| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michel J Grothe, Alexis Moscoso, Nicholas J Ashton, Thomas K Karikari, Juan Lantero-Rodriguez, Anniina Snellman, Henrik Zetterberg, Kaj Blennow, Michael Schöl. Associations of Fully Automated CSF and Novel Plasma Biomarkers With Alzheimer Disease Neuropathology at Autopsy. Neurology. 2021-10-01. PMID:34266917. |
to study cerebrospinal fluid (csf) biomarkers of alzheimer's disease (ad) analyzed by fully automated elecsys immunoassays in comparison to neuropathologic gold standards, and compare their accuracy to plasma phosphorylated tau (p-tau181) measured using a novel simoa method. |
2021-10-01 |
2023-08-13 |
Not clear |
| Xieze Wei, Pengchong Du, Zhiying Zha. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's disease. Neuroscience letters. vol 763. 2021-10-01. PMID:34437990. |
impacts of dna methylation on tau protein related genes in the brains of patients with alzheimer's disease. |
2021-10-01 |
2023-08-13 |
Not clear |
| Xieze Wei, Pengchong Du, Zhiying Zha. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's disease. Neuroscience letters. vol 763. 2021-10-01. PMID:34437990. |
in this paper, the process and role of gene methylation in abnormal tau modification and aggregation in the development of alzheimer's disease were discussed. |
2021-10-01 |
2023-08-13 |
Not clear |
| Xieze Wei, Pengchong Du, Zhiying Zha. Impacts of DNA methylation on Tau protein related genes in the brains of patients with Alzheimer's disease. Neuroscience letters. vol 763. 2021-10-01. PMID:34437990. |
the effect of dna methylation on tau protein in the brain of patients with alzheimer's disease will help to find new targets in the development of drugs for treating alzheimer's disease. |
2021-10-01 |
2023-08-13 |
Not clear |
| Cristina M Pedrero-Prieto, Javier Frontiñán-Rubio, Francisco J Alcaín, Mario Durán-Prado, Juan R Peinado, Yoana Rabanal-Rui. Biological Significance of the Protein Changes Occurring in the Cerebrospinal Fluid of Alzheimer's Disease Patients: Getting Clues from Proteomic Studies. Diagnostics (Basel, Switzerland). vol 11. issue 9. 2021-10-01. PMID:34573996. |
during the last decade, biomarker discovery has been especially fruitful for the identification new proteins that appear in the csf of alzheimer's disease (ad) patients together with amyloid-β (aβ42), total tau (t-tau), and phosphorylated tau (p-tau). |
2021-10-01 |
2023-08-13 |
Not clear |
| Peng Wang, Yihong Y. Astrocytes in Neurodegenerative Diseases: A Perspective from Tauopathy and α-Synucleinopathy. Life (Basel, Switzerland). vol 11. issue 9. 2021-10-01. PMID:34575087. |
this review summarizes our current understanding of the complex molecular interplays between astrocyte and neuron, emphasizing on tau and α-synuclein (α-syn), the disease-driving proteins for alzheimer's and parkinson's diseases, respectively. |
2021-10-01 |
2023-08-13 |
Not clear |
| Chih Hung L. Recent advances in cellular biosensor technology to investigate tau oligomerization. Bioengineering & translational medicine. vol 6. issue 3. 2021-10-01. PMID:34589603. |
tau is a microtubule binding protein which plays an important role in physiological functions but it is also involved in the pathogenesis of alzheimer's disease and related tauopathies. |
2021-10-01 |
2023-08-13 |
Not clear |
| Qingqin S Li, Louis De Muync. Differentially expressed genes in Alzheimer's disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1. Brain, behavior, & immunity - health. vol 13. 2021-10-01. PMID:34589742. |
alzheimer's disease (ad) is associated with abnormal tau and amyloid-β accumulation in the brain, leading to neurofibrillary tangles, neuropil threads and extracellular amyloid-β plaques. |
2021-10-01 |
2023-08-13 |
Not clear |
| R Dayne Mayfield, Li Zhu, Tyler A Smith, Gayatri R Tiwari, Haley O Tucke. The SMYD1 and skNAC transcription factors contribute to neurodegenerative diseases. Brain, behavior, & immunity - health. vol 9. 2021-10-01. PMID:34589886. |
finally, several defining features of alzheimer's pathology, including the brain-specific, axon-enriched microtubule-associated protein, tau, are deregulated upon smyd1 loss. |
2021-10-01 |
2023-08-13 |
mouse |
| Marco Bucci, Konstantinos Chiotis, Agneta Nordber. Alzheimer's disease profiled by fluid and imaging markers: tau PET best predicts cognitive decline. Molecular psychiatry. 2021-10-01. PMID:34593971. |
alzheimer's disease profiled by fluid and imaging markers: tau pet best predicts cognitive decline. |
2021-10-01 |
2023-08-13 |
human |
| Elijah Mak, Richard A I Bethlehem, Rafael Romero-Garcia, Simon Cervenka, Timothy Rittman, Silvy Gabel, Ajenthan Surendranathan, Richard W Bevan-Jones, Luca Passamonti, Patricia Vázquez Rodríguez, Li Su, Robert Arnold, Guy B Williams, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brie. In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 10. 2021-09-30. PMID:30426064. |
