| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paul A Rowley, Alexey A Samsonov, Tobey J Betthauser, Ali Pirasteh, Sterling C Johnson, Laura B Eisenmenge. Amyloid and Tau PET Imaging of Alzheimer Disease and Other Neurodegenerative Conditions. Seminars in ultrasound, CT, and MR. vol 41. issue 6. 2021-09-29. PMID:33308496. |
amyloid and tau pet imaging of alzheimer disease and other neurodegenerative conditions. |
2021-09-29 |
2023-08-13 |
Not clear |
| Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Huan Zhang, Sravan G Sreenivasmurthy, Zhou Zhu, Jia Liu, Cheng-Fu Su, Xin-Jie Guan, Zi-Ying Wang, King-Ho Cheung, Ju-Xian Song, Siva Sundara Kumar Durairajan, Min L. Qingyangshen mitigates amyloid-β and Tau aggregate defects involving PPARα-TFEB activation in transgenic mice of Alzheimer's disease. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 91. 2021-09-29. PMID:34332287. |
qingyangshen mitigates amyloid-β and tau aggregate defects involving pparα-tfeb activation in transgenic mice of alzheimer's disease. |
2021-09-29 |
2023-08-13 |
mouse |
| Xiaomin Yin, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Junze Bao, Wei Qia. The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-09-29. PMID:34471085. |
the role of amyloid-beta and tau in the early pathogenesis of alzheimer's disease. |
2021-09-29 |
2023-08-13 |
Not clear |
| Xiaomin Yin, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Junze Bao, Wei Qia. The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-09-29. PMID:34471085. |
the abnormal accumulation of amyloid-b (ab) and neurofibrillary tangles (nfts) containing phosphorylated tau proteins are the main histopathological feature of alzheimer's disease (ad). |
2021-09-29 |
2023-08-13 |
Not clear |
| Xiaomin Yin, Yanyan Qiu, Chenhao Zhao, Zheng Zhou, Junze Bao, Wei Qia. The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-09-29. PMID:34471085. |
this review aims to provide an update on the role of oligomeric ab and soluble hyperphosphorylated tau in the early pathogenesis of alzheimer's disease and to develop a new treatment strategy based on this. |
2021-09-29 |
2023-08-13 |
Not clear |
| Ayesha Majeed, Ben Marwick, Haoqing Yu, Hassan Fadavi, Mitra Tavakol. Ophthalmic Biomarkers for Alzheimer's Disease: A Review. Frontiers in aging neuroscience. vol 13. 2021-09-29. PMID:34566623. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by neuronal loss, extracellular amyloid-β (aβ) plaques, and intracellular neurofibrillary tau tangles. |
2021-09-29 |
2023-08-13 |
Not clear |
| Yanni Wang, Huan Li, Jingsi Zhang, Yingchao Han, Jing Song, Linping Wang, Yanxia Hao, Chanting He, Jisheng Nie, Qinli Zhang, Xiaoting Lu, Qiao Ni. Effect of aluminum combined with ApoEε4 on Tau phosphorylation and Aβ deposition. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). vol 64. 2021-09-28. PMID:33316730. |
studies have shown that alzheimer's disease (ad) is characterized by abnormally phosphorylated tau and aβ deposition, aluminum exposure can lead to abnormal phosphorylated tau and aβ deposition. |
2021-09-28 |
2023-08-13 |
Not clear |
| Fang-Lin Weng, Ling H. Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422896. |
disrupted ubiquitin proteasome system underlying tau accumulation in alzheimer's disease. |
2021-09-28 |
2023-08-13 |
Not clear |
| Fang-Lin Weng, Ling H. Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422896. |
accumulation of phosphorylated tau (p-tau) has long been an underappreciated hallmark of alzheimer's disease. |
2021-09-28 |
2023-08-13 |
Not clear |
| Fang-Lin Weng, Ling H. Disrupted ubiquitin proteasome system underlying tau accumulation in Alzheimer's disease. Neurobiology of aging. vol 99. 2021-09-28. PMID:33422896. |
this review endeavors to exam the potential role of ups in p-tau aggregation, and how pathogenic tau may inflict other abnormalities such as amyloid beta accumulation in alzheimer's disease. |
2021-09-28 |
2023-08-13 |
Not clear |
| Feng Han, Jing Chen, Aaron Belkin-Rosen, Yameng Gu, Liying Luo, Orfeu M Buxton, Xiao Li. Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology. PLoS biology. vol 19. issue 6. 2021-09-28. PMID:34061820. |
the glymphatic system plays an important role in clearing the amyloid-β (aβ) and tau proteins that are closely linked to alzheimer disease (ad) pathology. |
2021-09-28 |
2023-08-13 |
Not clear |
