| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emanuele Gabellieri, Francesca Capotosti, Jerome Molette, Nampally Sreenivasachary, Andre Mueller, Mathias Berndt, Hanno Schieferstein, Tanja Juergens, Yvan Varisco, Felix Oden, Heribert Schmitt-Willich, David Hickman, Ludger Dinkelborg, Andrew Stephens, Andrea Pfeifer, Heiko Krot. Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies. European journal of medicinal chemistry. vol 204. 2021-05-21. PMID:32771872. |
discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9h-pyrrolo[2,3-b:4,5-c']dipyridine ([18f]pi-2014) as pet tracer for the detection of pathological aggregated tau in alzheimer's disease and other tauopathies. |
2021-05-21 |
2023-08-13 |
mouse |
| Emanuele Gabellieri, Francesca Capotosti, Jerome Molette, Nampally Sreenivasachary, Andre Mueller, Mathias Berndt, Hanno Schieferstein, Tanja Juergens, Yvan Varisco, Felix Oden, Heribert Schmitt-Willich, David Hickman, Ludger Dinkelborg, Andrew Stephens, Andrea Pfeifer, Heiko Krot. Discovery of 2-(4-(2-fluoroethoxy)piperidin-1-yl)-9-methyl-9H-pyrrolo[2,3-b:4,5-c']dipyridine ([18F]PI-2014) as PET tracer for the detection of pathological aggregated tau in Alzheimer's disease and other tauopathies. European journal of medicinal chemistry. vol 204. 2021-05-21. PMID:32771872. |
the compound screening was initiated with a direct staining assay to identify compounds binding to tau aggregates and not abeta plaques using human brain sections derived from late stage alzheimer's disease donors. |
2021-05-21 |
2023-08-13 |
mouse |
| Churaibhon Wisessaowapak, Daranee Visitnonthachai, Piyajit Watcharasit, Jutamaad Satayaviva. Prolonged arsenic exposure increases tau phosphorylation in differentiated SH-SY5Y cells: The contribution of GSK3 and ERK1/2. Environmental toxicology and pharmacology. vol 84. 2021-05-19. PMID:33621689. |
arsenic is a metalloid that has been hypothesized to be an environmental risk factor for alzheimer's disease (ad), a disease having hyperphosphorylated tau aggregate as a marker. |
2021-05-19 |
2023-08-13 |
human |
| Siranjeevi Nagaraj, Andrew Want, Katarzyna Laskowska-Kaszub, Aleksandra Fesiuk, Sara Vaz, Elsa Logarinho, Urszula Wojd. Candidate Alzheimer's Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression. International journal of molecular sciences. vol 22. issue 7. 2021-05-19. PMID:33915734. |
candidate alzheimer's disease biomarker mir-483-5p lowers tau phosphorylation by direct erk1/2 repression. |
2021-05-19 |
2023-08-13 |
Not clear |
| Huiming Zhang, Xiaojuan Wang, Pu Xu, Xuefei Ji, Tianyan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models. The journal of physiological sciences : JPS. vol 70. issue 1. 2021-05-18. PMID:32517647. |
tolfenamic acid inhibits gsk-3β and pp2a mediated tau hyperphosphorylation in alzheimer's disease models. |
2021-05-18 |
2023-08-13 |
mouse |
| Huiming Zhang, Xiaojuan Wang, Pu Xu, Xuefei Ji, Tianyan Chi, Peng Liu, Libo Zo. Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models. The journal of physiological sciences : JPS. vol 70. issue 1. 2021-05-18. PMID:32517647. |
tolfenamic acid, a nonsteroidal anti-inflammatory drug, alleviated learning and memory deficits and decreased the expression of specificity protein 1 (sp1)-mediated cyclin-dependent kinase-5 (cdk5), a major protein kinase that regulates hyperphosphorylated tau, in alzheimer's disease (ad) transgenic mice. |
2021-05-18 |
2023-08-13 |
mouse |