in vivo coupling of tau pathology and cortical thinning in alzheimer's disease. |
2021-09-30 |
2023-08-13 |
Not clear |
| M Reichenstein, N Borovok, A Sheinin, T Brider, I Michaelevsk. Abelson Kinases Mediate the Depression of Spontaneous Synaptic Activity Induced by Amyloid Beta 1-42 Peptides. Cellular and molecular neurobiology. vol 41. issue 3. 2021-09-30. PMID:32399753. |
recent publications indicate that some of the neurotoxic effects of amyloid beta peptides may be mediated via the activation of proteins belonging to the abelson non-receptor tyrosine kinase (abl) family, that are known to regulate actin cytoskeleton structure as well as phosphorylate microtubule-associated tau protein, a hallmark of alzheimer's disease. |
2021-09-30 |
2023-08-13 |
Not clear |
| Joanne M Tennant, Davin M Henderson, Thomas M Wisniewski, Edward A Hoove. RT-QuIC detection of tauopathies using full-length tau substrates. Prion. vol 14. issue 1. 2021-09-30. PMID:33171070. |
here we use full-length recombinant tau substrates to detect tau seeding activity in alzheimer's disease and other human tauopathies. |
2021-09-30 |
2023-08-13 |
human |
| Ying Wang, Axel Leppert, Shuai Tan, Bram van der Gaag, Nailin Li, Marianne Schultzberg, Erik Hjort. Maresin 1 attenuates pro-inflammatory activation induced by β-amyloid and stimulates its uptake. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-30. PMID:33225628. |
alzheimer's disease (ad) is the most common dementia, characterized by pathological accumulation of β-amyloid (aβ) and hyperphosphorylation of tau protein, together with a damaging chronic inflammation. |
2021-09-30 |
2023-08-13 |
human |
| Jorge A Aguilar-Pineda, Karin J Vera-Lopez, Pallavi Shrivastava, Miguel A Chávez-Fumagalli, Rita Nieto-Montesinos, Karla L Alvarez-Fernandez, Luis D Goyzueta Mamani, Gonzalo Davila Del-Carpio, Badhin Gomez-Valdez, Clint L Miller, Rajeev Malhotra, Mark E Lindsay, Christian L Lino Cardena. Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. iScience. vol 24. issue 9. 2021-09-30. PMID:34505007. |
vascular smooth muscle cell dysfunction contribute to neuroinflammation and tau hyperphosphorylation in alzheimer disease. |
2021-09-30 |
2023-08-13 |
Not clear |
| Cynthia Picard, Nathalie Nilsson, Anne Labonté, Daniel Auld, Pedro Rosa-Neto, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, John C B Breitner, Sylvia Villeneuve, Judes Poirie. Apolipoprotein B is a novel marker for early tau pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-30. PMID:34590423. |
apolipoprotein b is a novel marker for early tau pathology in alzheimer's disease. |
2021-09-30 |
2023-08-13 |
Not clear |
| Yanni Liu, Lin Wang, Fuheng Xie, Xiao Wang, Yuanyuan Hou, Xiaomeng Wang, Juan Li. Overexpression of miR-26a-5p Suppresses Tau Phosphorylation and Aβ Accumulation in the Alzheimer's Disease Mice by Targeting DYRK1A. Current neurovascular research. vol 17. issue 3. 2021-09-29. PMID:32286945. |
overexpression of mir-26a-5p suppresses tau phosphorylation and aβ accumulation in the alzheimer's disease mice by targeting dyrk1a. |
2021-09-29 |
2023-08-13 |
mouse |
| Yun Cao, Bingjin Liu, Weiqi Xu, Lin Wang, Fangxiao Shi, Na Li, Ying Lei, Jianzhi Wang, Qing Tian, Xinwen Zho. Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice. Brain research bulletin. vol 162. 2021-09-29. PMID:32599128. |
alzheimer's disease (ad) and type 2 diabetes mellitus (t2dm) share some pathological features, including tau hyperphosphorylation and deficits in insulin signaling, but the underlying mechanism and effective drugs for treating ad are unknown. |
2021-09-29 |
2023-08-13 |
mouse |
| Nils Richter, Gérard N Bischof, Julian Dronse, Nils Nellessen, Bernd Neumaier, Karl-Josef Langen, Alexander Drzezga, Gereon R Fink, Thilo van Eimeren, Juraj Kukolja, Oezguer A Onu. Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33164934. |
entorhinal tau predicts hippocampal activation and memory deficits in alzheimer's disease. |
2021-09-29 |
2023-08-13 |
Not clear |
| Ayush Singh, Dyron Allen, Anna Fracassi, Batbayar Tumurbaatar, Chandramouli Natarajan, Pietro Scaduto, Randy Woltjer, Rakez Kayed, Agenor Limon, Balaji Krishnan, Giulio Taglialatel. Functional Integrity of Synapses in the Central Nervous System of Cognitively Intact Individuals with High Alzheimer's Disease Neuropathology Is Associated with Absence of Synaptic Tau Oligomers. Journal of Alzheimer's disease : JAD. vol 78. issue 4. 2021-09-29. PMID:33185603. |
functional integrity of synapses in the central nervous system of cognitively intact individuals with high alzheimer's disease neuropathology is associated with absence of synaptic tau oligomers. |
2021-09-29 |
2023-08-13 |
Not clear |