| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Filippa Lo Cascio, Stephanie Garcia, Mauro Montalbano, Nicha Puangmalai, Salome McAllen, Andrea Pace, Antonio Palumbo Piccionello, Rakez Kaye. Modulating disease-relevant tau oligomeric strains by small molecules. The Journal of biological chemistry. vol 295. issue 44. 2021-03-29. PMID:32737202. |
the pathological aggregation of tau plays an important role in alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. |
2021-03-29 |
2023-08-13 |
Not clear |
| Leonora Szabo, Anne Eckert, Amandine Grim. Insights into Disease-Associated Tau Impact on Mitochondria. International journal of molecular sciences. vol 21. issue 17. 2021-03-29. PMID:32882957. |
abnormal tau protein aggregation in the brain is a hallmark of tauopathies, such as frontotemporal lobar degeneration and alzheimer's disease. |
2021-03-29 |
2023-08-13 |
Not clear |
| Yelena Losev, Moran Frenkel-Pinter, Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Donna Elyashiv-Revivo, Rana Geries, Isam Khalaila, Ehud Gazit, Daniel Sega. Differential effects of putative N-glycosylation sites in human Tau on Alzheimer's disease-related neurodegeneration. Cellular and molecular life sciences : CMLS. vol 78. issue 5. 2021-03-29. PMID:32926180. |
differential effects of putative n-glycosylation sites in human tau on alzheimer's disease-related neurodegeneration. |
2021-03-29 |
2023-08-13 |
human |
| Yelena Losev, Moran Frenkel-Pinter, Malak Abu-Hussien, Guru Krishnakumar Viswanathan, Donna Elyashiv-Revivo, Rana Geries, Isam Khalaila, Ehud Gazit, Daniel Sega. Differential effects of putative N-glycosylation sites in human Tau on Alzheimer's disease-related neurodegeneration. Cellular and molecular life sciences : CMLS. vol 78. issue 5. 2021-03-29. PMID:32926180. |
amyloid assemblies of tau are associated with alzheimer's disease (ad). |
2021-03-29 |
2023-08-13 |
human |
| Young-Hee Shin, Hana Cho, Bo Young Choi, Jonghoon Kim, Jaeyoung Ha, Sang Won Suh, Seung Bum Par. Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling. Angewandte Chemie (International ed. in English). vol 60. issue 4. 2021-03-29. PMID:33210431. |
tau protein aggregates are a recognized neuropathological feature in alzheimer's disease as well as many other neurodegenerative disorders, known as tauopathies. |
2021-03-29 |
2023-08-13 |
mouse |
| Anna Fracassi, Michela Marcatti, Olga Zolochevska, Natalie Tabor, Randall Woltjer, Sandra Moreno, Giulio Taglialatel. Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 3. 2021-03-29. PMID:33239403. |
alzheimer's disease (ad) is characterized by progressive neurodegeneration in the cerebral cortex, histopathologically hallmarked by amyloid β (aβ) extracellular plaques and intracellular neurofibrillary tangles, constituted by hyperphosphorylated tau protein. |
2021-03-29 |
2023-08-13 |
human |
| Le Minh Tu Phan, Thi Xoan Hoang, Thuy Anh Thu Vo, Hoang Lan Pham, Hien T Ngoc Le, Somasekhar R Chinnadayyala, Jae Young Kim, Sang-Myung Lee, Won Woo Cho, Young Hyo Kim, Seong Hye Choi, Sungbo Ch. Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer's Disease. Expert review of molecular diagnostics. vol 21. issue 2. 2021-03-29. PMID:33560154. |
nanomaterial-based optical and electrochemical biosensors for amyloid beta and tau: potential for early diagnosis of alzheimer's disease. |
2021-03-29 |
2023-08-13 |
Not clear |
| Jiao Yuan, Yanpeng Wu, Lu Li, Chuanqin Li. MicroRNA-425-5p promotes tau phosphorylation and cell apoptosis in Alzheimer's disease by targeting heat shock protein B8. Journal of neural transmission (Vienna, Austria : 1996). vol 127. issue 3. 2021-03-26. PMID:31919655. |
microrna-425-5p promotes tau phosphorylation and cell apoptosis in alzheimer's disease by targeting heat shock protein b8. |
2021-03-26 |
2023-08-13 |
Not clear |
| Elizabeth B Glennon, Dawn H-W Lau, Rebecca M C Gabriele, Matthew F Taylor, Claire Troakes, Sarah Opie-Martin, Christina Elliott, Richard Killick, Diane P Hanger, Beatriz G Perez-Nievas, Wendy Nobl. Bridging Integrator-1 protein loss in Alzheimer's disease promotes synaptic tau accumulation and disrupts tau release. Brain communications. vol 2. issue 1. 2021-03-26. PMID:32500121. |
bridging integrator-1 protein loss in alzheimer's disease promotes synaptic tau accumulation and disrupts tau release. |
2021-03-26 |
2023-08-13 |
Not clear |
| Ahmad Mobed, Mohammad Hasanzade. Biosensing: The best alternative for conventional methods in detection of Alzheimer's disease biomarkers. International journal of biological macromolecules. vol 161. 2021-03-26. PMID:32504710. |
