All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sat. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 7. 2021-09-15. PMID:34283221. elisa evaluation of tau accumulation in the brains of patients with alzheimer disease. 2021-09-15 2023-08-13 Not clear
Mitsuru Shinohara, Junko Hirokawa, Akemi Shimodaira, Yoshitaka Tashiro, Kaoru Suzuki, Ghupurjan Gheni, Akio Fukumori, Tomoyasu Matsubara, Maho Morishima, Yuko Saito, Shigeo Murayama, Naoyuki Sat. ELISA Evaluation of Tau Accumulation in the Brains of Patients with Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 7. 2021-09-15. PMID:34283221. despite the routine use of sandwich enzyme-linked immunosorbent assays (elisas) for quantifying tau levels in csf and plasma, tau accumulations in the brains of patients with alzheimer disease (ad) have rarely been evaluated by this method. 2021-09-15 2023-08-13 Not clear
Meissam Ali, Uzma Saleem, Fareeha Anwar, Muhammad Imran, Humaira Nadeem, Bashir Ahmad, Tahir Ali, Atta-Ur-Rehman, Tariq Ismai. Screening of Synthetic Isoxazolone Derivative Role in Alzheimer's Disease: Computational and Pharmacological Approach. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33486698. the aim of this study was to explore the anti-alzheimer's potential of a newly synthesized 3,4,5-trimethoxy isoxazolone derivative (tmi) that attenuated the beta amyloid (aβ1-42) and tau protein levels in streptozotocin (stz) induced alzheimer's disease mouse model. 2021-09-14 2023-08-13 mouse
Xiao Liu, Kaiyue Wang, Xing Wei, Tian Xie, Bin Lv, Qian Zhou, Xiaoying Wan. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33523396. the most important neuropathological features of alzheimer's disease (ad) are extracellular amyloid-β protein (aβ) deposition, tau protein hyperphosphorylation and activation of neurometabolic reaction in the brain accompanied by neuronal and synaptic damage, and impaired learning and memory function. 2021-09-14 2023-08-13 Not clear
Yang-Yang Wang, Zhen-Ting Huang, Ming-Hao Yuan, Feng Jing, Ruo-Lan Cai, Qian Zou, Yin-Shuang Pu, Sheng-Yuan Wang, Fei Chen, Wen-Min Yi, Hui-Ji Zhang, Zhi-You Ca. Role of Hypoxia Inducible Factor-1α in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33612545. amyloid-β (aβ) peptides and hyperphosphorylated tau protein are the most important pathological markers of alzheimer's disease (ad). 2021-09-14 2023-08-13 Not clear
Soyeon Kim, Kiwon Kim, Kwangsik Nho, Woojae Myung, Hong-Hee Wo. Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33646147. whether the epidemiological association of amyloid-β (aβ) and tau pathology in late-onset alzheimer's disease (load) is causal remains unclear. 2021-09-14 2023-08-13 Not clear
Julia Klein, Xinyu Yan, Aubrey Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S Honig, Adam M Brickman, Yaakov Stern, D P Devanand, Seonjoo Lee, William C Kreis. Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33646153. olfactory impairment is related to tau pathology and neuroinflammation in alzheimer's disease. 2021-09-14 2023-08-13 Not clear
Julia Klein, Xinyu Yan, Aubrey Johnson, Zeljko Tomljanovic, James Zou, Krista Polly, Lawrence S Honig, Adam M Brickman, Yaakov Stern, D P Devanand, Seonjoo Lee, William C Kreis. Olfactory Impairment Is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33646153. olfactory impairment is evident in alzheimer's disease (ad); however, its precise relationships with clinical biomarker measures of tau pathology and neuroinflammation are not well understood. 2021-09-14 2023-08-13 Not clear
Anastasia Noël, Bénédicte Foveau, Andréa C LeBlan. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell death & disease. vol 12. issue 3. 2021-09-14. PMID:33649324. active caspase-6 (casp6) and tau cleaved by casp6 at amino acids 402 (tau∆d402) and 421 (tau∆d421) are present in early alzheimer disease intraneuronal neurofibrillary tangles, which are made primarily of filamentous tau aggregates. 2021-09-14 2023-08-13 mouse
Michael D Devous, Adam S Fleisher, Michael J Pontecorvo, Ming Lu, Andrew Siderowf, Michael Navitsky, Ian Kennedy, Sudeepti Southekal, Thomas S Harris, Mark A Mintu. Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33682705. relationships between cognition and neuropathological tau in alzheimer's disease assessed by 18f flortaucipir pet. 2021-09-14 2023-08-13 Not clear
Michael D Devous, Adam S Fleisher, Michael J Pontecorvo, Ming Lu, Andrew Siderowf, Michael Navitsky, Ian Kennedy, Sudeepti Southekal, Thomas S Harris, Mark A Mintu. Relationships Between Cognition and Neuropathological Tau in Alzheimer's Disease Assessed by 18F Flortaucipir PET. Journal of Alzheimer's disease : JAD. vol 80. issue 3. 2021-09-14. PMID:33682705. tau neurofibrillary tangle burden increases with alzheimer's disease (ad) stage and correlates with degree of cognitive impairment. 2021-09-14 2023-08-13 Not clear
