Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Alireza Majdi, Saeed Sadigh-Eteghad, Sepideh Rahigh Aghsan, Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Ali Namvaran, Javad Mahmoud. Amyloid-β, tau, and the cholinergic system in Alzheimer's disease: seeking direction in a tangle of clues. Reviews in the neurosciences. vol 31. issue 4. 2021-09-24. PMID:32017704. |
amyloid-β, tau, and the cholinergic system in alzheimer's disease: seeking direction in a tangle of clues. |
2021-09-24 |
2023-08-13 |
Not clear |
Steven S Plotkin, Neil R Cashma. Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of disease. vol 144. 2021-09-24. PMID:32682954. |
passive immunotherapies targeting aβ and tau in alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
Steven S Plotkin, Neil R Cashma. Passive immunotherapies targeting Aβ and tau in Alzheimer's disease. Neurobiology of disease. vol 144. 2021-09-24. PMID:32682954. |
amyloid-β (aβ) and tau proteins currently represent the two most promising targets to treat alzheimer's disease. |
2021-09-24 |
2023-08-13 |
Not clear |
Christos Proukaki. Somatic mutations in neurodegeneration: An update. Neurobiology of disease. vol 144. 2021-09-24. PMID:32712267. |
in common sporadic neurodegenerative disorders, relevant mutations have been reported in synucleinopathies, comprising somatic gains of snca in parkinson's disease and multiple system atrophy, and in alzheimer's disease, where a novel recombination mechanism leading to somatic variants of app, as well as an excess of somatic snvs affecting tau phosphorylation, have been reported. |
2021-09-24 |
2023-08-13 |
human |
Brendan P Luce. It's complicated: The relationship between sleep and Alzheimer's disease in humans. Neurobiology of disease. vol 144. 2021-09-24. PMID:32738506. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder characterized by an asymptomatic period of amyloid-β (aβ) deposition as insoluble extracellular plaque, intracellular tau aggregation, neuronal and synaptic loss, and subsequent cognitive dysfunction and dementia. |
2021-09-24 |
2023-08-13 |
Not clear |
Brent Race, Katie Williams, James F Striebel, Bruce Chesebr. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of disease. vol 144. 2021-09-24. PMID:32829029. |
tau aggregates consisting of hyperphosphorylated tau fibrils are associated with many neurodegenerative diseases, including alzheimer's disease, pick's disease, frontotemporal dementia, and progressive supranuclear palsy. |
2021-09-24 |
2023-08-13 |
mouse |
Jian-Lan Gu, Fei Li. Tau in Alzheimer's Disease: Pathological Alterations and an Attractive Therapeutic Target. Current medical science. vol 40. issue 6. 2021-09-24. PMID:33428128. |
tau in alzheimer's disease: pathological alterations and an attractive therapeutic target. |
2021-09-24 |
2023-08-13 |
Not clear |
Jian-Lan Gu, Fei Li. Tau in Alzheimer's Disease: Pathological Alterations and an Attractive Therapeutic Target. Current medical science. vol 40. issue 6. 2021-09-24. PMID:33428128. |
alzheimer's disease (ad) is an age-related neurodegenerative disease with two major hallmarks: extracellular amyloid plaques made of amyloid-β (aβ) and intracellular neurofibrillary tangles (nfts) of abnormally hyperphosphorylated tau. |
2021-09-24 |
2023-08-13 |
Not clear |
Deng-Lei Ma, Yi Luo, Rui Huang, Zi-Run Zhao, Li Zhang, Ya-Li Li, Qi Wang, Lin Li, Lan Zhan. Cornel Iridoid Glycoside Suppresses Hyperactivity Phenotype in rTg4510 Mice through Reducing Tau Pathology and Improving Synaptic Dysfunction. Current medical science. vol 40. issue 6. 2021-09-24. PMID:33428130. |
rtg4510 mice are transgenic mice expressing p301l mutant tau and have been developed as an animal model of tauopathies including alzheimer's disease (ad). |
2021-09-24 |
2023-08-13 |
mouse |
Yinan Yao, Seong Su Kang, Yiyuan Xia, Zhi-Hao Wang, Xia Liu, Thorsten Muller, Yi E Sun, Keqiang Y. A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies. Brain : a journal of neurology. vol 144. issue 6. 2021-09-24. PMID:33880508. |
the app c586-695 fragment, but not full-length app, strongly associates with cebpb and elicits its nuclear translocation and augments the transcriptional activities on app itself, mapt (microtubule-associated protein tau), δ-secretase and inflammatory cytokine mrna expression, finally triggering alzheimer's disease pathology and cognitive disorder in a viral overexpression mouse model. |
2021-09-24 |
2023-08-13 |
mouse |
Hatice Saray, Cem Süer, Bilal Koşar, Burak Tan, Nurcan Dursu. Rho-associated kinases contribute to the regulation of tau phosphorylation and amyloid metabolism during neuronal plasticity. Pharmacological reports : PR. vol 73. issue 5. 2021-09-24. PMID:34060063. |
since restoration of pi3-kinase signaling has therapeutic potential in alzheimer's disease, we investigated plasticity-related changes in tau and app metabolism by the selective rho-kinase inhibitor fasudil. |
2021-09-24 |
2023-08-13 |
Not clear |
