All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. taken together, our studies show that the loss of plcβ1 can promote alzheimer's disease by a combination of its catalytic activity and its interaction with mitotic proteins thus offering an orthogonal method to control tau aggregation. 2021-08-05 2023-08-13 Not clear
Jan R Detrez, Inès R H Ben-Nejma, Kristof Van Kolen, Debby Van Dam, Peter Paul De Deyn, Erik Fransen, Marleen Verhoye, Jean-Pierre Timmermans, Rony Nuydens, Annemie Van der Linden, Georgios A Keliris, Winnok H De Vo. Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice. Neurobiology of disease. vol 143. 2021-08-05. PMID:32653674. progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including alzheimer's disease. 2021-08-05 2023-08-13 mouse
Benjamin Lochocki, Baayla D C Boon, Sander R Verheul, Liron Zada, Jeroen J M Hoozemans, Freek Ariese, Johannes F de Boe. Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer's disease human brain tissue. Communications biology. vol 4. issue 1. 2021-08-05. PMID:33859370. alzheimer's disease (ad) neuropathology is characterized by hyperphosphorylated tau containing neurofibrillary tangles and amyloid-beta (aβ) plaques. 2021-08-05 2023-08-13 human
Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Felippo Bifi, Cristiane Matté, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry. vol 87. 2021-08-04. PMID:33065257. alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (aβ) peptide, which induces synaptic dysfunction, alteration of intracellular signaling pathways, hyperphosphorylation of the tau protein, and cognitive impairment. 2021-08-04 2023-08-13 rat
Xu Hou, Jens O Watzlawik, Casey Cook, Chia-Chen Liu, Silvia S Kang, Wen-Lang Lin, Michael DeTure, Michael G Heckman, Nancy N Diehl, Fadi S Hanna Al-Shaikh, Ronald L Walton, Owen A Ross, Heather L Melrose, Nilüfer Ertekin-Taner, Guojun Bu, Leonard Petrucelli, John D Fryer, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springe. Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-08-04. PMID:33090691. mitophagy alterations in alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. 2021-08-04 2023-08-13 Not clear
Aisling M Chaney, Francisco R Lopez-Picon, Sophie Serrière, Rui Wang, Daniela Bochicchio, Samuel D Webb, Matthias Vandesquille, Michael K Harte, Christina Georgiadou, Catherine Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frédéric Buron, Sylvain Routier, Tristan Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen E Davies, Juha O Rinne, Dervis A Salih, Frances A Edwards, Llwyd D Orton, Stephen R Williams, Sylvie Chalon, Hervé Bouti. Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study. Theranostics. vol 11. issue 14. 2021-08-04. PMID:34093845. mouse models of alzheimer's disease (ad) are valuable but do not fully recapitulate human ad pathology, such as spontaneous tau fibril accumulation and neuronal loss, necessitating the development of new ad models. 2021-08-04 2023-08-13 mouse
Siddhartha Mondragón-Rodríguez, Humberto Salgado-Burgos, Fernando Peña-Orteg. Circuitry and Synaptic Dysfunction in Alzheimer's Disease: A New Tau Hypothesis. Neural plasticity. vol 2020. 2021-08-03. PMID:32952546. circuitry and synaptic dysfunction in alzheimer's disease: a new tau hypothesis. 2021-08-03 2023-08-13 Not clear
Yao Sun, Yongqing Guo, Xuejian Feng, Lu Fu, Yayuan Zheng, Yue Dong, Yong Zhang, Xianghui Yu, Wei Kong, Hui W. Norovirus P particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of Alzheimer's disease. Signal transduction and targeted therapy. vol 6. issue 1. 2021-08-03. PMID:33579892. norovirus p particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of alzheimer's disease. 2021-08-03 2023-08-13 mouse
Sujin Kim, Yunkwon Nam, Min-Joo Ham, Chisoo Park, Minho Moon, Doo-Han Yo. Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review. Frontiers in aging neuroscience. vol 13. 2021-08-03. PMID:34335229. alzheimer's disease (ad) is an irreversible neurodegenerative brain disorder with aggregation of amyloid-beta (aβ) and tau as the pathological hallmarks. 2021-08-03 2023-08-13 Not clear
Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuh. Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease. Frontiers in physiology. vol 12. 2021-08-03. PMID:34335308. bayesian physics-based modeling of tau propagation in alzheimer's disease. 2021-08-03 2023-08-13 Not clear
Amelie Schäfer, Mathias Peirlinck, Kevin Linka, Ellen Kuh. Bayesian Physics-Based Modeling of Tau Propagation in Alzheimer's Disease. Frontiers in physiology. vol 12. 2021-08-03. PMID:34335308. amyloid-β and hyperphosphorylated tau protein are known drivers of neuropathology in alzheimer's disease. 2021-08-03 2023-08-13 Not clear
Qin Li, Chunmei Xiong, Hongli Liu, Huizhen Ge, Xiaojun Yao, Huanxiang Li. Computational Insights Into the Inhibition Mechanism of Proanthocyanidin B2 on Tau Hexapeptide (PHF6) Oligomer. Frontiers in chemistry. vol 9. 2021-08-03. PMID:34336783. the formation of amyloid fibrils from tau is a key pathogenic feature of alzheimer's disease (ad). 2021-08-03 2023-08-13 Not clear
Benjamin B Tournier, Kelly Ceyzériat, Farha N Bouteldja, Philippe Mille. Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes. ACS omega. vol 6. issue 29. 2021-08-03. PMID:34337211. apoptosis-dependent cell death of astrocytes has been described in alzheimer's disease and is linked to the presence of two markers of the pathology: the β-amyloid peptide (aβ) and the hyperphosphorylated tau protein. 2021-08-03 2023-08-13 Not clear
Sun Ah Park, Song Mi Han, Chae Eun Ki. New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer's disease. Experimental & molecular medicine. vol 52. issue 4. 2021-08-02. PMID:32284537. cerebrospinal fluid (csf) biomarkers based on the core pathological proteins associated with alzheimer's disease (ad), i.e., amyloid-β (aβ) and tau protein, are widely regarded as useful diagnostic biomarkers. 2021-08-02 2023-08-13 Not clear
Jae Seung Ki. Tau Imaging: New Era of Neuroimaging for Alzheimer's Disease. Nuclear medicine and molecular imaging. vol 54. issue 4. 2021-08-02. PMID:32831960. tau imaging: new era of neuroimaging for alzheimer's disease. 2021-08-02 2023-08-13 Not clear
Sompriya Chatterjee, Abbas Salimi, Jin Yong Le. Molecular mechanism of amyloidogenicity and neurotoxicity of a pro-aggregated tau mutant in the presence of histidine tautomerism Physical chemistry chemical physics : PCCP. vol 23. issue 17. 2021-08-02. PMID:33899866. molecular mechanism of amyloidogenicity and neurotoxicity of a pro-aggregated tau mutant in the presence of histidine tautomerism the accumulation of Δk280 tau mutant resulting in neurotoxic oligomeric aggregates is an important but yet mysterious procedure in alzheimer's disease (ad) development. 2021-08-02 2023-08-13 Not clear
Jing Jing, Gao Tu, Hongyan Yu, Rong Huang, Xianquan Ming, Haiqing Zhan, Feng Zhan, Weiwei Xu. Copper (Cu Physical chemistry chemical physics : PCCP. vol 23. issue 20. 2021-08-02. PMID:33982037. copper (cu tau misfolding plays a significant role in some neurodegenerative diseases such as alzheimer's disease (ad). 2021-08-02 2023-08-13 Not clear
N Arul Murugan, Agneta Nordberg, Hans Ågre. Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer's Tauopathy. ACS chemical neuroscience. vol 12. issue 13. 2021-08-02. PMID:34152739. cryptic sites in tau fibrils explain the preferential binding of the av-1451 pet tracer toward alzheimer's tauopathy. 2021-08-02 2023-08-13 Not clear
Paul Dent, Laurence Booth, Jane L Roberts, Andrew Poklepovic, Derek Cridebring, Eric M Reima. Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43. Aging. vol 13. issue 13. 2021-08-02. PMID:34252884. aberrant expression and denaturation of tau, amyloid-beta and tdp-43 can lead to cell death and is a major component of pathologies such as alzheimer's disease (ad). 2021-08-02 2023-08-13 Not clear
Dinah V Parum. Editorial: Targets for Disease-Modifying Therapies in Alzheimer's Disease, Including Amyloid β and Tau Protein. Medical science monitor : international medical journal of experimental and clinical research. vol 27. 2021-08-02. PMID:34305135. editorial: targets for disease-modifying therapies in alzheimer's disease, including amyloid β and tau protein. 2021-08-02 2023-08-13 Not clear