| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ryszard Pluta, Stanisław J Czuczwa. Ischemia-Reperfusion Programming of Alzheimer's Disease-Related Genes-A New Perspective on Brain Neurodegeneration after Cardiac Arrest. International journal of molecular sciences. vol 25. issue 2. 2024-01-27. PMID:38279289. |
the data include amyloid accumulation, tau protein modification, neurodegenerative and cognitive changes, and gene and protein changes associated with alzheimer's disease. |
2024-01-27 |
2024-01-29 |
Not clear |
| Catherine Sharo, Tianhua Zhai, Zuyi Huan. Investigation of Potential Drug Targets Involved in Inflammation Contributing to Alzheimer's Disease Progression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 1. 2024-01-26. PMID:38276010. |
alzheimer's disease is known to arise from a build-up of amyloid beta (aβ) plaques as well as tangles of tau proteins. |
2024-01-26 |
2024-01-28 |
Not clear |
| Jun-Fei Zhang, Zhi-Ting Fang, Jun-Ning Zhao, Gong-Ping Liu, Xin Shen, Gao-Feng Jiang, Qian Li. Acetylated tau exacerbates apoptosis by disturbing mitochondrial dynamics in HEK293 cells. Journal of neurochemistry. 2024-01-26. PMID:38275215. |
an increase in tau acetylation at k274 and k281 and abnormal mitochondrial dynamics have been observed in the brains of alzheimer's disease (ad) patients. |
2024-01-26 |
2024-01-28 |
human |
| Karthikeyan Selvarasu, Abhay Kumar Singh, Avinash Dakshinamoorthy, Sravan Gopalkrishnashetty Sreenivasmurthy, Ashok Iyaswamy, Moorthi Radhakrishnan, Supriti Patnaik, Jian-Dong Huang, Leonard L Williams, Sanjib Senapati, Siva Sundara Kumar Durairaja. Interaction of Tau with Kinesin-1: Effect of Kinesin-1 Heavy Chain Elimination on Autophagy-Mediated Mutant Tau Degradation. Biomedicines. vol 12. issue 1. 2024-01-26. PMID:38275365. |
natively unfolded tau has a low propensity to form aggregates, but in tauopathies, such as alzheimer's disease (ad), tau aggregates into paired helical filaments (phfs) and neurofibrillary tangles (nfts). |
2024-01-26 |
2024-01-28 |
mouse |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A Spindler, Thomas F Tropea, Daniel Weintraub, David A Wolk, Murray Grossman, Virginia Lee, Alice S Chen-Plotkin, Edward B Lee, David J Irwi. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of clinical and translational neurology. 2024-01-24. PMID:38263854. |
tau maturation in the clinicopathological spectrum of lewy body and alzheimer's disease. |
2024-01-24 |
2024-01-26 |
Not clear |
| Sanaz Arezoumandan, Katheryn A Q Cousins, Daniel T Ohm, MaKayla Lowe, Min Chen, James Gee, Jeffrey S Phillips, Corey T McMillan, Kelvin C Luk, Andres Deik, Meredith A Spindler, Thomas F Tropea, Daniel Weintraub, David A Wolk, Murray Grossman, Virginia Lee, Alice S Chen-Plotkin, Edward B Lee, David J Irwi. Tau maturation in the clinicopathological spectrum of Lewy body and Alzheimer's disease. Annals of clinical and translational neurology. 2024-01-24. PMID:38263854. |
here, we examined tau epitopes marking various stages of tangle maturation to test the hypotheses that tau maturation is more strongly associated with beta-amyloid compared to alpha-synuclein, and within the context of mixed pathology, mature tau is linked to alzheimer's disease clinical phenotype and negatively associated with lewy body dementia. |
2024-01-24 |
2024-01-26 |
Not clear |
| Huahua Shi, Yan Zha. Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255905. |
modulation of tau pathology in alzheimer's disease by dietary bioactive compounds. |
2024-01-23 |
2024-01-25 |
Not clear |
| Huahua Shi, Yan Zha. Modulation of Tau Pathology in Alzheimer's Disease by Dietary Bioactive Compounds. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255905. |
the abnormal intracellular accumulation of tau aggregates is a major characteristic of brains from patients with alzheimer's disease (ad) and other tauopathies. |
2024-01-23 |
2024-01-25 |
Not clear |
| Eduardo Pena, Rocio San Martin-Salamanca, Samia El Alam, Karen Flores, Karem Arriaz. Tau Protein Alterations Induced by Hypobaric Hypoxia Exposure. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38255962. |
one such factor is hypoxia, which is strongly linked to alzheimer's disease because of its association with obstructive sleep apnea and has been reported to affect molecular pathways related to the dysfunction and aggregation of tau proteins and other biomarkers of neurological damage. |
2024-01-23 |
2024-01-25 |
Not clear |
| Lise Colmant, Emilien Boyer, Thomas Gerard, Kristel Sleegers, Renaud Lhommel, Adrian Ivanoiu, Philippe Lefèvre, Pascal Kienlen-Campard, Bernard Hanseeu. Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia. International journal of molecular sciences. vol 25. issue 2. 2024-01-23. PMID:38256246. |
alzheimer's disease (ad) is characterized by amyloid beta (aβ) plaques and hyperphosphorylated tau in the brain. |
2024-01-23 |
2024-01-25 |
human |
| Monica Neațu, Anca Covaliu, Iulia Ioniță, Ana Jugurt, Eugenia Irene Davidescu, Bogdan Ovidiu Popesc. Monoclonal Antibody Therapy in Alzheimer's Disease. Pharmaceutics. vol 16. issue 1. 2024-01-23. PMID:38258071. |
