| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Azhaar Ashraf, Jérôme Jeandriens, Harold G Parkes, Po-Wah S. Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer's disease: Evidence of ferroptosis. Redox biology. vol 32. 2021-06-18. PMID:32199332. |
iron dyshomeostasis is implicated in alzheimer's disease (ad) alongside β-amyloid and tau pathologies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kimberly L Fiock, Martin E Smalley, John F Crary, Anca M Pasca, Marco M Heft. Increased Tau Expression Correlates with Neuronal Maturation in the Developing Human Cerebral Cortex. eNeuro. vol 7. issue 3. 2021-06-18. PMID:32393582. |
although best known for its role in alzheimer's disease (ad), tau is expressed throughout brain development, although it remains unclear when and which cell types this expression occurs and how it affects disease states in both fetal and neonatal periods. |
2021-06-18 |
2023-08-13 |
human |
| Swapna Bera, Nilanjan Gayen, Sk Abdul Mohid, Dipita Bhattacharyya, Janarthanan Krishnamoorthy, Dibakar Sarkar, Jihye Choi, Nirakar Sahoo, Atin K Mandal, DongKuk Lee, Anirban Bhuni. Comparison of Synthetic Neuronal Model Membrane Mimics in Amyloid Aggregation at Atomic Resolution. ACS chemical neuroscience. vol 11. issue 13. 2021-06-18. PMID:32492332. |
alzheimer's disease (ad) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (aβ) or the tau proteins in the brain. |
2021-06-18 |
2023-08-13 |
Not clear |
| David J Townsend, Barbora Mala, Eleri Hughes, Rohanah Hussain, Giuliano Siligardi, Nigel J Fullwood, David A Middleto. Circular Dichroism Spectroscopy Identifies the β-Adrenoceptor Agonist Salbutamol As a Direct Inhibitor of Tau Filament Formation ACS chemical neuroscience. vol 11. issue 14. 2021-06-18. PMID:32520518. |
circular dichroism spectroscopy identifies the β-adrenoceptor agonist salbutamol as a direct inhibitor of tau filament formation potential drug treatments for alzheimer's disease (ad) may be found by identifying compounds that block the assembly of the microtubule-associated protein tau into neurofibrillar tangles associated with neuron destabilization and cell death. |
2021-06-18 |
2023-08-13 |
Not clear |
| Anshua Ghosh, Keiko Mizuno, Sachin S Tiwari, Petroula Proitsi, Beatriz Gomez Perez-Nievas, Elizabeth Glennon, Rocio T Martinez-Nunez, K Peter Gies. Alzheimer's disease-related dysregulation of mRNA translation causes key pathological features with ageing. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32546772. |
alzheimer's disease (ad) is characterised by aβ and tau pathology as well as synaptic degeneration, which correlates best with cognitive impairment. |
2021-06-18 |
2023-08-13 |
mouse |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
one of the main features of neurodegenerative disorders such as alzheimer's disease and parkinson's disease is the amyloidogenic behavior of disease-specific proteins including amyloid β, tau, α-synuclein, and mutant huntingtin which participate in the formation, accumulation, and deposition of toxic misfolded aggregates. |
2021-06-18 |
2023-08-13 |
Not clear |
| Gabriela Henríquez, Alejandra Gomez, Erick Guerrero, Mahesh Naraya. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32822152. |
we explore the effectiveness of the polyphenols epigallocatechin-3-gallate, oleuropein aglycone, and quercetin on their ability to inhibit aggregation of amyloid β, tau, and α-synuclein and mitigate other pathological features for alzheimer's disease and parkinson's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Thomas K Karikari, Sophie Keeling, Emily Hill, Juan Lantero Rodrı Guez, David A Nagel, Bruno Becker, Kina Höglund, Henrik Zetterberg, Kaj Blennow, Eric J Hill, Kevin G Moffa. Extensive Plasmid Library to Prepare Tau Protein Variants and Study Their Functional Biochemistry. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32833429. |
tau neurofibrillary tangles are key pathological features of alzheimer's disease and other tauopathies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Chae Eun Heo, Jong Yoon Han, Sungsu Lim, Jeeyoung Lee, Dongjoon Im, Min Jae Lee, Yun Kyung Kim, Hugh I Ki. ATP Kinetically Modulates Pathogenic Tau Fibrillations. ACS chemical neuroscience. vol 11. issue 19. 2021-06-18. PMID:32915536. |
advanced understanding of alzheimer's disease (ad) and several tauopathies over the past decades indicates the pathological importance of tau aggregation in these diseases. |
2021-06-18 |
2023-08-13 |
human |
| Yuan Hu, Xiaochun Hu, Yonglin Lu, Shuo Shi, Danjing Yang, Tianming Ya. New Strategy for Reducing Tau Aggregation Cytologically by A Hairpinlike Molecular Inhibitor, Tannic Acid Encapsulated in Liposome. ACS chemical neuroscience. vol 11. issue 21. 2021-06-18. PMID:33048528. |
inhibition of tau protein aggregation is an attractive therapeutic target for alzheimer's disease. |
