| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiya Oba, Taro Saito, Akiko Asada, Sawako Shimizu, Koichi M Iijima, Kanae And. Microtubule affinity-regulating kinase 4 with an Alzheimer's disease-related mutation promotes tau accumulation and exacerbates neurodegeneration. The Journal of biological chemistry. vol 295. issue 50. 2021-03-16. PMID:33020179. |
accumulation of the microtubule-associated protein tau is associated with alzheimer's disease (ad). |
2021-03-16 |
2023-08-13 |
Not clear |
| Caitlin V M L Jie, Valerie Treyer, Roger Schibli, Linjing M. Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 14. issue 2. 2021-03-16. PMID:33573211. |
tauvid™: the first fda-approved pet tracer for imaging tau pathology in alzheimer's disease. |
2021-03-16 |
2023-08-13 |
Not clear |
| Caitlin V M L Jie, Valerie Treyer, Roger Schibli, Linjing M. Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 14. issue 2. 2021-03-16. PMID:33573211. |
tauvid has been approved by the u.s. food and drug administration (fda) in 2020 for positron emission tomography (pet) imaging of adult patients with cognitive impairments undergoing evaluation for alzheimer's disease (ad) based on tau pathology. |
2021-03-16 |
2023-08-13 |
Not clear |
| Liqing Song, Evan A Wells, Anne Skaja Robinso. Critical Molecular and Cellular Contributors to Tau Pathology. Biomedicines. vol 9. issue 2. 2021-03-16. PMID:33672982. |
tauopathies represent a group of neurodegenerative diseases including alzheimer's disease (ad) that are characterized by the deposition of filamentous tau aggregates in the brain. |
2021-03-16 |
2023-08-13 |
Not clear |
| Junjun Ni, Zhou W. Inflammation Spreading: Negative Spiral Linking Systemic Inflammatory Disorders and Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-03-16. PMID:33716675. |
there is increasing evidence suggesting that chronic neuroinflammation is the most relevant pathological feature of alzheimer's disease (ad), regulating other pathological features, such as the accumulation of amyloid-β (aβ) and hyperphosphorylation of tau. |
2021-03-16 |
2023-08-13 |
cat |
| Francesca Munari, Carlo G Barracchia, Cinzia Franchin, Francesca Parolini, Stefano Capaldi, Alessandro Romeo, Luigi Bubacco, Michael Assfalg, Giorgio Arrigoni, Mariapina D'Onofri. Semisynthetic and Enzyme-Mediated Conjugate Preparations Illuminate the Ubiquitination-Dependent Aggregation of Tau Protein. Angewandte Chemie (International ed. in English). vol 59. issue 16. 2021-03-15. PMID:32022419. |
in the brain of individuals with alzheimer's disease, the regulatory protein ubiquitin is found conjugated to different lysine residues of tau protein assembled into pathological paired helical filaments. |
2021-03-15 |
2023-08-13 |
Not clear |
| Diana Acosta, Tapojyoti Das, David Elieze. Probing IDP Interactions with Membranes by Fluorescence Spectroscopy. Methods in molecular biology (Clifton, N.J.). vol 2141. 2021-03-15. PMID:32696377. |
the microtubule-associated protein tau has been extensively studied as a culprit in alzheimer's disease and other neurodegenerative diseases known as tauopathies. |
2021-03-15 |
2023-08-13 |
Not clear |
| Sanjula P Wickramasinghe, Elizabeth Rhoade. Measuring Interactions Between Tau and Aggregation Inducers with Single-Molecule Förster Resonance Energy Transfer. Methods in molecular biology (Clifton, N.J.). vol 2141. 2021-03-15. PMID:32696388. |
tau is an intrinsically disordered protein implicated in the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2021-03-15 |
2023-08-13 |
Not clear |
| Tamara Šmidlehner, Hugues Bonnet, Sabine Chierici, Ivo Piantanid. Fluorescently-labelled amyloid paired helical filaments (PHF) in monitoring its fibrillation kinetics. Bioorganic chemistry. vol 104. 2021-03-15. PMID:32911188. |
the core of the tau fibrils in alzheimer disease is a hexapeptide sequence organized in paired helical filaments (phf). |
2021-03-15 |
2023-08-13 |
Not clear |
| Jagan A Pillai, Mykol Larvie, Jacqueline Chen, Anna Crawford, Jeffery L Cummings, Stephen E Jone. Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244036. |
