| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinyue Zhang, Bin Jiao, Ling Weng, Yafang Zhou, Lina Guo, Xin Wang, Lu Zhou, Xixi Liu, Xuewen Xiao, Hui Liu, Xiangyu Zhu, Chenping Li, Yuan Zhu, Qijie Yang, Zhuojie Lin, Yaling Jiang, Yafei Wen, Hui Zhou, Lu Shen, Xinxin Lia. Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population. The European journal of neuroscience. vol 52. issue 8. 2021-06-21. PMID:32506655. |
recently, functional studies have demonstrated that legumain (lgmn) cleaves both amyloid β-protein precursor and tau, promoting senile plaques and formation of neurofibrillary tangles, which may play a crucial role in the pathogenesis of alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |
| Jeremy D Baker, Rikki L Uhrich, Timothy J Strovas, Aleen D Saxton, Brian C Kraeme. Targeting Pathological Tau by Small Molecule Inhibition of the Poly(A):MSUT2 RNA-Protein Interaction. ACS chemical neuroscience. vol 11. issue 15. 2021-06-21. PMID:32589834. |
neurofibrillary tangles composed of aberrantly aggregating tau protein are a hallmark of alzheimer's disease and related dementia disorders. |
2021-06-21 |
2023-08-13 |
mouse |
| Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. |
an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. |
2021-06-21 |
2023-08-13 |
Not clear |
| Liangping Li, Jiawen Liang, Hongjun F. An update on the association between traumatic brain injury and Alzheimer's disease: Focus on Tau pathology and synaptic dysfunction. Neuroscience and biobehavioral reviews. vol 120. 2021-06-21. PMID:33171143. |
an update on the association between traumatic brain injury and alzheimer's disease: focus on tau pathology and synaptic dysfunction. |
2021-06-21 |
2023-08-13 |
Not clear |
| Evan Lester, Felicia K Ooi, Nadine Bakkar, Jacob Ayers, Amanda L Woerman, Joshua Wheeler, Robert Bowser, George A Carlson, Stanley B Prusiner, Roy Parke. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. vol 109. issue 10. 2021-06-21. PMID:33848474. |
tau aggregates contribute to neurodegenerative diseases, including frontotemporal dementia and alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
mouse |
| Hao Li, Nannan Li, Yingqi Tang, Jin Yong Le. Histidine Tautomeric Effect on the Key Fragment R3 of Tau Protein from Atomistic Simulations. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:33978396. |
self-assembly of hyperphosphorylated tau proteins into neurofibrillary tangles (nft) is a hallmark of alzheimer's disease. |
2021-06-21 |
2023-08-13 |
Not clear |
| Arpan Pradhan, Satyendra Mishra, Avadhesha Surolia, Dulal Pand. C1 Inhibits Liquid-Liquid Phase Separation and Oligomerization of Tau and Protects Neuroblastoma Cells against Toxic Tau Oligomers. ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34008959. |
the pathological aggregation of tau is one of the major contributing factors for several neurodegenerative tauopathies, including alzheimer's disease. |
2021-06-21 |
2023-08-13 |
Not clear |
| Anna Pasieka, Dawid Panek, Natalia Szałaj, Alba Espargaró, Anna Więckowska, Barbara Malawska, Raimon Sabaté, Marek Bajd. Dual Inhibitors of Amyloid-β and Tau Aggregation with Amyloid-β Disaggregating Properties: Extended ACS chemical neuroscience. vol 12. issue 11. 2021-06-21. PMID:34019757. |
dual inhibitors of amyloid-β and tau aggregation with amyloid-β disaggregating properties: extended in alzheimer's disease, neurons slowly degenerate due to the accumulation of misfolded amyloid β and tau proteins. |
2021-06-21 |
2023-08-13 |
Not clear |
| Juan Carlos Polanco, Jürgen Göt. Exosomal and vesicle-free tau seeds-propagation and convergence in endolysosomal permeabilization. The FEBS journal. 2021-06-21. PMID:34092031. |
in alzheimer's disease (ad), β-amyloid peptides aggregate to form amyloid plaques, and the microtubule-associated protein tau forms neurofibrillary tangles. |
2021-06-21 |
2023-08-13 |
Not clear |
| Shorena Janelidze, Sebastian Palmqvist, Antoine Leuzy, Erik Stomrud, Inge M W Verberk, Henrik Zetterberg, Nicholas J Ashton, Pedro Pesini, Leticia Sarasa, José Antonio Allué, Charlotte E Teunissen, Jeffrey L Dage, Kaj Blennow, Niklas Mattsson-Carlgren, Oskar Hansso. Detecting amyloid positivity in early Alzheimer's disease using combinations of plasma Aβ42/Aβ40 and p-tau. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-06-21. PMID:34151519. |