| Hendrik Wesseling, Waltraud Mair, Mukesh Kumar, Christoph N Schlaffner, Shaojun Tang, Pieter Beerepoot, Benoit Fatou, Amanda J Guise, Long Cheng, Shuko Takeda, Jan Muntel, Melissa S Rotunno, Simon Dujardin, Peter Davies, Kenneth S Kosik, Bruce L Miller, Sabina Berretta, John C Hedreen, Lea T Grinberg, William W Seeley, Bradley T Hyman, Hanno Steen, Judith A Stee. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. vol 183. issue 6. 2021-05-18. PMID:33188775. |
tau ptm profiles identify patient heterogeneity and stages of alzheimer's disease. |
2021-05-18 |
2023-08-13 |
human |
| Hendrik Wesseling, Waltraud Mair, Mukesh Kumar, Christoph N Schlaffner, Shaojun Tang, Pieter Beerepoot, Benoit Fatou, Amanda J Guise, Long Cheng, Shuko Takeda, Jan Muntel, Melissa S Rotunno, Simon Dujardin, Peter Davies, Kenneth S Kosik, Bruce L Miller, Sabina Berretta, John C Hedreen, Lea T Grinberg, William W Seeley, Bradley T Hyman, Hanno Steen, Judith A Stee. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. vol 183. issue 6. 2021-05-18. PMID:33188775. |
to elucidate the role of tau isoforms and post-translational modification (ptm) stoichiometry in alzheimer's disease (ad), we generated a high-resolution quantitative proteomics map of 95 ptms on multiple isoforms of tau isolated from postmortem human tissue from 49 ad and 42 control subjects. |
2021-05-18 |
2023-08-13 |
human |
| Hoda Nikookar, Mohammad Haddadi, Mehrnaz Haghi, Raheleh Masoud. DNT1 Downregulation and Increased Ethanol Sensitivity in Transgenic Drosophila Models of Alzheimer's Disease. Archives of gerontology and geriatrics. vol 94. 2021-05-18. PMID:33550108. |
two major pathological hallmarks of alzheimer's disease (ad) are amyloid plaques and neurofibrillary tangles of hyperphosphorylated tau. |
2021-05-18 |
2023-08-13 |
drosophila_melanogaster |
| Paola C Bello-Medina, Fernando Hernández-Quiroz, Marcel Pérez-Morales, Diego A González-Franco, Guadalupe Cruz-Pauseno, Jaime García-Mena, Sofía Díaz-Cintra, Gustavo Pacheco-Lópe. Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. Frontiers in neuroscience. vol 15. 2021-05-18. PMID:33994914. |
the irreversible and progressive neurodegenerative alzheimer's disease (ad) is characterized by cognitive decline, extracellular β-amyloid peptide accumulation, and tau neurofibrillary tangles in the cortex and hippocampus. |
2021-05-18 |
2023-08-13 |
mouse |
| Eugene Bok, Eunju Leem, Bo-Ram Lee, Ji Min Lee, Chang Jae Yoo, Eun Mi Lee, Jaekwang Ki. Role of the Lipid Membrane and Membrane Proteins in Tau Pathology. Frontiers in cell and developmental biology. vol 9. 2021-05-18. PMID:33996814. |
abnormal accumulation of misfolded tau aggregates is a pathological hallmark of various tauopathies including alzheimer's disease (ad). |
2021-05-18 |
2023-08-13 |
Not clear |
| Manon Thierry, Susana Boluda, Benoît Delatour, Serge Marty, Danielle Seilhean, Marie-Claude Potier, Charles Duyckaert. Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31822997. |
human subiculo-fornico-mamillary system in alzheimer's disease: tau seeding by the pillar of the fornix. |
2021-05-17 |
2023-08-13 |
human |
| Manon Thierry, Susana Boluda, Benoît Delatour, Serge Marty, Danielle Seilhean, Marie-Claude Potier, Charles Duyckaert. Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31822997. |
in alzheimer's disease (ad), tau and aβ aggregates involve sequentially connected regions, sometimes distantly separated. |
2021-05-17 |
2023-08-13 |
human |
| Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C Hall, Lai Ding, Alexandra DeSousa, Matthew P Frosch, John Collinge, David A Harris, Michael S Perkinton, Tara L Spires-Jones, Tracy L Young-Pearse, Andrew Billinton, Dominic M Wals. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta neuropathologica. vol 139. issue 3. 2021-05-17. PMID:31853635. |
using an all-human experimental paradigm involving: (1) isogenic ipsc-derived neurons expressing or lacking prnp, and (2) aqueous extracts from brains of individuals who died with alzheimer's disease, dementia with lewy bodies, and pick's disease, we demonstrate that aβ, α-synuclein and tau are toxic to neurons in a manner that requires prp |
2021-05-17 |
2023-08-13 |
mouse |
| Md Sahab Uddin, Abdullah Al Mamun, Md Ataur Rahman, Tapan Behl, Asma Perveen, Abdul Hafeez, May N Bin-Jumah, Mohamed M Abdel-Daim, Ghulam Md Ashra. Emerging Proof of Protein Misfolding and Interactions in Multifactorial Alzheimer's Disease. Current topics in medicinal chemistry. vol 20. issue 26. 2021-05-17. PMID:32479244. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder, characterized by the extracellular accumulations of amyloid beta (aβ) as senile plaques and intracellular aggregations of tau in the form of neurofibrillary tangles (nfts) in specific brain regions. |
2021-05-17 |
2023-08-13 |
Not clear |
| Aonan Zhao, Yuanyuan Li, Yulei Den. TNF receptors are associated with tau pathology and conversion to Alzheimer's dementia in subjects with mild cognitive impairment. Neuroscience letters. vol 738. 2021-05-17. PMID:32947003. |
tnf receptors are associated with tau pathology and conversion to alzheimer's dementia in subjects with mild cognitive impairment. |
2021-05-17 |
2023-08-13 |
human |
| Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Y. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:30382187. |
δ-secretase-cleaved tau stimulates aβ production via upregulating stat1-bace1 signaling in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Zhentao Zhang, Xiao-Guang Li, Zhi-Hao Wang, Mingke Song, Shan Ping Yu, Seong Su Kang, Xia Liu, Zhaohui Zhang, Manling Xie, Gong-Ping Liu, Jian-Zhi Wang, Keqiang Y. δ-Secretase-cleaved Tau stimulates Aβ production via upregulating STAT1-BACE1 signaling in Alzheimer's disease. Molecular psychiatry. vol 26. issue 2. 2021-05-14. PMID:30382187. |
δ-secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (app) and tau and is required for amyloid plaque and neurofibrillary tangle pathologies in alzheimer's disease (ad). |
2021-05-14 |
2023-08-13 |
Not clear |
| Heidi I L Jacobs, Joost M Riphagen, Inez H G B Ramakers, Frans R J Verhe. Alzheimer's disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms. Molecular psychiatry. vol 26. issue 3. 2021-05-14. PMID:31138892. |
the locus coeruleus (lc) supplies norepinephrine to the brain, is one of the first sites of tau deposition in alzheimer's disease (ad) and modulates a variety of behaviors and cognitive functions. |
2021-05-14 |
2023-08-13 |
mouse |
| Stella M Sánchez, Bárbara Duarte-Abritta, Carolina Abulafia, Gabriela De Pino, Hernan Bocaccio, Mariana N Castro, Gustavo E Sevlever, Greg A Fonzo, Charles B Nemeroff, Deborah R Gustafson, Salvador M Guinjoan, Mirta F Villarrea. White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease. Journal of psychiatric research. vol 122. 2021-05-14. PMID:31931231. |
tau accumulation affecting white matter tracts is an early neuropathological feature of late-onset alzheimer's disease (load). |
2021-05-14 |
2023-08-13 |
human |