| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sabrina Simoes, Jessica L Neufeld, Gallen Triana-Baltzer, Setareh Moughadam, Emily I Chen, Milankumar Kothiya, Yasir H Qureshi, Vivek Patel, Lawrence S Honig, Hartmuth Kolb, Scott A Smal. Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Science translational medicine. vol 12. issue 571. 2021-06-23. PMID:33239387. |
tau and other proteins found in alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. |
2021-06-23 |
2023-08-13 |
mouse |
| Pragati, Surajit Sarka. Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila. BioFactors (Oxford, England). vol 47. issue 3. 2021-06-23. PMID:33651466. |
neurodegenerative tauopathies such as alzheimer's and parkinson's diseases are characterized by hyperphosphorylation of tau protein and their subsequent aggregation in the forms of paired helical filaments and/or neurofibrillary tangles in specific areas of the brain. |
2021-06-23 |
2023-08-13 |
human |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
four distinct trajectories of tau deposition identified in alzheimer's disease. |
2021-06-23 |
2023-08-13 |
Not clear |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
alzheimer's disease (ad) is characterized by the spread of tau pathology throughout the cerebral cortex. |
2021-06-23 |
2023-08-13 |
Not clear |
| Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasse. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology. vol 191. 2021-06-23. PMID:33940010. |
the inducible p25 overexpression mouse model recapitulate many hallmark features of alzheimer's disase including progressive neuronal loss, elevated aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. |
2021-06-23 |
2023-08-13 |
mouse |
| Huang Kuang, Cheng-Yong Tan, Hui-Zhen Tian, Li-Hua Liu, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yan. Exploring the bi-directional relationship between autophagy and Alzheimer's disease. CNS neuroscience & therapeutics. vol 26. issue 2. 2021-06-22. PMID:31503421. |
alzheimer's disease (ad) is characterized by β-amyloid (aβ) deposition and tau phosphorylation, in which its pathogenesis has not been cleared so far. |
2021-06-22 |
2023-08-13 |
Not clear |
| Yuan Zhao, Yidan Zhang, Jian Zhang, Xiangjian Zhang, Guofeng Yan. Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer's Disease. Current neuropharmacology. vol 18. issue 8. 2021-06-22. PMID:31934838. |
alzheimer's disease (ad) is a neurodegenerative disorder of progressive dementia that is characterized by the accumulation of beta-amyloid (aβ)-containing neuritic plaques and intracellular tau protein tangles. |
2021-06-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Randall J Bateman, Christophe Hirtz, Philippe Marin, François Becher, Chihiro Sato, Audrey Gabelle, Sylvain Lehman. Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-22. PMID:32183883. |
cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine 181 (pt181) are currently used to discriminate between alzheimer's disease and other neurodegenerative diseases. |
2021-06-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Randall J Bateman, Christophe Hirtz, Philippe Marin, François Becher, Chihiro Sato, Audrey Gabelle, Sylvain Lehman. Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-22. PMID:32183883. |
however, these changes are not entirely specific to alzheimer's disease, and it is noteworthy that other phosphorylated isoforms of tau, possibly more specific for the disease process, have been described in the brain parenchyma of patients. |
2021-06-22 |
2023-08-13 |
Not clear |
| Mamali Das, Kasi Pandima Dev. Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology. vol 84. 2021-06-22. PMID:33617922. |
alzheimer's disease (ad) etiology has been studied for a long time and it is found to be multifaceted involving the accumulation of amyloid β and tau protein. |
2021-06-22 |
2023-08-13 |
human |
| Roberta Cascella, Cristina Cecch. Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34066371. |
alzheimer's disease (ad) is the most common age-related neurodegenerative disorder that is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles consisting of abnormally phosphorylated tau protein, and neuronal loss leading to cognitive decline and dementia. |
2021-06-22 |
2023-08-13 |
Not clear |
| Ping Kwan, Haruki Konno, Ka Yan Chan, Larry Bau. Rationale for the development of an Alzheimer's disease vaccine. Human vaccines & immunotherapeutics. vol 16. issue 3. 2021-06-21. PMID:31526227. |
however, amyloid β (aβ) or tau, which can act like infectious proteins, or prions, might induce alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |
| Xinyue Zhang, Bin Jiao, Ling Weng, Yafang Zhou, Lina Guo, Xin Wang, Lu Zhou, Xixi Liu, Xuewen Xiao, Hui Liu, Xiangyu Zhu, Chenping Li, Yuan Zhu, Qijie Yang, Zhuojie Lin, Yaling Jiang, Yafei Wen, Hui Zhou, Lu Shen, Xinxin Lia. Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population. The European journal of neuroscience. vol 52. issue 8. 2021-06-21. PMID:32506655. |
recently, functional studies have demonstrated that legumain (lgmn) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |
| Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraeme. Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction. ACS chemical neuroscience. vol 11. issue 15. 2021-06-21. PMID:32589834. |
neurofibrillary tangles composed of aberrantly aggregating tau protein are a hallmark of alzheimer's disease and related dementia disorders. |
2021-06-21 |
2023-08-13 |
mouse |
| Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. |
an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. |
2021-06-21 |
2023-08-13 |
Not clear |
| Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. |
an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. |
2021-06-21 |
2023-08-13 |
Not clear |
| Evan Lester, Felicia K Ooi, Nadine Bakkar, Jacob Ayers, Amanda L Woerman, Joshua Wheeler, Robert Bowser, George A Carlson, Stanley B Prusiner, Roy Parke. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. vol 109. issue 10. 2021-06-21. PMID:33848474. |
tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
mouse |
| Hao Li, Nannan Li, Yingqi Tang, Jin Yong Le. Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:33978396. |
self-assembly of hyperphosphorylated tau proteins into neurofibrillary tangles (nft) is a hallmark of alzheimer's disease. |
2021-06-21 |
2023-08-13 |
Not clear |
| Arpan Pradhan, Satyendra Mishra, Avadhesha Surolia, Dulal Pand. C1 Inhibits Liquid-Liquid Phase Separation and Oligomerization of Tau and Protects Neuroblastoma Cells against Toxic Tau Oligomers. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34008959. |
the pathological aggregation of tau is one of the major contributing factors for several neurodegenerative tauopathies, including alzheimer's disease. |
2021-06-21 |
2023-08-13 |
Not clear |
| Anna Pasieka, Dawid Panek, Natalia Szałaj, Alba Espargaró, Anna Więckowska, Barbara Malawska, Raimon Sabaté, Marek Bajd. Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34019757. |
dual inhibitors of amyloid-β and tau aggregation with amyloid-β disaggregating properties: extended in alzheimer's disease, neurons slowly degenerate due to the accumulation of misfolded amyloid β and tau proteins. |
2021-06-21 |
2023-08-13 |
Not clear |