| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fumihiko Yasuno, Hiroyuki Minam. Significant effects of cholinesterase inhibitors on tau pathology in the Alzheimer's disease continuum: An in vivo positron emission tomography study. International journal of geriatric psychiatry. vol 36. issue 8. 2021-08-09. PMID:33594726. |
no prior study has assessed the effects of cholinesterase inhibitors (cheis) on tau pathology in the brains of patients with alzheimer's disease (ad). |
2021-08-09 |
2023-08-13 |
human |
| Elizabeth E Moore, Dandan Liu, Judy Li, Samantha J Schimmel, Francis E Cambronero, James G Terry, Sangeeta Nair, Kimberly R Pechman, Marissa E Moore, Susan P Bell, Joshua A Beckman, Katherine A Gifford, Timothy J Hohman, Kaj Blennow, Henrik Zetterberg, John Jeffrey Carr, Angela L Jefferso. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology. vol 97. issue 4. 2021-08-09. PMID:34031194. |
to test the hypothesis that increased aortic stiffening is associated with greater csf evidence of core alzheimer disease pathology (β-amyloid [aβ], phosphorylated tau [p-tau]), neurodegeneration (total tau [t-tau]), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light [nfl]), and neuroinflammation (ykl-40, soluble triggering receptor expressed on myeloid cells 2 [strem2]), we analyzed pulse wave velocity (pwv) data and csf data among older adults. |
2021-08-09 |
2023-08-13 |
Not clear |
| Huan He, Yuying Liu, Yunxiang Sun, Feng Din. Misfolding and Self-Assembly Dynamics of Microtubule-Binding Repeats of the Alzheimer-Related Protein Tau. Journal of chemical information and modeling. vol 61. issue 6. 2021-08-09. PMID:34032430. |
pathological aggregation of intrinsically disordered tau protein, driven by the interactions between microtubule-binding (mtb) domains, is associated with alzheimer's disease. |
2021-08-09 |
2023-08-13 |
Not clear |
| Tosha Williams, Zachary Sorrentino, Mary Weinrich, Benoit I Giasson, Paramita Chakrabart. Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy. Brain communications. vol 2. issue 2. 2021-08-07. PMID:33094280. |
co-occurrence of tau and α-synuclein pathologies in a subset of alzheimer's disease patients has led to the idea that mixed pathologies may play a unique characteristic role in the alzheimer's disease neurodegenerative cascade. |
2021-08-07 |
2023-08-13 |
mouse |
| Ellen Singleton, Oskar Hansson, Yolande A L Pijnenburg, Renaud La Joie, William G Mantyh, Pontus Tideman, Erik Stomrud, Antoine Leuzy, Maurits Johansson, Olof Strandberg, Ruben Smith, Evi Berendrecht, Bruce L Miller, Leonardo Iaccarino, Lauren Edwards, Amelia Strom, Emma E Wolters, Emma Coomans, Denise Visser, Sandeep S V Golla, Hayel Tuncel, Femke Bouwman, John Cornelis Van Swieten, Janne M Papma, Bart van Berckel, Philip Scheltens, Anke A Dijkstra, Gil D Rabinovici, Rik Ossenkoppel. Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer's disease. Journal of neurology, neurosurgery, and psychiatry. 2021-08-07. PMID:33850001. |
heterogeneous distribution of tau pathology in the behavioural variant of alzheimer's disease. |
2021-08-07 |
2023-08-13 |
Not clear |
| Sagar Gaikwad, Nicha Puangmalai, Alice Bittar, Mauro Montalbano, Stephanie Garcia, Salome McAllen, Nemil Bhatt, Minal Sonawane, Urmi Sengupta, Rakez Kaye. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell reports. vol 36. issue 3. 2021-08-07. PMID:34289368. |
tau oligomer induced hmgb1 release contributes to cellular senescence and neuropathology linked to alzheimer's disease and frontotemporal dementia. |
2021-08-07 |
2023-08-13 |
mouse |
| Sagar Gaikwad, Nicha Puangmalai, Alice Bittar, Mauro Montalbano, Stephanie Garcia, Salome McAllen, Nemil Bhatt, Minal Sonawane, Urmi Sengupta, Rakez Kaye. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia. Cell reports. vol 36. issue 3. 2021-08-07. PMID:34289368. |
aging, pathological tau oligomers (tauo), and chronic inflammation in the brain play a central role in tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2021-08-07 |
2023-08-13 |
mouse |
| Neelam Younas, Saima Zafar, Mohsin Shafiq, Aneeqa Noor, Anna Siegert, Amandeep Singh Arora, Alexey Galkin, Ayesha Zafar, Mathias Schmitz, Christine Stadelmann, Olivier Andreoletti, Isidre Ferrer, Inga Zer. SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32577828. |
sfpq and tau: critical factors contributing to rapid progression of alzheimer's disease. |
2021-08-06 |
2023-08-13 |
mouse |
| Juan Lantero Rodriguez, Thomas K Karikari, Marc Suárez-Calvet, Claire Troakes, Andrew King, Andreja Emersic, Dag Aarsland, Abdul Hye, Henrik Zetterberg, Kaj Blennow, Nicholas J Ashto. Plasma p-tau181 accurately predicts Alzheimer's disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32720099. |
the neuropathological confirmation of amyloid-β (aβ) plaques and tau neurofibrillary tangles (nft) remains the gold standard for a definitive diagnosis of alzheimer's disease (ad). |
2021-08-06 |
2023-08-13 |
Not clear |
| Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. |
