| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maud Gratuze, David M Holtzma. Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits. Neuron. vol 109. issue 5. 2021-03-11. PMID:33662267. |
synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in alzheimer's disease and tauopathies. |
2021-03-11 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
transition metal nickel prevents tau aggregation in alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
the multifaceted effectors of alzheimer's disease primarily include tau, amyloid-β along with hyper activation of kinases, oxidative stress and mutations etc., makes it challenging to design therapeutics. |
2021-03-10 |
2023-08-13 |
Not clear |
| b' Elisabetta Lauretti, Domenico Pratic\\xc3\\xb. Alzheimer\'s disease: phenotypic approaches using disease models and the targeting of tau protein. Expert opinion on therapeutic targets. vol 24. issue 4. 2021-03-10. PMID:32116063.' |
alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein. |
2021-03-10 |
2023-08-13 |
Not clear |
| Pranglada Jearjaroen, Kanet Pakdeepak, Chainarong Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Jiraporn Tocharu. Inhibitory Effect of Hexahydrocurcumin on Memory Impairment and Amyloidogenesis in Dexamethasone-Treated Mice. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:32852718. |
a dexamethasone administration model induces overproduction of amyloid-β (aβ) and tau protein hyperphosphorylation and shows abnormalities of cholinergic function similar to alzheimer's disease (ad). |
2021-03-10 |
2023-08-13 |
mouse |
| Mohammed Amir Husain, Benoit Laurent, Mélanie Plourd. APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in neuroscience. vol 15. 2021-03-10. PMID:33679311. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (aβ) and intraneuronal tau protein aggregations. |
2021-03-10 |
2023-08-13 |
Not clear |
| Lanier Heyburn, Rania Abutarboush, Samantha Goodrich, Rodrigo Urioste, Andrew Batuure, Jaimena Wheel, Donna M Wilder, Peethambaran Arun, Stephen T Ahlers, Joseph B Long, Venkatasivasai Sujith Sajj. Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model. Frontiers in cellular neuroscience. vol 15. 2021-03-10. PMID:33679327. |
while repeated exposure to 8.5 psi bop led to a reduction in the alzheimer's disease (ad)-related proteins amyloid-β (aβ)40 and aβ42, these changes were not observed in the 10 psi group, which had a significant reduction in phosphorylated tau. |
2021-03-10 |
2023-08-13 |
rat |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Brain Ischemia as a Prelude to Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-03-10. PMID:33679381. |
recent studies on post-ischemic brain neurodegeneration have revealed the dysregulation of alzheimer's disease-associated genes such as amyloid protein precursor, α-secretase, β-secretase, presenilin 1, presenilin 2, and tau protein. |
2021-03-10 |
2023-08-13 |
rat |
| Jisu Shin, Seung-Hoon Yang, Young Eun Du, Keunwan Park, DaWon Kim, Daniel Shin, Jungwoo Kim, Seong-Hwan Kim, Yun Kyung Kim, Jongheon Shin, Dong-Chan Oh, YoungSoo Ki. Borrelidin from Saltern-Derived Halophilic Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-03-10. PMID:33681712. |
borrelidin from saltern-derived halophilic alzheimer's disease (ad) is characterized by the aggregation of two pathological proteins, amyloid-β (aβ) and tau, leading to neuronal and cognitive dysfunction. |
2021-03-10 |
2023-08-13 |
Not clear |
| Murray Andrews, Ryan Ross, Atul Malhotra, Sonia Ancoli-Israel, James B Brewer, Sarah J Bank. Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-03-10. PMID:33681715. |
sleep and tau pathology in vietnam war veterans with preclinical and prodromal alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
correlation of alzheimer disease neuropathologic staging with amyloid and tau scintigraphic imaging biomarkers. |
2021-03-09 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
these elements are the extent of involvement (spread) by cerebral aβ based on the progression model defined by the thal aβ phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. |
2021-03-09 |
2023-08-13 |
Not clear |
| Henryk Barthe. First Tau PET Tracer Approved: Toward Accurate In Vivo Diagnosis of Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:33004646. |
first tau pet tracer approved: toward accurate in vivo diagnosis of alzheimer disease. |
2021-03-09 |
2023-08-13 |
Not clear |
| Che-Wei Chang, Eric Shao, Lennart Muck. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). vol 371. issue 6532. 2021-03-09. PMID:33632820. |
several lines of evidence implicate the protein tau in the pathogenesis of multiple brain disorders, including alzheimer's disease, other neurodegenerative conditions, autism, and epilepsy. |
2021-03-09 |
2023-08-13 |
Not clear |
| Isabel Castanho, Tracey K Murray, Eilis Hannon, Aaron Jeffries, Emma Walker, Emma Laing, Hedley Baulf, Joshua Harvey, Lauren Bradshaw, Andrew Randall, Karen Moore, Paul O'Neill, Katie Lunnon, David A Collier, Zeshan Ahmed, Michael J O'Neill, Jonathan Mil. Transcriptional Signatures of Tau and Amyloid Neuropathology. Cell reports. vol 30. issue 6. 2021-03-08. PMID:32049030. |
alzheimer's disease (ad) is associated with the intracellular aggregation of hyperphosphorylated tau and the accumulation of β-amyloid in the neocortex. |
2021-03-08 |
2023-08-13 |
mouse |
| Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J Czuczwa. Gut microbiota and pro/prebiotics in Alzheimer's disease. Aging. vol 12. issue 6. 2021-03-08. PMID:32191919. |
alzheimer's disease is characterized by the accumulation of amyloid and dysfunctional tau protein in the brain along with the final development of dementia. |
2021-03-08 |
2023-08-13 |
Not clear |
| Caitlin N Suire, Malcolm A Leissrin. Cathepsin D: A Candidate Link between Amyloid β-protein and Tauopathy in Alzheimer Disease. Journal of experimental neurology. vol 2. issue 1. 2021-03-08. PMID:33665647. |
alzheimer disease (ad) is a debilitating neurodegenerative disorder characterized by extracellular deposition of the amyloid β-protein (aβ) and intraneuronal accumulation of the microtubule-associated protein, tau. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chih Hung Lo, Jonathan N Sach. The role of wild-type tau in Alzheimer's disease and related tauopathies. Journal of life sciences (Westlake Village, Calif.). vol 2. issue 4. 2021-03-08. PMID:33665646. |
the role of wild-type tau in alzheimer's disease and related tauopathies. |
2021-03-08 |
2023-08-13 |
Not clear |
| Chih Hung Lo, Jonathan N Sach. The role of wild-type tau in Alzheimer's disease and related tauopathies. Journal of life sciences (Westlake Village, Calif.). vol 2. issue 4. 2021-03-08. PMID:33665646. |
tau oligomers have recently emerged as the principal toxic species in alzheimer's disease (ad) and tauopathies. |
2021-03-08 |
2023-08-13 |
Not clear |
| Pankaj Teli, Nusrat Sahiba, Jay Soni, Ayushi Sethiya, Dinesh Kumar Agarwal, Shikha Agarwa. Exploration of Potent Multi-Target-Directed-Ligands as Anti-Alzheimer's Disease Agents: A Moiety Based Review. Mini reviews in medicinal chemistry. 2021-03-05. PMID:33663363. |
alzheimer's disease deteriorates cognitive functions with the passage of time and consists of multifaceted factors such as decline of acetylcholine level, amyloid β-aggregation, tau hyperphosphorylation, oxidative stress, etc. |
2021-03-05 |
2023-08-13 |
Not clear |