| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iván Fernández-Cruz, Enrique Reynau. Proteasome Subunits Involved in Neurodegenerative Diseases. Archives of medical research. vol 52. issue 1. 2021-03-24. PMID:32962866. |
proteasome subunits interact with proteins that are known to accumulate in neurodegenerative diseases such as α-synuclein in parkinson's, tau in alzheimer's, and huntingtin in huntington's diseases. |
2021-03-24 |
2023-08-13 |
Not clear |
| Noemi Esteras, Andrey Y Abramo. Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology. Cells. vol 9. issue 9. 2021-03-24. PMID:32967303. |
aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as alzheimer's disease (ad) and other tauopathies including frontotemporal dementia (ftd). |
2021-03-24 |
2023-08-13 |
Not clear |
| Saleha Anwar, Anas Shamsi, Rajiv K Kar, Aarfa Queen, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. International journal of biological macromolecules. vol 161. 2021-03-23. PMID:32535203. |
since the role of mark4 in the phosphorylation of tau protein and subsequently alzheimer's disease has been established, therefore, we have investigated the binding affinity and mark4 inhibitory potential of cholic acid (cha) using both computational and spectroscopic methods. |
2021-03-23 |
2023-08-13 |
Not clear |
| Friedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E Meyer, Eva Maria Mandelkow, Bettina Warscheid, Eckhard Mandelko. A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33106314. |
abnormal changes of neuronal tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in alzheimer's disease. |
2021-03-23 |
2023-08-13 |
human |
| Nora Lemke, Valeria Melis, Dilyara Lauer, Mandy Magbagbeolu, Boris Neumann, Charles R Harrington, Gernot Riedel, Claude M Wischik, Franz Theuring, Karima Schwa. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33127647. |
synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2021-03-23 |
2023-08-13 |
mouse |
| Michele Longoni Calió, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimélia Aparecida Porcionatt. Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease. Neurobiology of disease. vol 148. 2021-03-23. PMID:33301880. |
alzheimer's disease (ad) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (aβ) and neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-03-23 |
2023-08-13 |
mouse |
| Nicha Puangmalai, Nemil Bhatt, Mauro Montalbano, Urmi Sengupta, Sagar Gaikwad, Frank Ventura, Salome McAllen, Anna Ellsworth, Stephanie Garcia, Rakez Kaye. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell death & disease. vol 11. issue 5. 2021-03-22. PMID:32366836. |
internalization mechanisms of brain-derived tau oligomers from patients with alzheimer's disease, progressive supranuclear palsy and dementia with lewy bodies. |
2021-03-22 |
2023-08-13 |
Not clear |
| Nicha Puangmalai, Nemil Bhatt, Mauro Montalbano, Urmi Sengupta, Sagar Gaikwad, Frank Ventura, Salome McAllen, Anna Ellsworth, Stephanie Garcia, Rakez Kaye. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell death & disease. vol 11. issue 5. 2021-03-22. PMID:32366836. |
soluble tau aggregates (tau oligomers) are the most toxic species that initiate neurodegeneration in tauopathies, such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2021-03-22 |
2023-08-13 |
Not clear |
| Yun Kwon, Jisu Shin, Kwangho Nam, Joon Soo An, Seung-Hoon Yang, Seong-Heon Hong, Munhyung Bae, Kyuho Moon, Yakdol Cho, Jiwan Woo, Keunwan Park, Kyeonghwan Kim, Jongheon Shin, Byung-Yong Kim, YoungSoo Kim, Dong-Chan O. Rhizolutin, a Novel 7/10/6-Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease. Angewandte Chemie (International ed. in English). vol 59. issue 51. 2021-03-22. PMID:32844539. |
during an unbiased screening of natural product libraries, this novel compound was found to dissociate amyloid-β (aβ) plaques and tau tangles, which are key pathological hallmarks of alzheimer's disease (ad). |
2021-03-22 |
2023-08-13 |
mouse |
| Miao Zhang, Di Zhao, Guanghong Zhou, Chunbao L. Dietary Pattern, Gut Microbiota, and Alzheimer's Disease. Journal of agricultural and food chemistry. vol 68. issue 46. 2021-03-19. PMID:32090565. |
evidence suggests that diet may affect β-amyloid production and tau processing or may regulate inflammation, metabolism, and oxidative stress associated with alzheimer's disease, which can be exerted by gut microbiota. |
2021-03-19 |
2023-08-13 |