hyperphosphorylation of the neuronal tau protein contributes to alzheimer's disease (ad) by promoting tau pathology and neuronal and cognitive deficits. |
2021-08-06 |
2023-08-13 |
mouse |
| Arne Ittner, Prita Riana Asih, Amanda R P Tan, Emmanuel Prikas, Josefine Bertz, Kristie Stefanoska, Yijun Lin, Alexander M Volkerling, Yazi D Ke, Fabien Delerue, Lars M Ittne. Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ. Acta neuropathologica. vol 140. issue 3. 2021-08-06. PMID:32725265. |
furthermore, genome editing of the t205 codon in the murine mapt gene showed that this single side chain in endogenous tau critically modulates memory deficits in app-transgenic alzheimer's mice. |
2021-08-06 |
2023-08-13 |
mouse |
| Sreeja Lakshmi, Shamprasad Varija Raghu, Preetham Elumalai, Sureshkumar Siva. Alkoxy glycerol enhanced activity of Oxyresveratrol in Alzheimer's disease by rescuing Tau protein. Neuroscience letters. vol 759. 2021-08-06. PMID:34023407. |
alkoxy glycerol enhanced activity of oxyresveratrol in alzheimer's disease by rescuing tau protein. |
2021-08-06 |
2023-08-13 |
drosophila_melanogaster |
| Ting-Ting Hou, Yun-Dan Han, Lin Cong, Cui-Cui Liu, Xiao-Yan Liang, Fu-Zhong Xue, Yi-Feng D. Apolipoprotein E Facilitates Amyloid-β Oligomer-Induced Tau Phosphorylation. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065788. |
hyperphosphorylated tau is one of the key characteristics of alzheimer's disease (ad), and tau pathology correlates with cognitive impairment in ad better than amyloid-β (aβ) pathology. |
2021-08-05 |
2023-08-13 |
mouse |
| Laetitia Miguel, Thierry Frebourg, Dominique Campion, Magalie Lecourtoi. Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau Oligomerization. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065789. |
alzheimer's disease (ad) is neuropathologically defined by two key hallmarks: extracellular senile plaques composed primarily of amyloid-β (aβ) peptide and intraneuronal neurofibrillary tangles, containing abnormally hyperphosphorylated tau protein. |
2021-08-05 |
2023-08-13 |
drosophila_melanogaster |
| Maureen Okafor, Jonathon A Nye, Mahsa Shokouhi, Leslie M Shaw, Felicia Goldstein, Ihab Hajja. 18F-Flortaucipir PET Associations with Cerebrospinal Fluid, Cognition, and Neuroimaging in Mild Cognitive Impairment due to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 74. issue 2. 2021-08-05. PMID:32065800. |
tau positron emission tomography (pet) imaging is used in research, but its relation to cerebrospinal fluid (csf) tau and other alzheimer's disease (ad)-related clinical measures is unclear in mild cognitive impairment with ad biomarkers (mci-ad). |
2021-08-05 |
2023-08-13 |
Not clear |
| Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. |
alzheimer's disease is typified by calcium dysfunction and neurofibrillary tangles of tau aggregates along with mitotic proteins. |
2021-08-05 |
2023-08-13 |
Not clear |
| Osama Garwain, V Siddartha Yerramilli, Kate Romero, Suzanne Scarlat. The Gαq/phospholipase Cβ signaling system represses tau aggregation. Cellular signalling. vol 71. 2021-08-05. PMID:32247043. |
taken together, our studies show that the loss of plcβ1 can promote alzheimer's disease by a combination of its catalytic activity and its interaction with mitotic proteins thus offering an orthogonal method to control tau aggregation. |
2021-08-05 |
2023-08-13 |
Not clear |
| Jan R Detrez, Inès R H Ben-Nejma, Kristof Van Kolen, Debby Van Dam, Peter Paul De Deyn, Erik Fransen, Marleen Verhoye, Jean-Pierre Timmermans, Rony Nuydens, Annemie Van der Linden, Georgios A Keliris, Winnok H De Vo. Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice. Neurobiology of disease. vol 143. 2021-08-05. PMID:32653674. |
progressive accumulation of hyperphosphorylated tau is a hallmark of various neurodegenerative disorders including alzheimer's disease. |
2021-08-05 |
2023-08-13 |
mouse |
| Benjamin Lochocki, Baayla D C Boon, Sander R Verheul, Liron Zada, Jeroen J M Hoozemans, Freek Ariese, Johannes F de Boe. Multimodal, label-free fluorescence and Raman imaging of amyloid deposits in snap-frozen Alzheimer's disease human brain tissue. Communications biology. vol 4. issue 1. 2021-08-05. PMID:33859370. |
alzheimer's disease (ad) neuropathology is characterized by hyperphosphorylated tau containing neurofibrillary tangles and amyloid-beta (aβ) plaques. |
2021-08-05 |
2023-08-13 |
human |
| Fernanda Dos Santos Petry, Juliana Bender Hoppe, Caroline Peres Klein, Bernardo Gindri Dos Santos, Régis Mateus Hözer, Felippo Bifi, Cristiane Matté, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein attenuates amyloid-beta-induced cognitive impairment in rats by modulation of hippocampal synaptotoxicity and hyperphosphorylation of Tau. The Journal of nutritional biochemistry. vol 87. 2021-08-04. PMID:33065257. |
alzheimer's disease is a progressive neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (aβ) peptide, which induces synaptic dysfunction, alteration of intracellular signaling pathways, hyperphosphorylation of the tau protein, and cognitive impairment. |
2021-08-04 |
2023-08-13 |
rat |