| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelko. FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments. Molecular neurodegeneration. vol 15. issue 1. 2021-07-01. PMID:32677995. |
tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several tauopathies, including alzheimer disease (ad). |
2021-07-01 |
2023-08-13 |
Not clear |
| Shinichiro Ochi, Jun-Ichi Iga, Yu Funahashi, Yuta Yoshino, Kiyohiro Yamazaki, Hiroshi Kumon, Hiroaki Mori, Yuki Ozaki, Takaaki Mori, Shu-Ichi Uen. Identifying Blood Transcriptome Biomarkers of Alzheimer's Disease Using Transgenic Mice. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32816243. |
the testing of pathological biomarkers of alzheimer's disease (ad), such as amyloid beta and tau, is time-consuming, expensive, and invasive. |
2021-07-01 |
2023-08-13 |
mouse |
| Sanjib Guha, Gail V W Johnson, Keith Nehrk. The Crosstalk Between Pathological Tau Phosphorylation and Mitochondrial Dysfunction as a Key to Understanding and Treating Alzheimer's Disease. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32851560. |
the crosstalk between pathological tau phosphorylation and mitochondrial dysfunction as a key to understanding and treating alzheimer's disease. |
2021-07-01 |
2023-08-13 |
Not clear |
| Chanisa Chotipanich, Monchaya Nivorn, Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Natphimol Boonkawin, Attapon Jantarat. Evaluation of Imaging Windows for Tau PET Imaging Using Molecular imaging. vol 19. 2021-07-01. PMID:32862780. |
evaluation of imaging windows for tau pet imaging using the study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (mci), and alzheimer's disease (ad) patients, using |
2021-07-01 |
2023-08-13 |
Not clear |
| Khadgawat Priya, J M Siddesha, Shashank Dharini, K Prasad Shashank. Interacting Models of Amyloid-β and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-07-01. PMID:34189412. |
interacting models of amyloid-β and tau proteins: an approach to identify drug targets in alzheimer's disease. |
2021-07-01 |
2023-08-13 |
Not clear |
| Mikael Marttinen, Catarina B Ferreira, Kaisa M A Paldanius, Mari Takalo, Teemu Natunen, Petra Mäkinen, Luukas Leppänen, Ville Leinonen, Kenji Tanigaki, Gina Kang, Noboru Hiroi, Hilkka Soininen, Kirsi Rilla, Annakaisa Haapasalo, Mikko Hiltune. Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ. Cells. vol 9. issue 11. 2021-06-30. PMID:33203136. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by aberrant amyloid-β (aβ) and hyperphosphorylated tau aggregation. |
2021-06-30 |
2023-08-13 |
mouse |
| Lalitha Venkataraman, Ping He, Philip Schulz, Michael R Sierk. Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants. Neurobiology of aging. vol 94. 2021-06-29. PMID:32497877. |
isolation and characterization of antibody fragment selective for human alzheimer's disease brain-derived tau variants. |
2021-06-29 |
2023-08-13 |
human |
| Lalitha Venkataraman, Ping He, Philip Schulz, Michael R Sierk. Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants. Neurobiology of aging. vol 94. 2021-06-29. PMID:32497877. |
reagents that can selectively recognize specific toxic tau variants associated with onset and progression of alzheimer's disease (ad) and other tauopathies can be effective diagnostic and therapeutic tools. |
2021-06-29 |
2023-08-13 |
human |
| Lalitha Venkataraman, Ping He, Philip Schulz, Michael R Sierk. Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants. Neurobiology of aging. vol 94. 2021-06-29. PMID:32497877. |
we identified 6 scfvs [alzheimer's disease tau (adt)-1 through 6] that readily distinguished between ad and control tissue and sera samples. |
2021-06-29 |
2023-08-13 |
human |
| Michael A Sugarman, Henrik Zetterberg, Kaj Blennow, Yorghos Tripodis, Ann C McKee, Thor D Stein, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Andrew E Budson, Ronald Killiany, Maureen K O'Connor, Rhoda Au, Wendy Wei Qiao Qiu, Lee E Goldstein, Neil W Kowall, Jesse Mez, Robert A Stern, Michael L Alosc. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiology of aging. vol 94. 2021-06-29. PMID:32585491. |
a longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of alzheimer's disease. |
2021-06-29 |
2023-08-13 |
human |
| Michael A Sugarman, Henrik Zetterberg, Kaj Blennow, Yorghos Tripodis, Ann C McKee, Thor D Stein, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Andrew E Budson, Ronald Killiany, Maureen K O'Connor, Rhoda Au, Wendy Wei Qiao Qiu, Lee E Goldstein, Neil W Kowall, Jesse Mez, Robert A Stern, Michael L Alosc. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiology of aging. vol 94. 2021-06-29. PMID:32585491. |