Not clear |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
alzheimer's disease, categorized by the piling of amyloid-β (aβ), hyperphosphorylated tau, phfs, nfts and mtor hyperactivity, is a neurodegenerative disorder, affecting people across the globe. |
2021-03-19 |
2023-08-13 |
Not clear |
| Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Ito. Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer's Disease with APP Osaka Mutation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580499. |
heavy tau burden with subtle amyloid β accumulation in the cerebral cortex and cerebellum in a case of familial alzheimer's disease with app osaka mutation. |
2021-03-19 |
2023-08-13 |
Not clear |
| Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Ito. Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer's Disease with APP Osaka Mutation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580499. |
to further explore the relationship between aβ, tau and neurodegeneration, we performed tau and aβ pet imaging in the proband of fad (osaka) and in patients with sporadic alzheimer's disease (sad) and healthy controls (hcs). |
2021-03-19 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia. International journal of molecular sciences. vol 21. issue 13. 2021-03-19. PMID:32605320. |
in this review, we summarize protein changes associated with alzheimer's disease and their gene expression (amyloid protein precursor and tau protein) after brain ischemia, and their roles in the postischemic period. |
2021-03-19 |
2023-08-13 |
Not clear |
| Rola Ismail, Peter Parbo, Lasse Stensvig Madsen, Allan K Hansen, Kim V Hansen, Jeppe L Schaldemose, Pernille L Kjeldsen, Morten G Stokholm, Hanne Gottrup, Simon F Eskildsen, David J Brook. The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study. Journal of neuroinflammation. vol 17. issue 1. 2021-03-18. PMID:32375809. |
the relationships between neuroinflammation, beta-amyloid and tau deposition in alzheimer's disease: a longitudinal pet study. |
2021-03-18 |
2023-08-13 |
Not clear |
| Rola Ismail, Peter Parbo, Lasse Stensvig Madsen, Allan K Hansen, Kim V Hansen, Jeppe L Schaldemose, Pernille L Kjeldsen, Morten G Stokholm, Hanne Gottrup, Simon F Eskildsen, David J Brook. The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer's disease: a longitudinal PET study. Journal of neuroinflammation. vol 17. issue 1. 2021-03-18. PMID:32375809. |
the aim of this longitudinal study was to assess with positron emission tomography (pet) the relationship between levels of inflammation and the loads of aggregated β-amyloid and tau at baseline and again after 2 years in prodromal alzheimer's disease. |
2021-03-18 |
2023-08-13 |
Not clear |
| Madhuri Chakravarthy, Suxiang Chen, Tao Wang, Rakesh N Veed. Development of Novel Chemically-Modified Nucleic Acid Molecules for Efficient Inhibition of Human Genes. vol 11. issue 6. 2021-03-18. PMID:32575375. |
development of novel chemically-modified nucleic acid molecules for efficient inhibition of human the hyperphosphorylation of the microtubule-associated protein tau (mapt) has been implicated in various neurological diseases, including alzheimer's disease. |
2021-03-18 |
2023-08-13 |
human |
| Sabine M Ulamec, David J Brockwell, Sheena E Radfor. Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins. Frontiers in neuroscience. vol 14. 2021-03-17. PMID:33335475. |
amyloid proteins are involved in many neurodegenerative disorders such as alzheimer's disease [tau, amyloid β (aβ)], parkinson's disease [alpha-synuclein (αsyn)], and amyotrophic lateral sclerosis (tdp-43). |
2021-03-17 |
2023-08-13 |
Not clear |
| Yanchao Liu, Shujuan Zhang, Xiaoguang Li, Enjie Liu, Xin Wang, Qiuzhi Zhou, Jinwang Ye, Jian-Zhi Wan. Peripheral inflammation promotes brain tau transmission via disrupting blood-brain barrier. Bioscience reports. vol 40. issue 2. 2021-03-16. PMID:32043530. |
abnormal aggregation of pathological tau protein is a neuropathological feature of alzheimer's disease (ad). |
2021-03-16 |
2023-08-13 |
human |
| Toshiya Oba, Taro Saito, Akiko Asada, Sawako Shimizu, Koichi M Iijima, Kanae And. Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration. The Journal of biological chemistry. vol 295. issue 50. 2021-03-16. PMID:33020179. |
microtubule affinity-regulating kinase 4 with an alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration. |
2021-03-16 |
2023-08-13 |
Not clear |