to estimate regional alzheimer disease (ad) pathology burden clinically, analysis methods that enable tracking brain amyloid or tau positron emission tomography (pet) with magnetic resonance imaging (mri) measures are needed. |
2021-03-15 |
2023-08-13 |
Not clear |
| Mahmood Haj-Yahya, Pushparathinam Gopinath, Kolla Rajasekhar, Hilda Mirbaha, Marc I Diamond, Hilal A Lashue. Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding. Angewandte Chemie (International ed. in English). vol 59. issue 10. 2021-03-12. PMID:31863676. |
the consistent observation of phosphorylated tau in the pathology of alzheimer's disease has contributed to the emergence of a model where hyperphosphorylation triggers both tau disassociation from microtubules and its subsequent aggregation. |
2021-03-12 |
2023-08-13 |
Not clear |
| Laura Strohm, Christian Behrend. Glia-specific autophagy dysfunction in ALS. Seminars in cell & developmental biology. vol 99. 2021-03-11. PMID:31132469. |
prominent examples are amyloid beta and tau in alzheimer's disease, α-synuclein in parkinson's disease and transactive response dna binding protein 43 kda (tdp-43) in als and ftd. |
2021-03-11 |
2023-08-13 |
Not clear |
| Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstette. Biomolecular condensation of the microtubule-associated protein tau. Seminars in cell & developmental biology. vol 99. 2021-03-11. PMID:31260737. |
recent evidence suggests that the protein tau, which plays an important role in alzheimer's disease and other neurodegenerative disorders, phase separates in solution, forms tau phases with microtubules, and associates with phase-separated rna-binding protein granules in cells. |
2021-03-11 |
2023-08-13 |
Not clear |
| Joseph Therriault, Andrea L Benedet, Tharick A Pascoal, Sulantha Mathotaarachchi, Melissa Savard, Mira Chamoun, Emilie Thomas, Min Su Kang, Firoza Lussier, Cecile Tissot, Jean-Paul Soucy, Gassan Massarweh, Soham Rej, Paramita Saha-Chaudhuri, Judes Poirier, Serge Gauthier, Pedro Rosa-Net. APOEε4 potentiates the relationship between amyloid-β and tau pathologies. Molecular psychiatry. 2021-03-11. PMID:32161362. |
however, the association between apoeε4 and tau pathology, the other major proteinopathy of alzheimer's disease, has been controversial. |
2021-03-11 |
2023-08-13 |
human |
| Maud Gratuze, David M Holtzma. Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits. Neuron. vol 109. issue 5. 2021-03-11. PMID:33662267. |
synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in alzheimer's disease and tauopathies. |
2021-03-11 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
transition metal nickel prevents tau aggregation in alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
the multifaceted effectors of alzheimer's disease primarily include tau, amyloid-β along with hyper activation of kinases, oxidative stress and mutations etc., makes it challenging to design therapeutics. |
2021-03-10 |
2023-08-13 |
Not clear |
| b' Elisabetta Lauretti, Domenico Pratic\\xc3\\xb. Alzheimer\'s disease: phenotypic approaches using disease models and the targeting of tau protein. Expert opinion on therapeutic targets. vol 24. issue 4. 2021-03-10. PMID:32116063.' |
alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein. |
2021-03-10 |
2023-08-13 |
Not clear |
| Pranglada Jearjaroen, Kanet Pakdeepak, Chainarong Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Jiraporn Tocharu. Inhibitory Effect of Hexahydrocurcumin on Memory Impairment and Amyloidogenesis in Dexamethasone-Treated Mice. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:32852718. |
a dexamethasone administration model induces overproduction of amyloid-β (aβ) and tau protein hyperphosphorylation and shows abnormalities of cholinergic function similar to alzheimer's disease (ad). |
2021-03-10 |
2023-08-13 |
mouse |
| Mohammed Amir Husain, Benoit Laurent, Mélanie Plourd. APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in neuroscience. vol 15. 2021-03-10. PMID:33679311. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (aβ) and intraneuronal tau protein aggregations. |
2021-03-10 |
2023-08-13 |
Not clear |