| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Justin S Sanchez, J Alex Becker, Heidi I L Jacobs, Bernard J Hanseeuw, Shu Jiang, Aaron P Schultz, Michael J Properzi, Samantha R Katz, Alexa Beiser, Claudia L Satizabal, Adrienne O'Donnell, Charles DeCarli, Ron Killiany, Georges El Fakhri, Marc D Normandin, Teresa Gómez-Isla, Yakeel T Quiroz, Dorene M Rentz, Reisa A Sperling, Sudha Seshadri, Jean Augustinack, Julie C Price, Keith A Johnso. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science translational medicine. vol 13. issue 577. 2021-07-12. PMID:33472953. |
advances in molecular positron emission tomography (pet) have enabled anatomic tracking of brain pathology in longitudinal studies of normal aging and dementia, including assessment of the central model of alzheimer's disease (ad) pathogenesis, according to which tau pathology begins focally but expands catastrophically under the influence of amyloid-β (aβ) pathology to mediate neurodegeneration and cognitive decline. |
2021-07-12 |
2023-08-13 |
human |
| Yanmin Chang, Yi Yao, Rong Ma, Zemin Wang, Junjie Hu, Yanqing Wu, Xingjun Jiang, Lulu Li, Gang L. Dl-3-n-Butylphthalide Reduces Cognitive Deficits and Alleviates Neuropathology in P301S Tau Transgenic Mice. Frontiers in neuroscience. vol 15. 2021-07-12. PMID:33642981. |
alzheimer's disease (ad) is a destructive and burdensome neurodegenerative disease, one of the most common characteristics of which are neurofibrillary tangles (nfts) that are composed of abnormal tau protein. |
2021-07-12 |
2023-08-13 |
mouse |
| Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. |
antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with alzheimer's disease. |
2021-07-12 |
2023-08-13 |
mouse |
| Gai Ayalon, Seung-Hye Lee, Oskar Adolfsson, Corinne Foo-Atkins, Jasvinder K Atwal, Mira Blendstrup, Helen Booler, Joseph Bravo, Robert Brendza, Flavia Brunstein, Ruby Chan, Priya Chandra, Jessica A Couch, Akash Datwani, Barthélemy Demeule, Danielle DiCara, Rich Erickson, James A Ernst, Oded Foreman, Dongping He, Isidro Hötzel, Michael Keeley, Michael C M Kwok, Julien Lafrance-Vanasse, Han Lin, Yanmei Lu, Wilman Luk, Paul Manser, Andreas Muhs, Hai Ngu, Andrea Pfeifer, Maria Pihlgren, Gautham K Rao, Kimberly Scearce-Levie, Stephen P Schauer, William B Smith, Hilda Solanoy, Edmond Teng, Kristin R Wildsmith, Daniela Bumbaca Yadav, Yong Ying, Reina N Fuji, Geoffrey A Kerchne. Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease. Science translational medicine. vol 13. issue 593. 2021-07-12. PMID:33980574. |
tau has become an attractive alternative target for passive immunotherapy efforts for alzheimer's disease (ad). |
2021-07-12 |
2023-08-13 |
mouse |
| Chrysoula Dioli, Patrícia Patrício, Lucilia-Goreti Pinto, Clemence Marie, Mónica Morais, Sheela Vyas, João M Bessa, Luisa Pinto, Ioannis Sotiropoulo. Adult neurogenic process in the subventricular zone-olfactory bulb system is regulated by Tau protein under prolonged stress. Cell proliferation. vol 54. issue 7. 2021-07-12. PMID:33988263. |
in alzheimer's disease (ad)], it remains unknown whether tau plays a role in the neurogenic process of the svz and ob system under conditions of chronic stress, a well-known sculptor of brain and risk factor for ad. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ari W Schaler, Avery M Runyan, Catherine L Clelland, Eric J Sydney, Stephanie L Fowler, Helen Y Figueroa, Seiji Shioda, Ismael Santa-Maria, Karen E Duff, Natura Myek. PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. Science translational medicine. vol 13. issue 595. 2021-07-12. PMID:34039738. |
accumulation of pathological tau in synapses has been identified as an early event in alzheimer's disease (ad) and correlates with cognitive decline in patients with ad. |
2021-07-12 |
2023-08-13 |
mouse |
| Ahmed A Elbatrawy, Seung Jae Hyeon, Nan Yue, Essam Eldin A Osman, Seung Hyeo Choi, Sungsu Lim, Yun Kyung Kim, Hoon Ryu, Mengchao Cui, Ghilsoo Na. "Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking. ACS sensors. vol 6. issue 6. 2021-07-12. PMID:34115933. |
"turn-on" quinoline-based fluorescent probe for selective imaging of tau aggregates in alzheimer's disease: rational design, synthesis, and molecular docking. |
2021-07-12 |
2023-08-13 |
Not clear |
| Ahmed A Elbatrawy, Seung Jae Hyeon, Nan Yue, Essam Eldin A Osman, Seung Hyeo Choi, Sungsu Lim, Yun Kyung Kim, Hoon Ryu, Mengchao Cui, Ghilsoo Na. "Turn-On" Quinoline-Based Fluorescent Probe for Selective Imaging of Tau Aggregates in Alzheimer's Disease: Rational Design, Synthesis, and Molecular Docking. ACS sensors. vol 6. issue 6. 2021-07-12. PMID:34115933. |
tau aggregation is believed to have a strong association with the level of cognitive deficits in alzheimer's disease (ad). |
2021-07-12 |
2023-08-13 |
Not clear |
