Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Hoda Nikookar, Mohammad Haddadi, Mehrnaz Haghi, Raheleh Masoud. DNT1 Downregulation and Increased Ethanol Sensitivity in Transgenic Drosophila Models of Alzheimer's Disease. Archives of gerontology and geriatrics. vol 94. 2021-05-18. PMID:33550108. |
two major pathological hallmarks of alzheimer's disease (ad) are amyloid plaques and neurofibrillary tangles of hyperphosphorylated tau. |
2021-05-18 |
2023-08-13 |
drosophila_melanogaster |
Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. |
the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. |
2021-05-18 |
2023-08-13 |
mouse |
Eugene Bok, Eunju Leem, Bo-Ram Lee, Ji Min Lee, Chang Jae Yoo, Eun Mi Lee, Jaekwang Ki. Role of the Lipid Membrane and Membrane Proteins in Tau Pathology. Frontiers in cell and developmental biology. vol 9. 2021-05-18. PMID:33996814. |
abnormal accumulation of misfolded tau aggregates is a pathological hallmark of various tauopathies including alzheimer's disease (ad). |
2021-05-18 |
2023-08-13 |
Not clear |
Manon Thierry, Susana Boluda, Benoît Delatour, Serge Marty, Danielle Seilhean, Marie-Claude Potier, Charles Duyckaert. Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31822997. |
human subiculo-fornico-mamillary system in alzheimer's disease: tau seeding by the pillar of the fornix. |
2021-05-17 |
2023-08-13 |
human |
Manon Thierry, Susana Boluda, Benoît Delatour, Serge Marty, Danielle Seilhean, Marie-Claude Potier, Charles Duyckaert. Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31822997. |
in alzheimer's disease (ad), tau and aβ aggregates involve sequentially connected regions, sometimes distantly separated. |
2021-05-17 |
2023-08-13 |
human |
Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C Hall, Lai Ding, Alexandra DeSousa, Matthew P Frosch, John Collinge, David A Harris, Michael S Perkinton, Tara L Spires-Jones, Tracy L Young-Pearse, Andrew Billinton, Dominic M Wals. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31853635. |
using an all-human experimental paradigm involving: (1) isogenic ipsc-derived neurons expressing or lacking prnp, and (2) aqueous extracts from brains of individuals who died with alzheimer's disease, dementia with lewy bodies, and pick's disease, we demonstrate that aβ, α-synuclein and tau are toxic to neurons in a manner that requires prp |
2021-05-17 |
2023-08-13 |
mouse |
Md Sahab Uddin, Abdullah Al Mamun, Md Ataur Rahman, Tapan Behl, Asma Perveen, Abdul Hafeez, May N Bin-Jumah, Mohamed M Abdel-Daim, Ghulam Md Ashra. Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease. Current topics in medicinal chemistry. vol 20. issue 26. 2021-05-17. PMID:32479244. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder, characterized by the extracellular accumulations of amyloid beta (aβ) as senile plaques and intracellular aggregations of tau in the form of neurofibrillary tangles (nfts) in specific brain regions. |
2021-05-17 |
2023-08-13 |
Not clear |
Aonan Zhao, Yuanyuan Li, Yulei Den. TNF receptors are associated with tau pathology and conversion to Alzheimer's dementia in subjects with mild cognitive impairment. Neuroscience letters. vol 738. 2021-05-17. PMID:32947003. |
tnf receptors are associated with tau pathology and conversion to alzheimer's dementia in subjects with mild cognitive impairment. |
2021-05-17 |
2023-08-13 |
human |
Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Y. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:30382187. |
δ-secretase-cleaved tau stimulates aβ production via upregulating stat1-bace1 signaling in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Y. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:30382187. |
δ-secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (app) and tau and is required for amyloid plaque and neurofibrillary tangle pathologies in alzheimer's disease (ad). |
2021-05-14 |
2023-08-13 |
Not clear |
Heidi I L Jacobs, Joost M Riphagen, Inez H G B Ramakers, Frans R J Verhe. Alzheimer's disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31138892. |