Akash G Patel, Pramod N Nehete, Sara R Krivoshik, Xuewei Pei, Elizabeth L Cho, Bharti P Nehete, Margish D Ramani, Yongzhao Shao, Lawrence E Williams, Thomas Wisniewski, Henrieta Scholtzov. Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys. Brain : a journal of neurology. vol 144. issue 7. 2021-09-24. PMID:34128045. |
we have shown in multiple transgenic alzheimer's disease mouse models that harnessing innate immunity via tlr9 agonist cpg oligodeoxynucleotides (odns) modulates age-related defects associated with immune cells and safely reduces amyloid plaques, oligomeric amyloid-β, tau pathology, and cerebral amyloid angiopathy (caa) while promoting cognitive benefits. |
2021-09-24 |
2023-08-13 |
mouse |
Akash G Patel, Pramod N Nehete, Sara R Krivoshik, Xuewei Pei, Elizabeth L Cho, Bharti P Nehete, Margish D Ramani, Yongzhao Shao, Lawrence E Williams, Thomas Wisniewski, Henrieta Scholtzov. Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys. Brain : a journal of neurology. vol 144. issue 7. 2021-09-24. PMID:34128045. |
we demonstrate that long-term use of class b cpg odn 2006 induces a favourable degree of innate immunity stimulation without producing excessive or sustained inflammation, resulting in efficient amelioration of both caa and tau alzheimer's disease-related pathologies in association with behavioural improvements and in the absence of microhaemorrhages in aged elderly squirrel monkeys. |
2021-09-24 |
2023-08-13 |
mouse |
Hoi-Khoanh Giong, Manivannan Subramanian, Kweon Yu, Jeong-Soo Le. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of International journal of molecular sciences. vol 22. issue 16. 2021-09-24. PMID:34445171. |
non-rodent genetic animal models for studying tauopathy: review of tauopathy refers to a group of progressive neurodegenerative diseases, including frontotemporal lobar degeneration and alzheimer's disease, which correlate with the malfunction of microtubule-associated protein tau (mapt) due to abnormal hyperphosphorylation, leading to the formation of intracellular aggregates in the brain. |
2021-09-24 |
2023-08-13 |
Not clear |
Song Li, Che Wang, Zhen Wang, Jun Ta. Involvement of cerebrovascular abnormalities in the pathogenesis and progression of Alzheimer's disease: an adrenergic approach. Aging. vol 13. issue 17. 2021-09-24. PMID:34479211. |
alzheimer's disease (ad), as the most common neurodegenerative disease in elder population, is pathologically characterized by β-amyloid (aβ) plaques, neurofibrillary tangles composed of highly-phosphorylated tau protein and consequently progressive neurodegeneration. |
2021-09-24 |
2023-08-13 |
Not clear |
Murali Vijayan, Mathew George, Lloyd E Bunquin, Chhanda Bose, P Hemachandra Redd. Protective effects of a small-molecule inhibitor DDQ against tau-induced toxicities in a transgenic tau mouse model of Alzheimer's disease. Human molecular genetics. 2021-09-24. PMID:34559191. |
protective effects of a small-molecule inhibitor ddq against tau-induced toxicities in a transgenic tau mouse model of alzheimer's disease. |
2021-09-24 |
2023-08-13 |
mouse |
Murali Vijayan, Mathew George, Lloyd E Bunquin, Chhanda Bose, P Hemachandra Redd. Protective effects of a small-molecule inhibitor DDQ against tau-induced toxicities in a transgenic tau mouse model of Alzheimer's disease. Human molecular genetics. 2021-09-24. PMID:34559191. |
the purpose of our study is to determine, ddq (diethyl (3,4-dihydroxyphenethylamino) (quinolin-4-yl) methylphosphonate) is a newly discovered molecule that has been shown to protect against phosphorylated tau (p-tau) in alzheimer's disease (ad) pathogenesis. |
2021-09-24 |
2023-08-13 |
mouse |
L A Sandusky-Beltran, E M Sigurdsso. Tau immunotherapies: Lessons learned, current status and future considerations. Neuropharmacology. vol 175. 2021-09-23. PMID:32360477. |
the majority of clinical trials targeting the tau protein in alzheimer's disease and other tauopathies are tau immunotherapies. |
2021-09-23 |
2023-08-13 |
mouse |
L A Sandusky-Beltran, E M Sigurdsso. Tau immunotherapies: Lessons learned, current status and future considerations. Neuropharmacology. vol 175. 2021-09-23. PMID:32360477. |
because tau pathology correlates better with the degree of dementia than amyloid-β lesions, targeting tau is likely to be more effective in improving cognition than clearing amyloid-β in alzheimer's disease. |
2021-09-23 |
2023-08-13 |
mouse |
Viviana Soto-Mercado, Miguel Mendivil-Perez, Marlene Jimenez-Del-Rio, Carlos Velez-Pard. Multi-Target Effects of the Cannabinoid CP55940 on Familial Alzheimer's Disease PSEN1 E280A Cholinergic-Like Neurons: Role of CB1 Receptor. Journal of Alzheimer's disease : JAD. vol 82. issue s1. 2021-09-23. PMID:33252082. |
alzheimer's disease (ad) is characterized by structural damage, death, and functional disruption of cholinergic neurons (chns) as a result of intracellular amyloid-β (aβ) aggregation, extracellular neuritic plaques, and hyperphosphorylation of protein tau (p-tau) overtime. |
2021-09-23 |
2023-08-13 |
Not clear |