alzheimer's disease is a neurodegenerative condition marked by the progressive deterioration of cognitive abilities, memory impairment, and the accumulation of abnormal proteins, specifically beta-amyloid plaques and tau tangles, within the brain. |
2024-01-23 |
2024-01-25 |
Not clear |
| Chloé Jacquemin, Nicolas Villain, Rita Azevedo, Susana Boluda, Etienne A Thévenot, François Fenaille, Foudil Lamari, François Beche. Evaluation of SP3 for antibody-free quantification of tau in CSF mimic and brain by mass spectrometry. European journal of mass spectrometry (Chichester, England). 2024-01-23. PMID:38258392. |
tubulin-associated unit (tau) has an important role in the pathogenesis and the diagnosis of alzheimer's disease (ad) and other tauopathies. |
2024-01-23 |
2024-01-25 |
human |
| Yang Ye, Mingzhu Gao, Wentao Shi, Yan Gao, Yilu Li, Wenhui Yang, Xiaomin Zheng, Xiaojie L. The immunomodulatory effects of mesenchymal stem cell-derived extracellular vesicles in Alzheimer's disease. Frontiers in immunology. vol 14. 2024-01-23. PMID:38259476. |
neuroinflammation has been identified as another significant pathogenic factor in alzheimer's disease following aβ amyloid deposition and tau protein hyperphosphorylation, activated in the central nervous system by glial cells in response to injury-related and pathogen-related molecular patterns. |
2024-01-23 |
2024-01-25 |
Not clear |
| August Yue Huang, Zinan Zhou, Maya Talukdar, Michael B Miller, Brian Chhouk, Liz Enyenihi, Ila Rosen, Edward Stronge, Boxun Zhao, Dachan Kim, Jaejoon Choi, Sattar Khoshkhoo, Junho Kim, Javier Ganz, Kyle Travaglini, Mariano Gabitto, Rebecca Hodge, Eitan Kaplan, Ed Lein, Philip L De Jager, David A Bennett, Eunjung Alice Lee, Christopher A Wals. Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer's disease microglia. bioRxiv : the preprint server for biology. 2024-01-23. PMID:38260600. |
alzheimer's disease (ad) is an age-associated neurodegenerative disorder characterized by progressive neuronal loss and pathological accumulation of the misfolded proteins amyloid-β and tau |
2024-01-23 |
2024-01-25 |
Not clear |
| Aubrey S Johnson, Galen Ziaggi, Anna C Smith, Hannah Houlihan, Lauren B Heuer, Diana S Guzmán, Amarachukwu Okafor, Edward D Huey, Daniel Talmasov, Frank Provenzano, William C Kreisl, Patrick J La. Psychotic symptoms are associated with elevated tau PET signal in the amygdala independent of Alzheimer's disease clinical severity and amyloid burden. medRxiv : the preprint server for health sciences. 2024-01-23. PMID:38260648. |
psychotic symptoms are associated with elevated tau pet signal in the amygdala independent of alzheimer's disease clinical severity and amyloid burden. |
2024-01-23 |
2024-01-25 |
Not clear |
| Gang Wang, Shi Tang, Yixi Dong, Fangbo Zou, Jin Jiao, Yang Xian. Template-controllable rolling circle amplification for dual protein sensitive analysis. Journal of materials chemistry. B. 2024-01-22. PMID:38247432. |
this method exhibits excellent analytical performance and can successfully achieve the analysis of tau and aβo in alzheimer's disease clinical cerebrospinal fluid samples. |
2024-01-22 |
2024-01-24 |
Not clear |
| Samantha P Martin, Beth A Leeman-Markowsk. Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer's disease, and epilepsy. Frontiers in neurology. vol 14. 2024-01-22. PMID:38249745. |
proposed mechanisms of tau: relationships to traumatic brain injury, alzheimer's disease, and epilepsy. |
2024-01-22 |
2024-01-24 |
Not clear |
| Samantha P Martin, Beth A Leeman-Markowsk. Proposed mechanisms of tau: relationships to traumatic brain injury, Alzheimer's disease, and epilepsy. Frontiers in neurology. vol 14. 2024-01-22. PMID:38249745. |
traumatic brain injury (tbi), alzheimer's disease (ad), and epilepsy share proposed mechanisms of injury, including neuronal excitotoxicity, cascade signaling, and activation of protein biomarkers such as tau. |
2024-01-22 |
2024-01-24 |
Not clear |
| Nicholas J Ashton, Wagner S Brum, Guglielmo Di Molfetta, Andrea L Benedet, Burak Arslan, Erin Jonaitis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterber. Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology. JAMA neurology. 2024-01-22. PMID:38252443. |
diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for alzheimer disease pathology. |
2024-01-22 |
2024-01-24 |
Not clear |
| Nicholas J Ashton, Wagner S Brum, Guglielmo Di Molfetta, Andrea L Benedet, Burak Arslan, Erin Jonaitis, Rebecca E Langhough, Karly Cody, Rachael Wilson, Cynthia M Carlsson, Eugeen Vanmechelen, Laia Montoliu-Gaya, Juan Lantero-Rodriguez, Nesrine Rahmouni, Cecile Tissot, Jenna Stevenson, Stijn Servaes, Joseph Therriault, Tharick Pascoal, Alberto Lleó, Daniel Alcolea, Juan Fortea, Pedro Rosa-Neto, Sterling Johnson, Andreas Jeromin, Kaj Blennow, Henrik Zetterber. Diagnostic Accuracy of a Plasma Phosphorylated Tau 217 Immunoassay for Alzheimer Disease Pathology. JAMA neurology. 2024-01-22. PMID:38252443. |
phosphorylated tau (p-tau) is a specific blood biomarker for alzheimer disease (ad) pathology, with p-tau217 considered to have the most utility. |
2024-01-22 |
2024-01-24 |
Not clear |