All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Kyle Eckhoff, Robert Morris, Valeria Zuluaga, Rebecca Polsky, Feng Chen. The Association between Tau Protein Level in Cerebrospinal Fluid and Cognitive Status: A Large-Scale Analysis of GAAIN Database. Brain sciences. vol 11. issue 7. 2021-07-27. PMID:34209512. in addition, transcriptomic data derived from mouse microglial cells showed multiple genes upregulated in toll-like receptor signaling and alzheimer's disease pathways, including tnf, tlr2, il-1β, and cox subunits, suggesting that the mechanism of action that relates p-tau and mmse scores may be through overactivation of pro-inflammatory microglial activity by aβ peptides, tnf-mediated hyperphosphorylation of tau, and the infectious spread of pathological tau across healthy neurons. 2021-07-27 2023-08-13 mouse
Alberto Lleó, Henrik Zetterberg, Jordi Pegueroles, Thomas K Karikari, María Carmona-Iragui, Nicholas J Ashton, Victor Montal, Isabel Barroeta, Juan Lantero-Rodríguez, Laura Videla, Miren Altuna, Bessy Benejam, Susana Fernandez, Silvia Valldeneu, Diana Garzón, Alexandre Bejanin, Maria Florencia Iulita, Valle Camacho, Santiago Medrano-Martorell, Olivia Belbin, Jordi Clarimon, Sylvain Lehmann, Daniel Alcolea, Rafael Blesa, Kaj Blennow, Juan Forte. Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome. Nature communications. vol 12. issue 1. 2021-07-27. PMID:34262030. plasma tau phosphorylated at threonine 181 (p-tau181) predicts alzheimer's disease (ad) pathology with high accuracy in the general population. 2021-07-27 2023-08-13 Not clear
Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitze. Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles. Frontiers in aging neuroscience. vol 13. 2021-07-24. PMID:34295239. in alzheimer's disease, the severity of symptoms is linked to a loss of synaptic density and the spread of pathologically hyperphosphorylated tau. 2021-07-24 2023-08-13 Not clear
Janine Utz, Judith Berner, Luis Enrique Muñoz, Timo Jan Oberstein, Johannes Kornhuber, Martin Herrmann, Juan Manuel Maler, Philipp Spitze. Cerebrospinal Fluid of Patients With Alzheimer's Disease Contains Increased Percentages of Synaptophysin-Bearing Microvesicles. Frontiers in aging neuroscience. vol 13. 2021-07-24. PMID:34295239. the established cerebrospinal fluid markers aβ, tau and phospho-tau reflect the histopathological hallmarks of alzheimer's disease but do not indicate disease progression. 2021-07-24 2023-08-13 Not clear
Lindsay H Burns, Hoau-Yan Wan. Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer's disease. Neuroimmunology and neuroinflammation. vol 4. issue 12. 2021-07-24. PMID:34295950. altered filamin a enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in alzheimer's disease. 2021-07-24 2023-08-13 Not clear
Lindsay H Burns, Hoau-Yan Wan. Altered filamin A enables amyloid beta-induced tau hyperphosphorylation and neuroinflammation in Alzheimer's disease. Neuroimmunology and neuroinflammation. vol 4. issue 12. 2021-07-24. PMID:34295950. alzheimer's disease (ad) is a neurodegenerative disease with proteopathy characterized by abnormalities in amyloid beta (aβ) and tau proteins. 2021-07-24 2023-08-13 Not clear
Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo León-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296096. tau protein hyperphosphorylation and aggregation have been associated with loss or alterations of dendritic spines in neurodegenerative diseases, such as alzheimer's disease (ad). 2021-07-24 2023-08-13 Not clear
Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. female-specific risk of alzheimer's disease is associated with tau phosphorylation processes: a transcriptome-wide interaction analysis. 2021-07-23 2023-08-13 Not clear
Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. the levels of tau phosphorylation differ between sexes in alzheimer's disease (ad). 2021-07-23 2023-08-13 Not clear