we studied usefulness of combining blood amyloid beta (aβ)42/aβ40, phosphorylated tau (p-tau)217, and neurofilament light (nfl) to detect abnormal brain aβ deposition in different stages of early alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |
| Ahmad Abu Turab Naqvi, Deeba Shamim Jairajpuri, Omar Mohammed Ali Noman, Afzal Hussain, Asimul Islam, Faizan Ahmad, Mohammed F Alajmi, Md Imtaiyaz Hassa. Evaluation of pyrazolopyrimidine derivatives as microtubule affinity regulating kinase 4 inhibitors: Towards therapeutic management of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 38. issue 13. 2021-06-18. PMID:31512980. |
hyperphosphorylation of tau protein causes the formation of paired helical fragments and neurofibrillary tangles, the hallmarks of alzheimer's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Parveen Salahuddin, Rizwan Hasan Khan, Vladimir N Uversk. Comprehensive analysis of the molecular docking of small molecule inhibitors to the Aβ Journal of biomolecular structure & dynamics. vol 38. issue 15. 2021-06-18. PMID:31779527. |
comprehensive analysis of the molecular docking of small molecule inhibitors to the aβ alzheimer's disease (ad) is the most common form of age-related neurodegeneration occurs because of deposition of proteins in the form of extracellular plaques containing aggregated amyloid beta (aβ) peptide and intracellular neurofibrillary tangles composed of aggregated microtubule-binding protein tau. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh, Hoon Ryu, Jae-Bong Par. Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. Redox biology. vol 32. 2021-06-18. PMID:32046944. |
both the accumulation of amyloid-β (aβ) in plaques and phosphorylation of tau protein (p-tau) in neurofibrillary tangles have been identified as two major symptomatic features of alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
mouse |
| Azhaar Ashraf, Jérôme Jeandriens, Harold G Parkes, Po-Wah S. Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox biology. vol 32. 2021-06-18. PMID:32199332. |
iron dyshomeostasis is implicated in alzheimer's disease (ad) alongside β-amyloid and tau pathologies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kimberly L Fiock, Martin E Smalley, John F Crary, Anca M Pasca, Marco M Heft. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393582. |
although best known for its role in alzheimer's disease (ad), tau is expressed throughout brain development, although it remains unclear when and which cell types this expression occurs and how it affects disease states in both fetal and neonatal periods. |
2021-06-18 |
2023-08-13 |
human |
| Swapna Bera, Nilanjan Gayen, Sk Abdul Mohid, Dipita Bhattacharyya, Janarthanan Krishnamoorthy, Dibakar Sarkar, Jihye Choi, Nirakar Sahoo, Atin K Mandal, DongKuk Lee, Anirban Bhuni. Comparison of Synthetic Neuronal Model Membrane Mimics in Amyloid Aggregation at Atomic Resolution. ACS chemical neuroscience. vol 11. issue 13. 2021-06-18. PMID:32492332. |
alzheimer's disease (ad) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (aβ) or the tau proteins in the brain. |
2021-06-18 |
2023-08-13 |
Not clear |
| David J Townsend, Barbora Mala, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, Nigel J Fullwood, David A Middleto. Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation ACS chemical neuroscience. vol 11. issue 14. 2021-06-18. PMID:32520518. |
circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation potential drug treatments for alzheimer's disease (ad) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. |
2021-06-18 |
2023-08-13 |
Not clear |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32546772. |
alzheimer's disease (ad) is characterised by aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. |
2021-06-18 |
2023-08-13 |
mouse |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
one of the main features of neurodegenerative disorders such as alzheimer's disease and parkinson's disease is the amyloidogenic behavior of disease-specific proteins including amyloid β, tau, α-synuclein, and mutant huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. |
2021-06-18 |
2023-08-13 |
Not clear |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
we explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid β, tau, and α-synuclein and mitigate other pathological features for alzheimer's disease and parkinson's disease. |
2021-06-18 |
2023-08-13 |
Not clear |