| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hui Zhou, Youcong Gong, Yanan Liu, Anlian Huang, Xufeng Zhu, Jiawei Liu, Guanglong Yuan, Li Zhang, Ji-An Wei, Jie Li. Intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of Alzheimer's disease. Biomaterials. vol 237. 2021-05-14. PMID:32035322. |
intelligently thermoresponsive flower-like hollow nano-ruthenium system for sustained release of nerve growth factor to inhibit hyperphosphorylation of tau and neuronal damage for the treatment of alzheimer's disease. |
2021-05-14 |
2023-08-13 |
mouse |
| Georgia Watt, Magdalena Przybyla, Valeria Zak, Janet van Eersel, Arne Ittner, Lars M Ittner, Tim Kar. Novel Behavioural Characteristics of Male Human P301S Mutant Tau Transgenic Mice - A Model for Tauopathy. Neuroscience. vol 431. 2021-05-14. PMID:32058066. |
alzheimer's disease (ad) is a neurodegenerative disease characterised by progressive cognitive decline and the accumulation of two hallmark proteins, amyloid-beta (aβ) and tau. |
2021-05-14 |
2023-08-13 |
mouse |
| Lata Rani, Jeetain Mittal, Sairam S Mallajosyul. Effect of Phosphorylation and O-GlcNAcylation on Proline-Rich Domains of Tau. The journal of physical chemistry. B. vol 124. issue 10. 2021-05-14. PMID:32065850. |
aggregation of tau is the leading cause of tauopathies such as alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Ling-Qi Ye, Xiao-Yan Li, Yan-Bin Zhang, Hong-Rong Cheng, Yin Ma, Dian-Fu Chen, Qing-Qing Tao, Hong-Lei Li, Zhi-Ying W. The discriminative capacity of CSF β-amyloid 42 and Tau in neurodegenerative diseases in the Chinese population. Journal of the neurological sciences. vol 412. 2021-05-14. PMID:32142967. |
in the past few years, the β-amyloid 42 peptide and tau protein in cerebrospinal fluid (csf) have become primary diagnostic biomarkers in differentiating alzheimer's disease (ad) and cognitive normal controls. |
2021-05-14 |
2023-08-13 |
Not clear |
| Philippe Derreumaux, Viet Hoang Man, Junmei Wang, Phuong H Nguye. Tau R3-R4 Domain Dimer of the Wild Type and Phosphorylated Ser356 Sequences. I. In Solution by Atomistic Simulations. The journal of physical chemistry. B. vol 124. issue 15. 2021-05-14. PMID:32216358. |
in alzheimer's disease, neurofibrillary lesions correlate with cognitive deficits and consist of inclusions of tau protein with cross-β structure. |
2021-05-14 |
2023-08-13 |
Not clear |
| Emma E Wolters, Rik Ossenkoppele, Sander C J Verfaillie, Emma M Coomans, Tessa Timmers, Denise Visser, Hayel Tuncel, Sandeep S V Golla, Albert D Windhorst, Ronald Boellaard, Wiesje M van der Flier, Charlotte E Teunissen, Philip Scheltens, Bart N M van Bercke. Regional [ European journal of nuclear medicine and molecular imaging. vol 47. issue 12. 2021-05-14. PMID:32291510. |
regional [ in vivo alzheimer's disease (ad) biomarkers for tau pathology are cerebrospinal fluid (csf) phosphorylated tau (p-tau) and [ |
2021-05-14 |
2023-08-13 |
Not clear |
| Jonas Elias Schweig, Hailan Yao, Chao Jin, Fiona Crawford, Michael Mullan, Daniel Pari. Neuronal Spleen tyrosine kinase (SYK) mediates cytokine release in Transgenic Tau P301S mice organotypic brain slice cultures. Neuroscience letters. vol 729. 2021-05-14. PMID:32334108. |
we have previously shown that syk is overactive in the brains of human alzheimer's disease (ad) patients, as well as mouse models of ad and tauopathy including tg tau p301s mice. |
2021-05-14 |
2023-08-13 |
mouse |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
post-translational modification of tau, a microtubule-associated protein in the neuronal cell, plays a major role in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
in alzheimer's disease, gpcrs are involved in phosphorylation of tau through various downstream kinases such as gsk-3β, cdk-5 and erks signalling cascade. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hariharakrishnan Chidambaram, Subashchandrabose Chinnathamb. G-Protein Coupled Receptors and Tau-different Roles in Alzheimer's Disease. Neuroscience. vol 438. 2021-05-14. PMID:32335218. |
specific agonists/antagonists and allosteric modulators could be the potential target for therapy against gpcr-mediated tau phosphorylation in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 47. issue 12. 2021-05-14. PMID:32350558. |
temporal trajectories of in vivo tau and amyloid-β accumulation in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Yong Choi, Jae Hoon Lee, Young Hoon Ryu, Myung Sik Lee, Chul Hyoung Lyo. Temporal trajectories of in vivo tau and amyloid-β accumulation in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 47. issue 12. 2021-05-14. PMID:32350558. |
to investigate the temporal trajectories of tau and amyloid-β (aβ) accumulation in alzheimer's disease (ad) by using the longitudinal positron emission tomography (pet) study. |
