All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
M A Berezutsky, N A Durnova, L E Sigarev. [Neurobiological effects of tenuigenin and the opportunity of it's using in the therapy of Alzheimer's and Parkinson's diseases (literature review).] Advances in gerontology = Uspekhi gerontologii. vol 34. issue 2. 2021-07-13. PMID:34245502. it was noted, that the capacities of the tenuigenin to decrease the secretion of beta amyloid and to protect of neurons from damage by already made beta ameloids, to inhibit the processes of the tau proteins` hyperphosphorylation and inflammations in microglia, as well as increase the main synaptic transmission can be used by the development of effective therapeutic drugs aimed to reduce the pathogenesis of alzheimer`s disease. 2021-07-13 2023-08-13 Not clear
Xiaomin Yin, Chenhao Zhao, Yanyan Qiu, Zheng Zhou, Junze Bao, Wei Qia. Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-13. PMID:34248498. dendritic/post-synaptic tau and early pathology of alzheimer's disease. 2021-07-13 2023-08-13 Not clear
Xiaomin Yin, Chenhao Zhao, Yanyan Qiu, Zheng Zhou, Junze Bao, Wei Qia. Dendritic/Post-synaptic Tau and Early Pathology of Alzheimer's Disease. Frontiers in molecular neuroscience. vol 14. 2021-07-13. PMID:34248498. microtubule-associated protein tau forms insoluble neurofibrillary tangles (nfts), which is one of the major histopathological hallmarks of alzheimer's disease (ad). 2021-07-13 2023-08-13 Not clear
Hriday K Das, Silahis S Hontivero. Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling. Frontiers in bioscience (Landmark edition). vol 25. 2021-07-12. PMID:32114428. administration of rapamycin in 3xtg-ad mouse model of alzheimer's disease (ad) rescues cognitive deficits and ameliorates abeta and tau pathology. 2021-07-12 2023-08-13 mouse
Aya Ogata, Yasuyuki Kimura, Hiroshi Ikenuma, Takashi Yamada, Junichiro Abe, Hiroko Koyama, Masaaki Suzuki, Masanori Ichise, Takashi Kato, Kengo It. Brain pharmacokinetics and biodistribution of Nuclear medicine and biology. vol 86-87. 2021-07-12. PMID:32532591. recently, isoproterenol has been reported to have the potential as a drug for the treatment of alzheimer's disease by inhibiting the aggregation of tau protein. 2021-07-12 2023-08-13 Not clear
Ronald B Brow. Stress, inflammation, depression, and dementia associated with phosphate toxicity. Molecular biology reports. vol 47. issue 12. 2021-07-12. PMID:33226563. furthermore, alzheimer's disease is associated with hyperphosphorylated tau which self-assembles into neurofibrillary tangles from excessive amounts of phosphate in the brain and central nervous system. 2021-07-12 2023-08-13 Not clear
Justin S Sanchez, J Alex Becker, Heidi I L Jacobs, Bernard J Hanseeuw, Shu Jiang, Aaron P Schultz, Michael J Properzi, Samantha R Katz, Alexa Beiser, Claudia L Satizabal, Adrienne O'Donnell, Charles DeCarli, Ron Killiany, Georges El Fakhri, Marc D Normandin, Teresa Gómez-Isla, Yakeel T Quiroz, Dorene M Rentz, Reisa A Sperling, Sudha Seshadri, Jean Augustinack, Julie C Price, Keith A Johnso. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science translational medicine. vol 13. issue 577. 2021-07-12. PMID:33472953. advances in molecular positron emission tomography (pet) have enabled anatomic tracking of brain pathology in longitudinal studies of normal aging and dementia, including assessment of the central model of alzheimer's disease (ad) pathogenesis, according to which tau pathology begins focally but expands catastrophically under the influence of amyloid-β (aβ) pathology to mediate neurodegeneration and cognitive decline. 2021-07-12 2023-08-13 human
Yanmin Chang, Yi Yao, Rong Ma, Zemin Wang, Junjie Hu, Yanqing Wu, Xingjun Jiang, Lulu Li, Gang L. Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice. Frontiers in neuroscience. vol 15. 2021-07-12. PMID:33642981. alzheimer's disease (ad) is a destructive and burdensome neurodegenerative disease, one of the most common characteristics of which are neurofibrillary tangles (nfts) that are composed of abnormal tau protein. 2021-07-12 2023-08-13 mouse
Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with alzheimer's disease. 2021-07-12 2023-08-13 mouse
Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. tau has become an attractive alternative target for passive immunotherapy efforts for alzheimer's disease (ad). 2021-07-12 2023-08-13 mouse
Chrysoula Dioli, Patrícia Patrício, Lucilia-Goreti Pinto, Clemence Marie, Mónica Morais, Sheela Vyas, João M Bessa, Luisa Pinto, Ioannis Sotiropoulo. Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress. Cell proliferation. vol 54. issue 7. 2021-07-12. PMID:33988263. in alzheimer's disease (ad)], it remains unknown whether tau plays a role in the neurogenic process of the svz and ob system under conditions of chronic stress, a well-known sculptor of brain and risk factor for ad. 2021-07-12 2023-08-13 Not clear
Ari W Schaler, Avery M Runyan, Catherine L Clelland, Eric J Sydney, Stephanie L Fowler, Helen Y Figueroa, Seiji Shioda, Ismael Santa-Maria, Karen E Duff, Natura Myek. PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. Science translational medicine. vol 13. issue 595. 2021-07-12. PMID:34039738. accumulation of pathological tau in synapses has been identified as an early event in alzheimer's disease (ad) and correlates with cognitive decline in patients with ad. 2021-07-12 2023-08-13 mouse
Ahmed A Elbatrawy, Seung Jae Hyeon, Nan Yue, Essam Eldin A Osman, Seung Hyeo Choi, Sungsu Lim, Yun Kyung Kim, Hoon Ryu, Mengchao Cui, Ghilsoo Na. "Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking. ACS sensors. vol 6. issue 6. 2021-07-12. PMID:34115933. "turn-on" quinoline-based fluorescent probe for selective imaging of tau aggregates in alzheimer's disease: rational design, synthesis, and molecular docking. 2021-07-12 2023-08-13 Not clear
Ahmed A Elbatrawy, Seung Jae Hyeon, Nan Yue, Essam Eldin A Osman, Seung Hyeo Choi, Sungsu Lim, Yun Kyung Kim, Hoon Ryu, Mengchao Cui, Ghilsoo Na. "Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking. ACS sensors. vol 6. issue 6. 2021-07-12. PMID:34115933. tau aggregation is believed to have a strong association with the level of cognitive deficits in alzheimer's disease (ad). 2021-07-12 2023-08-13 Not clear
Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Cher. Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34158119. tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including alzheimer's disease (ad). 2021-07-12 2023-08-13 mouse
John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. cytoplasmic mislocalization of rna polymerase ii subunit rpb1 in alzheimer disease is linked to pathologic tau. 2021-07-10 2023-08-13 mouse
John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. recent data suggest nucleocytoplasmic transport may be compromised by tau in alzheimer disease. 2021-07-10 2023-08-13 mouse
John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. in summary, this study provides evidence that tau induces mislocalization of rpb1 in alzheimer disease, and since rpb1 is essential for transcription, this raises the possibility that rpb1 mislocalization could lead to fundamental alterations in neuronal health. 2021-07-10 2023-08-13 mouse
Pooja Patil, Ashima Thakur, Abha Sharma, Swaran Jeet Singh Flor. Natural products and their derivatives as multifunctional ligands against Alzheimer's disease. Drug development research. vol 81. issue 2. 2021-07-09. PMID:31820476. alzheimer's disease (ad), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta-amyloid (βa) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. 2021-07-09 2023-08-13 Not clear
Léa Rodriguez, Sandrine Joly, Fayçal Zine-Eddine, Julius Baya Mdzomba, Vincent Perne. Tau modulates visual plasticity in adult and old mice. Neurobiology of aging. vol 95. 2021-07-09. PMID:32858248. tau is a microtubule-associated protein involved in alzheimer's disease. 2021-07-09 2023-08-13 mouse