we examined baseline and longitudinal associations between plasma neurofilament light (nfl) and total tau (t-tau), and the clinical presentation of alzheimer's disease (ad). |
2021-06-29 |
2023-08-13 |
human |
| Frank S Fa. Assessing the Possible Influence of Residues of Ractopamine, a Livestock Feed Additive, in Meat on Alzheimer Disease. Dementia and geriatric cognitive disorders extra. vol 11. issue 2. 2021-06-29. PMID:34178014. |
finally, it has been demonstrated that the β-adrenergic agonist salbutamol could bind directly to tau protein and interfere with the tau filament formation seen in the prodromal phase of alzheimer disease. |
2021-06-29 |
2023-08-13 |
mouse |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. |
maintained memory and long-term potentiation in a mouse model of alzheimer's disease with both amyloid pathology and human tau. |
2021-06-28 |
2023-08-13 |
mouse |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. |
one of the key knowledge gaps in the field of alzheimer's disease research is the lack of understanding of how amyloid beta and tau cooperate to cause neurodegeneration. |
2021-06-28 |
2023-08-13 |
mouse |
| Jane Tulloch, Olga Netsyk, Eleanor K Pickett, Abigail G Herrmann, Pooja Jain, Anna J Stevenson, Iris Oren, Oliver Hardt, Tara L Spires-Jone. Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. The European journal of neuroscience. vol 53. issue 2. 2021-06-28. PMID:33169893. |
these data are important as they highlight potential functional differences between mouse and human tau and the need to use multiple models to fully understand alzheimer's disease pathogenesis and develop effective therapeutic strategies. |
2021-06-28 |
2023-08-13 |
mouse |
| Guiliang Zhang, Jiahui Wu, Chunhui Huang, Jiehong Cheng, Zhiyang Su, Zeyu Zhu, Xifei Yang, Baojian Guo, Liangmiao Wu, Zaijun Zhang, Gaoxiao Zhang, Haiyun Chen, Yewei Sun, Yuqiang Wan. The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 71. issue 7. 2021-06-28. PMID:33403592. |
the tetramethylpyrazine analogue t-006 alleviates cognitive deficits by inhibition of tau expression and phosphorylation in transgenic mice modeling alzheimer's disease. |
2021-06-28 |
2023-08-13 |
mouse |
| Maurits Johansson, Erik Stomrud, Philip S Insel, Antoine Leuzy, Per Mårten Johansson, Ruben Smith, Zahinoor Ismail, Shorena Janelidze, Sebastian Palmqvist, Danielle van Westen, Niklas Mattsson-Carlgren, Oskar Hansso. Mild behavioral impairment and its relation to tau pathology in preclinical Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33500386. |
mild behavioral impairment and its relation to tau pathology in preclinical alzheimer's disease. |
2021-06-28 |
2023-08-13 |
human |
| Céline H De Jager, Charles C White, David A Bennett, Yiyi M. Neuroticism alters the transcriptome of the frontal cortex to contribute to the cognitive decline and onset of Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33627625. |
accumulating evidence has suggested that the molecular transcriptional mechanism contributes to alzheimer's disease (ad) and its endophenotypes of cognitive decline and neuropathological traits, β-amyloid (aβ) and phosphorylated tangles (tau). |
2021-06-28 |
2023-08-13 |
human |
| Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette M Hartmann, Bernd Holleczek, Ben Schöttker, Julia Stockmann, Klaus Gerwert, Hermann Brenne. Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease. Translational psychiatry. vol 11. issue 1. 2021-06-28. PMID:33934115. |
alzheimer's disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. |
2021-06-28 |
2023-08-13 |
Not clear |
| Atsushi Michael Kimura, Mayumi Tsuji, Taro Yasumoto, Yukiko Mori, Tatsunori Oguchi, Yuya Tsuji, Masakazu Umino, Asami Umino, Toru Nishikawa, Shiro Nakamura, Tomio Inoue, Yuji Kiuchi, Masahito Yamada, David B Teplow, Kenjiro On. Myricetin prevents high molecular weight Aβ Free radical biology & medicine. vol 171. 2021-06-28. PMID:34015458. |
myricetin prevents high molecular weight aβ excessive accumulation of amyloid β-protein (aβ) is one of the primary mechanisms that leads to neuronal death with phosphorylated tau in the pathogenesis of alzheimer's disease (ad). |
2021-06-28 |
2023-08-13 |
Not clear |