| Chaahat S B Singh, Kyung Bok Choi, Lonna Munro, Hong Yue Wang, Cheryl G Pfeifer, Wilfred A Jefferie. Reversing pathology in a preclinical model of Alzheimer's disease by hacking cerebrovascular neoangiogenesis with advanced cancer therapeutics. EBioMedicine. vol 71. 2021-09-28. PMID:34534764. |
cognitive decline leading to dementia, accompanied by the accumulation of amyloid-beta (aβ) in neuritic plaques together with the appearance of neurofibrillary tangles (nft) composed of hyperphosphorylated tau protein (tau), are previously noted hallmarks of alzheimer's disease (ad). |
2021-09-28 |
2023-08-13 |
Not clear |
| Claire Sexton, Heather Snyder, Dirk Beher, Adam L Boxer, Pat Brannelly, Jean-Pierre Brion, Luc Buée, Angela M Cacace, Gaël Chételat, Martin Citron, Sarah L DeVos, Kristophe Diaz, Howard H Feldman, Bess Frost, Alison M Goate, Michael Gold, Bradley Hyman, Keith Johnson, Celeste M Karch, Diana R Kerwin, Walter J Koroshetz, Irene Litvan, Huw R Morris, Catherine J Mummery, James Mutamba, Marc C Patterson, Yakeel T Quiroz, Gil D Rabinovici, Amy Rommel, Melanie B Shulman, Leticia M Toledo-Sherman, Stacie Weninger, Kristin R Wildsmith, Susan L Worley, Maria C Carrill. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-28. PMID:34581500. |
in february 2020, leading tau experts from around the world convened for the first-ever tau2020 global conference in washington, dc, co-organized and cosponsored by the rainwater charitable foundation, the alzheimer's association, and curepsp. |
2021-09-28 |
2023-08-13 |
Not clear |
| Isabel J Sible, Daniel A Natio. Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain imaging and behavior. 2021-09-28. PMID:34581957. |
a subset (n = 252) underwent lumbar puncture to determine alzheimer's disease cerebral spinal fluid amyloid-beta and phosphorylated tau biomarker abnormality. |
2021-09-28 |
2023-08-13 |
human |
| Isabel J Sible, Daniel A Natio. Blood pressure variability and medial temporal atrophy in apolipoprotein ϵ4 carriers. Brain imaging and behavior. 2021-09-28. PMID:34581957. |
a similar pattern emerged in subsets with alzheimer's disease pathophysiology (i.e., abnormal levels of both amyloid-beta and phosphorylated tau). |
2021-09-28 |
2023-08-13 |
human |
| Marta Milà-Alomà, Gemma Salvadó, Juan Domingo Gispert, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, Eider M Arenaza-Urquijo, Marta Crous-Bou, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuev. Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32573951. |
amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the alzheimer's continuum. |
2021-09-27 |
2023-08-13 |
Not clear |
| Chia-Chen Liu, Yu Yamazaki, Michael G Heckman, Yuka A Martens, Lin Jia, Akari Yamazaki, Nancy N Diehl, Jing Zhao, Na Zhao, Michael DeTure, Mary D Davis, Lindsey M Felton, Wenhui Qiao, Yonghe Li, Hongmei Li, Yuan Fu, Na Wang, Melissa Wren, Tomonori Aikawa, Marie-Louise Holm, Hiroshi Oue, Cynthia Linares, Mariet Allen, Minerva M Carrasquillo, Melissa E Murray, Ronald C Petersen, Nilüfer Ertekin-Taner, Dennis W Dickson, Takahisa Kanekiyo, Guojun B. Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32827351. |
tau and apolipoprotein e modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in alzheimer's disease. |
2021-09-27 |
2023-08-13 |
Not clear |
| Yuemang Yao, Goodwell Nzou, Thibault Alle, Wangchen Tsering, Shaniya Maimaiti, John Q Trojanowski, Virginia M-Y Lee, Carlo Ballatore, Kurt R Brunde. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 10. 2021-09-27. PMID:32918367. |
the hallmark pathologies of the alzheimer's disease (ad) brain are amyloid beta (aβ)-containing senile plaques and neurofibrillary tangles formed from the microtubule (mt)-binding tau protein. |
2021-09-27 |
2023-08-13 |
mouse |
| H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. |
the most common dementia worldwide, alzheimer's disease is often diagnosed via biomarkers in cerebrospinal fluid, including reduced levels of aβ1-42, and increases in total tau and phosphorylated tau-181. |
2021-09-27 |
2023-08-13 |
mouse |
| H-Y Wang, Z Pei, K-C Lee, E Lopez-Brignoni, B Nikolov, C A Crowley, M R Marsman, R Barbier, N Friedmann, L H Burn. PTI-125 Reduces Biomarkers of Alzheimer's Disease in Patients. The journal of prevention of Alzheimer's disease. vol 7. issue 4. 2021-09-27. PMID:32920628. |
the result is reduced tau hyperphosphorylation and neuroinflammation, with multiple functional improvements demonstrated in transgenic mice and postmortem alzheimer's disease brain. |
2021-09-27 |
2023-08-13 |
mouse |