Jodie Lord, Anna Zettergren, Nicholas J Ashton, Thomas K Karikari, Andrea L Benedet, Joel Simrén, Abdul Hye, Dag Aarsland, Kaj Blennow, Henrik Zetterberg, Petroula Proits. A genome-wide association study of plasma phosphorylated tau181. Neurobiology of aging. vol 106. 2021-09-14. PMID:34119372. plasma phosphorylated tau at threonine-181 (p-tau181) demonstrates promise as an accessible blood-based biomarker specific to alzheimer's disease (ad), with levels recently demonstrating high predictive accuracy for ad-relevant pathology. 2021-09-14 2023-08-13 human
Wei Siang Lee, Daniel Cs Tan, Yuanyuan Deng, Annika van Hummel, Stefania Ippati, Claire Stevens, Paulina Carmona-Mora, Daryl Ariawan, Liming Hou, Holly Stefen, Tamara Tomanic, Mian Bi, Florence Tomasetig, Adam Martin, Thomas Fath, Stephen Palmer, Yazi D Ke, Lars M Ittne. Syntaxins 6 and 8 facilitate tau into secretory pathways. The Biochemical journal. vol 478. issue 7. 2021-09-13. PMID:33769438. tau pathology initiates in defined brain regions and is known to spread along neuronal connections as symptoms progress in alzheimer's disease (ad) and other tauopathies. 2021-09-13 2023-08-13 Not clear
Xian-Ji Pan, Afzal Misrani, Sidra Tabassum, Li Yan. Mitophagy pathways and Alzheimer's disease: From pathogenesis to treatment. Mitochondrion. vol 59. 2021-09-13. PMID:33872797. alzheimer's disease (ad) is an age-dependent, incurable mental illness that is associated with the accumulation of aggregates of amyloid-beta (aβ) and hyperphosphorylated tau fragments (p-tau). 2021-09-13 2023-08-13 mouse
Susanne Wegmann, Jacek Biernat, Eckhard Mandelko. A current view on Tau protein phosphorylation in Alzheimer's disease. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33892381. a current view on tau protein phosphorylation in alzheimer's disease. 2021-09-13 2023-08-13 Not clear
Susanne Wegmann, Jacek Biernat, Eckhard Mandelko. A current view on Tau protein phosphorylation in Alzheimer's disease. Current opinion in neurobiology. vol 69. 2021-09-13. PMID:33892381. elevated phosphorylation and aggregation of tau are widely considered pathological hallmarks in alzheimer's disease (ad) and other tauopathies, triggering the quest for tau posttranslational modifications in the disease context. 2021-09-13 2023-08-13 Not clear
Lauren E McCollum, Sandhitsu R Das, Long Xie, Robin de Flores, Jieqiong Wang, Sharon X Xie, Laura E M Wisse, Paul A Yushkevich, David A Wol. Oh brother, where art tau? Amyloid, neurodegeneration, and cognitive decline without elevated tau. NeuroImage. Clinical. vol 31. 2021-09-13. PMID:34119903. the national institute on aging and alzheimer's association (nia-aa) a/t/(n) [β-amyloid/tau/(neurodegeneration)] ad research framework, which classifies research participants according to three binary biomarkers [β-amyloid (a+/a-), tau (t+/t-), and neurodegeneration (n+/n-)], provides an indirect means of identifying such cases. 2021-09-13 2023-08-13 human
Jeffrey S Phillips, Frederick J Nitchie, Fulvio Da Re, Christopher A Olm, Philip A Cook, Corey T McMillan, David J Irwin, James C Gee, Jacob G Dubroff, Murray Grossman, Ilya M Nasralla. Rates of longitudinal change in Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-09-13. PMID:34515411. rates of longitudinal change in longitudinal positron emission tomography (pet) studies of tau accumulation in alzheimer's disease (ad) have noted reduced increases or frank decreases in tau signal. 2021-09-13 2023-08-13 Not clear
Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. tracking longitudinal tau tangles accumulation across the alzheimer's disease continuum is crucial to better understand the natural history of tau pathology and for clinical trials. 2021-09-13 2023-08-13 human
Tharick A Pascoal, Andrea L Benedet, Dana L Tudorascu, Joseph Therriault, Sulantha Mathotaarachchi, Melissa Savard, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Min Su Kang, Jenna Stevenson, Gassan Massarweh, Marie-Christine Guiot, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages. Brain : a journal of neurology. 2021-09-13. PMID:34515754. we studied 125 living individuals (65 cognitively unimpaired elderly amyloid-β negative, 22 cognitively unimpaired elderly amyloid-β positive, 21 mild cognitive impairment amyloid-β positive, 17 alzheimer's disease dementia amyloid-β positive) with baseline amyloid-β [18f]azd4694 pet and baseline and follow-up tau [18f]mk-6240 pet. 2021-09-13 2023-08-13 human