the locus coeruleus (lc) supplies norepinephrine to the brain, is one of the first sites of tau deposition in alzheimer's disease (ad) and modulates a variety of behaviors and cognitive functions. |
2021-05-14 |
2023-08-13 |
mouse |
Stella M Sánchez, Bárbara Duarte-Abritta, Carolina Abulafia, Gabriela De Pino, Hernan Bocaccio, Mariana N Castro, Gustavo E Sevlever, Greg A Fonzo, Charles B Nemeroff, Deborah R Gustafson, Salvador M Guinjoan, Mirta F Villarrea. White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease. Journal of psychiatric research. vol 122. 2021-05-14. PMID:31931231. |
tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset alzheimer's disease (load). |
2021-05-14 |
2023-08-13 |
human |
Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-An Wei, Jie Li. Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials. vol 237. 2021-05-14. PMID:32035322. |
intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of alzheimer's disease. |
2021-05-14 |
2023-08-13 |
mouse |
Georgia Watt, Magdalena Przybyla, Valeria Zak, Janet van Eersel, Arne Ittner, Lars M Ittner, Tim Kar. Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice - A Model for Tauopathy. Neuroscience. vol 431. 2021-05-14. PMID:32058066. |
alzheimer's disease (ad) is a neurodegenerative disease characterised by progressive cognitive decline and the accumulation of two hallmark proteins, amyloid-beta (aβ) and tau. |
2021-05-14 |
2023-08-13 |
mouse |
Lata Rani, Jeetain Mittal, Sairam S Mallajosyul. Effect of Phosphorylation and O-GlcNAcylation on Proline-Rich Domains of Tau. The journal of physical chemistry. B. vol 124. issue 10. 2021-05-14. PMID:32065850. |
aggregation of tau is the leading cause of tauopathies such as alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
Ling-Qi Ye, Xiao-Yan Li, Yan-Bin Zhang, Hong-Rong Cheng, Yin Ma, Dian-Fu Chen, Qing-Qing Tao, Hong-Lei Li, Zhi-Ying W. The discriminative capacity of CSF β-amyloid 42 and Tau in neurodegenerative diseases in the Chinese population. Journal of the neurological sciences. vol 412. 2021-05-14. PMID:32142967. |
in the past few years, the β-amyloid 42 peptide and tau protein in cerebrospinal fluid (csf) have become primary diagnostic biomarkers in differentiating alzheimer's disease (ad) and cognitive normal controls. |
2021-05-14 |
2023-08-13 |
Not clear |
Philippe Derreumaux, Viet Hoang Man, Junmei Wang, Phuong H Nguye. Tau R3-R4 Domain Dimer of the Wild Type and Phosphorylated Ser356 Sequences. I. In Solution by Atomistic Simulations. The journal of physical chemistry. B. vol 124. issue 15. 2021-05-14. PMID:32216358. |
in alzheimer's disease, neurofibrillary lesions correlate with cognitive deficits and consist of inclusions of tau protein with cross-β structure. |
2021-05-14 |
2023-08-13 |
Not clear |
Emma E Wolters, Rik Ossenkoppele, Sander C J Verfaillie, Emma M Coomans, Tessa Timmers, Denise Visser, Hayel Tuncel, Sandeep S V Golla, Albert D Windhorst, Ronald Boellaard, Wiesje M van der Flier, Charlotte E Teunissen, Philip Scheltens, Bart N M van Bercke. Regional [ European journal of nuclear medicine and molecular imaging. vol 47. issue 12. 2021-05-14. PMID:32291510. |
regional [ in vivo alzheimer's disease (ad) biomarkers for tau pathology are cerebrospinal fluid (csf) phosphorylated tau (p-tau) and [ |
2021-05-14 |
2023-08-13 |
Not clear |
Jonas Elias Schweig, Hailan Yao, Chao Jin, Fiona Crawford, Michael Mullan, Daniel Pari. Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures. Neuroscience letters. vol 729. 2021-05-14. PMID:32334108. |
we have previously shown that syk is overactive in the brains of human alzheimer's disease (ad) patients, as well as mouse models of ad and tauopathy including tg tau p301s mice. |
2021-05-14 |
2023-08-13 |
mouse |
Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
post-translational modification of tau, a microtubule-associated protein in the neuronal cell, plays a major role in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |