| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mamen Regalado-Reyes, Ruth Benavides-Piccione, Isabel Fernaud-Espinosa, Javier DeFelipe, Gonzalo León-Espinos. Effect of Phosphorylated Tau on Cortical Pyramidal Neuron Morphology during Hibernation. Cerebral cortex communications. vol 1. issue 1. 2021-07-24. PMID:34296096. |
tau protein hyperphosphorylation and aggregation have been associated with loss or alterations of dendritic spines in neurodegenerative diseases, such as alzheimer's disease (ad). |
2021-07-24 |
2023-08-13 |
Not clear |
| Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. |
female-specific risk of alzheimer's disease is associated with tau phosphorylation processes: a transcriptome-wide interaction analysis. |
2021-07-23 |
2023-08-13 |
Not clear |
| Alejandro Cáceres, Juan R Gonzále. Female-specific risk of Alzheimer's disease is associated with tau phosphorylation processes: A transcriptome-wide interaction analysis. Neurobiology of aging. vol 96. 2021-07-23. PMID:32977080. |
the levels of tau phosphorylation differ between sexes in alzheimer's disease (ad). |
2021-07-23 |
2023-08-13 |
Not clear |
| Baihong Guo, Yangmei Huang, Qingtao Gao, Qiang Zho. Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice. Neurobiology of aging. vol 96. 2021-07-23. PMID:33039900. |
one major pathological process in alzheimer's disease is mediated by hyperphosphorylated tau, which includes altered microtubules (mts) and functions associated with tau. |
2021-07-23 |
2023-08-13 |
mouse |
| Anna H Boerwinkle, Julie K Wisch, Charles D Chen, Brian A Gordon, Omar H Butt, Suzanne E Schindler, Courtney Sutphen, Shaney Flores, Aylin Dincer, Tammie L S Benzinger, Anne M Fagan, John C Morris, Beau M Ance. Temporal Correlation of CSF and Neuroimaging in the Amyloid-Tau-Neurodegeneration Model of Alzheimer Disease. Neurology. vol 97. issue 1. 2021-07-23. PMID:33931538. |
to evaluate temporal correlations between csf and neuroimaging (pet and mri) measures of amyloid, tau, and neurodegeneration in relation to alzheimer disease (ad) progression. |
2021-07-23 |
2023-08-13 |
Not clear |
| Sebastiaan Bijttebier, Clara Theunis, Farid Jahouh, Dina Rodrigues Martins, Marc Verhemeldonck, Karolien Grauwen, Lieve Dillen, Marc Mercke. Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. Journal of chromatography. A. vol 1651. 2021-07-22. PMID:34107398. |
development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from alzheimer disease patients. |
2021-07-22 |
2023-08-13 |
human |
| Sebastiaan Bijttebier, Clara Theunis, Farid Jahouh, Dina Rodrigues Martins, Marc Verhemeldonck, Karolien Grauwen, Lieve Dillen, Marc Mercke. Development of immunoprecipitation - two-dimensional liquid chromatography - mass spectrometry methodology as biomarker read-out to quantify phosphorylated tau in cerebrospinal fluid from Alzheimer disease patients. Journal of chromatography. A. vol 1651. 2021-07-22. PMID:34107398. |
in alzheimer's disease (ad) brain, one of the histopathological hallmarks is the neurofibrillary tangles consisting of aggregated and hyperphosphorylated tau. |
2021-07-22 |
2023-08-13 |
human |
| Lea L Weston, Shanya Jiang, Devon Chisholm, Lauren L Jantzie, Kiran Bhaska. Interleukin-10 deficiency exacerbates inflammation-induced tau pathology. Journal of neuroinflammation. vol 18. issue 1. 2021-07-22. PMID:34275478. |
the presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in alzheimer's disease and related tauopathies. |
2021-07-22 |
2023-08-13 |
Not clear |
| Shifeng Xiao, Yafei Lu, Qiuping Wu, Jiaying Yang, Jierui Chen, Suyue Zhong, David Eliezer, Qiulong Tan, Chengchen W. Fisetin inhibits tau aggregation by interacting with the protein and preventing the formation of β-strands. International journal of biological macromolecules. vol 178. 2021-07-21. PMID:33662414. |
the neurofibrillary tangles formed by tau protein aggregation are one of the defining characteristics of alzheimer's disease, so tau protein has become a key target for the drug design. |
2021-07-21 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. |
novel tau biomarkers phosphorylated at t181, t217 or t231 rise in the initial stages of the preclinical alzheimer's continuum when only subtle changes in aβ pathology are detected. |
