| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kaj Blenno. A Review of Fluid Biomarkers for Alzheimer's Disease: Moving from CSF to Blood. Neurology and therapy. vol 6. issue Suppl 1. 2021-04-21. PMID:28733960. |
a set of core cerebrospinal fluid (csf) biomarkers for alzheimer's disease (ad) includes total tau (t-tau), phosphorylated tau (p-tau) and β-amyloid 42 (aβ42). |
2021-04-21 |
2023-08-13 |
Not clear |
| Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Ju-Xian Song, Chuan-Bin Yang, Venkatapathy Kaliyamoorthy, Huan Zhang, Sravan G Sreenivasmurthy, Sandeep Malampati, Zi-Ying Wang, Zhou Zhu, Benjamin Chun-Kit Tong, King-Ho Cheung, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Min L. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. Journal of food and drug analysis. vol 28. issue 1. 2021-04-21. PMID:31883601. |
neurodefend, a novel chinese medicine, attenuates amyloid-β and tau pathology in experimental alzheimer's disease models. |
2021-04-21 |
2023-08-13 |
mouse |
| Hossein Ashrafian, Elaheh Hadi Zadeh, Rizwan Hasan Kha. Review on Alzheimer's disease: Inhibition of amyloid beta and tau tangle formation. International journal of biological macromolecules. vol 167. 2021-04-21. PMID:33278431. |
review on alzheimer's disease: inhibition of amyloid beta and tau tangle formation. |
2021-04-21 |
2023-08-13 |
Not clear |
| Inês Silva, Jéssica Silva, Rita Ferreira, Diogo Trig. Glymphatic system, AQP4, and their implications in Alzheimer's disease. Neurological research and practice. vol 3. issue 1. 2021-04-21. PMID:33499944. |
the clearance of alzheimer's associated proteins amyloid β and tau is diminished by glymphatic system impairment, due to lack of aqp4. |
2021-04-21 |
2023-08-13 |
Not clear |
| Giovanni Bellomo, Antonio Indaco, Davide Chiasserini, Emanuela Maderna, Federico Paolini Paoletti, Lorenzo Gaetani, Silvia Paciotti, Maya Petricciuolo, Fabrizio Tagliavini, Giorgio Giaccone, Lucilla Parnetti, Giuseppe Di Fed. Machine Learning Driven Profiling of Cerebrospinal Fluid Core Biomarkers in Alzheimer's Disease and Other Neurological Disorders. Frontiers in neuroscience. vol 15. 2021-04-21. PMID:33867925. |
amyloid-beta (aβ) 42/40 ratio, tau phosphorylated at threonine-181 (p-tau), and total-tau (t-tau) are considered core biomarkers for the diagnosis of alzheimer's disease (ad). |
2021-04-21 |
2023-08-13 |
human |
| Chelsea C Hays, Zvinka Z Zlatar, M J Meloy, Jessica Osuna, Thomas T Liu, Douglas R Galasko, Christina E Wiereng. Anterior Cingulate Structure and Perfusion is Associated with Cerebrospinal Fluid Tau among Cognitively Normal Older Adult APOEɛ4 Carriers. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-20. PMID:31743999. |
significant interactions of csf tau and apoe on cth/cbf were not observed in two posterior reference regions implicated in alzheimer's disease. |
2021-04-20 |
2023-08-13 |
Not clear |
| Eliot J Davidowitz, Pavan K Krishnamurthy, Patricia Lopez, Heidy Jimenez, Leslie Adrien, Peter Davies, James G Mo. In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice. Journal of Alzheimer's disease : JAD. vol 73. issue 1. 2021-04-20. PMID:31771053. |
tau oligomers have been shown to transmit tau pathology from diseased neurons to healthy neurons through seeding, tau misfolding, and aggregation that is thought to play an influential role in the progression of alzheimer's disease (ad) and related tauopathies. |
2021-04-20 |
2023-08-13 |
mouse |
| Taiki Shimizu, Keiko Hirose, Chiyoko Uchida, Takafumi Uchid. Growth arrest specific protein 7 inhibits tau fibrillogenesis. Biochemical and biophysical research communications. vol 526. issue 2. 2021-04-20. PMID:32216967. |
these results suggest that gas7 may serve to protect against alzheimer's disease and other tauopathies by preventing tau fibrillogenesis. |
2021-04-20 |
2023-08-13 |
Not clear |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
alzheimer's disease extracellular vesicles were significantly enriched in epitope-specific tau oligomers in comparison to prodromal alzheimer's disease or control extracellular vesicles as determined by dot blot and atomic force microscopy. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
