| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Murray Andrews, Ryan Ross, Atul Malhotra, Sonia Ancoli-Israel, James B Brewer, Sarah J Bank. Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-03-10. PMID:33681715. |
sleep and tau pathology in vietnam war veterans with preclinical and prodromal alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
correlation of alzheimer disease neuropathologic staging with amyloid and tau scintigraphic imaging biomarkers. |
2021-03-09 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
these elements are the extent of involvement (spread) by cerebral aβ based on the progression model defined by the thal aβ phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. |
2021-03-09 |
2023-08-13 |
Not clear |
| Henryk Barthe. First Tau PET Tracer Approved: Toward Accurate In Vivo Diagnosis of Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:33004646. |
first tau pet tracer approved: toward accurate in vivo diagnosis of alzheimer disease. |
2021-03-09 |
2023-08-13 |
Not clear |
| Che-Wei Chang, Eric Shao, Lennart Muck. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). vol 371. issue 6532. 2021-03-09. PMID:33632820. |
several lines of evidence implicate the protein tau in the pathogenesis of multiple brain disorders, including alzheimer's disease, other neurodegenerative conditions, autism, and epilepsy. |
2021-03-09 |
2023-08-13 |
Not clear |
| Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049030. |
alzheimer's disease (ad) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. |
2021-03-08 |
2023-08-13 |
mouse |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Gut microbiota and pro/prebiotics in Alzheimer's disease. Aging. vol 12. issue 6. 2021-03-08. PMID:32191919. |
alzheimer's disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. |
2021-03-08 |
2023-08-13 |
Not clear |
| Caitlin N Suire, Malcolm A Leissrin. Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease. Journal of experimental neurology. vol 2. issue 1. 2021-03-08. PMID:33665647. |
alzheimer disease (ad) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (aβ) and intraneuronal accumulation of the microtubule-associated protein, tau. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chih Hung Lo, Jonathan N Sach. The role of wild-type tau in Alzheimer's disease and related tauopathies. Journal of life sciences (Westlake Village, Calif.). vol 2. issue 4. 2021-03-08. PMID:33665646. |
the role of wild-type tau in alzheimer's disease and related tauopathies. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chih Hung Lo, Jonathan N Sach. The role of wild-type tau in Alzheimer's disease and related tauopathies. Journal of life sciences (Westlake Village, Calif.). vol 2. issue 4. 2021-03-08. PMID:33665646. |
tau oligomers have recently emerged as the principal toxic species in alzheimer's disease (ad) and tauopathies. |
2021-03-08 |
2023-08-13 |
Not clear |
| Pankaj Teli, Nusrat Sahiba, Jay Soni, Ayushi Sethiya, Dinesh Kumar Agarwal, Shikha Agarwa. Exploration of Potent Multi-Target-Directed-Ligands as Anti-Alzheimer's Disease Agents: A Moiety Based Review. Mini reviews in medicinal chemistry. 2021-03-05. PMID:33663363. |
alzheimer's disease deteriorates cognitive functions with the passage of time and consists of multifaceted factors such as decline of acetylcholine level, amyloid β-aggregation, tau hyperphosphorylation, oxidative stress, etc. |
2021-03-05 |
2023-08-13 |
Not clear |
| Hui Wang, Ling Xiao, Huiling Wang, Gaohua Wan. Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model. Physiology & behavior. vol 215. 2021-03-04. PMID:31770536. |
low-density lipoprotein receptor-related protein 1 (lrp1) and tau play an important role in developing alzheimer's disease. |
2021-03-04 |
2023-08-13 |
rat |
| Ching-On Won. Endosomal-Lysosomal Processing of Neurodegeneration-Associated Proteins in Astrocytes. International journal of molecular sciences. vol 21. issue 14. 2021-03-04. PMID:32708198. |