Baihong Guo, Yangmei Huang, Qingtao Gao, Qiang Zho. Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice. Neurobiology of aging. vol 96. 2021-07-23. PMID:33039900. one major pathological process in alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (mts) and functions associated with tau. 2021-07-23 2023-08-13 mouse
Anna H Boerwinkle, Julie K Wisch, Charles D Chen, Brian A Gordon, Omar H Butt, Suzanne E Schindler, Courtney Sutphen, Shaney Flores, Aylin Dincer, Tammie L S Benzinger, Anne M Fagan, John C Morris, Beau M Ance. Temporal Correlation of CSF and Neuroimaging in the Amyloid-Tau-Neurodegeneration Model of Alzheimer Disease. Neurology. vol 97. issue 1. 2021-07-23. PMID:33931538. to evaluate temporal correlations between csf and neuroimaging (pet and mri) measures of amyloid, tau, and neurodegeneration in relation to alzheimer disease (ad) progression. 2021-07-23 2023-08-13 Not clear
Sebastiaan Bijttebier, Clara Theunis, Farid Jahouh, Dina Rodrigues Martins, Marc Verhemeldonck, Karolien Grauwen, Lieve Dillen, Marc Mercke. Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. Journal of chromatography. A. vol 1651. 2021-07-22. PMID:34107398. development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from alzheimer disease patients. 2021-07-22 2023-08-13 human
Sebastiaan Bijttebier, Clara Theunis, Farid Jahouh, Dina Rodrigues Martins, Marc Verhemeldonck, Karolien Grauwen, Lieve Dillen, Marc Mercke. Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. Journal of chromatography. A. vol 1651. 2021-07-22. PMID:34107398. in alzheimer's disease (ad) brain, one of the histopathological hallmarks is the neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. 2021-07-22 2023-08-13 human
Lea L Weston, Shanya Jiang, Devon Chisholm, Lauren L Jantzie, Kiran Bhaska. Interleukin-10 deficiency exacerbates inflammation-induced tau pathology. Journal of neuroinflammation. vol 18. issue 1. 2021-07-22. PMID:34275478. the presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in alzheimer's disease and related tauopathies. 2021-07-22 2023-08-13 Not clear
Shifeng Xiao, Yafei Lu, Qiuping Wu, Jiaying Yang, Jierui Chen, Suyue Zhong, David Eliezer, Qiulong Tan, Chengchen W. Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International journal of biological macromolecules. vol 178. 2021-07-21. PMID:33662414. the neurofibrillary tangles formed by tau protein aggregation are one of the defining characteristics of alzheimer's disease, so tau protein has become a key target for the drug design. 2021-07-21 2023-08-13 Not clear
Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. novel tau biomarkers phosphorylated at t181, t217 or t231 rise in the initial stages of the preclinical alzheimer's continuum when only subtle changes in aβ pathology are detected. 2021-07-20 2023-08-13 Not clear
Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. in alzheimer's disease (ad), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (csf) and blood is a dynamic process that changes during disease evolution. 2021-07-20 2023-08-13 Not clear
Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. the main aim of our study was to characterize the pattern of changes in phosphorylated tau (p-tau) in the preclinical stage of the alzheimer's continuum. 2021-07-20 2023-08-13 Not clear
Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. our results support the idea that early changes in neuronal tau metabolism in preclinical alzheimer, likely in response to aβ exposure, can be detected with these novel p-tau assays. 2021-07-20 2023-08-13 Not clear
Patricia Chastagner, Frida Loria, Jessica Y Vargas, Josh Tois, Marc I Diamond, George Okafo, Christel Brou, Chiara Zurzol. Fate and propagation of endogenously formed Tau aggregates in neuronal cells. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33179866. tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as alzheimer's disease (ad). 2021-07-20 2023-08-13 Not clear