Hansson, Richard Batrla, Britta Brix, Maria C Carrillo, Veronika Corradini, Rebecca M Edelmayer, Rianne N Esquivel, Christina Hall, John Lawson, Nathalie Le Bastard, José Luis Molinuevo, Laura K Nisenbaum, Sandra Rutz, Salvatore J Salamone, Charlotte E Teunissen, Christopher Traynham, Robert M Umek, Hugo Vanderstichele, Manu Vandijck, Simone Wahl, Christopher J Weber, Henrik Zetterberg, Kaj Blenno. The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 9. 2021-10-13. PMID:33788410. |
the alzheimer's association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau. |
2021-10-13 |
2023-08-13 |
Not clear |
| Oskar Hansson, Richard Batrla, Britta Brix, Maria C Carrillo, Veronika Corradini, Rebecca M Edelmayer, Rianne N Esquivel, Christina Hall, John Lawson, Nathalie Le Bastard, José Luis Molinuevo, Laura K Nisenbaum, Sandra Rutz, Salvatore J Salamone, Charlotte E Teunissen, Christopher Traynham, Robert M Umek, Hugo Vanderstichele, Manu Vandijck, Simone Wahl, Christopher J Weber, Henrik Zetterberg, Kaj Blenno. The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid β and tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17. issue 9. 2021-10-13. PMID:33788410. |
the core cerebrospinal fluid (csf) alzheimer's disease (ad) biomarkers amyloid beta (aβ42 and aβ40), total tau, and phosphorylated tau, have been extensively clinically validated, with very high diagnostic performance for ad, including the early phases of the disease. |
2021-10-13 |
2023-08-13 |
Not clear |
| Shubir Dutt, Yanrong Li, Mara Mather, Daniel A Natio. Brainstem substructures and cognition in prodromal Alzheimer's disease. Brain imaging and behavior. vol 15. issue 5. 2021-10-12. PMID:33646514. |
neuropathological research suggests the tau pathology of alzheimer's disease may originate in brainstem nuclei, yet it remains unknown whether tau-mediated degeneration of brainstem nuclei influences cognitive impairment in prodromal alzheimer's disease. |
2021-10-12 |
2023-08-13 |
human |
| Toshiki Tezuka, Keisuke Takahata, Morinobu Seki, Hajime Tabuchi, Yuki Momota, Mika Shiraiwa, Natsumi Suzuki, Ayaka Morimoto, Tadaki Nakahara, Yu Iwabuchi, Eisuke Miura, Yasuharu Yamamoto, Yasunori Sano, Kei Funaki, Bun Yamagata, Ryo Ueda, Takahito Yoshizaki, Kyoko Mashima, Mamoru Shibata, Munenori Oyama, Kensuke Okada, Masahito Kubota, Hajime Okita, Masaki Takao, Masahiro Jinzaki, Jin Nakahara, Masaru Mimura, Daisuke It. Evaluation of [ Brain communications. vol 3. issue 4. 2021-10-12. PMID:34632382. |
evaluation of [ tau aggregates represent a key pathologic feature of alzheimer's disease and other neurodegenerative diseases. |
2021-10-12 |
2023-08-13 |
Not clear |
| Woo Shik Shin, Jing Di, Kevin A Murray, Chuanqi Sun, Binsen Li, Gal Bitan, Lin Jian. Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. Frontiers in molecular neuroscience. vol 12. 2021-10-11. PMID:31787880. |
alzheimer's disease (ad) pathology is characterized by the aggregation of beta-amyloid (aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain. |
2021-10-11 |
2023-08-13 |
mouse |
| Pallavi Duggal, Kuldeep S Jadaun, Ehraz M Siqqiqui, Sidharth Meha. Investigation of Low Dose Cabazitaxel Potential as Microtubule Stabilizer in Experimental Model of Alzheimer's Disease: Restoring Neuronal Cytoskeleton. Current Alzheimer research. vol 17. issue 7. 2021-10-11. PMID:33030130. |
tau hyperphosphorylation mediated mt destabilization results in axonopathy, additionally neurotransmitter deficit and ultimately causing alzheimer's disease. |
2021-10-11 |
2023-08-13 |
Not clear |
| Pallavi Duggal, Kuldeep S Jadaun, Ehraz M Siqqiqui, Sidharth Meha. Investigation of Low Dose Cabazitaxel Potential as Microtubule Stabilizer in Experimental Model of Alzheimer's Disease: Restoring Neuronal Cytoskeleton. Current Alzheimer research. vol 17. issue 7. 2021-10-11. PMID:33030130. |
pre-clinically, streptozotocin (3mg/kg, 10μl/ unilateral, icv) stereotaxically mimics the behavioral and neurochemical alterations similar to alzheimer's tau pathology resulting in mt assembly defects further lead to neuropathological cascades. |
2021-10-11 |
2023-08-13 |
Not clear |
| L Lemoine, A Ledreux, E J Mufson, S E Perez, G Simic, E Doran, I Lott, S Carroll, K Bharani, S Thomas, A Gilmore, E D Hamlett, A Nordberg, A C Granhol. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Molecular neurodegeneration. vol 15. issue 1. 2021-10-11. PMID:33222700. |
tau pathology is a major age-related event in down syndrome with alzheimer's disease (ds-ad). |
2021-10-11 |
2023-08-13 |
Not clear |