2021-06-18 |
2023-08-13 |
mouse |
| Jie Zhao, Qihui Shi, Hongda Tian, Youzhi Li, Yan Liu, Zhen Xu, Anne Robert, Qiong Liu, Bernard Meunie. TDMQ20, a Specific Copper Chelator, Reduces Memory Impairments in Alzheimer's Disease Mouse Models. ACS chemical neuroscience. vol 12. issue 1. 2021-06-18. PMID:33322892. |
besides targeting amyloid or tau metabolisms, regulation of redox metal ions is a recognized therapeutic target for alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
mouse |
| Philip R Lindstedt, Ross J Taylor, Gonçalo J L Bernardes, Michele Vendruscol. Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis. ACS chemical neuroscience. vol 12. issue 3. 2021-06-18. PMID:33464820. |
we illustrate this approach by performing site-specific phosphorylation and methylation of tau, a protein that stabilizes microtubules and whose aggregation is closely linked with alzheimer's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Hongli Liu, Qin Li, Chunmei Xiong, Haiyang Zhong, Qianqian Zhang, Huanxiang Liu, Xiaojun Ya. Uncovering the Effect of pS202/pT205/pS208 Triple Phosphorylations on the Conformational Features of the Key Fragment G192-T212 of Tau Protein. ACS chemical neuroscience. vol 12. issue 6. 2021-06-18. PMID:33663205. |
microtubule-associated protein tau is abnormally phosphorylated and forms the aggregates of paired helical filaments in alzheimer's disease (ad) and other tauopathies. |
2021-06-18 |
2023-08-13 |
Not clear |
| Taylor J Fiolek, Katarina L Keel, Jetze J Tep. Fluspirilene Analogs Activate the 20S Proteasome and Overcome Proteasome Impairment by Intrinsically Disordered Protein Oligomers. ACS chemical neuroscience. vol 12. issue 8. 2021-06-18. PMID:33788542. |
oligomerization of aggregation-prone intrinsically disordered proteins (idps), such as α-synuclein, amyloid β, and tau, has been shown to be associated with the pathogenesis of several neurodegenerative diseases, including parkinson's and alzheimer's disease. |
2021-06-18 |
2023-08-13 |
Not clear |
| Segev Naveh Tassa, Shani Ben Zichri, Shiran Lacham-Hartman, Ofek Oren, Zeev Slobodnik, Ekaterina Eremenko, Debra Toiber, Raz Jelinek, Niv Pap. A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells. ACS chemical neuroscience. vol 12. issue 9. 2021-06-18. PMID:33904703. |
it is currently believed that molecular agents that specifically bind to and neutralize the toxic proteins/peptides, amyloid β (aβ42), tau, and the tau-derived peptide phf6, hold the key to attenuating the progression of alzheimer's disease (ad). |
2021-06-18 |
2023-08-13 |
Not clear |
| Tiago Mendes, Adrien Herledan, Florence Leroux, Benoit Deprez, Jean-Charles Lambert, Devrim Kilin. High-Content Screening for Protein-Protein Interaction Modulators Using Proximity Ligation Assay in Primary Neurons. Current protocols in cell biology. vol 86. issue 1. 2021-06-17. PMID:31876395. |
we recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds using a pla between tau and bridging integrator 1, a genetic risk factor for alzheimer's disease. |
2021-06-17 |
2023-08-13 |
rat |
| Sunil Kumar Vimal, Hua Zuo, Zhengwu Wang, Hongrun Wang, Zhiliang Long, Sanjib Bhattacharyy. Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 16. 2021-06-17. PMID:32191383. |
self-therapeutic nanoparticle that alters tau protein and ameliorates tauopathy toward a functional nanomedicine to tackle alzheimer's. |
2021-06-17 |
2023-08-13 |
mouse |
| Sunil Kumar Vimal, Hua Zuo, Zhengwu Wang, Hongrun Wang, Zhiliang Long, Sanjib Bhattacharyy. Self-Therapeutic Nanoparticle That Alters Tau Protein and Ameliorates Tauopathy Toward a Functional Nanomedicine to Tackle Alzheimer's. Small (Weinheim an der Bergstrasse, Germany). vol 16. issue 16. 2021-06-17. PMID:32191383. |
similarly, a high level of tau is found in macaque monkey serum and au-peg inhibits amyloidosis of alzheimer's patients and primate's serum samples ex vivo. |
2021-06-17 |
2023-08-13 |
mouse |
| Noemi Esteras, Franziska Kundel, Giuseppe F Amodeo, Evgeny V Pavlov, David Klenerman, Andrey Y Abramo. Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase. The FEBS journal. vol 288. issue 1. 2021-06-17. PMID:32338825. |
one of these proteins, tau, is involved in a number of pathologies including alzheimer's disease and frontotemporal dementia. |
2021-06-17 |
2023-08-13 |
Not clear |
| Tyler C Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K Crane, Fanny Elahi, David A Ziegler, Gongbo Liang, Qiang Cheng, Lucille M Yanckello, Nathan Jacobs, Ai-Ling Li. β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline. Communications biology. vol 3. issue 1. 2021-06-17. PMID:32632135. |
β-amyloid and tau drive early alzheimer's disease decline while glucose hypometabolism drives late decline. |
2021-06-17 |
2023-08-13 |
human |