| Ching-Pang Chang, Ya-Gin Chang, Pei-Yun Chuang, Thi Ngoc Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin-Jhong Cheng, Hui-Mei Chen, Lee-Way Jin, Kevin Carvalho, Vincent Huin, Luc Buée, Yung-Feng Liao, Chun-Jung Lin, David Blum, Yijuang Cher. Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy. Acta neuropathologica communications. vol 9. issue 1. 2021-07-12. PMID:34158119. |
tau pathology is instrumental in the gradual loss of neuronal functions and cognitive decline in tauopathies, including alzheimer's disease (ad). |
2021-07-12 |
2023-08-13 |
mouse |
| John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. |
cytoplasmic mislocalization of rna polymerase ii subunit rpb1 in alzheimer disease is linked to pathologic tau. |
2021-07-10 |
2023-08-13 |
mouse |
| John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. |
recent data suggest nucleocytoplasmic transport may be compromised by tau in alzheimer disease. |
2021-07-10 |
2023-08-13 |
mouse |
| John R Dickson, Hyejin Yoon, Matthew P Frosch, Bradley T Hyma. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of neuropathology and experimental neurology. vol 80. issue 6. 2021-07-10. PMID:33990839. |
in summary, this study provides evidence that tau induces mislocalization of rpb1 in alzheimer disease, and since rpb1 is essential for transcription, this raises the possibility that rpb1 mislocalization could lead to fundamental alterations in neuronal health. |
2021-07-10 |
2023-08-13 |
mouse |
| Pooja Patil, Ashima Thakur, Abha Sharma, Swaran Jeet Singh Flor. Natural products and their derivatives as multifunctional ligands against Alzheimer's disease. Drug development research. vol 81. issue 2. 2021-07-09. PMID:31820476. |
alzheimer's disease (ad), a complex neurodegenerative disorder causing multiple cellular changes including impaired cholinergic system, beta-amyloid (βa) aggregation, tau hyperphosphorylation, metal dyshomeostasis, neuroinflammation, and many other pathways are involved in the pathogenesis of the disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Léa Rodriguez, Sandrine Joly, Fayçal Zine-Eddine, Julius Baya Mdzomba, Vincent Perne. Tau modulates visual plasticity in adult and old mice. Neurobiology of aging. vol 95. 2021-07-09. PMID:32858248. |
tau is a microtubule-associated protein involved in alzheimer's disease. |
2021-07-09 |
2023-08-13 |
mouse |
| Huiwei Zhang, Min Wang, Jiaying Lu, Weiqi Bao, Ling Li, Jiehui Jiang, Chuantao Zu. Parametric Estimation of Reference Signal Intensity for Semi-Quantification of Tau Deposition: A Flortaucipir and [ Frontiers in neuroscience. vol 15. 2021-07-09. PMID:34234637. |
parametric estimation of reference signal intensity for semi-quantification of tau deposition: a flortaucipir and [ tau positron emission tomography (pet) imaging can reveal the pathophysiology and neurodegeneration that occurs in alzheimer's disease (ad) |
2021-07-09 |
2023-08-13 |
Not clear |
| Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Man. Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease. Molecular systems biology. vol 16. issue 6. 2021-07-08. PMID:32485097. |
alzheimer's disease (ad) patients have higher csf levels of tau, but we lack knowledge of systems-wide changes of csf protein levels that accompany ad. |
2021-07-08 |
2023-08-13 |
Not clear |
| Jakob M Bader, Philipp E Geyer, Johannes B Müller, Maximilian T Strauss, Manja Koch, Frank Leypoldt, Peter Koertvelyessy, Daniel Bittner, Carola G Schipke, Enise I Incesoy, Oliver Peters, Nikolaus Deigendesch, Mikael Simons, Majken K Jensen, Henrik Zetterberg, Matthias Man. Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease. Molecular systems biology. vol 16. issue 6. 2021-07-08. PMID:32485097. |
csf proteome changes in alzheimer's disease prove to be widespread and often correlated with tau concentrations. |
2021-07-08 |
2023-08-13 |
Not clear |
| Madhurima Dey, Frank J Gunn-Moore, Bettina Platt, Terry K Smit. Brain region-specific lipid alterations in the PLB4 hBACE1 knock-in mouse model of Alzheimer's disease. Lipids in health and disease. vol 19. issue 1. 2021-07-08. PMID:32867761. |
lipid dysregulation is associated with several key characteristics of alzheimer's disease (ad), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfunction. |
2021-07-08 |
2023-08-13 |
mouse |
| Nicole S Tommasi, Christopher Gonzalez, Danielle Briggs, Michael J Properzi, Jennifer R Gatchel, Gad A Marshal. Affective symptoms and regional cerebral tau burden in early-stage Alzheimer's disease. International journal of geriatric psychiatry. vol 36. issue 7. 2021-07-08. PMID:33682933. |
affective symptoms and regional cerebral tau burden in early-stage alzheimer's disease. |
2021-07-08 |
2023-08-13 |
Not clear |
| Seong Gak Jeon, Hyun-Ju Lee, HyunHee Park, Kyung-Min Han, Hyang-Sook Ho. The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice. Molecular brain. vol 13. issue 1. 2021-07-07. PMID:32977842. |
alzheimer's disease (ad) is a highly prevalent neurodegenerative disease characterized by aβ accumulation and tau hyperphosphorylation. |
2021-07-07 |
2023-08-13 |
mouse |