this review mainly focuses on major biomarkers in alzheimer's disease, routine and old methods in identifying biomarkers of ad and their advantages and limitation, and biosensors to the identification of amyloid beta, tau protein and micrnas biomarkers. |
2021-03-26 |
2023-08-13 |
Not clear |
| Adriana Savastano, David Flores, Harindranath Kadavath, Jacek Biernat, Eckhard Mandelkow, Markus Zweckstette. Disease-Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates. Angewandte Chemie (International ed. in English). vol 60. issue 2. 2021-03-26. PMID:33017094. |
the idp tau, which promotes the assembly of microtubules and is hyperphosphorylated in alzheimer's disease, undergoes llps in solution and on the surface of microtubules. |
2021-03-26 |
2023-08-13 |
Not clear |
| Engie Prifti, Eleni N Tsakiri, Ergina Vourkou, George Stamatakis, Martina Samiotaki, Katerina Papanikolopoulo. The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its Pathogenicity The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 4. 2021-03-26. PMID:33334867. |
the two cysteines of tau protein are functionally distinct and contribute differentially to its pathogenicity although tau accumulation is clearly linked to pathogenesis in alzheimer's disease and other tauopathies, the mechanism that initiates the aggregation of this highly soluble protein |
2021-03-26 |
2023-08-13 |
Not clear |
| Crystal M Vander Zanden, Eva Y Ch. Passive Immunotherapies Targeting Amyloid Beta and Tau Oligomers in Alzheimer's Disease. Journal of pharmaceutical sciences. vol 109. issue 1. 2021-03-25. PMID:31647950. |
passive immunotherapies targeting amyloid beta and tau oligomers in alzheimer's disease. |
2021-03-25 |
2023-08-13 |
Not clear |
| Matthew R Barron, Jane Gartlon, Lee A Dawson, Peter J Atkinson, Marie-Christine Pardo. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in immunology. vol 11. 2021-03-25. PMID:32194553. |
inflammation is considered a mechanistic driver of alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (nfts). |
2021-03-25 |
2023-08-13 |
mouse |
| Shu Lu, Xiaomin Yin, Jia Wang, Qun Gu, Qin Huang, Nana Jin, Dandan Chu, Ziqi Xu, Fei Liu, Wei Qia. SIRT1 regulates O-GlcNAcylation of tau through OGT. Aging. vol 12. issue 8. 2021-03-25. PMID:32310828. |
the o-glcnacylation levels of tau are decreased in alzheimer's disease (ad) brain. |
2021-03-25 |
2023-08-13 |
human |
| Mehrdad Ameri, Zahra Shabaninejad, Ahmad Movahedpour, Amirhossein Sahebkar, Soheila Mohammadi, Saereh Hosseindoost, Mohammad Saeid Ebrahimi, Amir Savardashtaki, Mohammad Karimipour, Hamed Mirzae. Biosensors for detection of Tau protein as an Alzheimer's disease marker. International journal of biological macromolecules. vol 162. 2021-03-25. PMID:32603732. |
biosensors for detection of tau protein as an alzheimer's disease marker. |
2021-03-25 |
2023-08-13 |
Not clear |
| Mehrdad Ameri, Zahra Shabaninejad, Ahmad Movahedpour, Amirhossein Sahebkar, Soheila Mohammadi, Saereh Hosseindoost, Mohammad Saeid Ebrahimi, Amir Savardashtaki, Mohammad Karimipour, Hamed Mirzae. Biosensors for detection of Tau protein as an Alzheimer's disease marker. International journal of biological macromolecules. vol 162. 2021-03-25. PMID:32603732. |
tau dysfunction is mainly associated with neurodegenerative diseases, particularly alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 2. 2021-03-25. PMID:33219003. |
studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of β-amyloid (aβ) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Sushil K Mishra, Yoshiki Yamaguchi, Makoto Higuchi, Naruhiko Sahar. Pick's Tau Fibril Shows Multiple Distinct PET Probe Binding Sites: Insights from Computational Modelling. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396273. |
positron emission tomography (pet) radiotracers that bind to tau filaments in alzheimer's disease (ad) are in common use, but pet tracers binding to tau filaments of rarer, age-related dementias, such as pick's disease, have not been widely explored. |
2021-03-25 |
2023-08-13 |
Not clear |
| Elaine Wan Ling Chan, Emilia Tze Ying Yeo, Kelly Wang Ling Wong, Mun Ling See, Ka Yan Wong, Jeremy Kean Yi Yap, Sook Yee Ga. Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells. Current Alzheimer research. 2021-03-25. PMID:33761853. |
in alzheimer's disease, accumulation of beta amyloid (aβ) triggers amyloidogenesis and hyperphosphorylation of tau protein leading to neuronal cell death. |
2021-03-25 |
2023-08-13 |
Not clear |