alzheimer's disease extracellular vesicles were more efficiently internalized by murine cortical neurons, as well as more efficient in transferring and misfolding tau, than prodromal alzheimer's disease and control extracellular vesicles in vitro. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
strikingly, the inoculation of alzheimer's disease or prodromal alzheimer's disease extracellular vesicles containing only 300 pg of tau into the outer molecular layer of the dentate gyrus of 18-month-old c57bl/6 mice resulted in the accumulation of abnormally phosphorylated tau throughout the hippocampus by 4.5 months, whereas inoculation of an equal amount of tau from control extracellular vesicles, isolated tau oligomers, or fibrils from the same alzheimer's disease donor showed little tau pathology. |
2021-04-20 |
2023-08-13 |
mouse |
| Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I Luebke, Tsuneya Ikez. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33246331. |
furthermore, alzheimer's disease extracellular vesicles induced misfolding of endogenous tau in both oligomeric and sarkosyl-insoluble forms in the hippocampal region. |
2021-04-20 |
2023-08-13 |
mouse |
| Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöl. Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33257949. |
tau phosphorylated at threonine 181 (p-tau181) measured in blood plasma has recently been proposed as an accessible, scalable, and highly specific biomarker for alzheimer's disease. |
2021-04-20 |
2023-08-13 |
human |
| Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöl. Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33257949. |
we performed brain-wide analyses to investigate the associations of plasma p-tau181 baseline levels and longitudinal change with progression of regional amyloid-β pathology and tau burden 6 years later, and estimated the time course of changes in plasma p-tau181 and other alzheimer's disease biomarkers using a previously developed method for the construction of long-term biomarker temporal trajectories using shorter-term longitudinal data. |
2021-04-20 |
2023-08-13 |
human |
| Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöl. Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33257949. |
cross-sectional and particularly longitudinal measures of plasma p-tau181 were associated with widespread cortical tau aggregation 6 years later, covering temporoparietal regions typical for neurofibrillary tangle distribution in alzheimer's disease. |
2021-04-20 |
2023-08-13 |
human |
| Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suárez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Schöl. Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33257949. |
our findings suggest that plasma p-tau181 increases are associated with the presence of widespread cortical amyloid-β pathology and with prospective alzheimer's disease typical tau aggregation, providing clear implications for the use of this novel blood biomarker as a diagnostic and screening tool for alzheimer's disease. |
2021-04-20 |
2023-08-13 |
human |
| Joana B Pereira, Shorena Janelidze, Rik Ossenkoppele, Hlin Kvartsberg, Ann Brinkmalm, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33279949. |
untangling the association of amyloid-β and tau with synaptic and axonal loss in alzheimer's disease. |
2021-04-20 |
2023-08-13 |
Not clear |
| Joana B Pereira, Shorena Janelidze, Rik Ossenkoppele, Hlin Kvartsberg, Ann Brinkmalm, Niklas Mattsson-Carlgren, Erik Stomrud, Ruben Smith, Henrik Zetterberg, Kaj Blennow, Oskar Hansso. Untangling the association of amyloid-β and tau with synaptic and axonal loss in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 1. 2021-04-20. PMID:33279949. |
it is currently unclear how amyloid-β and tau deposition are linked to changes in synaptic function and axonal structure over the course of alzheimer's disease. |
2021-04-20 |
2023-08-13 |
Not clear |
| Allan K Hansen, Peter Parbo, Rola Ismail, Karen Østergaard, David J Brooks, Per Borghamme. Tau Tangles in Parkinson's Disease: A 2-Year Follow-Up Flortaucipir PET Study. Journal of Parkinson's disease. vol 10. issue 1. 2021-04-19. PMID:31815700. |
flortaucipir pet, a marker of tau tangles, has shown lower than expected cortical uptake in parkinson's disease (pd), than would be predicted from neuropathologic estimates of alzheimer's disease co-pathology. |
2021-04-19 |
2023-08-13 |
Not clear |