this review aims at summarizing the mounting evidence that has established the essential role of astrocytic endosomal-lysosomal organelles in the processing of amyloid precursor proteins, apolipoprotein e (apoe), tau, alpha synuclein, and huntingtin, which are associated with nds such as alzheimer's, parkinson's, and huntington diseases. |
2021-03-04 |
2023-08-13 |
Not clear |
| G Siano, M Varisco, A Scarlatti, M C Caiazza, K Dunville, F Cremisi, M Costa, L Pancrazi, C Di Primio, A Cattane. Gene Expression of Disease-related Genes in Alzheimer's Disease is Impaired by Tau Aggregation. Journal of molecular biology. vol 432. issue 24. 2021-03-04. PMID:33058882. |
gene expression of disease-related genes in alzheimer's disease is impaired by tau aggregation. |
2021-03-04 |
2023-08-13 |
Not clear |
| b' Anna Chiarini, Ubaldo Armato, Peng Hu, Ilaria Dal Pr\\xc3\\xa. Danger-Sensing/Patten Recognition Receptors and Neuroinflammation in Alzheimer\'s Disease. International journal of molecular sciences. vol 21. issue 23. 2021-03-04. PMID:33261147.' |
fibrillar aggregates and soluble oligomers of both amyloid-β peptides (aβs) and hyperphosphorylated tau proteins (p-tau-es), as well as a chronic neuroinflammation are the main drivers causing progressive neuronal losses and dementia in alzheimer's disease (ad). |
2021-03-04 |
2023-08-13 |
human |
| Jitendra Subhash Rane, Anuradha Kumari, Dulal Pand. The Acetyl Mimicking Mutation, K274Q in Tau, Enhances the Metal Binding Affinity of Tau and Reduces the Ability of Tau to Protect DNA. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31886644. |
the aggregation of tau, a microtubule-associated protein, is known to play an important role in several neurological disorders including alzheimer's disease. |
2021-03-03 |
2023-08-13 |
Not clear |
| Jitendra Subhash Rane, Anuradha Kumari, Dulal Pand. The Acetyl Mimicking Mutation, K274Q in Tau, Enhances the Metal Binding Affinity of Tau and Reduces the Ability of Tau to Protect DNA. ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31886644. |
tau is predominately acetylated at the k274 residue in alzheimer's disease, and the acetylation of the k274 residue is thought to be linked with dementia. |
2021-03-03 |
2023-08-13 |
Not clear |
| Vasko Kramer, Allen F Brooks, Arlette Haeger, Rodrigo O Kuljis, Waqas Rafique, Robert A Koeppe, David M Raffel, Kirk A Frey, Horacio Amaral, Peter J H Scott, Patrick J Ris. Evaluation of [ ACS chemical neuroscience. vol 11. issue 3. 2021-03-03. PMID:31898886. |
evaluation of [ development of positron emission tomography (pet) imaging agents capable of quantifying tau aggregates in neurodegenerative disorders such as alzheimer's disease (ad) is of enormous importance in the field of dementia research. |
2021-03-03 |
2023-08-13 |
Not clear |
| Mohammad Arastoo, Richard Lofthouse, Lewis K Penny, Charles R Harrington, Andy Porter, Claude M Wischik, Soumya Palliyi. Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 22. 2021-03-03. PMID:33212983. |
this review emphasises the need for a more comprehensive analysis and interrogation of tau within biological fluids, to aid in obtaining a disease specific molecular signature for each stage of alzheimer's disease. |
2021-03-03 |
2023-08-13 |
Not clear |
| Jun Maeda, Takeharu Minamihisamatsu, Masafumi Shimojo, Xiaoyun Zhou, Maiko Ono, Yukio Matsuba, Bin Ji, Hideki Ishii, Masanao Ogawa, Hiroyasu Akatsu, Daita Kaneda, Yoshio Hashizume, John L Robinson, Virginia M-Y Lee, Takashi Saito, Takaomi C Saido, John Q Trojanowski, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi, Naruhiko Sahar. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain communications. vol 3. issue 1. 2021-03-03. PMID:33644757. |
distinct microglial response against alzheimer's amyloid and tau pathologies characterized by p2y12 receptor. |
2021-03-03 |
2023-08-13 |
Not clear |