2021-07-20 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. |
in alzheimer's disease (ad), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (csf) and blood is a dynamic process that changes during disease evolution. |
2021-07-20 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. |
the main aim of our study was to characterize the pattern of changes in phosphorylated tau (p-tau) in the preclinical stage of the alzheimer's continuum. |
2021-07-20 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà-Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau-Rivera, Eider M Arenaza-Urquijo, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuev. Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33169916. |
our results support the idea that early changes in neuronal tau metabolism in preclinical alzheimer, likely in response to aβ exposure, can be detected with these novel p-tau assays. |
2021-07-20 |
2023-08-13 |
Not clear |
| Patricia Chastagner, Frida Loria, Jessica Y Vargas, Josh Tois, Marc I Diamond, George Okafo, Christel Brou, Chiara Zurzol. Fate and propagation of endogenously formed Tau aggregates in neuronal cells. EMBO molecular medicine. vol 12. issue 12. 2021-07-20. PMID:33179866. |
tau accumulation in the form of neurofibrillary tangles in the brain is a hallmark of tauopathies such as alzheimer's disease (ad). |
2021-07-20 |
2023-08-13 |
Not clear |
| Isabel Ubeda-Bañon, Daniel Saiz-Sanchez, Alicia Flores-Cuadrado, Ernesto Rioja-Corroto, Melania Gonzalez-Rodriguez, Sandra Villar-Conde, Veronica Astillero-Lopez, Juan Pablo Cabello-de la Rosa, Maria Jose Gallardo-Alcañiz, Julia Vaamonde-Gamo, Fernanda Relea-Calatayud, Lucia Gonzalez-Lopez, Alicia Mohedano-Moriano, Alberto Rabano, Alino Martinez-Marco. The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's diseases. Translational neurodegeneration. vol 9. issue 1. 2021-07-19. PMID:32493457. |
neuropathologically, both are proteinopathies with pathological aggregates (plaques of amyloid-β peptide and neurofibrillary tangles of tau protein in alzheimer's disease, and lewy bodies mostly composed of α-synuclein in parkinson's disease). |
2021-07-19 |
2023-08-13 |
human |
| Diane L Ritchie, Marcelo A Barri. Prion Diseases: A Unique Transmissible Agent or a Model for Neurodegenerative Diseases? Biomolecules. vol 11. issue 2. 2021-07-19. PMID:33540845. |
the accumulation and propagation in the brain of misfolded proteins is a pathological hallmark shared by many neurodegenerative diseases such as alzheimer's disease (aβ and tau), parkinson's disease (α-synuclein), and prion disease (prion protein). |
2021-07-19 |
2023-08-13 |
Not clear |
| T B Thompson, G Meisl, T P J Knowles, A Goriel. The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases. The Journal of chemical physics. vol 154. issue 12. 2021-07-19. PMID:33810689. |
in alzheimer's disease, the formation of amyloid-β plaques and neurofibrillary tangles of the tau protein is associated with the appearance of symptoms and pathology. |
2021-07-19 |
2023-08-13 |
Not clear |
| Julia Neitzel, Nicolai Franzmeier, Anna Rubinski, Martin Dichgans, Matthias Brendel, Rainer Malik, Michael Ewer. KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-07-19. PMID:34158479. |
kl-vs heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in alzheimer's disease. |
2021-07-19 |
2023-08-13 |
Not clear |
| Jack Hashem, Mei Hu, Jian Zhang, Fei Gao, Chu Che. Inhibition of 2-Arachidonoylglycerol Metabolism Alleviates Neuropathology and Improves Cognitive Function in a Tau Mouse Model of Alzheimer's Disease. Molecular neurobiology. vol 58. issue 8. 2021-07-17. PMID:33939165. |
inhibition of 2-arachidonoylglycerol metabolism alleviates neuropathology and improves cognitive function in a tau mouse model of alzheimer's disease. |
2021-07-17 |
2023-08-13 |
mouse |
| Antonio Valencia, Veronica L Reinhart Bieber, Bekim Bajrami, Galina Marsh, Stefan Hamann, Ru Wei, Karen Ling, Frank Rigo, H Moore Arnold, Olga Golonzhka, Heike Herin. Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice. Frontiers in neurology. vol 12. 2021-07-16. PMID:34262517. |
acetylation of tau protein is dysregulated in alzheimer's disease (ad). |
2021-07-16 |
2023-08-13 |
mouse |