| L Lemoine, A Ledreux, E J Mufson, S E Perez, G Simic, E Doran, I Lott, S Carroll, K Bharani, S Thomas, A Gilmore, E D Hamlett, A Nordberg, A C Granhol. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Molecular neurodegeneration. vol 15. issue 1. 2021-10-11. PMID:33222700. |
although recently, several different tau pet tracers have been developed as biomarkers for ad, these tracers showed different binding properties in alzheimer disease and other non-ad tauopathies. |
2021-10-11 |
2023-08-13 |
Not clear |
| Huber S Padilla-Zambrano, Ezequiel García-Ballestas, Gabriel A Quiñones-Ossa, Andrés E Sibaja-Perez, Amit Agrawal, Luis R Moscote-Salazar, Manuel Menéndez-Gonzále. The Prion-like Properties of Amyloid-beta Peptide and Tau: Is there Any Risk of Transmitting Alzheimer's Disease During Neurosurgical Interventions? Current Alzheimer research. vol 17. issue 9. 2021-10-11. PMID:33280597. |
the prion-like properties of amyloid-beta peptide and tau: is there any risk of transmitting alzheimer's disease during neurosurgical interventions? |
2021-10-11 |
2023-08-13 |
human |
| Huber S Padilla-Zambrano, Ezequiel García-Ballestas, Gabriel A Quiñones-Ossa, Andrés E Sibaja-Perez, Amit Agrawal, Luis R Moscote-Salazar, Manuel Menéndez-Gonzále. The Prion-like Properties of Amyloid-beta Peptide and Tau: Is there Any Risk of Transmitting Alzheimer's Disease During Neurosurgical Interventions? Current Alzheimer research. vol 17. issue 9. 2021-10-11. PMID:33280597. |
the tau protein and the amyloid β peptide represent the theoretical pillars of alzheimer's disease development. |
2021-10-11 |
2023-08-13 |
human |
| Victor L Villemagne, Frederik Barkhof, Valentina Garibotto, Susan M Landau, Agneta Nordberg, Bart N M van Bercke. Molecular Imaging Approaches in Dementia. Radiology. vol 298. issue 3. 2021-10-11. PMID:33464184. |
molecular imaging using pet/spect is able to show amyloid and tau deposition in alzheimer disease and dopamine depletion in parkinsonian disorders starting decades before symptom onset. |
2021-10-11 |
2023-08-13 |
Not clear |
| Paula Duarte-Guterman, Arianne Y Albert, Cindy K Barha, Liisa A M Galea, On Behalf Of The Alzheimer's Disease Neuroimaging Initiativ. Sex influences the effects of APOE genotype and Alzheimer's diagnosis on neuropathology and memory. Psychoneuroendocrinology. vol 129. 2021-10-11. PMID:33962245. |
alzheimer's disease (ad) is characterized by severe cognitive decline and pathological changes in the brain (brain atrophy, hyperphosphorylation of tau, and deposition of amyloid-beta protein). |
2021-10-11 |
2023-08-13 |
Not clear |
| Teuntje A D Pelgrim, Magdalena Beran, Emma L Twait, Mirjam I Geerlings, Jet M J Von. Cross-sectional associations of tau protein biomarkers with semantic and episodic memory in older adults without dementia: A systematic review and meta-analysis. Ageing research reviews. vol 71. 2021-10-11. PMID:34400308. |
pathological tau is suggested to play a role in cognitive deterioration in the preclinical phase of alzheimer's disease. |
2021-10-11 |
2023-08-13 |
Not clear |
| Shi-Dong Chen, Jia-Ying Lu, Hong-Qi Li, Yu-Xiang Yang, Jie-Hui Jiang, Mei Cui, Chuan-Tao Zuo, Lan Tan, Qiang Dong, Jin-Tai Y. Staging tau pathology with tau PET in Alzheimer's disease: a longitudinal study. Translational psychiatry. vol 11. issue 1. 2021-10-11. PMID:34537810. |
staging tau pathology with tau pet in alzheimer's disease: a longitudinal study. |
2021-10-11 |
2023-08-13 |
Not clear |
| Etienne Leveille, Owen A Ross, Ziv Gan-O. Tau and MAPT genetics in tauopathies and synucleinopathies. Parkinsonism & related disorders. vol 90. 2021-10-11. PMID:34593302. |
abnormal tau can also be observed in secondary tauopathies such as alzheimer's disease (ad) and synucleinopathies such as parkinson's disease (pd). |
2021-10-11 |
2023-08-13 |
Not clear |
| Chad A Sallaberry, Barbie J Voss, Jaroslaw Majewski, Jacek Biernat, Eckhard Mandelkow, Eva Y Chi, Crystal M Vander Zande. Tau and Membranes: Interactions That Promote Folding and Condensation. Frontiers in cell and developmental biology. vol 9. 2021-10-09. PMID:34621743. |
tau misfolding and assembly is linked to a number of neurodegenerative diseases collectively described as tauopathies, including alzheimer's disease (ad) and parkinson's disease. |
2021-10-09 |
2023-08-13 |
Not clear |
| Oskar Hansson, Nicholas Cullen, Henrik Zetterberg, Kaj Blennow, Niklas Mattsson-Carlgre. Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease. Annals of clinical and translational neurology. vol 8. issue 1. 2021-10-08. PMID:33249783. |
we examined if plasma phosphorylated tau is associated with neurodegeneration in alzheimer's disease. |
2021-10-08 |
2023-08-13 |
human |