| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Linnea Ransom, Janneca Ames, Gloria Shen, Christopher B Lietz, Zhenze Jiang, Anthony J O'Donoghue, Charisse Winston, Tsuneya Ikezu, Robert A Rissman, Shauna Yuan, Vivian Hoo. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & cellular proteomics : MCP. vol 19. issue 6. 2021-06-03. PMID:32295833. |
accumulation and propagation of hyperphosphorylated tau (p-tau) is a common neuropathological hallmark associated with neurodegeneration of alzheimer's disease (ad), frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), and related tauopathies. |
2021-06-03 |
2023-08-13 |
mouse |
| Satoshi Muraoka, Annina M DeLeo, Manveen K Sethi, Kayo Yukawa-Takamatsu, Zijian Yang, Jina Ko, John D Hogan, Zhi Ruan, Yang You, Yuzhi Wang, Maria Medalla, Seiko Ikezu, Mei Chen, Weiming Xia, Santhi Gorantla, Howard E Gendelman, David Issadore, Joseph Zaia, Tsuneya Ikez. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 6. 2021-06-03. PMID:32301581. |
extracellular vesicles (evs) from human alzheimer's disease (ad) biospecimens contain amyloid beta (aβ) peptide and tau. |
2021-06-03 |
2023-08-13 |
human |
| Robin de Flores, Laura E M Wisse, Sandhitsu R Das, Long Xie, Corey T McMillan, John Q Trojanowski, John L Robinson, Murray Grossman, Edward Lee, David J Irwin, Paul A Yushkevich, David A Wol. Contribution of mixed pathology to medial temporal lobe atrophy in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 16. issue 6. 2021-06-03. PMID:32323446. |
it is unclear how different proteinopathies (tau, transactive response dna-binding protein 43 [tdp-43], amyloid β [aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (mtl) subregions in alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| Maricarmen Hernández-Rodríguez, Ivonne Maciel Arciniega-Martínez, Iohanan Daniel García-Marín, José Correa-Basurto, Martha Cecilia Rosales-Hernánde. Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats. Molecular neurobiology. vol 57. issue 9. 2021-06-03. PMID:32638218. |
the increase of amyloid beta (aβ) release and hyperphosphorylation of tau protein represents the main events related to alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
mouse |
| Laura Gil, Sandra A Niño, Gabriela Capdeville, María E Jiménez-Capdevill. Aging and Alzheimer's disease connection: Nuclear Tau and lamin A. Neuroscience letters. vol 749. 2021-06-03. PMID:33610669. |
aging and alzheimer's disease connection: nuclear tau and lamin a. age-related pathologies like alzheimer`s disease (ad) imply cellular responses directed towards repairing dna damage. |
2021-06-03 |
2023-08-13 |
Not clear |
| Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Giovanni B Frisoni, Valentina Garibotto, Benjamin B Tournie. Learning from the Past: A Review of Clinical Trials Targeting Amyloid, Tau and Neuroinflammation in Alzheimer's Disease. Current Alzheimer research. vol 17. issue 2. 2021-06-02. PMID:32129164. |
learning from the past: a review of clinical trials targeting amyloid, tau and neuroinflammation in alzheimer's disease. |
2021-06-02 |
2023-08-13 |
Not clear |
| Mithun Singh Rajput, Nilesh Prakash Nirmal, Devashish Rathore, Rashmi Dahim. Dimethyl Fumarate Mitigates Tauopathy in Aβ-Induced Neuroblastoma SH-SY5Y Cells. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32816241. |
alzheimer's disease pathogenesis is measured by two key hallmarks viz extracellular senile plaques composed of insoluble amyloid beta (aβ) and neurofibrillary tangles composed of hyperphosphorylated tau, resulting in microtubule destabilization, synaptic damage and neurodegeneration. |
2021-06-02 |
2023-08-13 |
Not clear |
| Sreeja Lakshmi, Musthafa Mohamed Essa, Richard E Hartman, Gilles J Guillemin, Sureshkumar Sivan, Preetham Elumala. Exosomes in Alzheimer's Disease: Potential Role as Pathological Mediators, Biomarkers and Therapeutic Targets. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32840760. |
while underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of alzheimer's disease (ad), the most prevailing multifactorial neurodegenerative disorder. |
2021-06-02 |
2023-08-13 |
Not clear |
| Yidan Zhang, Yuan Zhao, Jian Zhang, Guofeng Yan. Mechanisms of NLRP3 Inflammasome Activation: Its Role in the Treatment of Alzheimer's Disease. Neurochemical research. vol 45. issue 11. 2021-06-02. PMID:32929691. |
alzheimer's disease (ad) is a common neurodegenerative disease of progressive dementia which is characterized pathologically by extracellular neuritic plaques containing aggregated amyloid beta (aβ) and intracellular hyperphosphorylated tau protein tangles in cerebrum. |
2021-06-02 |
2023-08-13 |
mouse |
| Elena Britti, Joaquim Ros, Noemi Esteras, Andrey Y Abramo. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. Cell calcium. vol 86. 2021-06-01. PMID:31918031. |
aggregation or phosphorylation of the microtubule-associated protein tau is the pathological hallmark in a number of diseases termed tauopathies, which include the most common neurodegenerative disorder, alzheimer's disease; or frontotemporal dementia, linked to mutations in the gene mapt encoding tau. |
2021-06-01 |
2023-08-13 |
Not clear |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Jian Li, Tammie L S Benzinger, Jie Lu, Yun Zho. Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease. Theranostics. vol 10. issue 23. 2021-06-01. PMID:32929366. |
association of sex and apoe ε4 with brain tau deposition and atrophy in older adults with alzheimer's disease. |
2021-06-01 |
2023-08-13 |
Not clear |
| Shaozhen Yan, Chaojie Zheng, Manish D Paranjpe, Jian Li, Tammie L S Benzinger, Jie Lu, Yun Zho. Association of sex and APOE ε4 with brain tau deposition and atrophy in older adults with Alzheimer's disease. Theranostics. vol 10. issue 23. 2021-06-01. PMID:32929366. |
the objective of this study was to assess the association of sex and the apolipoprotein e (apoe) ε4 allele with brain tau deposition and atrophy in older adults with alzheimer's disease (ad) using quantitative |
2021-06-01 |
2023-08-13 |
Not clear |
| Ruozhen Wu, Longfei Li, Ruirui Shi, Yan Zhou, Nana Jin, Jianlan Gu, Yunn Chyn Tung, Fei Liu, Dandan Ch. Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer's Brain. Frontiers in molecular neuroscience. vol 14. 2021-06-01. PMID:34054426. |
dephosphorylation passivates the seeding activity of oligomeric tau derived from alzheimer's brain. |
2021-06-01 |
2023-08-13 |
Not clear |
| Ruozhen Wu, Longfei Li, Ruirui Shi, Yan Zhou, Nana Jin, Jianlan Gu, Yunn Chyn Tung, Fei Liu, Dandan Ch. Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer's Brain. Frontiers in molecular neuroscience. vol 14. 2021-06-01. PMID:34054426. |
accumulation of intracellular neurofibrillary tangles (nfts), which are constituted of abnormally phosphorylated tau, is one of the neuropathological hallmarks of alzheimer's disease (ad). |
2021-06-01 |
2023-08-13 |
Not clear |
| Hiroyuki Watanabe, Takeaki Kishimoto, Sho Kaide, Yuta Tarumizu, Haruka Tatsumi, Shimpei Iikuni, Masahiro On. Characterization and Optimization of Benzimidazopyrimidine and Pyridoimidazopyridine Derivatives as Tau-SPECT Probes. ACS medicinal chemistry letters. vol 12. issue 5. 2021-06-01. PMID:34055229. |
the accumulation of hyperphosphorylated tau protein in the brain is regarded as one of the hallmarks of alzheimer's disease (ad). |
2021-06-01 |
2023-08-13 |
Not clear |
| Nalini V Gorantla, Lisni P Sunny, Kolla Rajasekhar, Pramod G Nagaraju, Poornima Priyadarshini Cg, Thimmaiah Govindaraju, Subashchandrabose Chinnathamb. Amyloid-β-Derived Peptidomimetics Inhibits Tau Aggregation. ACS omega. vol 6. issue 17. 2021-06-01. PMID:34056268. |
the aggregation of tau protein is one of the hallmarks for alzheimer's disease, resulting in neurodegeneration. |
2021-06-01 |
2023-08-13 |
Not clear |
| Sonia Podvin, Alexander Jones, Qing Liu, Brent Aulston, Charles Mosier, Janneca Ames, Charisse Winston, Christopher B Lietz, Zhenze Jiang, Anthony J O'Donoghue, Tsuneya Ikezu, Robert A Rissman, Shauna H Yuan, Vivian Hoo. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. ACS omega. vol 6. issue 20. 2021-06-01. PMID:34056454. |
the accumulation and propagation of hyperphosphorylated tau (p-tau) is a neuropathological hallmark occurring with neurodegeneration of alzheimer's disease (ad). |
2021-06-01 |
2023-08-13 |
mouse |
| Nicolai Franzmeier, Rik Ossenkoppele, Matthias Brendel, Anna Rubinski, Ruben Smith, Atul Kumar, Niklas Mattsson-Carlgren, Olof Strandberg, Marco Duering, Katharina Buerger, Martin Dichgans, Oskar Hansson, Michael Ewer. The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-06-01. PMID:34060233. |
the bin1 rs744373 alzheimer's disease risk snp is associated with faster aβ-associated tau accumulation and cognitive decline. |
2021-06-01 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Rik Ossenkoppele, Matthias Brendel, Anna Rubinski, Ruben Smith, Atul Kumar, Niklas Mattsson-Carlgren, Olof Strandberg, Marco Duering, Katharina Buerger, Martin Dichgans, Oskar Hansson, Michael Ewer. The BIN1 rs744373 Alzheimer's disease risk SNP is associated with faster Aβ-associated tau accumulation and cognitive decline. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-06-01. PMID:34060233. |
the bin1 rs744373 single nucleotide polymorphism (snp) is a key genetic risk locus for alzheimer's disease (ad) associated with tau pathology. |
2021-06-01 |
2023-08-13 |
Not clear |
| Guanghao Liu, Kimberly L Fiock, Yona Levites, Todd E Golde, Marco M Hefti, Gloria Le. Fyn depletion ameliorates tau Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32665013. |
fyn depletion ameliorates tau the src family non-receptor tyrosine kinase fyn has been implicated in neurodegeneration of alzheimer's disease through interaction with amyloid β (aβ). |
2021-05-31 |
2023-08-13 |
Not clear |