2021-05-14 |
2023-08-13 |
Not clear |
| Hector Rosas-Hernandez, Elvis Cuevas, James B Raymick, Bonnie L Robinson, Sumit Sarka. Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer's Disease. Neuroscience. vol 440. 2021-05-14. PMID:32450297. |
alzheimer's disease (ad) pathology is characterized by amyloid plaques containing amyloid beta (aβ) peptides, neurofibrillary tangles containing hyperphosphorylated tau protein, and neuronal loss. |
2021-05-14 |
2023-08-13 |
mouse |
| Denise Visser, Emma E Wolters, Sander C J Verfaillie, Emma M Coomans, Tessa Timmers, Hayel Tuncel, Juhan Reimand, Ronald Boellaard, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Rik Ossenkoppele, Bart N M van Bercke. Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 47. issue 13. 2021-05-14. PMID:32462397. |
tau pathology and relative cerebral blood flow are independently associated with cognition in alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Denise Visser, Emma E Wolters, Sander C J Verfaillie, Emma M Coomans, Tessa Timmers, Hayel Tuncel, Juhan Reimand, Ronald Boellaard, Albert D Windhorst, Philip Scheltens, Wiesje M van der Flier, Rik Ossenkoppele, Bart N M van Bercke. Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease. European journal of nuclear medicine and molecular imaging. vol 47. issue 13. 2021-05-14. PMID:32462397. |
we aimed to investigate associations between tau pathology and relative cerebral blood flow (rcbf), and their relationship with cognition in alzheimer's disease (ad), by using a single dynamic [ |
2021-05-14 |
2023-08-13 |
Not clear |
| D Monteiro-Fernandes, N Sousa, O F X Almeida, I Sotiropoulo. Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain. Neuroscience. vol 454. 2021-05-14. PMID:32512138. |
these fluctuations in sex and adrenal steroid secretion may be relevant to age-related neurodegenerative disorders such as alzheimer's disease (ad) in which hyperphosphorylation of tau protein is a key pathological event. |
2021-05-14 |
2023-08-13 |
rat |
| Mark E Schmidt, Luc Janssens, Diederik Moechars, Frederik J R Rombouts, Maarten Timmers, Olivier Barret, Cristian C Constantinescu, Jennifer Madonia, David S Russell, Christine M Sandiego, Hartmuth Kol. Clinical evaluation of [ European journal of nuclear medicine and molecular imaging. vol 47. issue 13. 2021-05-14. PMID:32535652. |
clinical evaluation of [ the accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with alzheimer's disease (ad) being the most common. |
2021-05-14 |
2023-08-13 |
human |
| Claudia A Razzino, Verónica Serafín, Maria Gamella, María Pedrero, Ana Montero-Calle, Rodrigo Barderas, Miguel Calero, Anderson O Lobo, Paloma Yáñez-Sedeño, Susana Campuzano, José M Pingarró. An electrochemical immunosensor using gold nanoparticles-PAMAM-nanostructured screen-printed carbon electrodes for tau protein determination in plasma and brain tissues from Alzheimer patients. Biosensors & bioelectronics. vol 163. 2021-05-14. PMID:32568700. |
an electrochemical immunosensor using gold nanoparticles-pamam-nanostructured screen-printed carbon electrodes for tau protein determination in plasma and brain tissues from alzheimer patients. |
2021-05-14 |
2023-08-13 |
Not clear |
| Claudia A Razzino, Verónica Serafín, Maria Gamella, María Pedrero, Ana Montero-Calle, Rodrigo Barderas, Miguel Calero, Anderson O Lobo, Paloma Yáñez-Sedeño, Susana Campuzano, José M Pingarró. An electrochemical immunosensor using gold nanoparticles-PAMAM-nanostructured screen-printed carbon electrodes for tau protein determination in plasma and brain tissues from Alzheimer patients. Biosensors & bioelectronics. vol 163. 2021-05-14. PMID:32568700. |
this work reports a new sensitive strategy for the determination of tau protein, a hallmark of alzheimer's disease (ad), involving a sandwich immunoassay and amperometric detection at disposable screen-printed carbon electrodes (spces) modified with a gold nanoparticles-poly(amidoamine) (pamam) dendrimer nanocomposite (3d-au-pamam) covalently immobilized onto electrografted p-aminobenzoic acid (p-aba). |
2021-05-14 |
2023-08-13 |
Not clear |
| Chia-Lin Tsai, Chih-Sung Liang, Chun-Pai Yang, Jiunn-Tay Lee, Tsung-Han Ho, Ming-Wei Su, Guan-Yu Lin, Yu-Kai Lin, Hsuan-Te Chu, Yu-Wei Hsu, Fu-Chi Yan. Indicators of rapid cognitive decline in amnestic mild cognitive impairment: The role of plasma biomarkers using magnetically labeled immunoassays. Journal of psychiatric research. vol 129. 2021-05-14. PMID:32592947. |
plasma levels of biomarkers change with the progression of alzheimer's disease (ad), which involves the accumulation of pathological amyloid β (aβ) and tau protein tangles. |
2021-05-14 |
2023-08-13 |
human |